What did this study show ?

[Guest guest]

What does this mean in everday langauge ? What did the study show?

> >

> > This is an article I found a while back maybe it will help..

> >

> > Study Shows That Arimidex Boosts Testosterone

> >

> > Estrogen suppression in males: metabolic effects.

> > J Clin Endocrinol Metab 2000 Jul;85(7):2370-7 (ISSN: 0021-972X)

> > Mauras N; O'Brien KO; Klein KO; V nmauras@...

> >

> > We have shown that testosterone (T) deficiency per se is

associated with

> > marked catabolic effects on protein, calcium metabolism, and body

> > composition in men independent of changes in GH or insulin-like

growth

> > factor I production. It is not clear,,however, whether estrogens

have a

> > major role in whole body anabolism in males. We investigated the

metabolic

> > effects of selective estrogen suppression in the male using a

potent

> > aromatase inhibitor, Arimidex (Anastrozole). First, a dose-

response study of

> > 12 males (mean age, 16.1 +/- 0.3 yr) was conducted, and blood

withdrawn at

> > baseline and after 10 days of oral Arimidex given as two

different doses

> > (either 0.5 or 1 mg) in random order with a 14-day washout in

between. A

> > sensitive estradiol (E2) assay showed an approximately 50%

decrease in E2

> > concentrations with either of the two doses; hence, a 1-mg dose

was

> > selected for other studies. Subsequently, eight males (aged 15-

22 yr; four

> > adults and four late pubertal) had isotopic infusions of [(13)C]

leucine and

> > (42)Ca/(44)Ca, indirect calorimetry, dual energy x-ray

absorptiometry,

> > isokinetic dynamometry, and growth factors measurements

performed before and

> > after 10 weeks of daily doses of Arimidex. Contrary to the

effects of T

> > withdrawal, there were no significant changes in body

composition (body mass

> > index, fat mass, and fat-free mass) after estrogen suppression

or in rates

> > of protein synthesis or degradation; carbohydrate, lipid, or

protein

> > oxidation; muscle strength; calcium kinetics; or bone growth

factors

> > concentrations. However, E2 concentrations decreased 48% (P =

0.006), with

> > no significant change in mean and peak GH concentrations, but

with an 18%

> > decrease in plasma insulin-like growth factor I concentrations.

There was a

> > 58% increase in serum T (P = 0.0001), sex hormone-binding

globulin did not

> > change, whereas LH and FSH concentrations increased (P < 0.02,

both).

> > Serum bone markers, osteocalcin and bone alkaline phosphatase

> > concentrations, and

> > rates of bone calcium deposition and resorption did not change.

In

> > conclusion, these data suggest that in the male 1) estrogens do

not

> > contribute significantly to the changes in body composition and

protein

> > synthesis observed with changing androgen levels; 2) estrogen is

a main

> > regulator of the gonadal-pituitary feedback for the gonadotropin

axis; and

> > 3) this level of aromatase inhibition does not negatively impact

either

> > kinetically measured rates of bone calcium turnover or indirect

markers of

> > bone calcium turnover, at least in the short term. Further

studies will

> > provide valuable information on whether timed aromatase

inhibition can be

> > useful in increasing the height potential of pubertal boys with

profound

> > growth retardation without the confounding negative effects of

gonadal

> > androgen suppression

> >

> >

> > O

> >

> >

>

>

>

[Guest guest]

> > >

> > > This is an article I found a while back maybe it will help..

> > >

> > > Study Shows That Arimidex Boosts Testosterone

> > >

> > > Estrogen suppression in males: metabolic effects.

> > > J Clin Endocrinol Metab 2000 Jul;85(7):2370-7 (ISSN: 0021-972X)

> > > Mauras N; O'Brien KO; Klein KO; V nmauras@

> > >

> > > We have shown that testosterone (T) deficiency per se is

> associated with

> > > marked catabolic effects on protein, calcium metabolism, and body

> > > composition in men independent of changes in GH or insulin-like

> growth

> > > factor I production. It is not clear,,however, whether estrogens

> have a

> > > major role in whole body anabolism in males. We investigated the

> metabolic

> > > effects of selective estrogen suppression in the male using a

> potent

> > > aromatase inhibitor, Arimidex (Anastrozole). First, a dose-

> response study of

> > > 12 males (mean age, 16.1 +/- 0.3 yr) was conducted, and blood

> withdrawn at

> > > baseline and after 10 days of oral Arimidex given as two

> different doses

> > > (either 0.5 or 1 mg) in random order with a 14-day washout in

> between. A

> > > sensitive estradiol (E2) assay showed an approximately 50%

> decrease in E2

> > > concentrations with either of the two doses; hence, a 1-mg dose

> was

> > > selected for other studies. Subsequently, eight males (aged 15-

> 22 yr; four

> > > adults and four late pubertal) had isotopic infusions of [(13)C]

> leucine and

> > > (42)Ca/(44)Ca, indirect calorimetry, dual energy x-ray

> absorptiometry,

> > > isokinetic dynamometry, and growth factors measurements

> performed before and

> > > after 10 weeks of daily doses of Arimidex. Contrary to the

> effects of T

> > > withdrawal, there were no significant changes in body

> composition (body mass

> > > index, fat mass, and fat-free mass) after estrogen suppression

> or in rates

> > > of protein synthesis or degradation; carbohydrate, lipid, or

> protein

> > > oxidation; muscle strength; calcium kinetics; or bone growth

> factors

> > > concentrations. However, E2 concentrations decreased 48% (P =

> 0.006), with

> > > no significant change in mean and peak GH concentrations, but

> with an 18%

> > > decrease in plasma insulin-like growth factor I concentrations.

> There was a

> > > 58% increase in serum T (P = 0.0001), sex hormone-binding

> globulin did not

> > > change, whereas LH and FSH concentrations increased (P < 0.02,

> both).

> > > Serum bone markers, osteocalcin and bone alkaline phosphatase

> > > concentrations, and

> > > rates of bone calcium deposition and resorption did not change.

> In

> > > conclusion, these data suggest that in the male 1) estrogens do

> not

> > > contribute significantly to the changes in body composition and

> protein

> > > synthesis observed with changing androgen levels; 2) estrogen is

> a main

> > > regulator of the gonadal-pituitary feedback for the gonadotropin

> axis; and

> > > 3) this level of aromatase inhibition does not negatively impact

> either

> > > kinetically measured rates of bone calcium turnover or indirect

> markers of

> > > bone calcium turnover, at least in the short term. Further

> studies will

> > > provide valuable information on whether timed aromatase

> inhibition can be

> > > useful in increasing the height potential of pubertal boys with

> profound

> > > growth retardation without the confounding negative effects of

> gonadal

> > > androgen suppression

> > >

> > >

> > > O

> > >

> > >

> >

> >

> >