Guest guest Posted June 29, 2007 Report Share Posted June 29, 2007 I use 1/2 Arimidex & 2 DIM 3 times a week. No noticable side effects. Lowered E2 to mid-range. " T " is in upper 1/4 of range. T:E2 ratio is 30:1 last tests. I prefer it higher. 50:1 seems great for me. > > Does anyone have any comments, or can interpret qualitatively, these > results; > Tests done by Quest Diagnostics on an afternoon blood draw; on > androgel, and also 300 IU of HCG every 2-3days. > > Some physicians do not trust the accuracy of the Quest testing, but; > Estrone " out of range " at 70 pg/ml vs. a reference range of < or = 68 > > Estradiol " out of range " at 42 pg/ml vs. a reference range of < or = 29 > > The numbers are a bit high, and correlate with symptoms: night sweats, > etc. > I notice a good result after 2 days of DIMS but could not tolerate the > GI problems. > I can get a prescription for Arimadex; my internist was somewhat > concerned that there would be mood swings? Does anyone have any > experience with these tests and problems at these levels? > > My thanks to those of you who have written about these issues. > Regards, Tom > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 29, 2007 Report Share Posted June 29, 2007 I got dam sick doing Arimidex and Indolplex/DIM. My Dr. thought this would be a good combo but I was breaking out in a bad rash on the back of my legs and the sides of my belly. It took a long time to figure this out I ran out it Indolplex/DIM and it was on back order. Then I started feeling better. gin2c <no_reply > wrote: I use 1/2 Arimidex & 2 DIM 3 times a week. No noticable side effects. Lowered E2 to mid-range. " T " is in upper 1/4 of range. T:E2 ratio is 30:1 last tests. I prefer it higher. 50:1 seems great for me. > > Does anyone have any comments, or can interpret qualitatively, these > results; > Tests done by Quest Diagnostics on an afternoon blood draw; on > androgel, and also 300 IU of HCG every 2-3days. > > Some physicians do not trust the accuracy of the Quest testing, but; > Estrone " out of range " at 70 pg/ml vs. a reference range of < or = 68 > > Estradiol " out of range " at 42 pg/ml vs. a reference range of < or = 29 > > The numbers are a bit high, and correlate with symptoms: night sweats, > etc. > I notice a good result after 2 days of DIMS but could not tolerate the > GI problems. > I can get a prescription for Arimadex; my internist was somewhat > concerned that there would be mood swings? Does anyone have any > experience with these tests and problems at these levels? > > My thanks to those of you who have written about these issues. > Regards, Tom > Co-Moderator " Don't believe anything you hear and only half of what you see. " Phil --------------------------------- Now that's room service! Choose from over 150,000 hotels in 45,000 destinations on Travel to find your fit. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 7, 2009 Report Share Posted June 7, 2009 I am on Testosterone shots for low T. I have a 2mm Pituitary adenoma that I guess is causing all the problems. I received weekly shots of alternating amounts. It is a regimen of 1cc of 200 mg/ml one week and then .5cc the following and then switching back. I've been on this for about 2 months. I feel like crap. I am tired all the time. My blood pressure skyrocketed shortly after starting the shots. I am on bp meds now to control it. I paid for a complete set of blood work and there are weird readings all over the place. My E2 level is 79, my T level is 890. My CBC had several high readings, which my understanding is that is normal. Previous to this regimen, I was on 1cc every week but my t level was 1600 so she went to the new regimen. I was really hoping to feel better but I don't. I have no interest in sex at all and couldn't do it anyway if I was if you catch my drift. I am so frustrated. I've gained 40lbs and just cannot loose weight. I went on a strict low fat vegan diet for 6 weeks and lost about 1 pound. I am trying to exercise but am just too exhausted to do much of anything although I do try to do something for 30 minutes 3 times a week. I have a dr. appt coming up and don't know what to ask. I have high serum iron readings but low ferritin levels (stored iron). Any suggestions? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 8, 2009 Report Share Posted June 8, 2009 First let me say you have a pituitary problem this can make a lot of your hormones come in low normal. For me I am Hypopituitary do to a head injury. I went 23 yrs being told I am Primary meaning my testis don't work. You need to treat all hormones that are low or even low normal. I treat now my low Cortisol, Thyroid, Iron, Aldosterone and Renin. Your big problem is 1cc of 200mgs/ml. shot this is a dam big 200 mg shot. To add this this your doing this big shot one week and a shot half this amount the next week so your on a roller coaster ride up one week and crashing the next. Also doing this is driving your body nuts trying keep you leveled. Every time your levels fall your body takes from other hormones trying to fix this mess. Your also driving your Estradiol E2 levels way up this takes away the good the TRT does. You need to stop them big shots and do a shot say 100 mgs every week and bring your E2 down to about 20 pg/ml doing this will bring your morning wood back stop any ED your having if this is a problem and up your libido. E2 is the bad guy when we are on TRT and doing big shot like this drives it up. If you need more then a 100 mgs a week go up 25 mgs then test in 8 weeks you need to try to get your Total T levels up into the upper 1/3 of your labs range and keep your E2 down at about 20 pg/ml I gage this by my night time and morning wood when this comes back you at the sweet spot level for E2. Start on Arimidex .5 mgs every other day you will get your wood back keep taking this dose but if your wood stops your going down to low. So stop the arimidex until the wood comes back that day go back on it but do less say .5 every 3 day or .25 every 2 days Arimidex has a half life of 50 hrs so don't go more then 3 days with out taking it for starters. Some men later find they do good taking a low dose 2x's a week. You need to keep a log on what your doing and how you feel so you can tell if your E2 is going to high or to low. I do good gaging my wood and doing labs every 8 weeks. If you need more then 125 mgs a week then do 75mgs 2 x's a week. After a time when your leveled and feeling good add HCG to your TRT this will keep all your LH cells working and keep your testis from getting small. I can't say what is going on with your Ferritin levels with out seeing your labs with the ranges and units along with a CBC. Your Dr. treating your low T levels this way tells me he or she is not up on doing this read the AACE Guildlines it states to do shots every week the same dose. http://www.aace.com/pub/pdf/guidelines/hypogonadism.pdf Also go to www.allthingsmale.com and read TRT: A Recipe for Success and the HCG update Dr. puts this out there free for you and your Dr. If you can't get your Dr. to treat your high E2 find a better one or your will not do well for a long time been there done that. Co-Moderator Phil > From: noonanjg <jgnoonan@...