What NOT to take with LDN!!

[Guest guest]

Do not take LDN (Naltrexone) with any of the following:

• disulfiram (Antabuse);• thioridazine (Mellaril);• buprenorphine (Buprenex, Subutrex);• codeine (Tylenol with Codeine, and other brand names);• hydrocodone (Lorcet, Lortab, Vicodin, Vicoprofen, and other brand names);• hydromorphone (Dilaudid);• levorphanol (Levo-Dromoran);• meperidine (Demerol);• methadone (Dolophine, Methadose);• morphine (Kadian, MS Contin, MSIR, OMS, Roxanol, Oramorph SR, and other brand names);• oxycodone (M-Oxy, OxyContin, OxyIR, Roxicodone, Percocet, Percodan, and other brand names);• oxymorphone (Numorphan); or• propoxyphene (Darvon, and other brand names).

· Ultram (tramadol)

· Novantrone

· Rebif

· Avonex

· Betaseron

· Tysabri

· Chemo's

· Cellcept is a chemotherapy

· methotrexate

· Remicade - Called Skip's Pharmacy at the suggestion of people in this group, and the pharmacist there told me you have to be off Remicade for 50 days before starting LDN. Since the two meds have opposing effects on the immune system, LDN won't work while on Remicade. http://www.skipspha rmacy.com/

· 6MP - called Skip's about 6MP they said you should be off it for about a week before starting LDN.It sounded like you wouldn't want to take 6MP concurrent with LDN, since 6MP is an immunosuppressant and would have opposing effect on immune system as LDN.

· Humira

Dr. Jill said to stop Humira for 2 weeks before starting on LDN.

And this was the reply someone got when they asked the question if we had to stop Humira before starting LDN on the LDN website:

A person with Crohn's who receives Humira can begin LDN immediately (because H. is not a narcotic and thus is not contraindicated) -- however, Humira's effects in suppressing the immune system can seriously blunt the potential benefits from LDN (which should strengthen the immune system). The sooner off Humira, which is dangerous, the better.

Ø Cautionary warnings:

Because LDN blocks opioid receptors throughout the body for three or four hours, people using medicine that is an opioid agonist, i.e. narcotic medication — such as Ultram (tramadol), morphine, Percocet, Duragesic patch or codeine-containing medication — should not take LDN until such medicine is completely out of one's system. Patients who have become dependant on daily use of narcotic-containing pain medication may require 10 days to 2 weeks of slowly weaning off of such drugs entirely (while first substituting full doses of non-narcotic pain medications) before being able to begin LDN safely.

I believe that steroids, short term, are ok with LDN.

Dr. Skip

Drugs that may interact with Low Dose Naltrexone

Generic Name

Brand Name*

Mixed Opiate Agonists/Antagonists

Buprenorphine

Buprenex®, Suboxone®, Subutex®

Butorphanol

Dorolex®, Stadol®

Nalbuphine

Nubain®

Pentazocine

Naloxone®, Talwin®

Opiate Agonists

Alfentinil

Alfenta®

Clonidine

Catapres®

Codeine

N/A

Dronabinol, THC

Marinol®

Fentanyl

Duragesic®, Aqtic®, Sublimaze®, Fentora®

Hydrocodone

Lorcet®, Lortab®, Vicodin®

Hydromorphone

Dilaudid®

Levorphanol

Levo-Dromoran®

Meperidine

Demerol®, Meperitab®

Methadone

Dolophine®, Methodose®

Morphine

Kadian®, MSContin®

Oxycodone

Percocet®, Endocet®, Roxicodone®, Endocodone®

Oxymorphone

Opana®, Numorphone®

Propoxyphene

Darvocet®, Darvon®

Remifentinil

Ultiva®

Sufentinil

Sufenta®

Other Medications

Disulfuram

Antabuse®

Dronabinol, THC

Marinol®

Nabilone

Cesamet®

Thioridazine

Mellaril®

Clonidine

Catapres®

* May not include each brand name available on the market in the United States

References:

