Guest guest Posted March 1, 2009 Report Share Posted March 1, 2009 Has anyone had or heard of anyone that has had a loss of sense of smell? Elaine B Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 1, 2009 Report Share Posted March 1, 2009 > > Has anyone had or heard of anyone that has had a loss of sense of smell? Yes, altho I suspect it is not what you are looking for. When I was younger, a friend of mine fell off her skateboard and cracked her skull. She lost her sense of smell and taste. Dana Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 1, 2009 Report Share Posted March 1, 2009 Hi Elaine, I think the scientific/medical term for it is anosia. There was someone in my neighborhood when I was a kid who had this but I didn't really know the person. Besides eating issues it can cause safety concerns regarding smelling gas leaks, chemicals, fire. S S Loss of sense of smell Posted by: " ebrock1950 " kbrock@... ebrock1950 Sun Mar 1, 2009 6:46 am (PST) Has anyone had or heard of anyone that has had a loss of sense of smell? Elaine B ------------------------------------------------------------ Click here to find the perfect banking opportunity! Banking http://tagline.excite.com/fc/FgElN1g2Xnb1wQVonrgo53dOd1Txk6NskKpqUD7t7JDccDTVPRm\ KoJMmP3C/ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 1, 2009 Report Share Posted March 1, 2009 My mom has had a loss of smell...which effects taste aswell. I don't really know the cause but I think that it might be some of the medication because of her ostep-arthritis...anyway, I suggested to her to take the odorless garlic for her thyroid and she said that she has started to regain some smell as a side effect...fairly good side effect I would say!LOL Anyway, I don't know if that helps or not but that is the closest I know of! > > Hi Elaine, > I think the scientific/medical term for it is anosia. There was someone in my neighborhood when I was a kid who had this but I didn't really know the person. Besides eating issues it can cause safety concerns regarding smelling gas leaks, chemicals, fire. > S S > > Loss of sense of smell > Posted by: " ebrock1950 " kbrock@... ebrock1950 > Sun Mar 1, 2009 6:46 am (PST) > > Has anyone had or heard of anyone that has had a loss of sense of smell? > > Elaine B > > > > ------------------------------------------------------------ > Click here to find the perfect banking opportunity! > Banking > http://tagline.excite.com/fc/FgElN1g2Xnb1wQVonrgo53dOd1Txk6NskKpqUD7t7 JDccDTVPRmKoJMmP3C/ > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 1, 2009 Report Share Posted March 1, 2009 My dh hasn't smelled anything in 10 or more years. He is celiac(diagnosed 2003), and intolerant to so much more food.(everything) When is eats any sugars or starches he gets severe sinus issues,insomia etc. as well as crohns symptoms. His child also have a lot of autoimmune issues, as well as toxic metals... they can only eat scd, if they stray from the diet they get very sick. The kids can eat more food than their father b/c of the time on strict scd diet. c. > > Has anyone had or heard of anyone that has had a loss of sense of smell? > > Elaine B > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 1, 2009 Report Share Posted March 1, 2009 Zinc deficiency causes this as well. Barb [ ] Re: Loss of sense of smell My mom has had a loss of smell...which effects taste aswell. I don't really know the cause but I think that it might be some of the medication because of her ostep-arthritis...anyway, I suggested to her to take the odorless garlic for her thyroid and she said that she has started to regain some smell as a side effect...fairly good side effect I would say!LOL Anyway, I don't know if that helps or not but that is the closest I know of! > > Hi Elaine, > I think the scientific/medical term for it is anosia. There was someone in my neighborhood when I was a kid who had this but I didn't really know the person. Besides eating issues it can cause safety concerns regarding smelling gas leaks, chemicals, fire. > S S > > Loss of sense of smell > Posted by: " ebrock1950 " kbrock@... ebrock1950 > Sun Mar 1, 2009 6:46 am (PST) > > Has anyone had or heard of anyone that has had a loss of sense of smell? > > Elaine B > > > > ---------------------------------------------------------- > Click here to find the perfect banking opportunity! > Banking > http://tagline.excite.com/fc/FgElN1g2Xnb1wQVonrgo53dOd1Txk6NskKpqUD7t7 JDccDTVPRmKoJMmP3C/ > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 1, 2009 Report Share Posted March 1, 2009 Have you all considered NAET? www.naet.com S S Re: Loss of sense of smell Posted by: " cathy " cjb202207@... cjb202207 Sun Mar 1, 2009 10:01 am (PST) My dh hasn't smelled anything in 10 or more years. He is celiac(diagnosed 2003), and intolerant to so much more food.(everything) When is eats any sugars or starches he gets severe sinus issues,insomia etc. as well as crohns symptoms. His child also have a lot of autoimmune issues, as well as toxic metals... they can only eat scd, if they stray from the diet they get very sick. The kids can eat more food than their father b/c of the time on strict scd diet. c. ------------------------------------------------------------ Countertops High quality, custom countertops at bargain prices. Click Now! http://tagline.excite.com/fc/FgElN1gwaVwr4Q5hC0tDfy5eSWyp2Kkrqy7vGLApnngVY6Ij1Oo\ JWhaQDk8/ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 1, 2009 Report Share Posted March 1, 2009 This happened to my friend's mother after a flu shot. PJ > > Hi Elaine, > I think the scientific/medical term for it is anosia. There was someone in my neighborhood when I was a kid who had this but I didn't really know the person. Besides eating issues it can cause safety concerns regarding smelling gas leaks, chemicals, fire. > S S > > Loss of sense of smell > Posted by: " ebrock1950 " kbrock@... ebrock1950 > Sun Mar 1, 2009 6:46 am (PST) > > Has anyone had or heard of anyone that has had a loss of sense of smell? > > Elaine B > > > > ------------------------------------------------------------ > Click here to find the perfect banking opportunity! > Banking > http://tagline.excite.com/fc/FgElN1g2Xnb1wQVonrgo53dOd1Txk6NskKpqUD7t7JDccDTV PRmKoJMmP3C/ > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 1, 2009 Report Share Posted March 1, 2009 I know someone that lost their smell... and was told there is no hope. She then went to a accuncturist and after one visit ... got it back. On Mar 1, 2009, at 4:41 PM, jromkema wrote: > Zinc deficiency causes this as well. > > Barb > [ ] Re: Loss of sense of smell > > My mom has had a loss of smell...which effects taste aswell. I don't > really know the cause but I think that it might be some of the > medication because of her ostep-arthritis...anyway, I suggested to > her to take the odorless garlic for her thyroid and she said that she > has started to regain some smell as a side effect...fairly good side > effect I would say!LOL Anyway, I don't know if that helps or not but > that is the closest I know of! > > > > > > > > Hi Elaine, > > I think the scientific/medical term for it is anosia. There was > someone in my neighborhood when I was a kid who had this but I didn't > really know the person. Besides eating issues it can cause safety > concerns regarding smelling gas leaks, chemicals, fire. > > S S > > > > Loss of sense of smell > > Posted by: " ebrock1950 " kbrock@... ebrock1950 > > Sun Mar 1, 2009 6:46 am (PST) > > > > Has anyone had or heard of anyone that has had a loss of sense of > smell? > > > > Elaine B > > > > > > > > ---------------------------------------------------------- > > Click here to find the perfect banking opportunity! > > Banking > > > http://tagline.excite.com/fc/FgElN1g2Xnb1wQVonrgo53dOd1Txk6NskKpqUD7t7 > JDccDTVPRmKoJMmP3C/ > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 1, 2009 Report Share Posted March 1, 2009 Grandmother and a few of her kids (but not my father) cannot smell. Apparently, born that way. Never thought about before in relation to my son. He has oversensitive sense of smell. > > Has anyone had or heard of anyone that has had a loss of sense of smell? > > Elaine B > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2009 Report Share Posted March 2, 2009 I know that loss of smell is a common first symptom for indicating Alzheimer's disease. Perhaps it is a universal autoimmune symptom? > > > > Has anyone had or heard of anyone that has had a loss of sense of smell? > > > > Elaine B > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2009 Report Share Posted March 2, 2009 Also MS can cause the loss of smell. My dh has 2 uncles with MS. On the same side of the family the cousins of Crohns, celiac, food allergies, asthma, cancers, I think any neurological type autoimmune disorder that puts plaque on the brain can cause loss of smell. But loss of smell can be as simple as poylps in the sinises or sinises full of yeast. > > > > > > Has anyone had or heard of anyone that has had a loss of sense of > smell? > > > > > > Elaine B > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2010 Report Share Posted February 15, 2010 What causes partial loss do you think? I can smell some things and not others all in the same day. Tami Loss of Sense of Smell It may not sound new to everybody to write that inflammation causes SoS loss, but this abstract really is about an important step in discovering how SoS is lost and, much more important, how it could (conditional) be regained after the inflammation stops. Obviously, more work in this direction is needed. ----------- J Neurosci. 2010 Feb 10;30(6):2324-9. A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization. Lane AP, J, May L, R. Department of Otolaryngology-Head and Neck Surgery, Center for Sensory Biology, and Department of Molecular Biology and Genetics, The s Hopkins University School of Medicine, Baltimore, land 21287. Inflammatory sinus and nasal disease is a common cause of human olfactory loss. To explore the mechanisms underlying rhinosinusitis-associated olfactory loss, we have generated a transgenic mouse model of olfactory inflammation, in which tumor necrosis factor alpha (TNF-alpha) expression is induced in a temporally controlled manner specifically within the olfactory epithelium (OE). Like the human disease, TNF-alpha expression leads to a progressive infiltration of inflammatory cells into the OE. Using this model, we have defined specific phases of the pathologic process. An initial loss of sensation without significant disruption is observed, followed by a striking reorganization of the sensory neuroepithelium. An inflamed and disrupted state is sustained chronically by continued induction of cytokine expression. After prolonged maintenance in a deficient state, there is a dramatic recovery of function and a normal histologic appearance when TNF-alpha expression is extinguished. Although obstruction of airflow is also a contributing factor in human rhinosinusitis, this in vivo model demonstrates for the first time that direct effects of inflammation on OE structure and function are important mechanisms of olfactory dysfunction. These features mimic essential aspects of chronic rhinosinusitis-associated olfactory loss, and illuminate underlying cellular and molecular aspects of the disease. This manipulable model also serves as a platform for developing novel therapeutic interventions. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2010 Report Share Posted February 15, 2010 I'd love to know. My SOS came back, then disappeared again. Polyps can't regrow THAT quick after surgery, can they? It's only been 3 weeks! > > What causes partial loss do you think? I can smell some things and not others all in the same day. > Tami > > Loss of Sense of Smell > > > > > It may not sound new to everybody to write that inflammation causes SoS loss, but this abstract really is about an important step in discovering how SoS is lost and, much more important, how it could (conditional) be regained after the inflammation stops. Obviously, more work in this direction is needed. > > > ----------- > > > J Neurosci. 