> > Subject: Estradiol Levels > > Date: Sunday, June 7, 2009, 5:46 PM > I am on Testosterone shots for low > T. I have a 2mm Pituitary adenoma that I guess is > causing all the problems. I received weekly shots of > alternating amounts. It is a regimen of 1cc of 200 > mg/ml one week and then .5cc the following and then > switching back. I've been on this for about 2 > months. I feel like crap. I am tired all the > time. My blood pressure skyrocketed shortly after > starting the shots. I am on bp meds now to control > it. I paid for a complete set of blood work and there > are weird readings all over the place. My E2 level is > 79, my T level is 890. My CBC had several high > readings, which my understanding is that is normal. > Previous to this regimen, I was on 1cc every week but my t > level was 1600 so she went to the new regimen. I was > really hoping to feel better but I don't. I have no > interest in sex at all and couldn't do it anyway if I was if > you catch my drift. I am so frustrated. I've > gained 40lbs and just cannot loose weight. I went on a > strict low fat vegan diet for 6 weeks and lost about 1 > pound. I am trying to exercise but am just too > exhausted to do much of anything although I do try to do > something for 30 minutes 3 times a week. I have a dr. > appt coming up and don't know what to ask. I have high > serum iron readings but low ferritin levels (stored > iron). Any suggestions? > > > > ------------------------------------ > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 8, 2009 Report Share Posted June 8, 2009 On Sun, 07 Jun 2009 21:46:18 -0000, you wrote: >I am on Testosterone shots for low T. I have a 2mm Pituitary adenoma that I guess is causing all the problems. I received weekly shots of alternating amounts. It is a regimen of 1cc of 200 mg/ml one week and then .5cc the following and then switching back. I've been on this for about 2 months. I feel like crap. I am tired all the time. My blood pressure skyrocketed shortly after starting the shots. I am on bp meds now to control it. I paid for a complete set of blood work and there are weird readings all over the place. My E2 level is 79, my T level is 890. My CBC had several high readings, which my understanding is that is normal. Previous to this regimen, I was on 1cc every week but my t level was 1600 so she went to the new regimen. I was really hoping to feel better but I don't. I have no interest in sex at all and couldn't do it anyway if I was if you catch my drift. I am so frustrated. I've gained 40lbs and just cannot loose weight. I went on a strict low fat >vegan diet for 6 weeks and lost about 1 pound. I am trying to exercise but am just too exhausted to do much of anything although I do try to do something for 30 minutes 3 times a week. I have a dr. appt coming up and don't know what to ask. I have high serum iron readings but low ferritin levels (stored iron). Any suggestions? My primary thought is your E2 levels are very high. This will rob you of the benefit of the T and cause erection issues and libido issues. I susp[ect at levels like that you also find your self unusually emotional? Tearing up at movies? Anxious? Worrying? That can all disappear if you get E3 down to 20 to 30. It also makes it far easier to lose the weight and helps you find the energy to go do it. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 8, 2009 Report Share Posted June 8, 2009 > > >I am on Testosterone shots for low T. I have a 2mm Pituitary adenoma that I guess is causing all the problems. I received weekly shots of alternating amounts. It is a regimen of 1cc of 200 mg/ml one week and then .5cc the following and then switching back. I've been on this for about 2 months. I feel like crap. I am tired all the time. My blood pressure skyrocketed shortly after starting the shots. I am on bp meds now to control it. I paid for a complete set of blood work and there are weird readings all over the place. My E2 level is 79, my T level is 890. My CBC had several high readings, which my understanding is that is normal. Previous to this regimen, I was on 1cc every week but my t level was 1600 so she went to the new regimen. I was really hoping to feel better but I don't. I have no interest in sex at all and couldn't do it anyway if I was if you catch my drift. I am so frustrated. I've gained 40lbs and just cannot loose weight. I went on a strict low fat > >vegan diet for 6 weeks and lost about 1 pound. I am trying to exercise but am just too exhausted to do much of anything although I do try to do something for 30 minutes 3 times a week. I have a dr. appt coming up and don't know what to ask. I have high serum iron readings but low ferritin levels (stored iron). Any suggestions? > > > My primary thought is your E2 levels are very high. This will rob you > of the benefit of the T and cause erection issues and libido issues. I > susp[ect at levels like that you also find your self unusually > emotional? Tearing up at movies? Anxious? Worrying? > > That can all disappear if you get E3 down to 20 to 30. It also makes > it far easier to lose the weight and helps you find the energy to go > do it. > Actually, the main thing I am feeling is just exhausted. Aside from that, my penis is pretty much non-functional except for urinating. I have no energy or desire. I will talk to my doctor about the E2 level and see what she says. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 8, 2009 Report Share Posted June 8, 2009 Phil: Thanks for the extensive feedback. I've download the documents and have started reading them. I've talked to my doctor in the past about estrogen levels and she says it's not important. I am going to show her the blood work I had done to show her the current level and see if I can get her to do something about it. As far as the CBC, here it is: WBC 6.00 4.00-10.5 normal RBC 5.85 4.10-5.60 HIGH Hemoglobin 17.9 12.5-17.0 HIGH Hematocrit 53.0 36.0-50.0 HIGH MCV 91 80-98 normal MCH 30.5 27-34 normal MCHC 33.7 32-36 normal RDW 15.1 13.7-15.0 normal > > > From: noonanjg <jgnoonan@...> > > Subject: Estradiol Levels > > > > Date: Sunday, June 7, 2009, 5:46 PM > > I am on Testosterone shots for low > > T. I have a 2mm Pituitary adenoma that I guess is > > causing all the problems. I received weekly shots of > > alternating amounts. It is a regimen of 1cc of 200 > > mg/ml one week and then .5cc the following and then > > switching back. I've been on this for about 2 > > months. I feel like crap. I am tired all the > > time. My blood pressure skyrocketed shortly after > > starting the shots. I am on bp meds now to control > > it. I paid for a complete set of blood work and there > > are weird readings all over the place. My E2 level is > > 79, my T level is 890. My CBC had several high > > readings, which my understanding is that is normal. > > Previous to this regimen, I was on 1cc every week but my t > > level was 1600 so she went to the new regimen. I was > > really hoping to feel better but I don't. I have no > > interest in sex at all and couldn't do it anyway if I was if > > you catch my drift. I am so frustrated. I've > > gained 40lbs and just cannot loose weight. I went on a > > strict low fat vegan diet for 6 weeks and lost about 1 > > pound. I am trying to exercise but am just too > > exhausted to do much of anything although I do try to do > > something for 30 minutes 3 times a week. I have a dr. > > appt coming up and don't know what to ask. I have high > > serum iron readings but low ferritin levels (stored > > iron). Any suggestions? > > > > > > > > ------------------------------------ > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 9, 2009 Report Share Posted June 9, 2009 Great this is a good start and most of use men feel this way when T levels are to low and E2 Estradiol is to high. Fixing this by getting your T levels up into the upper 1/3 of your labs range and your E2 down to about 20 pg/ml you will know when it in the right level your night time and morning wood will come back no more ED and in time your libido will come back up. If not other things can do thie low Cortisol and Thyroid levels the list is long. Co-Moderator Phil > From: noonanjg <jgnoonan@...