Elevated testosterone kills brain cells

[Guest guest]

Endocrinology News

Hmmm. I'll look for the levels used in the study and post them.

Elevated Testosterone Kills Brain Cells

Main Category: Endocrinology News

Article Date: 28 Sep 2006 - 16:00pm (PDT)

A Yale School of Medicine study shows for the first time that a high

level of testosterone, such as that caused by the use of steroids to

increase muscle mass or for replacement therapy, can lead to a

catastrophic loss of brain cells.

Taking large doses of androgens, or steroids, is known to cause

hyperexcitability, a highly aggressive nature, and suicidal

tendencies. These behavioral changes could be evidence of alterations

in neuronal function caused by the steroids, said the senior author,

Barbara Ehrlich, professor of pharmacology and physiology.

" Next time a muscle-bound guy in a sports car cuts you off on the

highway, don't get mad, just take a deep breath and realize that it

might not be his fault, " said Ehrlich.

Testosterone is the main male hormone and it plays fundamental roles

in development, differentiation, and cellular growth. In neurons,

testosterone acts as a neurosteroid and can induce changes at the

cellular level, which in turn lead to changes in behavior, mood and

memory. Both neuroprotective and neurodegenerative effects of

androgens have been reported.

The researchers showed that high levels of testosterone triggered

programmed cell death in nerve cells in culture. Cell death, or

apoptosis, is critical in many life processes, including development

and disease. It is characterized by membrane instability, activation

of caspases, which are the executioner proteins in apoptosis, change

in membrane potential, and DNA fragmentation.

" In the present study we have demonstrated for the first time that the

treatment of neuroblastoma cells with elevated concentrations of

testosterone for relatively short periods, six to 12 hours, induces a

decrease in cell viability by activation of a cell death program, "

Ehrlich said. " Low concentrations of testosterone had no effects on

cell viability, whereas at high concentrations the cell viability

decreased with incremental increases in hormone concentration. "

The testosterone-induced apoptosis described in this study occurs

through overactivation of intracellular Ca2+ signaling pathways.

Overstimulation of the apoptotic program in neurons has been

associated with several neurological illnesses, such as Alzheimer

disease and Huntington disease.

________________

I am human; nothing in humanity is alien to me.

Terence

[Guest guest]

From a woman's point of view that testosterone kills brain

cells.....MY GOSH THAT EXPLAINS IT ALL!!!!!! Ha! We knew it all the

time an now science has confirmed our thoughts...men do think with

their...uh, brains? :>) You fellas have a great day....honest!

Vickie

In , retrogrouch@... wrote:

>

> Endocrinology News

>

>

> Hmmm. I'll look for the levels used in the study and post them.

>

>

> Elevated Testosterone Kills Brain Cells

> Main Category: Endocrinology News

> Article Date: 28 Sep 2006 - 16:00pm (PDT)

>

>

>

>

> A Yale School of Medicine study shows for the first time that a

high

> level of testosterone, such as that caused by the use of steroids

to

> increase muscle mass or for replacement therapy, can lead to a

> catastrophic loss of brain cells.

>

> Taking large doses of androgens, or steroids, is known to cause

> hyperexcitability, a highly aggressive nature, and suicidal

> tendencies. These behavioral changes could be evidence of

alterations

> in neuronal function caused by the steroids, said the senior

author,

> Barbara Ehrlich, professor of pharmacology and physiology.

>

> " Next time a muscle-bound guy in a sports car cuts you off on the

> highway, don't get mad, just take a deep breath and realize that it

> might not be his fault, " said Ehrlich.

>

> Testosterone is the main male hormone and it plays fundamental

roles

> in development, differentiation, and cellular growth. In neurons,

> testosterone acts as a neurosteroid and can induce changes at the

> cellular level, which in turn lead to changes in behavior, mood and

> memory. Both neuroprotective and neurodegenerative effects of

> androgens have been reported.

>

> The researchers showed that high levels of testosterone triggered

> programmed cell death in nerve cells in culture. Cell death, or

> apoptosis, is critical in many life processes, including

development

> and disease. It is characterized by membrane instability,

activation

> of caspases, which are the executioner proteins in apoptosis,

change

> in membrane potential, and DNA fragmentation.