2010 Feb 10;30(6):2324-9. > > A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization. > Lane AP, J, May L, R. > > Department of Otolaryngology-Head and Neck Surgery, Center for Sensory Biology, and Department of Molecular Biology and Genetics, The s Hopkins University School of Medicine, Baltimore, land 21287. > > Inflammatory sinus and nasal disease is a common cause of human olfactory loss. To explore the mechanisms underlying rhinosinusitis-associated olfactory loss, we have generated a transgenic mouse model of olfactory inflammation, in which tumor necrosis factor alpha (TNF-alpha) expression is induced in a temporally controlled manner specifically within the olfactory epithelium (OE). Like the human disease, TNF-alpha expression leads to a progressive infiltration of inflammatory cells into the OE. Using this model, we have defined specific phases of the pathologic process. An initial loss of sensation without significant disruption is observed, followed by a striking reorganization of the sensory neuroepithelium. An inflamed and disrupted state is sustained chronically by continued induction of cytokine expression. After prolonged maintenance in a deficient state, there is a dramatic recovery of function and a normal histologic appearance when TNF-alpha expression is extinguished. Although obstruction of airflow is also a contributing factor in human rhinosinusitis, this in vivo model demonstrates for the first time that direct effects of inflammation on OE structure and function are important mechanisms of olfactory dysfunction. These features mimic essential aspects of chronic rhinosinusitis-associated olfactory loss, and illuminate underlying cellular and molecular aspects of the disease. This manipulable model also serves as a platform for developing novel therapeutic interventions. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2010 Report Share Posted February 15, 2010 It took my SOS quite a while to come back after surgery -- it may still be due to healing from the surgery -- at least you know you have the potential to smell and that that hasn't been detroyed. Good luck! On Feb 15, 2010, at 7:11 PM, wrote: I'd love to know. My SOS came back, then disappeared again. Polyps can't regrow THAT quick after surgery, can they? It's only been 3 weeks! > > What causes partial loss do you think? I can smell some things and not others all in the same day. > Tami > > Loss of Sense of Smell > > > > > It may not sound new to everybody to write that inflammation causes SoS loss, but this abstract really is about an important step in discovering how SoS is lost and, much more important, how it could (conditional) be regained after the inflammation stops. Obviously, more work in this direction is needed. > > > ----------- > > > J Neurosci. 2010 Feb 10;30(6):2324-9. > > A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization. > Lane AP, J, May L, R. > > Department of Otolaryngology-Head and Neck Surgery, Center for Sensory Biology, and Department of Molecular Biology and Genetics, The s Hopkins University School of Medicine, Baltimore, land 21287. > > Inflammatory sinus and nasal disease is a common cause of human olfactory loss. To explore the mechanisms underlying rhinosinusitis-associated olfactory loss, we have generated a transgenic mouse model of olfactory inflammation, in which tumor necrosis factor alpha (TNF-alpha) expression is induced in a temporally controlled manner specifically within the olfactory epithelium (OE). Like the human disease, TNF-alpha expression leads to a progressive infiltration of inflammatory cells into the OE. Using this model, we have defined specific phases of the pathologic process. An initial loss of sensation without significant disruption is observed, followed by a striking reorganization of the sensory neuroepithelium. An inflamed and disrupted state is sustained chronically by continued induction of cytokine expression. After prolonged maintenance in a deficient state, there is a dramatic recovery of function and a normal histologic appearance when TNF-alpha expression is extinguished. Although obstruction of airflow is also a contributing factor in human rhinosinusitis, this in vivo model demonstrates for the first time that direct effects of inflammation on OE structure and function are important mechanisms of olfactory dysfunction. These features mimic essential aspects of chronic rhinosinusitis-associated olfactory loss, and illuminate underlying cellular and molecular aspects of the disease. This manipulable model also serves as a platform for developing novel therapeutic interventions. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2010 Report Share Posted February 15, 2010 Thanks for the optimism, Joan! That is a good point. My ENT will be taking a gander this Wednesday, I hope those polyps aren't back...after pred bursts, it usually took a month for them to start causing problems again. I would think they would take longer to regrow after surgical removal... > > > > > > What causes partial loss do you think? I can smell some things and not others all in the same day. > > > Tami > > > > > > Loss of Sense of Smell > > > > > > > > > > > > > > > It may not sound new to everybody to write that inflammation causes SoS loss, but this abstract really is about an important step in discovering how SoS is lost and, much more important, how it could (conditional) be regained after the inflammation stops. Obviously, more work in this direction is needed. > > > > > > > > > ----------- > > > > > > > > > J Neurosci. 