> > Subject: Re: Estradiol Levels > > Date: Monday, June 8, 2009, 6:59 PM > > > > > >I am on Testosterone shots for low T. I have > a 2mm Pituitary adenoma that I guess is causing all the > problems. I received weekly shots of alternating > amounts. It is a regimen of 1cc of 200 mg/ml one week > and then .5cc the following and then switching back. > I've been on this for about 2 months. I feel like > crap. I am tired all the time. My blood pressure > skyrocketed shortly after starting the shots. I am on > bp meds now to control it. I paid for a complete set > of blood work and there are weird readings all over the > place. My E2 level is 79, my T level is 890. My > CBC had several high readings, which my understanding is > that is normal. Previous to this regimen, I was on 1cc > every week but my t level was 1600 so she went to the new > regimen. I was really hoping to feel better but I > don't. I have no interest in sex at all and couldn't > do it anyway if I was if you catch my drift. I am so > frustrated. I've gained 40lbs and just cannot loose > weight. I went on a strict low fat > > >vegan diet for 6 weeks and lost about 1 > pound. I am trying to exercise but am just too > exhausted to do much of anything although I do try to do > something for 30 minutes 3 times a week. I have a dr. > appt coming up and don't know what to ask. I have high > serum iron readings but low ferritin levels (stored > iron). Any suggestions? > > > > > > My primary thought is your E2 levels are very high. > This will rob you > > of the benefit of the T and cause erection issues and > libido issues. I > > susp[ect at levels like that you also find your self > unusually > > emotional? Tearing up at movies? Anxious? Worrying? > > > > That can all disappear if you get E3 down to 20 to > 30. It also makes > > it far easier to lose the weight and helps you find > the energy to go > > do it. > > > > Actually, the main thing I am feeling is just > exhausted. Aside from that, my penis is pretty much > non-functional except for urinating. I have no energy > or desire. I will talk to my doctor about the E2 level > and see what she says. > > > > ------------------------------------ > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 9, 2009 Report Share Posted June 9, 2009 Your CBC looks like you were dehydreated drink at least 2 big glass's of water before testing and do your labs fasting in the morning. If you can't get your Dr. to test E2 find a new one life is to short. I am here because of seeing so dam many bad or Dr's not in the know about low T took me 23 yrs to get to the bottom of it. So I am here to help men not go through what I did. You can read my story at this link. http://forums.realthyroidhelp.com/viewtopic.php?f=5 & t=9239 Co-Moderator Phil > From: noonanjg <jgnoonan@...> > Subject: Re: Estradiol Levels > > Date: Monday, June 8, 2009, 7:19 PM > Phil: Thanks for the extensive > feedback. I've download the documents and have started > reading them. I've talked to my doctor in the past > about estrogen levels and she says it's not important. > I am going to show her the blood work I had done to show her > the current level and see if I can get her to do something > about it. As far as the CBC, here it is: > > WBC 6.00 > 4.00-10.5 normal > RBC 5.85 > 4.10-5.60 HIGH > Hemoglobin 17.9 > 12.5-17.0 HIGH > Hematocrit 53.0 > 36.0-50.0 HIGH > MCV 91 > 80-98 normal > MCH 30.5 > 27-34 normal > MCHC 33.7 > 32-36 normal > RDW 15.1 > 13.7-15.0 normal > > > > > > > > > > From: noonanjg <jgnoonan@...> > > > Subject: Estradiol Levels > > > > > > Date: Sunday, June 7, 2009, 5:46 PM > > > I am on Testosterone shots for low > > > T. I have a 2mm Pituitary adenoma that I guess > is > > > causing all the problems. I received weekly > shots of > > > alternating amounts. It is a regimen of 1cc of > 200 > > > mg/ml one week and then .5cc the following and > then > > > switching back. I've been on this for about 2 > > > months. I feel like crap. I am tired all the > > > time. My blood pressure skyrocketed shortly > after > > > starting the shots. I am on bp meds now to > control > > > it. I paid for a complete set of blood work and > there > > > are weird readings all over the place. My E2 > level is > > > 79, my T level is 890. My CBC had several high > > > readings, which my understanding is that is > normal. > > > Previous to this regimen, I was on 1cc every week > but my t > > > level was 1600 so she went to the new regimen. > I was > > > really hoping to feel better but I don't. I > have no > > > interest in sex at all and couldn't do it anyway > if I was if > > > you catch my drift. I am so frustrated. I've > > > gained 40lbs and just cannot loose weight. I > went on a > > > strict low fat vegan diet for 6 weeks and lost > about 1 > > > pound. I am trying to exercise but am just too > > > exhausted to do much of anything although I do > try to do > > > something for 30 minutes 3 times a week. I have > a dr. > > > appt coming up and don't know what to ask. I > have high > > > serum iron readings but low ferritin levels > (stored > > > iron). Any suggestions? > > > > > > > > > > > > ------------------------------------ > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 9, 2009 Report Share Posted June 9, 2009 On Mon, 08 Jun 2009 23:19:22 -0000, you wrote: >Phil: Thanks for the extensive feedback. I've download the documents and have started reading them. I've talked to my doctor in the past about estrogen levels and she says it's not important. I am going to show her the blood work I had done to show her the current level and see if I can get her to do something about it. As far as the CBC, here it is: > >WBC 6.00 4.00-10.5 normal >RBC 5.85 4.10-5.60 HIGH >Hemoglobin 17.9 12.5-17.0 HIGH >Hematocrit 53.0 36.0-50.0 HIGH >MCV 91 80-98 normal >MCH 30.5 27-34 normal >MCHC 33.7 32-36 normal >RDW 15.1 13.7-15.0 normal Are you taking T already? This raise hematorcrit and hemoglobin. You can give blood to pull these down some. Or adjust T levels - which you may need to -to bring E2 levels down some. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 10, 2009 Report Share Posted June 10, 2009 Yes, I am already getting T injections every week. I was worried about the hematocrit levels as well. > > >Phil: Thanks for the extensive feedback. I've download the documents and have started reading them. I've talked to my doctor in the past about estrogen levels and she says it's not important. I am going to show her the blood work I had done to show her the current level and see if I can get her to do something about it. As far as the CBC, here it is: > > > >WBC 6.00 4.00-10.5 normal > >RBC 5.85 4.10-5.60 HIGH > >Hemoglobin 17.9 12.5-17.0 HIGH > >Hematocrit 53.0 36.0-50.0 HIGH > >MCV 91 80-98 normal > >MCH 30.5 27-34 normal > >MCHC 33.7 32-36 normal > >RDW 15.1 13.7-15.0 normal > > > Are you taking T already? > > This raise hematorcrit and hemoglobin. > > You can give blood to pull these down some. Or adjust T levels - which > you may need to -to bring E2 levels down some. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 14, 2009 Report Share Posted June 14, 2009 What do you mean " sky high " on your BP? Mine is high usually 150's over 90's but both my test and adderall contribute to that. What are you taking for BP? Many bp meds are notorious for causing fatigue. See if you can cut your BP meds in half for a couple of weeks to see if that is the cause. If so maybe your doc can try another BP med if he thinks your BP is still too high. Also there is a " sweet spot " with the test/estrogen ratio. I find that is my test gets too high, libido takes a dive. I seem to function best around 200mg a week but sometimes my numbers get too high and I have to lay off for a few weeks to let it drop back down. Also be aware that test metabolizes much faster than estrogen so you'll need to drop the test at least a month or more to let the estrogen drop naturally. Talk to your doc about starting on a low dose arimidex to control the estrogen. Bottom line is that you will not see the full benefits of the test unless you control the estrogen. It's even worse if you are " estrogen sensitive " . Hope this helps. Another option. Some guys do the test shots twice a week 1/2cc Monday and another 1/2cc on Thursday to keep the test ahead of the estrogen. > > I am on Testosterone shots for low T. I have a 2mm Pituitary adenoma that I guess is causing all the problems. I received weekly shots of alternating amounts. It is a regimen of 1cc of 200 mg/ml one week and then .5cc the following and then switching back. I've been on this for about 2 months. I feel like crap. I am tired all the time. My blood pressure skyrocketed shortly after starting the shots. I am on bp meds now to control it. I paid for a complete set of blood work and there are weird readings all over the place. My E2 level is 79, my T level is 