Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 Recently a helpful group member from this site suggested I pose some of my questions concerning Hepatitis C and LDN to Dr. Zagon. I did and he responded the next day. I post his response here for anyone who is interested: Cheers, McGovern -----------------------------Dr Zagon's email below--------------- Dear Mr. McGovern: I am sorry to hear about your condition. Brief answers to your questions: 1) Do you know of any contraindications in the use of LDN with a compromised liver? Response: Yes. The liver processes LDN. In the case of liver disease, this metabolic machinery may be damaged. Therefore, LDN may last much longer. You know the trick - only block the opioids and receptors with LDN for a short (4-6 hr) time each day, and the rest of the time the good, elevated opioids and opioids receptors come together and give you the effect you want. Too long with LDN (12-24 hr) and you get just the opposite effect - this you do not want. My suggestion: take 1 mg/day and see how you feel and do. You might even want to take the 1 mg every other day. 2) Would a compromised liver affect the dosage of LDN and the duration of opioid receptor blockage? Response: See above. 3) What is the role of the liver in the breakdown and metabolism of LDN? Response: See above. 4) My Naturopath tells me the liver is most active between the hours of 1-3am..I am dosing in the mornings due to lack of sleep with night time dosing. Is this OK? Response: Take LDN when you wish. It will work anytime the same way as I mentioned earlier. 5) Given your work with LDN and your knowledge of viruses, What's your hunch about the chances of LDN assisting my immune system in lowering my HCV viral load and improving my body's fight against this disease? The HCV virus replicates extremely rapidly with a high rate of mutation. Response: LDN/OGF will control immune response - this depresses immune cell proliferation. And viruses as well!!! 6) Have you made any interesting discoveries about LDN and the liver that would be interesting for me to know? Response: We are publishing 5-15 papers a year. Look me up on MedLine or PubMed. We do have a clinical trial going on with OGF and hepatocellular carcinoma conducted by Dr. Kimchi at our medical center. He is actively recruiting patients for a phase I trial. 7) I am a member of A group focusing on alternative medicine in the treatment of Hepatitis C. May I post your answers to my questions in that group and in the LDN group? Response: Always delighted to help. Finally, Thank you for your tireless efforts. Your work has obviously made a *huge* positive difference in the lives of many people. Response: Thank you. Your comments make my day. ----------------end of Dr Zagon's Email--------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 Thanks for posting this info ...really interesting,informative, and I'm sure will help others. Jann Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 Thank you , This is good to know - a more gentle protocol for those with liver issues. Jaco > From: McGovern <pmcg@...> > Subject: [low dose naltrexone] Email from Dr Zagon > low dose naltrexone > Date: Wednesday, March 11, 2009, 2:16 AM > Recently a helpful group member from > this site suggested I pose some of my questions concerning > Hepatitis C and LDN to Dr. Zagon. I did and he responded the > next day. > > I post his response here for anyone who is interested: > > Cheers, > > McGovern > -----------------------------Dr Zagon's email > below--------------- > > Dear Mr. McGovern: > I am sorry to hear > about your condition. Brief answers to your questions: > 1) Do you know of any contraindications in the use of LDN > with a compromised liver? > Response: Yes. The liver > processes LDN. In the case of liver disease, this metabolic > machinery may be damaged. Therefore, LDN may last much > longer. You know the trick - only block the opioids and > receptors with LDN for a short (4-6 hr) time each day, and > the rest of the time the good, elevated opioids and opioids > receptors come together and give you the effect you want. > Too long with LDN (12-24 hr) and you get just the opposite > effect - this you do not want. > My > suggestion: take 1 mg/day and see how you feel and do. You > might even want to take the 1 mg every other day. > > 2) Would a compromised liver affect the dosage of LDN and > the duration of opioid receptor blockage? > > Response: See above. > > 3) What is the role of the liver in the breakdown and > metabolism of LDN? > > Response: See above. > > 4) My Naturopath tells me the liver is most active between > the hours of 1-3am..I am dosing in the mornings due to lack > of sleep with night time dosing. Is this OK? > > Response: Take LDN when you wish. It will > work anytime the same way as I mentioned earlier. > > 5) Given your work with LDN and your knowledge of viruses, > What's your hunch about the chances of LDN assisting my > immune system in lowering my HCV viral load and improving my > body's fight against this disease? The HCV virus replicates > extremely rapidly with a high rate of mutation. > > Response: LDN/OGF will control immune > response - this depresses immune cell proliferation. And > viruses as well!!! > > 6) Have you made any interesting discoveries about LDN and > the liver that would be interesting for me to know? > > Response: We are publishing 5-15 papers a > year. Look me up on MedLine or PubMed. We do have a > clinical trial going on with OGF and hepatocellular > carcinoma conducted by Dr. Kimchi at our medical > center. He is actively recruiting patients for a phase I > trial. > > 7) I am a member of A group focusing on alternative > medicine