>

> " In the present study we have demonstrated for the first time that

the

> treatment of neuroblastoma cells with elevated concentrations of

> testosterone for relatively short periods, six to 12 hours,

induces a

> decrease in cell viability by activation of a cell death program, "

> Ehrlich said. " Low concentrations of testosterone had no effects on

> cell viability, whereas at high concentrations the cell viability

> decreased with incremental increases in hormone concentration. "

>

> The testosterone-induced apoptosis described in this study occurs

> through overactivation of intracellular Ca2+ signaling pathways.

> Overstimulation of the apoptotic program in neurons has been

> associated with several neurological illnesses, such as Alzheimer

> disease and Huntington disease.

>

> ________________

> I am human; nothing in humanity is alien to me.

> Terence

>

[Guest guest]

LOL, I know plenty of women who will agree with this!

_____

From: [mailto: ]

On Behalf Of retrogrouch@...

Sent: Wednesday, October 18, 2006 7:14 AM

Subject: Elevated testosterone kills brain cells

Endocrinology News

Hmmm. I'll look for the levels used in the study and post them.

Elevated Testosterone Kills Brain Cells

Main Category: Endocrinology News

Article Date: 28 Sep 2006 - 16:00pm (PDT)

A Yale School of Medicine study shows for the first time that a high

level of testosterone, such as that caused by the use of steroids to

increase muscle mass or for replacement therapy, can lead to a

catastrophic loss of brain cells.

Taking large doses of androgens, or steroids, is known to cause

hyperexcitability, a highly aggressive nature, and suicidal

tendencies. These behavioral changes could be evidence of alterations

in neuronal function caused by the steroids, said the senior author,

Barbara Ehrlich, professor of pharmacology and physiology.

" Next time a muscle-bound guy in a sports car cuts you off on the

highway, don't get mad, just take a deep breath and realize that it

might not be his fault, " said Ehrlich.

Testosterone is the main male hormone and it plays fundamental roles

in development, differentiation, and cellular growth. In neurons,

testosterone acts as a neurosteroid and can induce changes at the

cellular level, which in turn lead to changes in behavior, mood and

memory. Both neuroprotective and neurodegenerative effects of

androgens have been reported.

The researchers showed that high levels of testosterone triggered

programmed cell death in nerve cells in culture. Cell death, or

apoptosis, is critical in many life processes, including development

and disease. It is characterized by membrane instability, activation

of caspases, which are the executioner proteins in apoptosis, change

in membrane potential, and DNA fragmentation.

" In the present study we have demonstrated for the first time that the

treatment of neuroblastoma cells with elevated concentrations of

testosterone for relatively short periods, six to 12 hours, induces a

decrease in cell viability by activation of a cell death program, "

Ehrlich said. " Low concentrations of testosterone had no effects on

cell viability, whereas at high concentrations the cell viability

decreased with incremental increases in hormone concentration. "

The testosterone-induced apoptosis described in this study occurs

through overactivation of intracellular Ca2+ signaling pathways.

Overstimulation of the apoptotic program in neurons has been

associated with several neurological illnesses, such as Alzheimer

disease and Huntington disease.

________________

I am human; nothing in humanity is alien to me.

Terence

[Guest guest]

which in turn lead to changes in behavior, mood and

memory.

the sentence above is interesting as its the same with

low testosterone anyway,if we have low testosteron

then b3ehaviour/mood and memory are affected,odd it

should be the same if too much

i guess that its really a better balance of all

hormones that is the main thing and probalby the

elevated testosterone they are talking about is above

the normal dosages anyway

be intersting to see what thy call elevated

___________________________________________________________

Try the all-new . " The New Version is radically easier to use " – The

Wall Street Journal

http://uk.docs./nowyoucan.html

[Guest guest]

Hi,

In my last visit to Dr. Gambrell, he made the comment that high levels

of T were given to help blood problems and I forget the other conditions.

He said there is no harm from high levels of T. I guess I would have

burned out all my fuses when I was a teenager if that was a problem.

Isn't the steroid form something entirely different?

ernestnolan

>

> Endocrinology News

>

>

> Hmmm. I'll look for the levels used in the study and post them.

>

>

> Elevated Testosterone Kills Brain Cells

> Main Category: Endocrinology News

> Article Date: 28 Sep 2006 - 16:00pm (PDT)

>

>

>

>

> A Yale School of Medicine study shows for the first time that a high

> level of testosterone, such as that caused by the use of steroids to

> increase muscle mass or for replacement therapy, can lead to a

> catastrophic loss of brain cells.