Clinical Pharmacology Online @ www.clinicalpharmacology.com (accessed 06/14/07)

In addition, because LDN stimulates the immune system and many of the drugs routinely used by the NHS in the treatment of MS further suppress the immune system, LDN cannot be used in company with steroids, beta interferon, methotrexate, azathioprine or mitozantrone or any other immune suppressant drug. If there is any doubt, please submit a full list of the drugs you are presently taking so that their compatibility may be assessed. In addition, because LDN will also block the analgesic effects of any opiate drugs (includes codeine, dihydrocodeine, morphine, pethidine or diamorphine) presently being taken, the use of LDN will initially greatly increase the level of pain experienced. It is therefore advisable that any opiate-like drugs be discontinued at least two weeks before this treatment is

initiated."

OTHER CAUTIONARIES:

Imodium ADNaltrexone tested at 25+ mg blocks the effect of loperamide hydrochloride (Imodium) against diarrhea. Bismuth compounds (Pepto-Bismol) may be used for mild nausea or diarrhea, and octreotide acetate (Sandostatin) may be used for severe diarrhea, and ondansetron hydrochloride (Zofran) may be used for nausea and vomiting, especially with accidental naltrexone-precipitated opiate withdrawal. It is unestablished whether Imodium AD at doses of under 5 mg would have the same effect..

This below is written by Dr. Bob Lawrence.When starting this LDN(Low Dose Naltrexone) therapy in the treatment of MS, there may also be some initial transient, though temporary, increase in MS symptoms. Experience in using this method has demonstrated most commonly, such as disturbed sleep, occasionally with vivid, bizarre and disturbing dreams, tiredness, fatigue, spasm and pain. These increased symptoms would not normally be expected to last more than seven to ten days.Rarely, other transient symptoms have included more severe pain and spasm, headache, diarrhea or vomiting. These additional symptoms would appear to be associated with the previous frequent use of strong analgesics, which effectively create an addiction and dependency, thus increasing the body's sensitivity to pain. This

temporary increase in symptoms may also perhaps be explained when we consider the manner in which this drug is expected to work.In addition, because LDN will also block the analgesic effects of any opiate drugs (includes codeine, dihydrocodeine, morphine, pethidine or diamorphine) presently being taken, the use of LDN will initially greatly increase the level of pain experienced. It is therefore advisable that any opiate-like drugs be discontinued at least two weeks before this treatment is initiated. When starting the treatment it is essential that any untoward or adverse side-effects are reported immediately so that the treatment process can be further assessed and, if necessary, modified.

May there be a miracle in YOUR life today and may you have the EYES to see it.From My Heart to Yours Love, Hugs & Blessings, CrystalLDN_Users Group OwnerDiagnosed November 2004 with Secondary Progressive MS, Transverse Myelitis and an Advocate for LDN!! 3 years 6 months on LDN with Skip's Pharmacy.....No Relapses.....Crystal's MS,TM & LDN Websitehttp://www.freewebs.com/crystalangel6267/index.htm LDN Website http://ww.ldninfo.org/Crystal's LDN Support GroupLDN_Users/

LDN MySpace

http://www.myspace.com/low dose naltrexone

Cris - Case Health - Health Success Storieshttp://casehealth.com/case/about..html

Low Dose Naltrexone Database

http://ldn-database.carnebeach.com/

Up the Creek with a Paddle

http://www.marybradleybooks.com/

Skip's Compounding Pharmacyhttp://www.skipspharmacy.com/

[Guest guest]

We have many good cases of chemo and LDN taken together. There are many who have done this with great benefit as we have discussed on the LDN4Cancer forum. The general theory of "immune suppresant and immune modulator cancel each other out" doesn't seem to apply in this constellation.People who do well on chemo alone seem to have relapses in a short period, since the immune system at the end of a treatment is very vulnerable. Maybe the simultaneous intake of LDN helps overcome this period to have a lasting regression?Anyway, I recommend revising this list and take out chemo, after all the majority of Dr. Bihari's cases who benefited from LDN were also on chemo.OkanFrom: Crystals MS TM LDN Website <angelindisguise67@...>Subject: [low dose naltrexone] What NOT to take with LDN!!low dose naltrexone , "LDN Group" <LDN_Users >Date: Saturday, 21 March, 2009, 5:53 AM