in the treatment of Hepatitis C. May I post your > answers to my questions in that group and in the LDN > group? > > Response: Always delighted to help. > Finally, Thank you for your tireless efforts. Your work has > obviously made a *huge* positive difference in the lives of > many people. > > Response: Thank > you. Your comments make my day. > ----------------end of Dr Zagon's Email--------------- > > > > ------------------------------------ > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 Interesting post, but... Dr. Zagon says to take 1mg LDN every day or every other day and he also says it is okay to take LDN at any time of the day. All of this information goes directly against what Dr. Bihari recommends. I have always been told 1mg would not be enough to halt/slow disease progression, especially for MS and cancer, and taking LDN during hours other than between 9pm - 3am one would miss the key time to introduce the endorphin blockade. I am wondering how Dr. Zagon determines his contrary advice. This is not meant as a put down, but was it through research only on animals whereas Dr. Bihari used humans. Occasionally, I have thought of trying a different dosing times due to sleep issues or just out of curiosity, but haven't because I don't want to risk an MS exacerbation. I agree a good night's sleep is very important for health recovery. So the question is who is one to believe, Zagon or Bihari? I will continue to recommend Dr. Bihari's protocol until more research results are produced. Art -- > > Recently a helpful group member from this site suggested I pose some of my questions concerning Hepatitis C and LDN to Dr. Zagon. I did and he responded the next day. > > I post his response here for anyone who is interested: > > Cheers, > > McGovern > -----------------------------Dr Zagon's email below--------------- > > Dear Mr. McGovern: > I am sorry to hear about your condition. Brief answers to your questions: > 1) Do you know of any contraindications in the use of LDN with a compromised liver? > Response: Yes. The liver processes LDN. In the case of liver disease, this metabolic machinery may be damaged. Therefore, LDN may last much longer. You know the trick - only block the opioids and receptors with LDN for a short (4-6 hr) time each day, and the rest of the time the good, elevated opioids and opioids receptors come together and give you the effect you want. Too long with LDN (12-24 hr) and you get just the opposite effect - this you do not want. > My suggestion: take 1 mg/day and see how you feel and do. You might even want to take the 1 mg every other day. > > 2) Would a compromised liver affect the dosage of LDN and the duration of opioid receptor blockage? > Response: See above. > > 3) What is the role of the liver in the breakdown and metabolism of LDN? > Response: See above. > > 4) My Naturopath tells me the liver is most active between the hours of 1-3am..I am dosing in the mornings due to lack of sleep with night time dosing. Is this OK? > Response: Take LDN when you wish. It will work anytime the same way as I mentioned earlier. > > 5) Given your work with LDN and your knowledge of viruses, What's your hunch about the chances of LDN assisting my immune system in lowering my HCV viral load and improving my body's fight against this disease? The HCV virus replicates extremely rapidly with a high rate of mutation. > Response: LDN/OGF will control immune response - this depresses immune cell proliferation. And viruses as well!!! > > 6) Have you made any interesting discoveries about LDN and the liver that would be interesting for me to know? > Response: We are publishing 5-15 papers a year. Look me up on MedLine or PubMed. We do have a clinical trial going on with OGF and hepatocellular carcinoma conducted by Dr. Kimchi at our medical center. He is actively recruiting patients for a phase I trial. > > 7) I am a member of A group focusing on alternative medicine in the treatment of Hepatitis C. May I post your answers to my questions in that group and in the LDN group? > Response: Always delighted to help. > Finally, Thank you for your tireless efforts. Your work has obviously made a *huge* positive difference in the lives of many people. > Response: Thank you. Your comments make my day. > ----------------end of Dr Zagon's Email--------------- > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 here it goes over people with liver problem where dr zagon thinks that they might accomulte naltrexone in the body and block the receptoren too long. > > > > Recently a helpful group member from this site suggested I pose some of my questions concerning Hepatitis C and LDN to Dr. Zagon. I did and he responded the next day. > > > > I post his response here for anyone who is interested: > > > > Cheers, > > > > McGovern > > -----------------------------Dr Zagon's email below--------------- > > > > Dear Mr. McGovern: > > I am sorry to hear about your condition. Brief answers to your questions: > > 1) Do you know of any contraindications in the use of LDN with a compromised liver? > > Response: Yes. The liver processes LDN. In the case of liver disease, this metabolic machinery may be damaged. Therefore, LDN may last much longer. You know the trick - only block the opioids and receptors with LDN for a short (4-6 hr) time each day, and the rest of the time the good, elevated opioids and opioids receptors come together and give you the effect you want. Too long with LDN (12-24 hr) and you get just the opposite effect - this you do not want. > > My suggestion: take 1 mg/day and see how you feel and do. You might even want to take the 1 mg every other day. > > > > 2) Would a compromised liver affect the dosage of LDN