2010 Feb 10;30(6):2324-9. > > > > > > A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization. > > > Lane AP, J, May L, R. > > > > > > Department of Otolaryngology-Head and Neck Surgery, Center for Sensory Biology, and Department of Molecular Biology and Genetics, The s Hopkins University School of Medicine, Baltimore, land 21287. > > > > > > Inflammatory sinus and nasal disease is a common cause of human olfactory loss. To explore the mechanisms underlying rhinosinusitis-associated olfactory loss, we have generated a transgenic mouse model of olfactory inflammation, in which tumor necrosis factor alpha (TNF-alpha) expression is induced in a temporally controlled manner specifically within the olfactory epithelium (OE). Like the human disease, TNF-alpha expression leads to a progressive infiltration of inflammatory cells into the OE. Using this model, we have defined specific phases of the pathologic process. An initial loss of sensation without significant disruption is observed, followed by a striking reorganization of the sensory neuroepithelium. An inflamed and disrupted state is sustained chronically by continued induction of cytokine expression. After prolonged maintenance in a deficient state, there is a dramatic recovery of function and a normal histologic appearance when TNF-alpha expression is extinguished. Although obstruction of airflow is also a contributing factor in human rhinosinusitis, this in vivo model demonstrates for the first time that direct effects of inflammation on OE structure and function are important mechanisms of olfactory dysfunction. These features mimic essential aspects of chronic rhinosinusitis-associated olfactory loss, and illuminate underlying cellular and molecular aspects of the disease. This manipulable model also serves as a platform for developing novel therapeutic interventions. > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 16, 2010 Report Share Posted February 16, 2010 5 WEEKS AFTER MY SURGERY i WAS TOTALLY OCCLUDED.SOS gone!!! > > > > What causes partial loss do you think? I can smell some things and not others all in the same day. > > Tami > > > > Loss of Sense of Smell > > > > > > > > > > It may not sound new to everybody to write that inflammation causes SoS loss, but this abstract really is about an important step in discovering how SoS is lost and, much more important, how it could (conditional) be regained after the inflammation stops. Obviously, more work in this direction is needed. > > > > > > ----------- > > > > > > J Neurosci. 2010 Feb 10;30(6):2324-9. > > > > A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization. > > Lane AP, J, May L, R. > > > > Department of Otolaryngology-Head and Neck Surgery, Center for Sensory Biology, and Department of Molecular Biology and Genetics, The s Hopkins University School of Medicine, Baltimore, land 21287. > > > > Inflammatory sinus and nasal disease is a common cause of human olfactory loss. To explore the mechanisms underlying rhinosinusitis-associated olfactory loss, we have generated a transgenic mouse model of olfactory inflammation, in which tumor necrosis factor alpha (TNF-alpha) expression is induced in a temporally controlled manner specifically within the olfactory epithelium (OE). Like the human disease, TNF-alpha expression leads to a progressive infiltration of inflammatory cells into the OE. Using this model, we have defined specific phases of the pathologic process. An initial loss of sensation without significant disruption is observed, followed by a striking reorganization of the sensory neuroepithelium. An inflamed and disrupted state is sustained chronically by continued induction of cytokine expression. After prolonged maintenance in a deficient state, there is a dramatic recovery of function and a normal histologic appearance when TNF-alpha expression is extinguished. Although obstruction of airflow is also a contributing factor in human rhinosinusitis, this in vivo model demonstrates for the first time that direct effects of inflammation on OE structure and function are important mechanisms of olfactory dysfunction. These features mimic essential aspects of chronic rhinosinusitis-associated olfactory loss, and illuminate underlying cellular and molecular aspects of the disease. This manipulable model also serves as a platform for developing novel therapeutic interventions. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 16, 2010 Report Share Posted February 16, 2010 Ugh. I'll let y'all know what the ENT says tomorrow... > > > > > > What causes partial loss do you think? I can smell some things and not others all in the same day. > > > Tami > > > > > > Loss of Sense of Smell > > > > > > > > > > > > > > > It may not sound new to everybody to write that inflammation causes SoS loss, but this abstract really is about an important step in discovering how SoS is lost and, much more important, how it could (conditional) be regained after the inflammation stops. Obviously, more work in this direction is needed. > > > > > > > > > ----------- > > > > > > > > > J Neurosci. 