>

> Taking large doses of androgens, or steroids, is known to cause

> hyperexcitability, a highly aggressive nature, and suicidal

> tendencies. These behavioral changes could be evidence of alterations

> in neuronal function caused by the steroids, said the senior author,

> Barbara Ehrlich, professor of pharmacology and physiology.

>

> " Next time a muscle-bound guy in a sports car cuts you off on the

> highway, don't get mad, just take a deep breath and realize that it

> might not be his fault, " said Ehrlich.

>

> Testosterone is the main male hormone and it plays fundamental roles

> in development, differentiation, and cellular growth. In neurons,

> testosterone acts as a neurosteroid and can induce changes at the

> cellular level, which in turn lead to changes in behavior, mood and

> memory. Both neuroprotective and neurodegenerative effects of

> androgens have been reported.

>

> The researchers showed that high levels of testosterone triggered

> programmed cell death in nerve cells in culture. Cell death, or

> apoptosis, is critical in many life processes, including development

> and disease. It is characterized by membrane instability, activation

> of caspases, which are the executioner proteins in apoptosis, change

> in membrane potential, and DNA fragmentation.

>

> " In the present study we have demonstrated for the first time that the

> treatment of neuroblastoma cells with elevated concentrations of

> testosterone for relatively short periods, six to 12 hours, induces a

> decrease in cell viability by activation of a cell death program, "

> Ehrlich said. " Low concentrations of testosterone had no effects on

> cell viability, whereas at high concentrations the cell viability

> decreased with incremental increases in hormone concentration. "

>

> The testosterone-induced apoptosis described in this study occurs

> through overactivation of intracellular Ca2+ signaling pathways.

> Overstimulation of the apoptotic program in neurons has been

> associated with several neurological illnesses, such as Alzheimer

> disease and Huntington disease.

>

> ________________

> I am human; nothing in humanity is alien to me.

> Terence

>

[Guest guest]

On Thu, 19 Oct 2006 00:25:24 -0000, you wrote:

>Hi,

>

>In my last visit to Dr. Gambrell, he made the comment that high levels

>of T were given to help blood problems and I forget the other conditions.

>

>He said there is no harm from high levels of T. I guess I would have

>burned out all my fuses when I was a teenager if that was a problem.

Maybe that explains a lot of teen mail behavior? ;->

>

>Isn't the steroid form something entirely different?

>

>ernestnolan

>

>

>>

>> Endocrinology News

>>

>>

>> Hmmm. I'll look for the levels used in the study and post them.

>>

>>

>> Elevated Testosterone Kills Brain Cells

>> Main Category: Endocrinology News

>> Article Date: 28 Sep 2006 - 16:00pm (PDT)

>>

>>

>>

>>

>> A Yale School of Medicine study shows for the first time that a high

>> level of testosterone, such as that caused by the use of steroids to

>> increase muscle mass or for replacement therapy, can lead to a

>> catastrophic loss of brain cells.

>>

>> Taking large doses of androgens, or steroids, is known to cause

>> hyperexcitability, a highly aggressive nature, and suicidal

>> tendencies. These behavioral changes could be evidence of alterations

>> in neuronal function caused by the steroids, said the senior author,

>> Barbara Ehrlich, professor of pharmacology and physiology.

>>

>> " Next time a muscle-bound guy in a sports car cuts you off on the

>> highway, don't get mad, just take a deep breath and realize that it

>> might not be his fault, " said Ehrlich.

>>

>> Testosterone is the main male hormone and it plays fundamental roles

>> in development, differentiation, and cellular growth. In neurons,

>> testosterone acts as a neurosteroid and can induce changes at the

>> cellular level, which in turn lead to changes in behavior, mood and

>> memory. Both neuroprotective and neurodegenerative effects of

>> androgens have been reported.

>>

>> The researchers showed that high levels of testosterone triggered

>> programmed cell death in nerve cells in culture. Cell death, or

>> apoptosis, is critical in many life processes, including development

>> and disease. It is characterized by membrane instability, activation

>> of caspases, which are the executioner proteins in apoptosis, change

>> in membrane potential, and DNA fragmentation.

>>

>> " In the present study we have demonstrated for the first time that the

>> treatment of neuroblastoma cells with elevated concentrations of

>> testosterone for relatively short periods, six to 12 hours, induces a

>> decrease in cell viability by activation of a cell death program, "

>> Ehrlich said. " Low concentrations of testosterone had no effects on

>> cell viability, whereas at high concentrations the cell viability

>> decreased with incremental increases in hormone concentration. "

>>

>> The testosterone-induced apoptosis described in this study occurs

>> through overactivation of intracellular Ca2+ signaling pathways.