Do not take LDN (Naltrexone) with any of the following: • disulfiram (Antabuse);• thioridazine (Mellaril);• buprenorphine (Buprenex, Subutrex);• codeine (Tylenol with Codeine, and other brand names);• hydrocodone (Lorcet, Lortab, Vicodin, Vicoprofen, and other brand names);• hydromorphone (Dilaudid);• levorphanol (Levo-Dromoran) ;• meperidine (Demerol);• methadone (Dolophine, Methadose);• morphine (Kadian, MS Contin, MSIR, OMS, Roxanol, Oramorph SR, and other brand names);• oxycodone (M-Oxy, OxyContin, OxyIR, Roxicodone, Percocet, Percodan, and other brand names);• oxymorphone (Numorphan); or• propoxyphene (Darvon, and other brand names). · Ultram (tramadol) · Novantrone · Rebif · Avonex · Betaseron · Tysabri · Chemo's · Cellcept is a chemotherapy · methotrexate · Remicade - Called Skip's Pharmacy at the suggestion of people in this group, and the pharmacist there told me you have to be off Remicade for 50 days before starting LDN. Since the two meds have opposing effects on the immune system, LDN won't work while on Remicade. http://www.skipspha rmacy.com/ · 6MP - called Skip's about 6MP they said you should be off it for about a week before starting LDN.It sounded like you wouldn't want to take 6MP concurrent with LDN, since 6MP is an immunosuppressant and would have opposing effect on immune system as LDN. · Humira Dr. Jill said to stop Humira for 2 weeks before starting on LDN. And this was the reply someone got when they asked the question if we had to stop Humira before starting LDN on the LDN website: A person with Crohn's who receives Humira can begin LDN immediately (because H. is not a narcotic and thus is not contraindicated) -- however, Humira's effects in suppressing the immune system can seriously blunt the potential benefits from LDN (which should strengthen the immune system). The sooner off Humira, which is dangerous, the better. Ø Cautionary warnings: Because LDN blocks opioid receptors throughout the body for three or four hours, people using medicine that is an opioid agonist, i.e. narcotic medication — such as Ultram (tramadol), morphine, Percocet, Duragesic patch or codeine-containing medication — should not take LDN until such medicine is completely out of one's system. Patients who have become dependant on daily use of narcotic-containing pain medication may require 10 days to 2 weeks of slowly weaning off of such drugs entirely (while first substituting full doses of non-narcotic pain medications) before being able to begin LDN safely. I believe that steroids, short term, are ok with LDN. Dr. Skip