2010 Feb 10;30(6):2324-9. > > > > > > A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization. > > > Lane AP, J, May L, R. > > > > > > Department of Otolaryngology-Head and Neck Surgery, Center for Sensory Biology, and Department of Molecular Biology and Genetics, The s Hopkins University School of Medicine, Baltimore, land 21287. > > > > > > Inflammatory sinus and nasal disease is a common cause of human olfactory loss. To explore the mechanisms underlying rhinosinusitis-associated olfactory loss, we have generated a transgenic mouse model of olfactory inflammation, in which tumor necrosis factor alpha (TNF-alpha) expression is induced in a temporally controlled manner specifically within the olfactory epithelium (OE). Like the human disease, TNF-alpha expression leads to a progressive infiltration of inflammatory cells into the OE. Using this model, we have defined specific phases of the pathologic process. An initial loss of sensation without significant disruption is observed, followed by a striking reorganization of the sensory neuroepithelium. An inflamed and disrupted state is sustained chronically by continued induction of cytokine expression. After prolonged maintenance in a deficient state, there is a dramatic recovery of function and a normal histologic appearance when TNF-alpha expression is extinguished. Although obstruction of airflow is also a contributing factor in human rhinosinusitis, this in vivo model demonstrates for the first time that direct effects of inflammation on OE structure and function are important mechanisms of olfactory dysfunction. These features mimic essential aspects of chronic rhinosinusitis-associated olfactory loss, and illuminate underlying cellular and molecular aspects of the disease. This manipulable model also serves as a platform for developing novel therapeutic interventions. > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 16, 2010 Report Share Posted February 16, 2010 Same here. 5 weeks later, no SOS. Total drag.... samters From: lbl626@...Date: Tue, 16 Feb 2010 15:00:51 +0000Subject: Re: Loss of Sense of Smell 5 WEEKS AFTER MY SURGERY i WAS TOTALLY OCCLUDED.SOS gone!!! > > > > What causes partial loss do you think? I can smell some things and not others all in the same day. > > Tami > > > > Loss of Sense of Smell > > > > > > > > > > It may not sound new to everybody to write that inflammation causes SoS loss, but this abstract really is about an important step in discovering how SoS is lost and, much more important, how it could (conditional) be regained after the inflammation stops. Obviously, more work in this direction is needed. > > > > > > ----------- > > > > > > J Neurosci. 2010 Feb 10;30(6):2324-9. > > > > A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization. > > Lane AP, J, May L, R. > > > > Department of Otolaryngology-Head and Neck Surgery, Center for Sensory Biology, and Department of Molecular Biology and Genetics, The s Hopkins University School of Medicine, Baltimore, land 21287. > > > > Inflammatory sinus and nasal disease is a common cause of human olfactory loss. To explore the mechanisms underlying rhinosinusitis-associated olfactory loss, we have generated a transgenic mouse model of olfactory inflammation, in which tumor necrosis factor alpha (TNF-alpha) expression is induced in a temporally controlled manner specifically within the olfactory epithelium (OE). Like the human disease, TNF-alpha expression leads to a progressive infiltration of inflammatory cells into the OE. Using this model, we have defined specific phases of the pathologic process. An initial loss of sensation without significant disruption is observed, followed by a striking reorganization of the sensory neuroepithelium. An inflamed and disrupted state is sustained chronically by continued induction of cytokine expression. After prolonged maintenance in a deficient state, there is a dramatic recovery of function and a normal histologic appearance when TNF-alpha expression is extinguished. Although obstruction of airflow is also a contributing factor in human rhinosinusitis, this in vivo model demonstrates for the first time that direct effects of inflammation on OE structure and function are important mechanisms of olfactory dysfunction. These features mimic essential aspects of chronic rhinosinusitis-associated olfactory loss, and illuminate underlying cellular and molecular aspects of the disease. This manipulable model also serves as a platform for developing novel therapeutic interventions. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 16, 2010 Report Share Posted February 16, 2010 Do all of you lose all sense of smell? Or just partial? Loss of Sense of Smell> > > > > > > > > > It may not sound new to everybody to write that inflammation causes SoS loss, but this abstract really is about an important step in discovering how SoS is lost and, much more important, how it could (conditional) be regained after the inflammation stops. Obviously, more work in this direction is needed.> > > > > > -----------> > > > > > J Neurosci. 2010 Feb 10;30(6):2324-9.> > > > A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization.> > Lane AP, J, May L, R.> > > > Department of Otolaryngology-Head and Neck Surgery, Center for Sensory Biology, and Department of Molecular Biology and Genetics, The s Hopkins University School of Medicine, Baltimore, land 21287.> > > > Inflammatory sinus and nasal disease is a common cause of human olfactory loss. To explore the mechanisms underlying rhinosinusitis-associated olfactory loss, we have generated a transgenic mouse model of olfactory inflammation, in which tumor necrosis factor alpha (TNF-alpha) expression is induced in a temporally controlled manner specifically within the olfactory epithelium (OE). Like the human disease, TNF-alpha expression leads to a progressive infiltration of inflammatory cells into the OE. Using this model, we have defined specific phases of the pathologic process. An initial loss of sensation without significant disruption is observed, followed by a striking reorganization of the sensory neuroepithelium. An inflamed and disrupted state is sustained chronically by continued induction of cytokine expression. After prolonged maintenance in a deficient state, there is a dramatic recovery of function and a normal histologic appearance when TNF-alpha expression is extinguished. Although obstruction of airflow is also a contributing factor in human rhinosinusitis, this in vivo model demonstrates for the first time that direct effects of inflammation on OE structure and function are important mechanisms of olfactory dysfunction. These features mimic essential aspects of chronic rhinosinusitis-associated olfactory loss, and illuminate underlying cellular and molecular aspects of the disease. This manipulable model also serves as a platform for developing novel therapeutic interventions.> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 16, 2010 Report Share Posted February 16, 2010 Right after my polyp surgey a few years ago, I had a Technicolor sense of smell for about a month to six weeks. It was glorious!Over the next few weeks, it slowly disappeared to the point that it was almost gone. Sometimes, vigorous exercise would cause a temporary return of my smell, but only for a couple of hours. Lately, I have been experimenting with soaking my sinuses in Pulmicort as described by several people here with great results. I have found that it took about three weeks of once a day soaking (one respule split between each nostril) for 10 minutes in a head upside down position to get my smell back. I can now do a treatment every other day and maintain a very good sense of smell. Burke Blevins samters From: tami1961@...Date: Tue, 16 Feb 2010 09:56:31 -0600Subject: Re: Re: Loss of Sense of Smell Do all of you lose all sense of smell? Or just partial? Loss of Sense of Smell> > > > > > > > > > It may not sound new to everybody to write that inflammation causes SoS loss, but this abstract really is about an important step in discovering how SoS is lost and, much more important, how it could (conditional) be regained after the inflammation stops. Obviously, more work in this direction is needed.> > > > > > -----------> > > > > > J Neurosci. 2010 Feb 10;30(6):2324-9.> > > > A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization.> > Lane AP, J, May L, R.> > > > Department of Otolaryngology-Head and Neck Surgery, Center for Sensory Biology, and Department of Molecular Biology and Genetics, The s Hopkins University School of Medicine, Baltimore, land 21287.> > > > Inflammatory sinus and nasal disease is a common cause of human olfactory loss. To explore the mechanisms underlying rhinosinusitis-associated olfactory loss, we have generated a transgenic mouse model of olfactory inflammation, in which tumor necrosis factor alpha (TNF-alpha) expression is induced in a temporally controlled manner specifically within the olfactory epithelium (OE). Like the human disease, TNF-alpha expression leads to a progressive infiltration of inflammatory cells into the OE. Using this model, we have defined specific phases of the pathologic process. An initial loss of sensation without significant disruption is observed, followed by a striking reorganization of the sensory neuroepithelium. An inflamed and disrupted state is sustained chronically by continued induction of cytokine expression. After prolonged maintenance in a deficient state, there is a dramatic recovery of function and a normal histologic appearance when TNF-alpha expression is extinguished. Although obstruction of airflow is also a contributing factor in human rhinosinusitis, this in vivo model demonstrates for the first time that direct effects of inflammation on OE structure and function are important mechanisms of olfactory dysfunction. These features mimic essential aspects of chronic rhinosinusitis-associated olfactory loss, and illuminate underlying cellular and molecular aspects of the disease. This manipulable model also serves as a platform for developing novel therapeutic interventions.> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 16, 2010 Report Share Posted February 16, 2010 I had surgery in Sept -- followed two weeks later by desens. it took about a month or more to get any sense of smell, but then it was good until I got a sinus infection mid -Dec. Lost my SOS completely, but when the antibiotic cleared up the sinus infection my SOS came back again and is quite good now. Have all of you who have lost your SOS completely been desensitized? On Feb 16, 2010, at 9:06 AM, Burke Blevins wrote: Right after my polyp surgey a few years ago, I had a Technicolor sense of smell for about a month to six weeks. It was glorious!Over the next few weeks, it slowly disappeared to the point that it was almost gone. Sometimes, vigorous exercise would cause a temporary return of my smell, but only for a couple of hours. Lately, I have been experimenting with soaking my sinuses in Pulmicort as described by several people here with great results. I have found that it took about three weeks of once a day soaking (one respule split between each nostril) for 10 minutes in a head upside down position to get my smell back. I can now do a treatment every other day and maintain a very good sense of smell. Burke Blevins samters From: tami1961verizon (DOT) netDate: Tue, 16 Feb 2010 09:56:31 -0600Subject: Re: Re: Loss of Sense of Smell Do all of you lose all sense of smell? Or just partial? Loss of Sense of Smell> > > > > > > > > > It may not sound new to everybody to write that inflammation causes SoS loss, but this abstract really is about an important step in discovering how SoS is lost and, much more important, how it could (conditional) be regained after the inflammation stops. Obviously, more work in this direction is needed.> > > > > > -----------> > > > > > J Neurosci. 2010 Feb 10;30(6):2324-9.> > > > A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization.> > Lane AP, J, May L, R.> > > > Department of Otolaryngology-Head and Neck Surgery, Center for Sensory Biology, and Department of Molecular Biology and Genetics, The s Hopkins University School of Medicine, Baltimore, land 21287.