Amla Vitamin C

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We are using Amla vit. C. I thought I would share this article I

came across about it accidentally, it's pretty interesting!

Amla (Emblica officinalis Gaertn.) Extracts Reduce Oxidative Stress

in Streptozotocin-Induced Diabetic Rats

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To cite this paper:

T.P. Rao, N. Sakaguchi, L.R. Juneja, E. Wada, T. Yokozawa. Journal of

Medicinal Food. September 1, 2005, 8(3): 362-368.

doi:10.1089/jmf.2005.8.362.

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Full Text PDF: • HiRes for printing (239.3 KB) • PDF Plus w/ links

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T.P. Rao

Bio-nutrition Division, Taiyo Kagaku Co. Ltd., Yokkaichi.

N. Sakaguchi

Bio-nutrition Division, Taiyo Kagaku Co. Ltd., Yokkaichi.

L.R. Juneja

Bio-nutrition Division, Taiyo Kagaku Co. Ltd., Yokkaichi.

E. Wada

Institute of Natural Medicine, Toyama Medical and Pharmaceutical

University, Toyama, Japan.

T. Yokozawa

Institute of Natural Medicine, Toyama Medical and Pharmaceutical

University, Toyama, Japan.

The antioxidant properties of amla extracts and their effects on the

oxidative stress in streptozotocin-induced diabetes were examined in

rats. Amla in the form of either the commercial enzymatic extract

SunAmla (Taiyo Kagaku Co. Ltd., Yokkaichi, Japan) (20 or 40 mg/kg of

body weight/day) or a polyphenol-rich fraction of ethyl acetate

extract (10 or 20 mg/kg of body weight/day) was given orally for 20

days to the streptozotocin-induced diabetic rats. Amla extracts

showed strong free radical scavenging activity. Amla also showed

strong inhibition of the production of advanced glycosylated end

products. The oral administration of amla extracts to the diabetic

rats slightly improved body weight gain and also significantly

alleviated various oxidative stress indices of the serum of the

diabetic rats. The elevated serum levels of 5-hydroxymethylfurfural,

which is a glycosylated protein that is an indicator of oxidative

stress, were significantly reduced dose-dependently in the diabetic

rats fed amla. Similarly, the serum level of creatinine, yet another

oxidative stress parameter, was also reduced. Furthermore,

thiobarbituric acid-reactive substances levels were significantly

reduced with amla, indicating a reduction in lipid peroxidation. In

addition, the decreased albumin levels in the diabetic rats were

significantly improved with amla. Amla also significantly improved

the serum adiponectin levels. These results form the scientific basis

supporting the efficacy of amla for relieving the oxidative stress

and improving glucose metabolism in diabetes.