and the duration of opioid receptor blockage? > > Response: See above. > > > > 3) What is the role of the liver in the breakdown and metabolism of LDN? > > Response: See above. > > > > 4) My Naturopath tells me the liver is most active between the hours of 1-3am..I am dosing in the mornings due to lack of sleep with night time dosing. Is this OK? > > Response: Take LDN when you wish. It will work anytime the same way as I mentioned earlier. > > > > 5) Given your work with LDN and your knowledge of viruses, What's your hunch about the chances of LDN assisting my immune system in lowering my HCV viral load and improving my body's fight against this disease? The HCV virus replicates extremely rapidly with a high rate of mutation. > > Response: LDN/OGF will control immune response - this depresses immune cell proliferation. And viruses as well!!! > > > > 6) Have you made any interesting discoveries about LDN and the liver that would be interesting for me to know? > > Response: We are publishing 5-15 papers a year. Look me up on MedLine or PubMed. We do have a clinical trial going on with OGF and hepatocellular carcinoma conducted by Dr. Kimchi at our medical center. He is actively recruiting patients for a phase I trial. > > > > 7) I am a member of A group focusing on alternative medicine in the treatment of Hepatitis C. May I post your answers to my questions in that group and in the LDN group? > > Response: Always delighted to help. > > Finally, Thank you for your tireless efforts. Your work has obviously made a *huge* positive difference in the lives of many people. > > Response: Thank you. Your comments make my day. > > ----------------end of Dr Zagon's Email--------------- > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 here it goes over people with liver problem where dr zagon thinks that they might accomulte naltrexone in the body and block the receptoren too long. This question of accumulation is one I have tried to get answered myself with no luck so far.... Celia Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 Dr. Zagon has had 25 years of human studies with LDN and Pancreatic Cancer along with working with Dr. Jill and Crhon's. He also is working with a Dr. from 's Hopkins, who now works at Penn State, with head, neck and throat cancer. He has measured the OGF, which is what the LDN's reaction to our bodies creates, and knows for a fact that the body stores this. This has been proven scientifically and in humans. To advise patients other wise, and mind you Dr. Bihari did a terrific thing by researching Dr. Zagon's work long ago and thinking out side the box and getting this much needed drug to us. But until we know for sure and there is proper documentation that our Government and the FDA will take a look at to allow everyone a chance to use LDN and not just some, lets not disregard science nor his studies. There is much more to this than we are aware of. I sudgest everyone get the book Elaine wrote " The Promise of Low Dose Naltrexone Therapy " This could answer some questions. > > > > Recently a helpful group member from this site suggested I pose some of my questions concerning Hepatitis C and LDN to Dr. Zagon. I did and he responded the next day. > > > > I post his response here for anyone who is interested: > > > > Cheers, > > > > McGovern > > -----------------------------Dr Zagon's email below--------------- > > > > Dear Mr. McGovern: > > I am sorry to hear about your condition. Brief answers to your questions: > > 1) Do you know of any contraindications in the use of LDN with a compromised liver? > > Response: Yes. The liver processes LDN. In the case of liver disease, this metabolic machinery may be damaged. Therefore, LDN may last much longer. You know the trick - only block the opioids and receptors with LDN for a short (4-6 hr) time each day, and the rest of the time the good, elevated opioids and opioids receptors come together and give you the effect you want. Too long with LDN (12-24 hr) and you get just the opposite effect - this you do not want. > > My suggestion: take 1 mg/day and see how you feel and do. You might even want to take the 1 mg every other day. > > > > 2) Would a compromised liver affect the dosage of LDN and the duration of opioid receptor blockage? > > Response: See above. > > > > 3) What is the role of the liver in the breakdown and metabolism of LDN? > > Response: See above. > > > > 4) My Naturopath tells me the liver is most active between the hours of 1-3am..I am dosing in the mornings due to lack of sleep with night time dosing. Is this OK? > > Response: Take LDN when you wish. It will work anytime the same way as I mentioned earlier. > > > > 5) Given your work with LDN and your knowledge of viruses, What's your hunch about the chances of LDN assisting my immune system in lowering my HCV viral load and improving my body's fight against this disease? The HCV virus replicates extremely rapidly with a high rate of mutation. > > Response: LDN/OGF will control immune response - this depresses immune cell proliferation. And viruses as well!!! > > > > 6) Have you made any interesting discoveries about LDN and the liver that would be interesting for me to know? > > Response: We are publishing 5-15 papers a year. Look me up on MedLine or PubMed. We do have a clinical trial going on with OGF and hepatocellular carcinoma conducted by Dr. Kimchi at our medical center. He is actively recruiting patients for a phase I trial. > > > > 7) I am a member of A group focusing on alternative medicine in the treatment of Hepatitis C. May I post your answers to my questions in that group and in the LDN group? > > Response: Always delighted to help. > > Finally, Thank you for your tireless