> > > > Inflammatory sinus and nasal disease is a common cause of human olfactory loss. To explore the mechanisms underlying rhinosinusitis-associated olfactory loss, we have generated a transgenic mouse model of olfactory inflammation, in which tumor necrosis factor alpha (TNF-alpha) expression is induced in a temporally controlled manner specifically within the olfactory epithelium (OE). Like the human disease, TNF-alpha expression leads to a progressive infiltration of inflammatory cells into the OE. Using this model, we have defined specific phases of the pathologic process. An initial loss of sensation without significant disruption is observed, followed by a striking reorganization of the sensory neuroepithelium. An inflamed and disrupted state is sustained chronically by continued induction of cytokine expression. After prolonged maintenance in a deficient state, there is a dramatic recovery of function and a normal histologic appearance when TNF-alpha expression is extinguished. Although obstruction of airflow is also a contributing factor in human rhinosinusitis, this in vivo model demonstrates for the first time that direct effects of inflammation on OE structure and function are important mechanisms of olfactory dysfunction. These features mimic essential aspects of chronic rhinosinusitis-associated olfactory loss, and illuminate underlying cellular and molecular aspects of the disease. This manipulable model also serves as a platform for developing novel therapeutic interventions.> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 16, 2010 Report Share Posted February 16, 2010 I had surgery (5th time) at the end of October and was desensitized in early December. My SOS was strongest in the weeks immediately after surgery and then held up, some days stronger than others, until the end of Jan. Now it's pretty much gone again even though I've been rinsing twice daily and my nose has remained relatively clear. I may do a round of Prednisone (I was on a monthly spurt dose pre-surgery) to see if it returns, or I may check back with my ENT doc to see if he could prescribe a better alternative to Nasonex. From my reading here, it seems people have had success with Pulmicort respules in the nostrils and with Flovent inhalers cut for nasal usage? Any other ideas? I feel like I need to take the lead on spray alternatives since I don't think my docs in VT see enough polyp/Samter's patients to be up on the latest innovations. Though I'm still freely breathing through my nose (which I definitely wasn't before surgery) and generally feeling good with little congestion and no asthma symptoms, it's frustrating to regain the SOS only to lose it again, and losing the SOS has always been the canary in the nasal coal mine signaling that the polyps are trying to rear their ugly heads again. Would be great to keep that momentum going as long as possible. Best Wishes to all, Ernie > > > > > > What causes partial loss do you think? I can smell some things and not others all in the same day. > > > Tami > > > > > > Loss of Sense of Smell > > > > > > > > > > > > > > > It may not sound new to everybody to write that inflammation causes SoS loss, but this abstract really is about an important step in discovering how SoS is lost and, much more important, how it could (conditional) be regained after the inflammation stops. Obviously, more work in this direction is needed. > > > > > > > > > ----------- > > > > > > > > > J Neurosci. 2010 Feb 10;30(6):2324-9. > > > > > > A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization. > > > Lane AP, J, May L, R. > > > > > > Department of Otolaryngology-Head and Neck Surgery, Center for Sensory Biology, and Department of Molecular Biology and Genetics, The s Hopkins University School of Medicine, Baltimore, land 21287. > > > > > > Inflammatory sinus and nasal disease is a common cause of human olfactory loss. To explore the mechanisms underlying rhinosinusitis-associated olfactory loss, we have generated a transgenic mouse model of olfactory inflammation, in which tumor necrosis factor alpha (TNF-alpha) expression is induced in a temporally controlled manner specifically within the olfactory epithelium (OE). Like the human disease, TNF-alpha expression leads to a progressive infiltration of inflammatory cells into the OE. Using this model, we have defined specific phases of the pathologic process. An initial loss of sensation without significant disruption is observed, followed by a striking reorganization of the sensory neuroepithelium. An inflamed and disrupted state is sustained chronically by continued induction of cytokine expression. After prolonged maintenance in a deficient state, there is a dramatic recovery of function and a normal histologic appearance when TNF-alpha expression is extinguished. Although obstruction of airflow is also a contributing factor in human rhinosinusitis, this in vivo model demonstrates for the first time that direct effects of inflammation on OE structure and function are important mechanisms of olfactory dysfunction. These features mimic essential aspects of chronic rhinosinusitis-associated olfactory loss, and illuminate underlying cellular and molecular aspects of the disease. This manipulable model also serves as a platform for developing novel therapeutic interventions. > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 16, 2010 Report Share Posted February 16, 2010 Yes, I failed to mention that I am desensitized, taking 650 mg of aspirin twice daily.Burke Blevins samters From: thomyris7@...Date: Tue, 16 Feb 2010 09:35:47 -0700Subject: Re: Re: Loss of Sense of Smell I had surgery in Sept -- followed two weeks later by desens. it took about a month or more to get any sense of smell, but then it was good until I got a sinus infection mid -Dec. Lost my SOS completely, but when the antibiotic cleared up the sinus infection my SOS came back again and is quite good now. Have all of you who have lost your SOS completely been desensitized? On Feb 16, 2010, at 9:06 AM, Burke Blevins wrote: Right after my polyp surgey a few years ago, I had a Technicolor sense of smell for about a month to six weeks. It was glorious!Over the next few weeks, it slowly disappeared to the