AIS (Androgen Insensitivity Syndrome)

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" Androgen insensitivity syndrome (AIS, or " Androgen resistance

syndrome " ) is a set of disorders of sexual differentiation that

results from mutations of the gene encoding the androgen receptor. It

has also been called androgen resistance in the medical literature.

The nature of the resulting problem varies according to the structure

and sensitivity of the abnormal receptor. "

" Androgen receptor mutations have also been discovered in men with

normal internal and external genitalia but infertility due to absence

of sperm (azoospermia). Androgenic body hair is normal and

gynecomastia uncommon. Some have mildly elevated testosterone and LH

levels but this is not invariable. Several surveys suggest that

androgen receptor mutations can be found in 30-40% of men with

infertility due to otherwise unexplained oligospermia or azoospermia.

AIS may also explain most cases of a rarer form of male infertility,

the Del Castillo or Sertoli-cell-only syndrome. "

Any one have any thoughts/ideas on this? It seems interesting. I have

2% functional sperms, and there are more people out there like me.

This may explain. (However my low sperm count could be due to other

reasons such as high E2, and on top my genes came out to be normal).

This is something good to add, and who knows it may help some people.

So share in your thoughts i.e. knowledge, experience, etc etc.