efforts. Your work has obviously made a *huge* positive difference in the lives of many people. > > Response: Thank you. Your comments make my day. > > ----------------end of Dr Zagon's Email--------------- > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 Art, It's not a matter of which one to believe, but rather, to understand that LDN's benefits are available to people with liver diseases and others who may have insurmountable difficulties with following the Bihari protocol.. Please put into context Dr. Zagon's recommendation of 1 mg every other day. He suggests this for who has liver disease. Art, did you know that naltrexone is contraindicated for people with liver disease? Dr. Zagon is not saying that you should take it every other day. If 's liver cannot handle the normal dose due to liver disease he can still have benefits from LDN by using a little less. It may even help to improve his liver distress, making possible an increase of dose in the future. We really are not all built alike. For instance I have a cancer of the neuroendocrine system. This is the interface between the nervous system and the endocrine system. The cancer plays havoc with almost every physiological process in my body and many neurological processes too. Metabolism, immune, digestive, circulatory including breathing, nervous, most and too many to name. It is important to me that I take LDN. I believe there are benefits to me from doing so, but I just simply do not fall within the category of patients who respond well to the Bihari protocol. That's all: it does not make me an evil anti-Biharist. It only makes me a very rare cancer sufferer who is looking for viable options. Let's be open-minded. Rigid doctrine inevitably will leave out a percentage of people, and the purpose(s) of dedicated researchers and clinicians surely is not to do that but to include as many victims of disease as possible. Jaco > From: Art Hansen <rtee54@...> > Subject: [low dose naltrexone] Re: Email from Dr Zagon > low dose naltrexone > Date: Wednesday, March 11, 2009, 1:46 PM > Interesting post, but... > > Dr. Zagon says to take 1mg LDN every day or every other day > and he also says it is okay to take LDN at any time of the > day. All of this information goes directly against what Dr. > Bihari recommends. I have always been told 1mg would not be > enough to halt/slow disease progression, especially for MS > and cancer, and taking LDN during hours other than between > 9pm - 3am one would miss the key time to introduce the > endorphin blockade. I am wondering how Dr. Zagon determines > his contrary advice. This is not meant as a put down, but > was it through research only on animals whereas Dr. Bihari > used humans. Occasionally, I have thought of trying a > different dosing times due to sleep issues or just out of > curiosity, but haven't because I don't want to risk an MS > exacerbation. I agree a good night's sleep is very important > for health recovery. > > So the question is who is one to believe, Zagon or Bihari? > I will continue to recommend Dr. Bihari's protocol until > more research results are produced. > > Art > -- > > > > > > Recently a helpful group member from this site > suggested I pose some of my questions concerning Hepatitis C > and LDN to Dr. Zagon. I did and he responded the next day. > > > > I post his response here for anyone who is > interested: > > > > Cheers, > > > > McGovern > > -----------------------------Dr Zagon's email > below--------------- > > > > Dear Mr. McGovern: > > I am sorry to hear > about your condition. Brief answers to your questions: > > 1) Do you know of any contraindications in the use of > LDN with a compromised liver? > > Response: > Yes. The liver processes LDN. In the case of liver disease, > this metabolic machinery may be damaged. Therefore, LDN may > last much longer. You know the trick - only block the > opioids and receptors with LDN for a short (4-6 hr) time > each day, and the rest of the time the good, elevated > opioids and opioids receptors come together and give you the > effect you want. Too long with LDN (12-24 hr) and you get > just the opposite effect - this you do not want. > > > My suggestion: take 1 mg/day and see how > you feel and do. You might even want to take the 1 mg every > other day. > > > > 2) Would a compromised liver affect the dosage of LDN > and the duration of opioid receptor blockage? > > > Response: See above. > > > > 3) What is the role of the liver in the breakdown and > metabolism of LDN? > > > Response: See above. > > > > 4) My Naturopath tells me the liver is most active > between the hours of 1-3am..I am dosing in the mornings due > to lack of sleep with night time dosing. Is this OK? > > > Response: Take LDN when you wish. It will work anytime the > same way as I mentioned earlier. > > > > 5) Given your work with LDN and your knowledge of > viruses, What's your hunch about the chances of LDN > assisting my immune system in lowering my HCV viral load and > improving my body's fight against this disease? The HCV > virus replicates extremely rapidly with a high rate of > mutation. > > > Response: LDN/OGF will control immune response - this > depresses immune cell proliferation. And viruses as well!!! > > > > 6) Have you made any interesting discoveries about LDN > and the liver that would be interesting for me to know? > > > Response: We are publishing 5-15 > papers a year. Look me up on MedLine or PubMed. We do > have a clinical trial going on with OGF and hepatocellular > carcinoma conducted by Dr. Kimchi at our medical > center. He is actively recruiting patients for a phase I > trial. > > > > 7) I am a member of A group focusing on > alternative medicine in the treatment of Hepatitis C. May I > post your answers to my questions in that group and in the > LDN group? > > > Response: Always delighted to > help. > > Finally, Thank you for your tireless efforts. Your > work has obviously made a *huge* positive difference in the > lives of many people. > > > Response: Thank > you. Your comments make my day. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 i do not think there is definite answer.if you know that your liver is not optimal you can try to lower the dose of naltrexone.if you see less results with ldn you can try to lower the dose of naltrexone. if everything is fine ,why change.i do not think there is a test ot measure it at this stage.much is by experience,trial and error. > > here it goes over people with liver problem where dr zagon thinks that they might accomulte naltrexone in the body and block the receptoren too long. > > > This question of accumulation is one I have tried to get answered myself with no luck so far.... > Celia > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 Could the liver function therefore be the determining factor as to a persons dosing tolerability to LDN? Jayne Please sign the petition to the UK Govt to fund trials for LDN http://petitions.number10.gov.uk/LowDNaltrexone/ From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of zahavi Sent: 11 March 2009 14:55 low dose naltrexone Subject: [low dose naltrexone] Re: Email from Dr Zagon i do not think there is definite answer.if you know that your liver is not optimal you can try to lower the dose of naltrexone.if you see less results with ldn you can try to lower the dose of naltrexone. if everything is fine ,why change.i do not think there is a test ot measure it at this stage.much is by experience,trial and error. > > here it goes over people with liver problem where dr zagon thinks that they might accomulte naltrexone in the body and block the receptoren too long. > > > This question of accumulation is one I have tried to get answered myself with no luck so far.... > Celia > No virus found in this incoming message. Checked by AVG. Version: 7.5.557 / Virus Database: 270.11.10/1994 - Release Date: 10/03/2009 19:51 No virus found in this outgoing message. Checked by AVG. Version: 7.5.557 / Virus Database: 270.11.10/1994 - Release Date: 10/03/2009 19:51 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 Hi Art This is Clare here.I feel much better now t hanks for your advice.I agree totally with your protocal. [low dose naltrexone] Re: Email from Dr Zagon Interesting post, but...Dr. Zagon says to take 1mg LDN every day or every other day and he also says it is okay to take LDN at any time of the day. All of this information goes directly against what Dr. Bihari recommends. I have always been told 1mg would not be enough to halt/slow disease progression, especially for MS and cancer, and taking LDN during hours other than between 9pm - 3am one would miss the key time to introduce the endorphin blockade. I am wondering how Dr. Zagon determines his contrary advice. This is not meant as a put down, but was it through research only on animals whereas Dr. Bihari used humans. Occasionally, I have thought of trying a different dosing times due to sleep issues or just out of curiosity, but haven't because I don't want to risk an MS exacerbation. I agree a good night's sleep is very important for health recovery.So the question is who is one to believe, Zagon or Bihari? I will continue to recommend Dr. Bihari's protocol until more research results are produced.Art-->> Recently a helpful group member from this site suggested I pose some of my questions concerning Hepatitis C and LDN to Dr. Zagon. I did and he responded the next day.> > I post his response here for anyone who is interested:> > Cheers,> > McGovern> -----------------------------Dr Zagon's email below---------------> > Dear Mr. McGovern:> I am sorry to hear about your condition. Brief answers to your questions:> 1) Do you know of any contraindications in the use of LDN with a compromised liver?> Response: Yes. The liver processes LDN. In the case of liver disease, this metabolic machinery may be damaged. Therefore, LDN may last much longer. You know the trick - only block the opioids and receptors with LDN for a short (4-6 hr) time each day, and the rest of the time the good, elevated opioids and opioids receptors come together and give you the effect you want. Too long with LDN (12-24 hr) and you get just the opposite effect - this you do not want.> My suggestion: take 1 mg/day and see how you feel and do. You might even want to take the 1 mg every other day.> > 2) Would a compromised liver affect the dosage of LDN and the duration of opioid receptor blockage?> Response: See above.> > 3) What is the role of the liver in the breakdown and metabolism of LDN?> Response: See above.> > 4) My Naturopath tells me the liver is most active between the hours of 1-3am..I am dosing in the mornings due to lack of sleep with night time dosing. Is this OK?> Response: Take LDN when you wish. It will work anytime the same way as I mentioned earlier.> > 5) Given your work with LDN and your knowledge of viruses, What's your hunch about the chances of LDN assisting my immune system in lowering my HCV viral load and improving my body's fight against this disease? The HCV virus replicates extremely rapidly with a high rate of mutation.> Response: LDN/OGF will control immune response - this depresses immune cell proliferation. And viruses as well!!!> > 6) Have you made any interesting discoveries about LDN and the liver that would be interesting for me to know?