point that it was almost gone. Sometimes, vigorous exercise would cause a temporary return of my smell, but only for a couple of hours. Lately, I have been experimenting with soaking my sinuses in Pulmicort as described by several people here with great results. I have found that it took about three weeks of once a day soaking (one respule split between each nostril) for 10 minutes in a head upside down position to get my smell back. I can now do a treatment every other day and maintain a very good sense of smell. Burke Blevins samters From: tami1961verizon (DOT) netDate: Tue, 16 Feb 2010 09:56:31 -0600Subject: Re: Re: Loss of Sense of Smell Do all of you lose all sense of smell? Or just partial? Loss of Sense of Smell> > > > > > > > > > It may not sound new to everybody to write that inflammation causes SoS loss, but this abstract really is about an important step in discovering how SoS is lost and, much more important, how it could (conditional) be regained after the inflammation stops. Obviously, more work in this direction is needed.> > > > > > -----------> > > > > > J Neurosci. 2010 Feb 10;30(6):2324-9.> > > > A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization.> > Lane AP, J, May L, R.> > > > Department of Otolaryngology-Head and Neck Surgery, Center for Sensory Biology, and Department of Molecular Biology and Genetics, The s Hopkins University School of Medicine, Baltimore, land 21287.> > > > Inflammatory sinus and nasal disease is a common cause of human olfactory loss. To explore the mechanisms underlying rhinosinusitis-associated olfactory loss, we have generated a transgenic mouse model of olfactory inflammation, in which tumor necrosis factor alpha (TNF-alpha) expression is induced in a temporally controlled manner specifically within the olfactory epithelium (OE). Like the human disease, TNF-alpha expression leads to a progressive infiltration of inflammatory cells into the OE. Using this model, we have defined specific phases of the pathologic process. An initial loss of sensation without significant disruption is observed, followed by a striking reorganization of the sensory neuroepithelium. An inflamed and disrupted state is sustained chronically by continued induction of cytokine expression. After prolonged maintenance in a deficient state, there is a dramatic recovery of function and a normal histologic appearance when TNF-alpha expression is extinguished. Although obstruction of airflow is also a contributing factor in human rhinosinusitis, this in vivo model demonstrates for the first time that direct effects of inflammation on OE structure and function are important mechanisms of olfactory dysfunction. These features mimic essential aspects of chronic rhinosinusitis-associated olfactory loss, and illuminate underlying cellular and molecular aspects of the disease. This manipulable model also serves as a platform for developing novel therapeutic interventions.> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 16, 2010 Report Share Posted February 16, 2010 MY SOS is minimal. But after being desensitized in April 2008 everything else is so much better. Polyps are present and small thus not much of a problem. I can breathe through both nostrils. I have actually gone a whole year without prednisone. Although I have a supply ready to go if necessary. Sometimes I want to take prednisone just so I can smell coffee again! I take 650 Mg of aspirin once a day. Re: Re: Loss of Sense of Smell Do all of you lose all sense of smell? Or just partial? Loss of Sense of Smell > > > > > > & g t; > > > It may not sound new to everybody to write that inflammation causes SoS loss, but this abstract really is about an important step in discovering how SoS is lost and, much more important, how it could (conditional) be regained after the inflammation stops. Obviously, more work in this direction is needed. > > > > > > ----------- > > > > > > J Neurosci. 2010 Feb 10;30(6):2324-9. > > > > A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization. > > Lane AP, J, May L, R. > > > > Department of Otolaryngology-Head and Neck Surgery, Center for Sensory Biology, and Department of Molecular Biology and Genetics, The s Hopkins University School of Medicine, Baltimore, land 21287. > > > > Inflammatory sinus and nasal disease is a common cause of human olfactory loss. To explore the mechanisms underlying rhinosinusitis-associated olfactory loss, we have generated a transgenic mouse model of olfactory inflammation, in which tumor necrosis factor alpha (TNF-alpha) expression is induced in a temporally controlled manner specifically within the olfactory epithelium (OE). Like the human disease, TNF-alpha expression leads to a progressive infiltration of inflammatory cells into the OE. Using this model, we have defined specific phases of the pathologic process. An initial loss of sensation without significant disruption is observed, followed by a striking reorganization of the sensory neuroepithelium. An inflamed and disrupted state is sustained chronically by continued induction of cytokine expression. After prolonged maintenance in a deficient state, there is a dramatic recovery of function and a normal histologic appearance when TNF-alpha expression is extinguished. Although obstruction of airflow is also a contributing factor in human rhinosinusitis, this in vivo model demonstrates for the first time that direct effects of inflammation on OE structure and function are important mechanisms of olfactory dysfunction. These features mimic essential aspects of chronic rhinosinusitis-associated olfactory loss, and illuminate underlying cellular and molecular aspects of the disease. This manipulable model also serves as a platform for developing novel therapeutic interventions. > > > Quote Link to comment Share on other sites More sharing options...
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