Fispemifene

[Guest guest]

Does anyone have any experience using this unapproved drug?

Fispemifene is a new, selective estrogen receptor antagonist that is being

developed as an oral treatment for testosterone deficiency and associated

disorders in men. Symptoms of low testosterone include sexual dysfunction,

muscle wasting, reduced bone density, lowered energy levels and glucose

intolerance. Unlike testosterone replacement therapies, fispemifene utilizes the

body's normal feedback mechanism to increase testosterone levels into, but not

beyond, the normal range. By blocking estrogen feedback to the pituitary with a

drug like fispemifene, the pituitary increases LH and FSH secretion which

increases testosterone secretion. As these rising testosterone levels feedback

on the pituitary, LH and FSH secretion return toward normal and testosterone

reaches a new, albeit higher, steady state level. Based on this mechanism of

action, fispemifene is being studied for the treatment of androgen deficiency

and associated symptoms. We believe that

increased production of testosterone may treat many of the symptoms of low

testosterone. In a Phase II study we conducted in hypogonadal men, fispemifene

increased total testosterone levels by 78% over 28 days of treatment.

PROGRAM PROFILE

Fispemifene is a selective estrogen antagonist that blocks estrogen effects on

pituitary, prostate and breast, but is an estrogen agonist on bone.

Advantages over existing therapies include:

¤ Naturally stimulates testosterone release without blocking regulatory

feedback

¤ Blocks adverse estrogen effects on the prostate

¤ Protects and potentially improves bone density

More information here

http://www.quatrx.com/clinical/fisp.htm

Regards,

Vergel

powerusa dot org