> Response: We are publishing 5-15 papers a year. Look me up on MedLine or PubMed. We do have a clinical trial going on with OGF and hepatocellular carcinoma conducted by Dr. Kimchi at our medical center. He is actively recruiting patients for a phase I trial.> > 7) I am a member of A group focusing on alternative medicine in the treatment of Hepatitis C. May I post your answers to my questions in that group and in the LDN group?> Response: Always delighted to help.> Finally, Thank you for your tireless efforts. Your work has obviously made a *huge* positive difference in the lives of many people.> Response: Thank you. Your comments make my day.> ----------------end of Dr Zagon's Email---------------> No virus found in this incoming message.Checked by AVG - www.avg.com Version: 8.0.237 / Virus Database: 270.11.10/1995 - Release Date: 03/11/09 08:28:00 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 I believe that is true. A diseased liver does not metabolize as efficiently as a healthy liver. Jaco > From: Jayne Crocker <jaynecrocker@...> > Subject: RE: [low dose naltrexone] Re: Email from Dr Zagon > low dose naltrexone > Date: Wednesday, March 11, 2009, 3:20 PM > > > Could the liver function > therefore be the determining factor as > to a persons dosing tolerability to LDN? > > > > > > Jayne > > > > Please sign the petition to the UK Govt > to fund trials for LDN > > http://petitions.number10.gov.uk/LowDNaltrexone/ > > From: low dose naltrexone > [mailto:low dose naltrexone ] On Behalf Of > zahavi > > Sent: 11 March 2009 14:55 > > low dose naltrexone > > Subject: [low dose naltrexone] Re: Email from Dr > Zagon > i do not think there is > definite answer.if you > know that your liver is not optimal you can try to lower > the dose of > naltrexone.if you see less results with ldn you can try to > lower the dose of > naltrexone. > > if everything is fine ,why change.i do not think there is a > test ot measure it > at this stage.much is by experience,trial and error. > > > > > > > > > > here it goes over people with liver problem where dr > zagon thinks that > they might accomulte naltrexone in the body and block the > receptoren too long. > > > > > > > > > This question of accumulation is one I have tried to > get answered myself > with no luck so far.... > > > Celia Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 the liver has to break the naltrxone and to get it out the system.when it does not function good the naltrxone stays and block the receptors too long and you do not get the benefits of ldn.the same people can do with a bit of other medecines while others with good liver need high doses to get the same effect. tolerability is another problem and from observation here for quite some time,it is people with adrenal fatique that has the problem and they should raise slowly the ldn. > > > > here it goes over people with liver problem where dr zagon thinks that > they might accomulte naltrexone in the body and block the receptoren too > long. > > > > > > This question of accumulation is one I have tried to get answered myself > with no luck so far.... > > Celia > > > > > > > > No virus found in this incoming message. > Checked by AVG. > Version: 7.5.557 / Virus Database: 270.11.10/1994 - Release Date: 10/03/2009 > 19:51 > > > No virus found in this outgoing message. > Checked by AVG. > Version: 7.5.557 / Virus Database: 270.11.10/1994 - Release Date: 10/03/2009 > 19:51 > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 I'm not certain that is the explanation, zahavi. If the LDN is not metabolized one could ask, how could it block any receptors except maybe for those in the liver, if there are any there. Jaco > From: zahavi <zahavi100@...> > Subject: [low dose naltrexone] Re: Email from Dr Zagon > low dose naltrexone > Date: Wednesday, March 11, 2009, 3:38 PM > the liver has to break the naltrxone > and to get it out the system.when it does not function > good the naltrxone stays and block the receptors too long > and you do not get the benefits of ldn.the same people can > do with a bit of other medecines while others with good > liver need high doses to get the same effect. > > tolerability is another problem and from observation here > for quite some time,it is people with adrenal fatique that > has the problem and they should raise slowly the ldn. > > > > > > > > > here it goes over people with liver problem where > dr zagon thinks that > > they might accomulte naltrexone in the body and block > the receptoren too > > long. > > > > > > > > > This question of accumulation is one I have tried > to get answered myself > > with no luck so far.... > > > Celia > > > > > > > > > > > > > > > No virus found in this incoming message. > > Checked by AVG. > > Version: 7.5.557 / Virus Database: 270.11.10/1994 - > Release Date: 10/03/2009 > > 19:51 > > > > > > No virus found in this outgoing message. > > Checked by AVG. > > Version: 7.5.557 / Virus Database: 270.11.10/1994 - > Release Date: 10/03/2009 > > 19:51 > > > > > > > ------------------------------------ > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 I'm not certain that is the explanation, zahavi. If the LDN is not metabolized one could ask, how could it block any receptors except maybe for those in the liver, if there are any there.Jaco If the LDN accumulates in the liver, then surely it will ultimately damage the liver and thus by consequence the whole body will suffer from toxicity? Celia Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 if i understand correct that is the explanation zagon self gave to a cancer patient in the ldn for cancer group by whom the ldn did not seem to help. > > > > > > > > here it goes over people with liver problem where > > dr zagon thinks that > > > they might accomulte naltrexone in the body and block > > the receptoren too > > > long. > > > > > > > > > > > > This question of accumulation is one I have tried > > to get answered myself > > > with no luck so far.... > > > > Celia > > > > > > > > > > > > > > > > > > > > > > No virus found in this incoming message. > > > Checked by AVG. > > > Version: 7.5.557 / Virus Database: 270.11.10/1994 - > > Release Date: 10/03/2009 > > > 19:51 > > > > > > > > > No virus found in this outgoing message. > > > Checked by AVG. > > > Version: 7.5.557 / Virus Database: 270.11.10/1994 - > > Release Date: 10/03/2009 > > > 19:51 > > > > > > > > > > > > > ------------------------------------ > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 Yes, you're right. Jaco > From: zahavi <zahavi100@...