>> Overstimulation of the apoptotic program in neurons has been

>> associated with several neurological illnesses, such as Alzheimer

>> disease and Huntington disease.

>>

>> ________________

>> I am human; nothing in humanity is alien to me.

>> Terence

>>

>

>

________________

" You never need an argument against the use of violence, you need an

argument for it. " Noam Chomsky

[Guest guest]

When you hear guys say they're taking steroids, they're usually taking test

cyp or test eth, the exact same stuff we're taking. The difference is in

the size of the dose.

_____

From: [mailto: ]

On Behalf Of ernestnolan

Sent: Wednesday, October 18, 2006 5:25 PM

Subject: Re: Elevated testosterone kills brain cells

Hi,

In my last visit to Dr. Gambrell, he made the comment that high levels

of T were given to help blood problems and I forget the other conditions.

He said there is no harm from high levels of T. I guess I would have

burned out all my fuses when I was a teenager if that was a problem.

Isn't the steroid form something entirely different?

ernestnolan

>

> Endocrinology News

>

>

> Hmmm. I'll look for the levels used in the study and post them.

>

>

> Elevated Testosterone Kills Brain Cells

> Main Category: Endocrinology News

> Article Date: 28 Sep 2006 - 16:00pm (PDT)

>

>

>

>

> A Yale School of Medicine study shows for the first time that a high

> level of testosterone, such as that caused by the use of steroids to

> increase muscle mass or for replacement therapy, can lead to a

> catastrophic loss of brain cells.

>

> Taking large doses of androgens, or steroids, is known to cause

> hyperexcitability, a highly aggressive nature, and suicidal

> tendencies. These behavioral changes could be evidence of alterations

> in neuronal function caused by the steroids, said the senior author,

> Barbara Ehrlich, professor of pharmacology and physiology.

>

> " Next time a muscle-bound guy in a sports car cuts you off on the

> highway, don't get mad, just take a deep breath and realize that it

> might not be his fault, " said Ehrlich.

>

> Testosterone is the main male hormone and it plays fundamental roles

> in development, differentiation, and cellular growth. In neurons,

> testosterone acts as a neurosteroid and can induce changes at the

> cellular level, which in turn lead to changes in behavior, mood and

> memory. Both neuroprotective and neurodegenerative effects of

> androgens have been reported.

>

> The researchers showed that high levels of testosterone triggered

> programmed cell death in nerve cells in culture. Cell death, or

> apoptosis, is critical in many life processes, including development

> and disease. It is characterized by membrane instability, activation

> of caspases, which are the executioner proteins in apoptosis, change

> in membrane potential, and DNA fragmentation.

>

> " In the present study we have demonstrated for the first time that the

> treatment of neuroblastoma cells with elevated concentrations of

> testosterone for relatively short periods, six to 12 hours, induces a

> decrease in cell viability by activation of a cell death program, "

> Ehrlich said. " Low concentrations of testosterone had no effects on

> cell viability, whereas at high concentrations the cell viability

> decreased with incremental increases in hormone concentration. "

>

> The testosterone-induced apoptosis described in this study occurs

> through overactivation of intracellular Ca2+ signaling pathways.

> Overstimulation of the apoptotic program in neurons has been

> associated with several neurological illnesses, such as Alzheimer

> disease and Huntington disease.

>

> ________________

> I am human; nothing in humanity is alien to me.

> Terence

>

[Guest guest]

Hey Retouch, I almost missed your response here - a single line of text in

the middle of a hundred lines of quoted text is pretty hard to spot.

No doubt that that's why teenage boys are the way they are. ;-)

_____

From: [mailto: ]

On Behalf Of retrogrouch@...

Sent: Wednesday, October 18, 2006 6:45 PM

Subject: Re: Re: Elevated testosterone kills brain cells

On Thu, 19 Oct 2006 00:25:24 -0000, you wrote:

>Hi,

>

>In my last visit to Dr. Gambrell, he made the comment that high levels

>of T were given to help blood problems and I forget the other conditions.

>

>He said there is no harm from high levels of T. I guess I would have

>burned out all my fuses when I was a teenager if that was a problem.

Maybe that explains a lot of teen mail behavior? ;->

>

>Isn't the steroid form something entirely different?

>

>ernestnolan

>

>

>>

>> Endocrinology News

>>

>>

>> Hmmm. I'll look for the levels used in the study and post them.