890. My CBC had several high readings, which my understanding is that is normal. Previous to this regimen, I was on 1cc every week but my t level was 1600 so she went to the new regimen. I was really hoping to feel better but I don't. I have no interest in sex at all and couldn't do it anyway if I was if you catch my drift. I am so frustrated. I've gained 40lbs and just cannot loose weight. I went on a strict low fat vegan diet for 6 weeks and lost about 1 pound. I am trying to exercise but am just too exhausted to do much of anything although I do try to do something for 30 minutes 3 times a week. I have a dr. appt coming up and don't know what to ask. I have high serum iron readings but low ferritin levels (stored iron). Any suggestions? > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 14, 2009 Report Share Posted June 14, 2009 BP went up to 160/110 and was pretty consistent. I had no problems with BP until about 3 months after starting the shots. I am on 10 mg of liprinosil. It seems to have gotten the BP under control. I am seeing my endo on 9/23. She has dismissed estrogen in the past as not an issue to worry about. I had to pay for the test out of pocket and it came in with a reading of 79 with the top of the range being 54. I know it is high, but is it too high? I don't really know. I'm going to force the issue when I see her. My johnson is pretty useless at this point (other than to pee). I get no nocturnal erections or morning ones either. When all this started, that was one of the first symptoms I noticed aside from the fatigue. It was that complaint that made my original doctor check my testosterone levels although I had to go to my current doctor to get anything that resembles decent treatment. I am hearing that Arimidex is not approved for use in males and that a lot of insurance companies won't pay for it. Is it expensive if I have to buy it on my own? Thanks for the reply. I will check my BP meds to see if there is anything about fatigue related to it. I was surprised that I had no side effects from the BP meds because if there is a side effect, I usually get it. > > > > I am on Testosterone shots for low T. I have a 2mm Pituitary adenoma that I guess is causing all the problems. I received weekly shots of alternating amounts. It is a regimen of 1cc of 200 mg/ml one week and then .5cc the following and then switching back. I've been on this for about 2 months. I feel like crap. I am tired all the time. My blood pressure skyrocketed shortly after starting the shots. I am on bp meds now to control it. I paid for a complete set of blood work and there are weird readings all over the place. My E2 level is 79, my T level is 890. My CBC had several high readings, which my understanding is that is normal. Previous to this regimen, I was on 1cc every week but my t level was 1600 so she went to the new regimen. I was really hoping to feel better but I don't. I have no interest in sex at all and couldn't do it anyway if I was if you catch my drift. I am so frustrated. I've gained 40lbs and just cannot loose weight. I went on a strict low fat vegan diet for 6 weeks and lost about 1 pound. I am trying to exercise but am just too exhausted to do much of anything although I do try to do something for 30 minutes 3 times a week. I have a dr. appt coming up and don't know what to ask. I have high serum iron readings but low ferritin levels (stored iron). Any suggestions? > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 15, 2009 Report Share Posted June 15, 2009 After my heart bypass sugary my Dr.'s put me on liprinosil, a beta blocker and water pill. I feel like passing out when I get up or turn fast so they had me cut the 3 pills in half. I do 5mgs of liprinosil now and still my BP at times is low when I feel like passing out I take it and it is 90/45 most mornings then by late day it's 110/70 to me this is still to low. I have white coat fever every time some one takes my BP they would get a high reading. 190/110 yet at home it was ok 140/85 for being over weight and having blockage this was a good reading. Now they took me off liprinosil and I felt dame good yet when they take my BP it's back up the do to white coat fever so dam if they did not put me back on it. So I have to be care full I don't pass out. As for Arimidex you need this and my Dr. would not put me on it at first because he did not feel BCBS would pay for it and did not want a call from my Drug Plain asking him why he is giving me a women's med. After trying all kinds of things that did not work I got mad and told him I don't care if they don't pay for it. So he gave me a script my BCBS pays for it I later found out a lot of men use this and there is big market on this for men. You can try Indolplex/DIM it is sold OTC and works but you need this brand. http://organicpharmacy.org/products/Indolplex.With.DIM/SKU:PP15336 So if you can't get your Dr. to give you arimidex try this. Here are some links about using Arimidex. http://www.medibolics.com/ArimidexBoostsTestosterone.htm http://jcem.endojournals.org/cgi/content/full/89/3/1174 http://www.smart-drugs.com/ias-estrogen.htm When you get this down you will feel like a new man and get your sex life back. Co-Moderator Phil > From: noonanjg <jgnoonan@...> > Subject: Re: Estradiol Levels > > Date: Sunday, June 14, 2009, 9:04 PM > BP went up to 160/110 and was pretty > consistent. I had no problems with BP until about 3 > months after starting the shots. I am on 10 mg of > liprinosil. It seems to have gotten the BP under > control. I am seeing my endo on 9/23. She has > dismissed estrogen in the past as not an issue to worry > about. I had to pay for the test out of pocket and it > came in with a reading of 79 with the top of the range being > 54. I know it is high, but is it too high? I > don't really know. I'm going to force the issue when I > see her. My johnson is pretty useless at this point > (other than to pee). I get no nocturnal erections or > morning ones either. When all this started, that was > one of the first symptoms I noticed aside from the > fatigue. It was that complaint that made my original > doctor check my testosterone levels although I had to go to > my current doctor to get anything that resembles decent > treatment. I am hearing that Arimidex is not approved > for use in males and that a lot of insurance companies won't > pay for it. Is it expensive if I have to buy it on my > own? > > Thanks for the reply. I will check my BP meds to see > if there is anything about fatigue related to it. I > was surprised that I had no side effects from the BP meds > because if there is a side effect, I usually get it. > > > > > > > > > I am on Testosterone shots for low T. I > have a 2mm Pituitary adenoma that I guess is causing all the > problems. I received weekly shots of alternating > amounts. It is a regimen of 1cc of 200 mg/ml one week > and then .5cc the following and then switching back. > I've been on this for about 2 months. I feel like > crap. I am tired all the time. My blood pressure > skyrocketed shortly after starting the shots. I am on > bp meds now to control it. I paid for a complete set > of blood work and there are weird readings all over the > place. My E2 level is 79, my T level is 890. My > CBC had several high readings, which my understanding is > that is normal. Previous to this regimen, I was on 1cc > every week but my t level was 1600 so she went to the new > regimen. I was really hoping to feel better but I > don't. I have no interest in sex at all and couldn't > do it anyway if I was if you catch my drift. I am so > frustrated. I've gained 40lbs and just cannot loose > weight. I went on a strict low fat vegan diet for 6 > weeks and lost about 1 pound. I am trying to exercise > but am just too exhausted to do much of anything although I > do try to do something for 30 minutes 3 times a week. > I have a dr. appt coming up and don't know what to > ask. I have high serum iron readings but low ferritin > levels (stored iron). Any suggestions? > > > > > > > > > > ------------------------------------ > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 15, 2009 Report Share Posted June 15, 2009 On Mon, 15 Jun 2009 01:04:31 -0000, you wrote: >BP went up to 160/110 and was pretty consistent. I had no problems with BP until about 3 months after starting the shots. I am on 10 mg of liprinosil. It seems to have gotten the BP under control. I am seeing my endo on 9/23. She has dismissed estrogen in the past as not an issue to worry about. I had to pay for the test out of pocket and it came in with a reading of 79 with the top of the range being 54. I know it is high, but is it too high? I don't really know. I'm going to force the issue when I see her. My johnson is pretty useless at this point (other than to pee). I get no nocturnal erections or morning ones either. When all this started, that was one of the first symptoms I noticed aside from the fatigue. It was that complaint that made my original doctor check my testosterone levels although I had to go to my current doctor to get anything that resembles decent treatment. I am hearing that Arimidex is not approved for use in males and that a lot of insurance >companies won't pay for it. Is it expensive if I have to buy it on my own? > >Thanks for the reply. I will check my BP meds to see if there is anything about fatigue related to it. I was surprised that I had no side effects from the BP meds because if there is a side effect, I usually get it. 79 is very high. For me personally around 45 I start seeing ED issues. High E2 does diminish your energy some, but not to fatigue levels. Are you on a beta blacker? I was on metoprolol and would get so tired I had to take 2 or 3 hour naps every afternoon - no choice in it. I was drop dead fatigued. There is something called beta blocker fatigue that effects some percentage of users. I stopped and recovered quickly to normal energy levels. I posted a bunch of abstracts and studies about E2 recently in the files section. Look them over. I posted them to get endos attention. High E2 causes coronary issues, BP and stroke. It also causes ED, and contributes hugely to prostate issues. How endos can ignore this is beyond me. But it's very difficult to find an open minded one that will take the time to read and listen and deal with it. I start to wonder if only the most insecure of Dr.s go into endocrinology. It's amazing how little close minded and incapable of listening and thinking they are. Imagine - they're still doing surgeries for breast growth in T patients - and can't stop to think that might be a bit abnormal and maybe they could adjust treatment to be more natural. Sometimes it seems like they're still dark age practitioners with leeches. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 15, 2009 Report Share Posted June 15, 2009 > > I am hearing that Arimidex is not approved for use in males and that a lot of insurance companies won't pay for it. Is it expensive if I have to buy it on my own? > Arimidex is a product of Astra-Zenica and they have a patent on it in the US. It is very expensive. Other countries (such as India) do not honor these patents and make a generic version, called anastrozole, and you can buy that online from offshore pharmacies. Compare these two pharmacies: One sells the generic, and the other sells Astra-Zenica's patented version. http://www.alldaychemist.com/common_generic/Anastrozole.html http://www.inhousepharmacy.com/womens-hrt/arimidex.html Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 16, 2009 Report Share Posted June 16, 2009 Phil: Thanks for the information. I ordered a bottle of the Indolplex and I'll see how that goes. I am going to bring this up with the endo when I see her on the 23rd. Thanks again! > > > > > > > > I am on Testosterone shots for low T. I > > have a 2mm Pituitary adenoma that I guess is causing all the > > problems. I received weekly shots of alternating > > amounts. It is a regimen of 1cc of 200 mg/ml one week > > and then .5cc the following and then switching back. > > I've been on this for about 2 months. I feel like > > crap. I am tired all the time. My blood pressure > > skyrocketed shortly after starting the shots. I am on > > bp meds now to control it. I paid for a complete set > > of blood work and there are weird readings all over the > > place. My E2 level is 79, my T level is 890. My > > CBC had several high readings, which my understanding is > > that is normal. Previous to this regimen, I was on 1cc > > every week but my t level was 1600 so she went to the new > > regimen. I was really hoping to feel better but I > > don't. I have no interest in sex at all and couldn't > > do it anyway if I was if you catch my drift. I am so > > frustrated. I've gained 40lbs and just cannot loose > > weight. I went on a strict low fat vegan diet for 6 > > weeks and lost about 1 pound. I am trying to exercise > > but am just too exhausted to do much of anything although I > > do try to do something for 30 minutes 3 times a week. > > I have a dr. appt coming up and don't know what to > > ask. I have high serum iron readings but low ferritin > > levels (stored iron). Any suggestions? > > > > > > > > > > > > > > > > > ------------------------------------ > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 18, 2009 Report Share Posted June 18, 2009 My opinion, after a bad reaction to Arimidex, and after viewing all of the side effects and after reading tons of forums all over where women have died and all of the bad reactions. WE NEED AN ALTERNATIVE - WHICH TO THE BEST OF MY KNOWLEDGE DOESN'T EXIST. DIM treat existing E2. BTW the Indoplex DIM everyone in here references is full of calcium and can bind other meds that you are taking. Take the time to do a conflicts check and ask your GP if there is potential interference with any other med. > > > > I am hearing that Arimidex is not approved for use in males and that a lot of insurance companies won't pay for it. Is it expensive if I have to buy it on my own? > > > > Arimidex is a product of Astra-Zenica and they have a patent on it in the US. It is very expensive. > > Other countries (such as India) do not honor these patents and make a generic version, called anastrozole, and you can buy that online from offshore pharmacies. > > Compare these two pharmacies: One sells the generic, and the other sells Astra-Zenica's patented version. > > http://www.alldaychemist.com/common_generic/Anastrozole.html > > http://www.inhousepharmacy.com/womens-hrt/arimidex.html > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 18, 2009 Report Share Posted June 18, 2009 Thanks for the information. I am currently on vitamin D with calcium and didn't realize there was also calcium in the Indoplex. I am on several meds right now, so I will have to do the due diligence to make sure there are no conflicts with my meds. I'm the type of person that typically gets side effects, so I do need to be wary. What side affects did you experience? > > > > > > I am hearing that Arimidex is not approved for use in males and that a lot of insurance companies won't pay for it. Is it expensive if I have to buy it on my own? > > > > > > > Arimidex is a product of Astra-Zenica and they have a patent on it in the US. It is very expensive. > > > > Other countries (such as India) do not honor these patents and make a generic version, called anastrozole, and you can buy that online from offshore pharmacies. > > > > Compare these two pharmacies: One sells the generic, and the other sells Astra-Zenica's patented version. > > > > http://www.alldaychemist.com/common_generic/Anastrozole.html > > > > http://www.inhousepharmacy.com/womens-hrt/arimidex.html > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 18, 2009 Report Share Posted June 18, 2009 I've noticed your other posts on Iron levels. My last blood test about two weeks ago had some odd readings: TIBC 457 High 250-450 ug/dl UIBC 282 Normal 150-375 ug/dl Iron, Serum 175 High 40-155 Iron Saturation 38% Hemoglobin A1c 5.8% Normal <7.0% Ferrotom, Serum 20 Low 22-322 ng/ml I can make no sense of these readings. I am seeing my doctor next week and don't even know what to ask. Any insight