Does DIM also lower DHT?

[Guest guest]

I have been away from the group for quite some time, so I first

searched through the myriad of posts as best I could but couldn't find

any postings that address my current question. I am hoping this has

been discussed or that somebody has some knowledge to contribute.

Specifically, is there any evidence of DIM also lowering or inhibiting

DHT? I am confident that after a couple of years of supplementing my

TRT (Testim) with DIM (Indolplex) that I have managed my E2 to my

satisfaction. I haven't had blood work in ages, but have learned

the " symptoms " of successful TRT well enough to be confident that I am

doing OK. Again - is there any opinions out there on whether DIM also

impacts DHT, up or down?

Thanks.../Dale

[Guest guest]

I have this cut and paste from this link.

http://www.lef.org/whatshot/2003_05.html#i3cb

Indole-3-carbinol byproduct acts as antiandrogen to halt prostate cancer

cell growth

In a study funded in part by the National Institutes of Health, to be

published in the June 6 2003 issue of the Journal of Biological Chemistry,

University of California, Berkeley researchers have found that a digestive

product of indole-3-carbinol, which occurs naturally in broccoli and other

cruciferous vegetables, halts the growth of prostate cancer cells in vitro. The

compound, 3,3’-diindolymethane (DIM), inhibits androgenic hormones that fuel

prostate cancer growth. Although androgen is important for the normal

development of the prostate, it is believed to be involved in the early stages

of prostate cancer.

The researchers administered DIM to androgen dependent and androgen

independent prostate cancer cells and found that androgen-dependent cells

experienced a 70 percent reduction in growth compared to those that did not

receive the compound. Androgen-independent prostate cancer cells were not

affected by DIM. The scientists went on to discover that DIM inhibited

dihydrotestosterone, the primary androgenic hormone that is believed to be the

culprit in prostate cancer. Dihydrotesterone stimulates prostate specific

antigen, or PSA, which is elevated in prostate cancer. When DIM was administered

to the androgen-dependent prostate cancer cells, PSA levels dropped.

A study of the molecular structure of DIM showed that it is similar to the

androgen-blocking drug Casodex. Lead author Hien Le, PhD, explained, “DIM works

by binding to the same receptor that DHT uses, so it's essentially blocking the

androgen from triggering the growth of the cancer cells. "

Principle researcher and professor nutritional sciences and toxicology at UC

Berkeley's College of Natural Resources, Leonard Bjeldanes, summarized, " As far

as we know, this is the first plant-derived chemical discovered that acts as an

antiandrogen. This is of considerable interest in the development of

therapeutics and preventive agents for prostate cancer. "

—D Dye

nayaiu2b <dbeckes@...> wrote: I have been away from the group for

quite some time, so I first

searched through the myriad of posts as best I could but couldn't find

any postings that address my current question. I am hoping this has

been discussed or that somebody has some knowledge to contribute.

Specifically, is there any evidence of DIM also lowering or inhibiting

DHT? I am confident that after a couple of years of supplementing my

TRT (Testim) with DIM (Indolplex) that I have managed my E2 to my

satisfaction. I haven't had blood work in ages, but have learned

the " symptoms " of successful TRT well enough to be confident that I am

doing OK. Again - is there any opinions out there on whether DIM also

impacts DHT, up or down?

Thanks.../Dale

Co-Moderator " Don't believe anything you hear and only half of what you see. "

Phil

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