>>

>>

>> Elevated Testosterone Kills Brain Cells

>> Main Category: Endocrinology News

>> Article Date: 28 Sep 2006 - 16:00pm (PDT)

>>

>>

>>

>>

>> A Yale School of Medicine study shows for the first time that a high

>> level of testosterone, such as that caused by the use of steroids to

>> increase muscle mass or for replacement therapy, can lead to a

>> catastrophic loss of brain cells.

>>

>> Taking large doses of androgens, or steroids, is known to cause

>> hyperexcitability, a highly aggressive nature, and suicidal

>> tendencies. These behavioral changes could be evidence of alterations

>> in neuronal function caused by the steroids, said the senior author,

>> Barbara Ehrlich, professor of pharmacology and physiology.

>>

>> " Next time a muscle-bound guy in a sports car cuts you off on the

>> highway, don't get mad, just take a deep breath and realize that it

>> might not be his fault, " said Ehrlich.

>>

>> Testosterone is the main male hormone and it plays fundamental roles

>> in development, differentiation, and cellular growth. In neurons,

>> testosterone acts as a neurosteroid and can induce changes at the

>> cellular level, which in turn lead to changes in behavior, mood and

>> memory. Both neuroprotective and neurodegenerative effects of

>> androgens have been reported.

>>

>> The researchers showed that high levels of testosterone triggered

>> programmed cell death in nerve cells in culture. Cell death, or

>> apoptosis, is critical in many life processes, including development

>> and disease. It is characterized by membrane instability, activation

>> of caspases, which are the executioner proteins in apoptosis, change

>> in membrane potential, and DNA fragmentation.

>>

>> " In the present study we have demonstrated for the first time that the

>> treatment of neuroblastoma cells with elevated concentrations of

>> testosterone for relatively short periods, six to 12 hours, induces a

>> decrease in cell viability by activation of a cell death program, "

>> Ehrlich said. " Low concentrations of testosterone had no effects on

>> cell viability, whereas at high concentrations the cell viability

>> decreased with incremental increases in hormone concentration. "

>>

>> The testosterone-induced apoptosis described in this study occurs

>> through overactivation of intracellular Ca2+ signaling pathways.

>> Overstimulation of the apoptotic program in neurons has been

>> associated with several neurological illnesses, such as Alzheimer

>> disease and Huntington disease.

>>

>> ________________

>> I am human; nothing in humanity is alien to me.

>> Terence

>>

>

>

________________

" You never need an argument against the use of violence, you need an

argument for it. " Noam Chomsky

[Guest guest]

On Wed, 18 Oct 2006 16:45:31 -0000, you wrote:

>From a woman's point of view that testosterone kills brain

>cells.....MY GOSH THAT EXPLAINS IT ALL!!!!!! Ha! We knew it all the

>time an now science has confirmed our thoughts...men do think with

>their...uh, brains? :>) You fellas have a great day....honest!

>Vickie

It's still a fair trade off. ;->

________________

" You never need an argument against the use of violence, you need an

argument for it. " Noam Chomsky

[Guest guest]

Hi Vickie-

Always nice to have a womens' point of view on the board. I was

trying to think of some pithy retort like maybe penis-envy, or being

able to drive a car but they all fell pretty flat. Lack of brain

cells I guess.

Rich

> >

> > Endocrinology News

> >

> >

> > Hmmm. I'll look for the levels used in the study and post them.

> >

> >

> > Elevated Testosterone Kills Brain Cells

> > Main Category: Endocrinology News

> > Article Date: 28 Sep 2006 - 16:00pm (PDT)

> >

> >

> >

> >

> > A Yale School of Medicine study shows for the first time that a

> high

> > level of testosterone, such as that caused by the use of steroids

> to

> > increase muscle mass or for replacement therapy, can lead to a

> > catastrophic loss of brain cells.

> >

> > Taking large doses of androgens, or steroids, is known to cause

> > hyperexcitability, a highly aggressive nature, and suicidal

> > tendencies. These behavioral changes could be evidence of

> alterations

> > in neuronal function caused by the steroids, said the senior

> author,

> > Barbara Ehrlich, professor of pharmacology and physiology.

> >

> > " Next time a muscle-bound guy in a sports car cuts you off on the

> > highway, don't get mad, just take a deep breath and realize that

it

> > might not be his fault, " said Ehrlich.