would be helpful. Thanks! Joe > > > > > > I am hearing that Arimidex is not approved for use in males and that a lot of insurance companies won't pay for it. Is it expensive if I have to buy it on my own? > > > > > > > Arimidex is a product of Astra-Zenica and they have a patent on it in the US. It is very expensive. > > > > Other countries (such as India) do not honor these patents and make a generic version, called anastrozole, and you can buy that online from offshore pharmacies. > > > > Compare these two pharmacies: One sells the generic, and the other sells Astra-Zenica's patented version. > > > > http://www.alldaychemist.com/common_generic/Anastrozole.html > > > > http://www.inhousepharmacy.com/womens-hrt/arimidex.html > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 18, 2009 Report Share Posted June 18, 2009 There are other melds that lower Estrada but they are suicide inhibitors so when you go to low it takes a much longer time to get your Estradiol levels back up when with arimidex if you go to low and lose your night time and morning wood. Stopping arimidex your levels will come back up in days. With the others it's weeks because they kill the aromatase enzyme. There are not many studys on men taking arimidex or the other ones and you can's site studys about women on them. Men and Women are not the same and the amount of Arimidex one needs as a man to keep estradiol down is very small compared to what women take. I have my IGF-1 tested all the time and if your Estradiol levels are to high it can mess up other hormones like Cortisol, Thyroid and Growth Hormones. As long as I keep my hormone levels good my IGF-1 levels are good. If your not comfortable taking Arimidex don't take it I don't know any one on it that has any of the problems your talking about short of going down to low. Co-Moderator Phil > From: ihor <ihor43us@...> > Subject: Re: Estradiol Levels > > Date: Thursday, June 18, 2009, 11:24 AM > There are alternatives....got this > from > > http://forum.bodybuilding.com/archive/index.php/t-40724.html > > Apparently Arimidex lowers iGF1 by 18% while letrozole > raises it by 24%. For muscle growth, letrozole is better... > > > The following 3 posts are copies of Zyglamail's posts on > Elite, > > 3rd Generation Anti-E's > Everyone by now has heard of Arimidex/Liquidex(ie > anastrozole) but there are a couple others with slightly > better estrogen suppression values as well as slight > differences in the way they affect the endocrine system. > > The other two 3rd generation Anti-e's are letrozole(femara) > and exemestane(aromasin). Letrozole and anastrozole are > aromatase inhibitors while exemestane is considered an > aromatase inactivator. > > While all of these seem to exert an effect on our LH/FSH > levels, some also have an effect on IGF-1 levels as well. > According to some studies for example, anastrzole was shown > to reduce IGF-1 levels by 18%(note 1), which is likely due > to reduced estrogen. Another abstract shows that letrozole > actually increased IGF-1 levels by an average of 24%(note > 2). > > Following are some detailed descriptions of the 3 > products. > > notes: > 1. J Clin Endocrinol Metab 2000 Jul;85(7):2370-7 > 2. J Steroid Biochem Mol Biol 1997 Nov-Dec;63(4-6):261-7 > > Letrozole. > DESCRIPTION > > Femara (letrozole tablets) for oral administration contain > 2.5 mg of letrozole, a nonsteroidal aromatase inhibitor > (inhibitor of estrogen synthesis). It is chemically > described as 4,4'-(1H-1,2,4 -Triazol-1-ylmethylene) > dibenzonitrile. > > Letrozole is a white to yellowish crystalline powder, > practically odorless, freely soluble in dichloromethane, > slightly soluble in ethanol, and practically insoluble in > water. It has a molecular weight of 285.31, empirical > formula C17H11N5 and a melting range of 184o C-185o C. > > Femara (letrozole tablets) is available as 2.5 mg tablets > for oral administration. > > Inactive Ingredients. > > Colloidal silicon dioxide, ferric oxide, hydroxypropyl > methylcellulose, lactose monohydrate, magnesium stearate, > maize starch, microcrystalline cellulose, polyethylene > glycol, sodium starch glycolate, talc, and titanium > dioxide. > > > CLINICAL PHARMACOLOGY > > Mechanism of Action > > The growth of some cancers of the breast are stimulated or > maintained by estrogens. Treatment of breast cancer thought > to be hormonally responsive (i.e., estrogen and/or > progesterone receptor positive or receptor unknown) has > included a variety of efforts to decrease estrogen levels > (ovariectomy, adrenalectomy, hypophysectomy) or inhibit > estrogen effects (antiestrogens and progestational agents). > These interventions lead to decreased tumor mass or delayed > progression of tumor growth in some women. > > In postmenopausal women, estrogens are mainly derived from > the action of the aromatase enzyme, which converts adrenal > androgens (primarily androstenedione and testosterone) to > estrone and estradiol. The suppression of estrogen > biosynthesis in peripheral tissues and in the cancer tissue > itself can therefore be achieved by specifically inhibiting > the aromatase enzyme. > > Letrozole is a nonsteroidal competitive inhibitor of the > aromatase enzyme system; it inhibits the conversion of > androgens to estrogens. In adult nontumor- and tumorbearing > female animals, letrozole is as effective as ovariectomy in > reducing uterine weight, elevating serum LH, and causing the > regression of estrogen-dependent tumors. In contrast to > ovariectomy, treatment with letrozole does not lead to an > increase in serum FSH. Letrozole selectively inhibits > gonadal steroidogenesis but has no significant effect on > adrenal mineralocorticoid or glucocorticoid synthesis. > > Letrozole inhibits the aromatase enzyme by competitively > binding to the heme of the cytochrome P450 subunit of the > enzyme, resulting in a reduction of estrogen biosynthesis in > all tissues. Treatment of women with letrozole significantly > lowers serum estrone, estradiol and estrone sulfate and has > not been shown to significantly affect adrenal > corticosteroid synthesis, aldosterone synthesis, or > synthesis of thyroid hormones. > > Pharmacokinetics > > Letrozole is rapidly and completely absorbed from the > gastrointestinal tract and absorption is not affected by > food. It is metabolized slowly to an inactive metabolite > whose glucuronide conjugate is excreted renally, > representing the major clearance pathway. About 90% of > radiolabeled letrozole is recovered in urine. Letrozole’s > terminal elimination half-life is about 2 days and > steady-state plasma concentration after daily 2.5mg dosing > is reached in 2-6 weeks. Plasma concentrations at > steady-state are 1.5 to 2 times higher than predicted from > the concentrations measured after a single dose, indicating > a slight nonlinearity in the pharmacokinetics of letrozole > upon daily administration of 2.5mg. These steady-state > levels are maintained over extended periods, however, and > continuous accumulation of letrozole does not occur. > Letrozole is weakly protein bound and has a large volume of > distribution (approximately 1.9 L/kg). > > Metabolism and Excretion > > Metabolism to a pharmacologically-inactive carbinol > metabolite (4, 4'-methanol-bisbenzonitrile) and renal > excretion of the glucuronide conjugate of this metabolite is > the major pathway of letrozole clearance. Of the radiolabel > recovered in urine, at least 75% was the glucuronide of the > carbinol metabolite, about 9% was two unidentified > metabolites, and 6% was unchanged letrozole. > > In human microsomes with specific CYP isozyme activity, CYP > 3A4 metabolized letrozole to the carbinol metabolite while > CYP 2A6 formed both this metabolite and its ketone analog. > In human liver microsomes, letrozole strongly inhibited CYP > 2A6 and moderately inhibited CYP 2C19. > > Special Populations > > Pediatric, Geriatric and Race: In the study populations > (adults ranging in age from 35 to >80 years), no change > in pharmacokinetic parameters was observed with increasing > age. Differences in letrozole