Drugs that may interact with Low Dose Naltrexone

Generic Name

Brand Name*

Mixed Opiate Agonists/Antagonist s

Buprenorphine

Buprenex®, Suboxone®, Subutex®

Butorphanol

Dorolex®, Stadol®

Nalbuphine

Nubain®

Pentazocine

Naloxone®, Talwin®

Opiate Agonists

Alfentinil

Alfenta®

Clonidine

Catapres®

Codeine

N/A

Dronabinol, THC

Marinol®

Fentanyl

Duragesic®, Aqtic®, Sublimaze®, Fentora®

Hydrocodone

Lorcet®, Lortab®, Vicodin®

Hydromorphone

Dilaudid®

Levorphanol

Levo-Dromoran®

Meperidine

Demerol®, Meperitab®

Methadone

Dolophine®, Methodose®

Morphine

Kadian®, MSContin®

Oxycodone

Percocet®, Endocet®, Roxicodone®, Endocodone®

Oxymorphone

Opana®, Numorphone®

Propoxyphene

Darvocet®, Darvon®

Remifentinil

Ultiva®

Sufentinil

Sufenta®

Other Medications

Disulfuram

Antabuse®

Dronabinol, THC

Marinol®

Nabilone

Cesamet®

Thioridazine

Mellaril®

Clonidine

Catapres® * May not include each brand name available on the market in the United States References: Clinical Pharmacology Online @ www.clinicalpharmac ology.com (accessed 06/14/07 ) In addition, because LDN stimulates the immune system and many of the drugs routinely used by the NHS in the treatment of MS further suppress the immune system, LDN cannot be used in company with steroids, beta interferon, methotrexate, azathioprine or mitozantrone or any other immune suppressant drug. If there is any doubt, please submit a full list of the drugs you are presently taking so that their compatibility may be assessed. In addition, because LDN will also block the analgesic effects of any opiate drugs (includes codeine, dihydrocodeine, morphine, pethidine or diamorphine) presently being taken, the use of LDN will initially greatly increase the level of pain experienced. It is therefore advisable that any opiate-like drugs be discontinued at least two weeks before this treatment is

initiated."

OTHER CAUTIONARIES:

Imodium ADNaltrexone tested at 25+ mg blocks the effect of loperamide hydrochloride (Imodium) against diarrhea. Bismuth compounds (Pepto-Bismol) may be used for mild nausea or diarrhea, and octreotide acetate (Sandostatin) may be used for severe diarrhea, and ondansetron hydrochloride (Zofran) may be used for nausea and vomiting, especially with accidental naltrexone-precipit ated opiate withdrawal. It is unestablished whether Imodium AD at doses of under 5 mg would have the same effect..

This below is written by Dr. Bob Lawrence.When starting this LDN(Low Dose Naltrexone) therapy in the treatment of MS, there may also be some initial transient, though temporary, increase in MS symptoms. Experience in using this method has demonstrated most commonly, such as disturbed sleep, occasionally with vivid, bizarre and disturbing dreams, tiredness, fatigue, spasm and pain. These increased symptoms would not normally be expected to last more than seven to ten days.Rarely, other transient symptoms have included more severe pain and spasm, headache, diarrhea or vomiting. These additional symptoms would appear to be associated with the previous frequent use of strong analgesics, which effectively create an addiction and dependency, thus increasing the body's sensitivity to pain. This

temporary increase in symptoms may also perhaps be explained when we consider the manner in which this drug is expected to work.In addition, because LDN will also block the analgesic effects of any opiate drugs (includes codeine, dihydrocodeine, morphine, pethidine or diamorphine) presently being taken, the use of LDN will initially greatly increase the level of pain experienced. It is therefore advisable that any opiate-like drugs be discontinued at least two weeks before this treatment is initiated. When starting the treatment it is essential that any untoward or adverse side-effects are reported immediately so that the treatment process can be further assessed and, if necessary, modified.

May there be a miracle in YOUR life today and may you have the EYES to see it.From My Heart to Yours Love, Hugs & Blessings, CrystalLDN_Users Group OwnerDiagnosed November 2004 with Secondary Progressive MS, Transverse Myelitis and an Advocate for LDN!! 3 years 6 months on LDN with Skip's Pharmacy.... .No Relapses.... .Crystal's MS,TM & LDN Websitehttp://www.freewebs .com/crystalange l6267/index. htm LDN Website

http://ww.ldninfo. org/Crystal's LDN Support Grouphttp://health. groups.. com/group/ LDN_Users/

LDN MySpace

http://www.myspace. com/lowdosenaltr exone

Cris - Case Health - Health Success Storieshttp://casehealth. com/case/ about..html

Low Dose Naltrexone Database

http://ldn-database .carnebeach. com/

Up the Creek with a Paddle

http://www.marybrad leybooks. com/

Skip's Compounding Pharmacyhttp://www.skipspha rmacy.com/

[Guest guest]

Hi Okan,

' ... We have many good cases of chemo and LDN taken together. There are

many who have done this with great benefit as we have discussed on the

LDN4Cancer forum. ... '

The term 'Chemo' refers to 'chemical therapy' in which there can be

numerous different combinations of drugs, at differing strengths, given at

differing intervals, and over differing periods of time.