> >

> > Testosterone is the main male hormone and it plays fundamental

> roles

> > in development, differentiation, and cellular growth. In neurons,

> > testosterone acts as a neurosteroid and can induce changes at the

> > cellular level, which in turn lead to changes in behavior, mood

and

> > memory. Both neuroprotective and neurodegenerative effects of

> > androgens have been reported.

> >

> > The researchers showed that high levels of testosterone triggered

> > programmed cell death in nerve cells in culture. Cell death, or

> > apoptosis, is critical in many life processes, including

> development

> > and disease. It is characterized by membrane instability,

> activation

> > of caspases, which are the executioner proteins in apoptosis,

> change

> > in membrane potential, and DNA fragmentation.

> >

> > " In the present study we have demonstrated for the first time

that

> the

> > treatment of neuroblastoma cells with elevated concentrations of

> > testosterone for relatively short periods, six to 12 hours,

> induces a

> > decrease in cell viability by activation of a cell death program, "

> > Ehrlich said. " Low concentrations of testosterone had no effects

on

> > cell viability, whereas at high concentrations the cell viability

> > decreased with incremental increases in hormone concentration. "

> >

> > The testosterone-induced apoptosis described in this study occurs

> > through overactivation of intracellular Ca2+ signaling pathways.

> > Overstimulation of the apoptotic program in neurons has been

> > associated with several neurological illnesses, such as Alzheimer

> > disease and Huntington disease.

> >

> > ________________

> > I am human; nothing in humanity is alien to me.

> > Terence

> >

>

[Guest guest]

guess it also means a lot of guys are going to have to dye their hair blond to

fit in

Rich <caliconine@...> wrote:

Hi Vickie-

Always nice to have a womens' point of view on the board. I was

trying to think of some pithy retort like maybe penis-envy, or being

able to drive a car but they all fell pretty flat. Lack of brain

cells I guess.

Rich

> >

> > Endocrinology News

> >

> >

> > Hmmm. I'll look for the levels used in the study and post them.

> >

> >

> > Elevated Testosterone Kills Brain Cells

> > Main Category: Endocrinology News

> > Article Date: 28 Sep 2006 - 16:00pm (PDT)

> >

> >

> >

> >

> > A Yale School of Medicine study shows for the first time that a

> high

> > level of testosterone, such as that caused by the use of steroids

> to

> > increase muscle mass or for replacement therapy, can lead to a

> > catastrophic loss of brain cells.

> >

> > Taking large doses of androgens, or steroids, is known to cause

> > hyperexcitability, a highly aggressive nature, and suicidal

> > tendencies. These behavioral changes could be evidence of

> alterations

> > in neuronal function caused by the steroids, said the senior

> author,

> > Barbara Ehrlich, professor of pharmacology and physiology.

> >

> > " Next time a muscle-bound guy in a sports car cuts you off on the

> > highway, don't get mad, just take a deep breath and realize that

it

> > might not be his fault, " said Ehrlich.

> >

> > Testosterone is the main male hormone and it plays fundamental

> roles

> > in development, differentiation, and cellular growth. In neurons,

> > testosterone acts as a neurosteroid and can induce changes at the

> > cellular level, which in turn lead to changes in behavior, mood

and

> > memory. Both neuroprotective and neurodegenerative effects of

> > androgens have been reported.

> >

> > The researchers showed that high levels of testosterone triggered

> > programmed cell death in nerve cells in culture. Cell death, or

> > apoptosis, is critical in many life processes, including

> development

> > and disease. It is characterized by membrane instability,

> activation

> > of caspases, which are the executioner proteins in apoptosis,

> change

> > in membrane potential, and DNA fragmentation.

> >

> > " In the present study we have demonstrated for the first time

that

> the

> > treatment of neuroblastoma cells with elevated concentrations of

> > testosterone for relatively short periods, six to 12 hours,

> induces a

> > decrease in cell viability by activation of a cell death program, "

> > Ehrlich said. " Low concentrations of testosterone had no effects

on

> > cell viability, whereas at high concentrations the cell viability

> > decreased with incremental increases in hormone concentration. "

> >

> > The testosterone-induced apoptosis described in this study occurs

> > through overactivation of intracellular Ca2+ signaling pathways.

> > Overstimulation of the apoptotic program in neurons has been

> > associated with several neurological illnesses, such as Alzheimer

> > disease and Huntington disease.

> >

> > ________________

> > I am human; nothing in humanity is alien to me.

> > Terence

> >

>

---------------------------------

Get your own web address for just $1.99/1st yr. We'll help. Small

Business.