pharmacokinetics between adult > and pediatric populations have not been studied. Differences > in letrozole pharmacokinetics due to race have not been > studied. > > Renal Insufficiency: In a study of volunteers with varying > renal function (24-hour creatinine clearance: 9-116 mL/min), > no effect of renal function on the pharmacokinetics of > single doses of 2.5mg of Femara (letrozole tablets) was > found. In addition, in a study of 347 patients with advanced > breast cancer, about half of whom received 2.5mg Femara and > half 0.5mg Femara, renal impairment (calculated creatinine > clearance: 20-50 mL/min) did not affect steady-state plasma > letrozole concentration. > > Hepatic Insufficiency: In a study of subjects with varying > degrees of non-metastatic hepatic dysfunction (e.g., > cirrhosis, Child-Pugh classification A and , the mean AUC > values of the volunteers with moderate hepatic impairment > were 37% higher than in normal subjects, but still within > the range seen in subjects without impaired function. > Patients with severe hepatic impairment (Child-Pugh > classification C) have not been studied (see DOSAGE AND > ADMINISTRATION, Hepatic Impairment). > > Drug/Drug Interactions > > A pharmacokinetic interaction study with cimetidine showed > no clinically significant effect on letrozole > pharmacokinetics. An interaction study with warfarin showed > no clinically significant effect of letrozole on warfarin > pharmacokinetics. > > There is no clinical experience to date on the use of > Femara in combination with other anti-cancer agents. > > Pharmacodynamics > > In postmenopausal patients with advanced breast cancer, > daily doses of 0.1 mg to 5 mg Femara suppress plasma > concentrations of estradiol, estrone, and estrone sulfate by > 75%-95% from baseline with maximal suppression achieved > within two-three days. Suppression is dose-related, with > doses of 0.5 mg and higher giving many values of estrone and > estrone sulfate that were below the limit of detection in > the assays. Estrogen suppression was maintained throughout > treatment in all patients treated at 0.5 mg or higher. > > Letrozole is highly specific in inhibiting aromatase > activity. There is no impairment of adrenal steroidogenesis. > No clinically-relevant changes were found in the plasma > concentrations of cortisol, aldosterone, 11-deoxycortisol, > 17-hydroxy-progesterone, ACTH or in plasma renin activity > among post-menopausal patients treated with a daily dose of > Femara 0.1 mg to 5 mg. The ACTH stimulation test performed > after 6 and 12 weeks of treatment with daily doses of 0.1, > 0.25, 0.5, 1, 2.5, and 5 mg did not indicate any attenuation > of aldosterone or cortisol production. Glucocorticoid or > mineralocorticoid supplementation is, therefore, not > necessary. > > No changes were noted in plasma concentrations of androgens > (androstenedione and testosterone) among healthy > postmenopausal women after 0.1, 0.5, and 2.5 mg single doses > of Femara or in plasma concentrations of androstenedione > among postmenopausal patients treated with daily doses of 0. > 1 mg to 5 mg. This indicates that the blockade of estrogen > biosynthesis does not lead to accumulation of androgenic > precursors. Plasma levels of LH and FSH were not affected by > letrozole in patients, nor was thyroid function as evaluated > by TSH levels, T3 uptake, and T4 levels. > Captin Swole > 06-27-2002, 07:25 PM > Exemestane. > DESCRIPTION > > AROMASIN Tablets for oral administration contain 25 mg of > exemestane, an irreversible, steroidal aromatase > inactivator. Exemestane is chemically described as > 6-methylenandrosta-1,4-diene-3, 17-dione. Its molecular > formula is C20H24O2. > > The active ingredient is a white to slightly yellow > crystalline powder with a molecular weight of 296.41. > Exemestane is freely soluble in N, N-dimethylformamide, > soluble in methanol, and practically insoluble in water. > > Each AROMASIN Tablet contains the following inactive > ingredients: mannitol, crospovidone, polysorbate 80, > hydroxypropyl methylcellulose, colloidal silicon dioxide, > microcrystalline cellulose, sodium starch glycolate, > magnesium stearate, simethicone, polyethylene glycol 6000, > sucrose, magnesium carbonate, titanium dioxide, > methylparaben, and polyvinyl alcohol. > > > CLINICAL PHARMACOLOGY > > Mechanism of Action > > Breast cancer cell growth may be estrogen-dependent. > Aromatase (exemestane) is the principal enzyme that converts > androgens to estrogens both in pre- and postmenopausal > women. While the main source of estrogen (primarily > estradiol) is the ovary in premenopausal women, the > principal source of circulating estrogens in postmenopausal > women is from conversion of adrenal and ovarian androgens > (androstenedione and testosterone) to estrogens (estrone and > estradiol) by the aromatase enzyme in peripheral tissues. > Estrogen deprivation through aromatase inhibition is an > effective and selective treatment for some postmenopausal > patients with hormone-dependent breast cancer. > > Exemestane is an irreversible, steroidal aromatase > inactivator, structurally related to the natural substrate > androstenedione. It acts as a false substrate for the > aromatase enzyme, and is processed to an intermediate that > binds irreversibly to the active site of the enzyme causing > its inactivation, an effect also known as “suicide > inhibition.†Exemestane significantly lowers circulating > estrogen concentrations in postmenopausal women, but has no > detectable effect on adrenal biosynthesis of corticosteroids > or aldosterone. Exemestane has no effect on other enzymes > involved in the steroidogenic pathway up to a concentration > at least 600 times higher than that inhibiting the aromatase > enzyme. > > Pharmacokinetics > > Following oral administration to healthy postmenopausal > women, exemestane is rapidly absorbed. After maximum plasma > concentration is reached, levels decline polyexponentially > with a mean terminal half-life of about 24 hours. Exemestane > is extensively distributed and is cleared from the systemic > circulation primarily by metabolism. The pharmacokinetics of > exemestane are dose proportional after single (10 to 200 mg) > or repeated oral doses (0.5 to 50 mg). Following repeated > daily doses of exemestane 25 mg, plasma concentrations of > unchanged drug are similar to levels measured after a single > dose. > > Pharmacokinetic parameters in postmenopausal women with > advanced breast cancer following single or repeated doses > have been compared with those in healthy, postmenopausal > women. Exemestane appeared to be more rapidly absorbed in > the women with breast cancer than in the healthy women, with > a mean tmax of 1.2 hours in the women with breast cancer and > 2.9 hours in the healthy women. After repeated dosing, the > average oral clearance in women with advanced breast cancer > was 45% lower than the oral clearance in healthy > postmenopausal women, with corresponding higher systemic > exposure. Mean AUC values following repeated doses in women > with breast cancer (75.4 ng•h/mL) were about twice those > in healthy women (41.4 ng•h/mL). > > Absorption: Following oral administration of radiolabeled > exemestane, at least 42% of radioactivity was absorbed from > the gastrointestinal tract. Exemestane plasma levels > increased by approximately 40% after a high-fat breakfast. > > Distribution: Exemestane is distributed extensively into > tissues. Exemestane is 90% bound to plasma proteins and the > fraction bound is independent of the total concentration. > Albumin and a1-acid glycoprotein both contribute to the > binding. The distribution of exemestane and its metabolites > into blood cells is negligible. > > Metabolism and Excretion: Following administration of > radiolabeled exemestane to healthy postmenopausal women, the > cumulative amounts of radioactivity excreted in urine and > feces were similar (42 ± 3% in urine and 42 ± 6% in feces > over a 1-week collection period). The amount of drug > excreted unchanged in urine was less than 1% of the