I hope you'll agree that when there are opposing forces, then the

composition, strength, and long-term influence of those opposing forces

will be relevant in each outcome.

Using the word 'chemo' in a generalist way doesn't reveal the composition,

strength, or long-term influence of all the opposing forces, or help to

qualify and quantify successes.

It would be clearer if you could relate the exact number of patients who've

succeeded using a combined chemical therapy - and specifically, what their

chemical therapies involved, i.e.; detailed records of the treatment each

received.

If they haven't been recorded yet, I'd be happy to help,

kind regards,

Cris

6b. Re: What NOT to take with LDN!!

Posted by: " Okan Erdem " okanerdem2003@... okanerdem2003

Date: Sun Mar 22, 2009 3:28 am ((PDT))

We have many good cases of chemo and LDN taken together. There are many who

have done this with great benefit as we have discussed on the LDN4Cancer

forum. The general theory of " immune suppresant and immune modulator

cancel each other out " doesn't seem to apply in this constellation.

People who do well on chemo alone seem to have relapses in a short period,

since the immune system at the end of a treatment is very vulnerable.

Maybe the simultaneous intake of LDN helps overcome this period to have a

lasting regression?

Anyway, I recommend revising this list and take out chemo, after all the

majority of Dr. Bihari's cases who benefited from LDN were also on chemo.

Okan

[Guest guest]

How about gemcitabine plus biotherapy of OGF?

Jaco

> From: Case Health Pty Ltd <casehealth@...>

> Subject: [low dose naltrexone] Re: What NOT to take with LDN!!

> low dose naltrexone

> Date: Sunday, March 22, 2009, 9:38 PM

> Hi Okan,

>

> ' ... We have many good cases of chemo and LDN taken

> together. There are

> many who have done this with great benefit as we have

> discussed on the

> LDN4Cancer forum. ... '

>

> The term 'Chemo' refers to 'chemical therapy' in which

> there can be

> numerous different combinations of drugs, at differing

> strengths, given at

> differing intervals, and over differing periods of time.

>

> I hope you'll agree that when there are opposing forces,

> then the

> composition, strength, and long-term influence of those

> opposing forces

> will be relevant in each outcome.

>

> Using the word 'chemo' in a generalist way doesn't reveal

> the composition,

> strength, or long-term influence of all the opposing

> forces, or help to

> qualify and quantify successes.

>

> It would be clearer if you could relate the exact number of

> patients who've

> succeeded using a combined chemical therapy - and

> specifically, what their

> chemical therapies involved, i.e.; detailed records of the

> treatment each

> received.

>

> If they haven't been recorded yet, I'd be happy to help,

> kind regards,

> Cris

>

> 6b. Re: What NOT to take with LDN!!

>     Posted by: " Okan Erdem " okanerdem2003@...

> okanerdem2003

>     Date: Sun Mar 22, 2009 3:28 am ((PDT))

>

> We have many good cases of chemo and LDN taken together.

> There are many who

> have done this with great benefit as we have discussed on

> the LDN4Cancer

> forum.  The general theory of " immune suppresant and

> immune modulator

> cancel each other out " doesn't seem to apply in this

> constellation.

>

> People who do well on chemo alone seem to have relapses in

> a short period,

> since the immune system at the end of a treatment is very

> vulnerable.

> Maybe the simultaneous intake of LDN helps overcome this

> period to have a

> lasting regression?

>

> Anyway, I recommend revising this list and take out chemo,

> after all the

> majority of Dr. Bihari's cases who benefited from LDN were

> also on chemo.

>

> Okan

>

>

>

> ------------------------------------

>

>

[Guest guest]

Hi Cris,

I know the word "chemo" is a generalization, and I was exactly opposing against this generalized approach; i.e. "do not take LDN with chemo".

Obviously if someone takes LDN and chemo together and gets a sustainable regression it is difficult to isolate the benefit of each. My approach is to look at the likelihood of getting a sustainable remission with a specific chemo alone for a specific cancer and use this as a basis for judgement.

