Cancer Subtypes /was: Karla:A RECONSIDERATION OF MY BELIEFS.

[Guest guest]

As far as colon cancer is concerned, cancers with a molecolar

profile called " high microsatellite instability " have better

prognosis (do not metastasize....)

But conventional oncologists do not test routinely for

microsatellite instability and they sell " preventive " chemo

to everyone...

karla

..

Colorectal cancers with high-frequency microsatellite instability

show peculiar clinicopathological features and a favorable clinical

outcome. We investigated whether the improved prognosis for these

cancers is related to the content of activated cytotoxic

intraepithelial T lymphocytes. Microsatellite instability and the

amount of activated cytotoxic lymphocytes were analyzed according to

clinicopathological features, survival, and disease recurrence in 109

right-sided colon carcinomas from 245 consecutive patients with stage

II/III colon cancer that underwent radical surgery. High-frequency

microsatellite instability was found in 43% of stage II/III proximal

colon cancers and was associated with significantly higher numbers of

activated cytotoxic lymphocytes. High-frequency microsatellite

instability, as well as the content of intratumoral-activated

cytotoxic T lymphocytes correlated with improved overall and disease-

free survival, particularly in patients with stage III tumors.

Multivariate analysis revealed that patients with both features had a

risk of death and relapse markedly lower than that associated with

microsatellite status or intratumoral cytotoxic lymphocytes

separately. The presence of local cytotoxic immune responses is

probably the major determinant of the good clinical course of

patients with microsatellite unstable colon cancer. Furthermore, high-

frequency microsatellite instability coupled with a high content of

intratumoral cytotoxic lymphocytes may identify a subset of colon

cancer patients with a favorable clinical outcome, particularly in

stage III disease

>

> Can you talk some more about the difference between benign and

aggressive subtypes?  Thanks. Jan