dose. > > Exemestane is extensively metabolized, with levels of the > unchanged drug in plasma accounting for less than 10% of the > total radioactivity. The initial steps in the metabolism of > exemestane are oxidation of the methylene group in position > 6 and reduction of the 17-keto group with subsequent > formation of many secondary metabolites. Each metabolite > accounts only for a limited amount of drug-related material. > The metabolites are inactive or inhibit aromatase with > decreased potency compared with the parent drug. One > metabolite may have androgenic activity (see > Pharmacodynamics: Other Endocrine Effects, below). Studies > using human liver preparations indicate that cytochrome P450 > 3A4 (CYP 3A4) is the principal isoenzyme involved in the > oxidation of exemestane. > > Special Populations > > Geriatric: Healthy postmenopausal women aged 43 to 68 years > were studied in the pharmacokinetic trials. Age-related > alterations in exemestane pharmacokinetics were not seen > over this age range. > > Gender: The pharmacokinetics of exemestane following > administration of a single, 25-mg tablet to fasted healthy > males (mean age 32 years) were similar to the > pharmacokinetics of exemestane in fasted healthy > postmenopausal women (mean age 55 years). > > Race: The influence of race on exemestane pharmacokinetics > has not been evaluated. > > Hepatic Insufficiency: The pharmacokinetics of exemestane > have been investigated in subjects with moderate or severe > hepatic insufficiency (Childs-Pugh B or C). Following a > single 25-mg oral dose, the AUC of exemestane was > approximately 3 times higher than that observed in healthy > volunteers. (See PRECAUTIONS.) > > Renal Insufficiency: The AUC of exemestane after a single > 25-mg dose was approximately 3 times higher in subjects with > moderate or severe renal insufficiency (creatinine clearance > <35 mL/min/1.73 m2 ) compared with the AUC in healthy > volunteers (see PRECAUTIONS). > > Pediatric: The pharmacokinetics of exemestane have not been > studied in pediatric patients. > > Drug-Drug Interactions > > Exemestane is metabolized by cytochrome P450 3A4 (CYP 3A4) > and aldoketoreductases. It does not inhibit any of the major > CYP isoenzymes, including CYP 1A2, 2C9, 2D6, 2E1, and 3A4. > In a clinical pharmacokinetic study, ketoconazole showed no > significant influence on the pharmacokinetics of exemestane. > Although no other formal drug-drug interaction studies have > been conducted, significant effects on exemestane clearance > by CYP isoenzymes inhibitors appear unlikely. However, a > possible decrease of exemestane plasma levels by known > inducers of CYP 3A4 cannot be excluded. > > Pharmacodynamics > > Effect on Estrogens: Multiple doses of exemestane ranging > from 0.5 to 600 mg/day were administered to postmenopausal > women with advanced breast cancer. Plasma estrogen > (estradiol, estrone, and estrone sulfate) suppression was > seen starting at a 5-mg daily dose of exemestane, with a > maximum suppression of at least 85% to 95% achieved at a > 25-mg dose. Exemestane 25 mg daily reduced whole body > aromatization (as measured by injecting radiolabeled > androstenedione) by 98% in postmenopausal women with breast > cancer. After a single dose of exemestane 25 mg, the maximal > suppression of circulating estrogens occurred 2 to 3 days > after dosing and persisted for 4 to 5 days. > > Effect on Corticosteroids: In multiple-dose trials of doses > up to 200 mg daily, exemestane selectivity was assessed by > examining its effect on adrenal steroids. Exemestane did not > affect cortisol or aldosterone secretion at baseline or in > response to ACTH at any dose. Thus, no glucocorticoid or > mineralocorticoid replacement therapy is necessary with > exemestane treatment. > > Other Endocrine Effects: Exemestane does not bind > significantly to steroidal receptors, except for a slight > affinity for the androgen receptor (0.28% relative to > dihydrotestosterone). The binding affinity of its > 17-dihydrometabolite for the androgen receptor, however, is > 100-times that of the parent compound. Daily doses of > exemestane up to 25 mg had no significant effect on > circulating levels of testosterone, androstenedione, > dehydroepiandrosterone sulfate, or 17-hydroxy-progesterone. > Increases in testosterone and androstenedione levels have > been observed at daily doses of 200 mg or more. A dose- > dependent decrease in sex hormone binding globulin (SHBG) > has been observed with daily exemestane doses of 2.5 mg or > higher. Slight, nondose-dependent increases in serum > lutenizing hormone (LH) and follicle-stimulating hormone > (FSH) levels have been observed even at low doses as a > consequence of feedback at the pituitary level. > > > > ------------------------------------ > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 18, 2009 Report Share Posted June 18, 2009 Good Point. Load staging at different times during the day is significant. > > > > > > > > I am hearing that Arimidex is > > not approved for use in males and that a lot of insurance > > companies won't pay for it. Is it expensive if I have > > to buy it on my own? > > > > > > > > > > Arimidex is a product of Astra-Zenica and they have a > > patent on it in the US. It is very expensive. > > > > > > Other countries (such as India) do not honor these > > patents and make a generic version, called anastrozole, and > > you can buy that online from offshore pharmacies. > > > > > > Compare these two pharmacies: One sells the > > generic, and the other sells Astra-Zenica's patented > > version. > > > > > > http://www.alldaychemist.com/common_generic/Anastrozole.html > > > > > > http://www.inhousepharmacy.com/womens-hrt/arimidex.html > > > > > > > > > > > > > ------------------------------------ > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 24, 2009 Report Share Posted June 24, 2009 Yes take one at dinner time and get some TMG take this at bed time it helps your liver was out the Good E's the convert from Estradiol using this. Also it will help you sleep some of it turns into SAM E. http://www.myvitanet.com/tmgtr7560tas.html Co-Moderator Phil > From: noonanjg <jgnoonan@...> > Subject: Re: Estradiol Levels > > Date: Wednesday, June 24, 2009, 9:11 AM > Phil: I bought the Indolplex > DIM. The dosage on the bottle says one a day. Is > that correct? > > > > > > > > > > > > I am on Testosterone shots for low T. > I > > > have a 2mm Pituitary adenoma that I guess is > causing all the > > > problems. I received weekly shots of > alternating > > > amounts. It is a regimen of 1cc of 200 mg/ml > one week > > > and then .5cc the following and then switching > back. > > > I've been on this for about 2 months. I feel > like > > > crap. I am tired all the time. My blood > pressure > > > skyrocketed shortly after starting the shots. I > am on > > > bp meds now to control it. I paid for a > complete set > > > of blood work and there are weird readings all > over the > > > place. My E2 level is 79, my T level is 890. > My > > > CBC had several high readings, which my > understanding is > > > that is normal. Previous to this regimen, I was > on 1cc > > > every week but my t level was 1600 so she went to > the new > > > regimen. I was really hoping to feel better but > I > > > don't. I have no interest in sex at all and > couldn't > > > do it anyway if I was if you catch my drift. I > am so > > > frustrated. I've gained 40lbs and just cannot > loose > > > weight. I went on a strict low fat vegan diet > for 6 > > > weeks and lost about 1 pound. I am trying to > exercise > > > but am just too exhausted to do much of anything > although I > > > do try to do something for 30 minutes 3 times a > week. > > > I have a dr. appt coming up and don't know what > to > > > ask. I have high serum iron readings but low > ferritin > > > levels (stored iron). Any suggestions? > > > > > > > > > > > > > > > > > > > > > > > > ------------------------------------ > > > > > > Quote Link to comment Share on other sites More sharing options...
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