> > Subject: [low dose naltrexone] Re: Email from Dr Zagon > low dose naltrexone > Date: Wednesday, March 11, 2009, 4:11 PM > if i understand correct that is the > explanation zagon self gave to a cancer patient in the ldn > for cancer group by whom the ldn did not seem to help. > > > > > > > > > > > > > here it goes over people with liver > problem where > > > dr zagon thinks that > > > > they might accomulte naltrexone in the body > and block > > > the receptoren too > > > > long. > > > > > > > > > > > > > > > This question of accumulation is one I > have tried > > > to get answered myself > > > > with no luck so far.... > > > > > Celia > > > > > > > > > > > > > > > > > > > > > > > > > > > > > No virus found in this incoming message. > > > > Checked by AVG. > > > > Version: 7.5.557 / Virus Database: > 270.11.10/1994 - > > > Release Date: 10/03/2009 > > > > 19:51 > > > > > > > > > > > > No virus found in this outgoing message. > > > > Checked by AVG. > > > > Version: 7.5.557 / Virus Database: > 270.11.10/1994 - > > > Release Date: 10/03/2009 > > > > 19:51 > > > > > > > > > > > > > > > > > > > ------------------------------------ > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 You'd think that Celia, but I don't know enough about the way the liver metabolizes substances, or what happens to what it can't metabolize. Maybe metabolism does take place but over a long period of time, a very slowed down process, which keeps the receptors blocked for too long. That seems to be what Dr. Zagon is saying, eh? Jaco > From: Celia <celia@...> > Subject: Re: [low dose naltrexone] Re: Email from Dr Zagon > low dose naltrexone > Date: Wednesday, March 11, 2009, 4:02 PM > > > > > > > > > > > > > > > > > > > > I'm not certain that is the explanation, zahavi. > If the LDN is not > metabolized one could ask, how could it block any receptors > except maybe for > those in the liver, if there are any there. > > Jaco > > If the LDN accumulates in > the liver, then surely it > will ultimately damage the liver and thus by consequence > the whole body will > suffer from toxicity? > Celia > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 it does not accomulate in the liver.only the liver might not be able to clear it quickly enough and then there is too much blockage of the receptors.more then few hours.if i remember correct you take ala and that should help the liver.unless there is something specific i would not worry.now spring come to scotland you caan eat fresh leafs of dandilion in the salat.it helps the liver. > > I'm not certain that is the explanation, zahavi. If the LDN is not metabolized one could ask, how could it block any receptors except maybe for those in the liver, if there are any there. > > Jaco > > If the LDN accumulates in the liver, then surely it will ultimately damage the liver and thus by consequence the whole body will suffer from toxicity? > Celia > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 Clare, You do understand that the advice to use 1 mg is only for people with liver disease. No one is suggesting you use such a low dose. But if your liver ever stops functioning well it is good to know you will still be able to enjoy the benefits of LDN. Jaco > From: Clare Magee <claremagee@...> > Subject: Re: [low dose naltrexone] Re: Email from Dr Zagon > low dose naltrexone > Date: Wednesday, March 11, 2009, 3:30 PM > > > > > > > > > > > > > > > > > > Hi Art > This is Clare > here.I feel much better now t hanks for your advice.I agree > totally with your > protocal. > > > [low dose naltrexone] Re: Email > from Dr Zagon > > > > Interesting post, but... > > Dr. Zagon says to take 1mg LDN every day or > every other day and he also says it is okay to take LDN > at any time of the > day. All of this information goes directly against what > Dr. Bihari recommends. > I have always been told 1mg would not be enough to > halt/slow disease > progression, especially for MS and cancer, and taking LDN > during hours other > than between 9pm - 3am one would miss the key time to > introduce the endorphin > blockade. I am wondering how Dr. Zagon determines his > contrary advice. This is > not meant as a put down, but was it through research only > on animals whereas > Dr. Bihari used humans. Occasionally, I have thought of > trying a different > dosing times due to sleep issues or just out of > curiosity, but haven't because > I don't want to risk an MS exacerbation. I agree a > good night's sleep is very > important for health recovery. > > So the question is who is one to > believe, Zagon or Bihari? I will continue to recommend > Dr. Bihari's protocol > until more research results are produced. > > Art > -- > > > > > > Recently a helpful > group member from this site suggested I pose some of my > questions concerning > Hepatitis C and LDN to Dr. Zagon. I did and he responded > the next day. > > > > > I post his response here for anyone who is > interested: > > > > > Cheers, > > > > McGovern > > > ------------ --------- --------Dr Zagon's email > below------- -------- > > > > Dear Mr. McGovern: > > I am > sorry to hear about your condition. Brief answers to your > questions: > > > 1) Do you know of any contraindications in the use of LDN > with a compromised > liver? > > Response: Yes. The liver processes LDN. In the case of > liver > disease, this metabolic machinery may be damaged. > Therefore, LDN may last much > longer. You know the trick - only block the opioids and > receptors with LDN for > a short (4-6 hr) time each day, and the rest of the time > the good, elevated > opioids and opioids receptors come together and give you > the effect you want. > Too long with LDN (12-24 hr) and you get just the > opposite effect - this you > do not want. > > My suggestion: take 1 mg/day and see how you feel and > do. > You might even want to take the 1 mg every other day. > > > > 2) > Would a compromised liver affect the dosage of LDN and > the duration of opioid > receptor blockage? > > Response: See above. > > > > 3) What is > the role of the liver in the breakdown and metabolism of > LDN? > > > Response: See above. > > > > 4) My Naturopath tells me the liver is > most active between the hours of 1-3am..I am dosing in > the mornings due to > lack of sleep with night time dosing. Is this OK? > > Response: Take LDN > when you wish. It will work anytime the same way as I > mentioned > earlier. > > > > 5) Given your work with LDN and your knowledge of > viruses, What's your hunch about the chances of LDN > assisting my immune system > in lowering my HCV viral load and improving my body's > fight against this > disease? The HCV virus replicates extremely rapidly with > a high rate of > mutation. > > Response: LDN/OGF will control immune response - this > depresses immune cell proliferation. And viruses as > well!!! > > > > > 6) Have you made any interesting discoveries about LDN > and the liver that > would be interesting for me to know? > > Response: We are publishing 5-15 > papers a year. Look me up on MedLine or PubMed. We do > have a clinical trial > going on with OGF and hepatocellular carcinoma conducted > by Dr. Kimchi at > our medical center. He is actively recruiting patients > for a phase I > trial. > > > > 7) I am a member of A group focusing on > alternative medicine in the treatment of Hepatitis C. May > I post your answers > to my questions in that group and in the LDN > group? > > Response: > Always delighted to help. > > Finally, Thank you for your tireless > efforts. Your work has obviously made a *huge* positive > difference in the > lives of many people. > > Response: Thank you. Your comments make my > day. > > ------------ ----end of Dr Zagon's > Email------- -------- > > > > > > > > > No virus found in this incoming message. > Checked by AVG - > www.avg.com > Version: 8.0.237 / Virus Database: 270.11.10/1995 - Release > > Date: 03/11/09 08:28:00 > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 From the little reading I have done I think there are receptors in the liver, but will read more on it. Marja and Jaco, what you both say makes good sense. Spring is not exactly here just yet!:-)))) Celia Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 if you feel your body is "holding on" to medications and other substances, take buffered Vit C high dose daily along with Milk Thistle. May take a little bit of time but they are both great liver support. Amy From: zahavi <zahavi100@...>Subject: [low dose naltrexone] Re: Email from Dr Zagonlow dose naltrexone Date: Wednesday, March 11, 2009, 10:54 AM i do not think there is definite answer.if you know that your liver is not optimal you can try to lower the dose of naltrexone.if you see less results with ldn you can try to lower the dose of naltrexone.if everything is fine ,why change.i do not think there is a test ot measure it at this stage.much is by experience,trial and error.>> here it goes over people with liver problem where dr zagon thinks that they might accomulte naltrexone in the body and block the receptoren too long.> > > This question of accumulation is one I have tried to get answered myself with no luck so far....> Celia> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 Thanks Celia, I didn't know that. I love learning new things. Jaco > From: Celia <celia@...> > Subject: Re: [low dose naltrexone] Re: Email from Dr Zagon > low dose naltrexone > Date: Wednesday, March 11, 2009, 4:39 PM > > > > > > > > > > > > > > > > > > > > From the little reading I > have done I think there > are receptors in the liver, but will read more on it. > Marja and Jaco, what > you both say makes good sense. Spring is not > exactly here just > yet!:-)))) > Celia > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2009 Report Share Posted March 11, 2009 I'm wondering ... does ldn applied topically in a cream form bypass the liver or does it just bypass the gut ? > > From the little reading I have done I think there are receptors in the liver, but will read more on it. Marja and Jaco, what you both say makes good sense. Spring is not exactly here just yet!:-)))) > Celia > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 12, 2009 Report Share Posted March 12, 2009 > > I'm wondering ... does ldn applied topically in a cream form bypass the liver or does it just bypass the gut ? > > ========= Transdermal Medicine Applications Formulations diffuse through the skin and enter into the bloodstream, thereby initially bypassing the liver, stomach, and digestive system (called 'first pass'). Many systemic side effects may be diminished or eliminated. Quote Link to comment Share on other sites More sharing options...
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