I did post that before but I can once more give the example of my wife.

When she started in Dec. 2007 to take LDN she had just been operated for the 2 remaining tumors after a 6 course treatment of Carboplatin + Paclitaxel (initially 18 tumors). She got her melanoma diagnosis in 1999, became Stage IV in 2005, got operated 2 times before.

Despite good response to chemo, successful operation and starting on LDN, the next Pet scan revealed many many new tumors (even more than first time). The doctor put her on Temazolomide and after due research (and despite the warning on the list of drugs not to be taken with LDN!) we judged that it was best to keep on taking the LDN as well. After all,her expectation of a total remission on Temazolomide alone would have been 1-2% according to statistics and sustainability almost out of question.

She was NED in her first Pet (after 3 courses), remained so after 6 courses and is on LDN alone since July 2008.

Again this is not a proof, but at least I can say that she was not disadvantaged by taking LDN and chemo together. Let me add, that unlike her first chemo experience there was no incidence of an infection or severe side effects during her second round, which I definetely attribute to LDN. Not to mention that her blood work was very good throughout.

I have listened to similar experiences from some others , both within the LDN cancer forum and also in real life, thus, I find it unjustified to classify "chemo in general" as something not complementary to LDN. Maybe , who runs the database can help out to formulate a decent list of LDN + chemo beneficiaries?

One more point, if you look at the LDN and Cancer section in the LDN website, you will see that out of the 450 cancer patients that Dr. Bihari treated over the years he is said to have a response rate (no progression or regression) of 60%. That makes roughly 270 out of 450. Out of the 270 responding only 88 were said to be on LDN alone, the rest were also on conventional treatment. Knowing the poor responses that one can expect from chemotherapy in Stage IV cancer, this, I believe, also demonstrates that many on chemo, have benefitted from taking LDN as well.

By the way, it provides evidence also that Dr. Bihari did not refuse to give LDN to patients who were on conventional treatments. So he didn't think it was contraindicated, right?

I appreciate that you offer to help make an analysis of this. The problem that seems to arise is that people who take LDN with chemo take also a variety of other unconventional therapies simultaneously, so how to isolate the benefits? Maybe you have an idea?

Kind regards,

Okan

From: Case Health Pty Ltd <casehealth@...>Subject: [low dose naltrexone] Re: What NOT to take with LDN!!low dose naltrexone Date: Sunday, 22 March, 2009, 11:38 PM

Hi Okan,' ... We have many good cases of chemo and LDN taken together. There aremany who have done this with great benefit as we have discussed on theLDN4Cancer forum. ... 'The term 'Chemo' refers to 'chemical therapy' in which there can benumerous different combinations of drugs, at differing strengths, given atdiffering intervals, and over differing periods of time.I hope you'll agree that when there are opposing forces, then thecomposition, strength, and long-term influence of those opposing forceswill be relevant in each outcome.Using the word 'chemo' in a generalist way doesn't reveal the composition,strength, or long-term influence of all the opposing forces, or help toqualify and quantify successes.It would be clearer if you could relate the exact number of patients who'vesucceeded using a combined chemical therapy - and specifically, what theirchemical therapies

involved, i.e.; detailed records of the treatment eachreceived.If they haven't been recorded yet, I'd be happy to help,kind regards,Cris6b. Re: What NOT to take with LDN!!Posted by: "Okan Erdem" okanerdem2003@ .co. uk okanerdem2003Date: Sun Mar 22, 2009 3:28 am ((PDT))We have many good cases of chemo and LDN taken together. There are many whohave done this with great benefit as we have discussed on the LDN4Cancerforum. The general theory of "immune suppresant and immune modulatorcancel each other out" doesn't seem to apply in this constellation.People who do well on chemo alone seem to have relapses in a short period,since the immune system at the end of a treatment is very vulnerable.Maybe the simultaneous intake of LDN

helps overcome this period to have alasting regression?Anyway, I recommend revising this list and take out chemo, after all themajority of Dr. Bihari's cases who benefited from LDN were also on chemo.Okan