Guest guest Posted January 22, 2003 Report Share Posted January 22, 2003 : What is Selegiline? Where does one buy it? My FIL has parkinsons pretty badly, he's 80. Maybe my husband should take it. The crazy thing is that Drs don't say that if you take Selegiline , before you are 45 (As I do and my wife and all my dear friends that hears this concept) you will stop the death of the 13% each 10 years, so you will reach 65 with your 23 % intact. With 65% You don't have Parkinson , you will have some tremors, so tis23 % make the great difference. Beyond that Selegiline is Immune Booster and increases the life of Flies, Rats and Dogs 20% . Also have a great effect on tumor reduction. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 22, 2003 Report Share Posted January 22, 2003 Dear : Selegiline is an IMAO inhibitor of Mono Amino oxidasa. The enzyme that when theneurotransmitter are reuptake from the synaptic gap , are meet with this lady and she destroys them (Serotonine, Dopamine, epinefrine and others) so they would be re proseced into de Synaptic Vesicle. If you inhibit the Imao, you will have more : Dopamine Serotonine Norepineprhine, But we are interested here in increasing the Dopamine in Mesolimbic area. The problem with your FIL has Parkinson's pretty badly, he's 80. Is that when using this IMAO you have to have a good fallow up from your Dr because of meds interaction. Also remember that at 74 , you may have 2 kidneys, butreally they also have lost the 50% of there cells (after this mails all will hate me!!!) so is very important to adjust the dose for the Kidney clearance. Selegiline for us guys and ladies from 45 to up is only PREVENTIVE, so we take 5 mg each 3 days : a times a week. But with Parkinson may be 10 mg everyday . DON'T GIVE THIS TO YOUR 80 YEARS FIL!! Let her Dr control the dose. Warm regards Re: Selegiline : What is Selegiline? Where does one buy it? My FIL has parkinsons pretty badly, he's 80. Maybe my husband should take it. The crazy thing is that Drs don't say that if you take Selegiline , before you are 45 (As I do and my wife and all my dear friends that hears this concept) you will stop the death of the 13% each 10 years, so you will reach 65 with your 23 % intact. With 65% You don't have Parkinson , you will have some tremors, so tis23 % make the great difference. Beyond that Selegiline is Immune Booster and increases the life of Flies, Rats and Dogs 20% . Also have a great effect on tumor reduction. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 22, 2003 Report Share Posted January 22, 2003 , I forgot the 50% kidney cells. I means that at 74 you have really ONE KIDNEY. Re: Selegiline : What is Selegiline? Where does one buy it? My FIL has parkinsons pretty badly, he's 80. Maybe my husband should take it. The crazy thing is that Drs don't say that if you take Selegiline , before you are 45 (As I do and my wife and all my dear friends that hears this concept) you will stop the death of the 13% each 10 years, so you will reach 65 with your 23 % intact. With 65% You don't have Parkinson , you will have some tremors, so tis23 % make the great difference. Beyond that Selegiline is Immune Booster and increases the life of Flies, Rats and Dogs 20% . Also have a great effect on tumor reduction. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 6, 2006 Report Share Posted February 6, 2006 What can anyone tell me about how it helps with Low T and libido in low doses. Phil Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 7, 2006 Report Share Posted February 7, 2006 Hey Phil, For me selegiline worked like magic for around a month, after that i could not tell if it was doing anything. My guess is that it works on people that have low levels of dopamine, and after the levels return to normal that great first effect is gone, it may have something to do with the idea of clean receptors for that hormone, and that the first wave of the missing hormone gets to those clean receptors and makes a larger then normal effect. Same effect like with booze, if you don't drink for awhile that first one can knock your socks off. Dopamine has a clear connection to libido, there is some good reading about GHB and how it works and how it's effects wear off. GHB is banned, but it is interesting to read about it. > > What can anyone tell me about how it helps with Low T and libido in > low doses. > Phil > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 7, 2006 Report Share Posted February 7, 2006 Did you have to watch your diet when you were thing selegiline and what dose did you do. Phil theta_2k <pohare@...> wrote: Hey Phil, For me selegiline worked like magic for around a month, after that i could not tell if it was doing anything. My guess is that it works on people that have low levels of dopamine, and after the levels return to normal that great first effect is gone, it may have something to do with the idea of clean receptors for that hormone, and that the first wave of the missing hormone gets to those clean receptors and makes a larger then normal effect. Same effect like with booze, if you don't drink for awhile that first one can knock your socks off. Dopamine has a clear connection to libido, there is some good reading about GHB and how it works and how it's effects wear off. GHB is banned, but it is interesting to read about it. > > What can anyone tell me about how it helps with Low T and libido in > low doses. > Phil > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 7, 2006 Report Share Posted February 7, 2006 Phil, At 10mg or less a day there is no problem with foods, but some caution with some meds. At the start 1-2mg was like lightning hit me it was so amazing, after a month or so even 10mg did nothing i could tell. Here is a good read here and lots of fun links. http://www.selegiline.com/ > > > > What can anyone tell me about how it helps with Low T and libido in > > low doses. > > Phil > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 7, 2006 Report Share Posted February 7, 2006 Here is what Dr. nco says about it posted at MESO a cut and past. Phil Originally Posted by Random987 marianco, Have you ever used deprenyl in your practice? I have used deprenyl/selegiline often in my practice, though less often recently. I am reexamining its use - particularly when the selegiline patch comes out. The patch will bypass intestinal monoamine oxidase, and thus reduce the risk of food and medication interactions that limit monoamine oxidase inhibitors use. Deprenyl/selegiline is a monoamine oxidase (MAO) inhibitor that is " specific " at " low " doses (generally 10 mg/day or less) to the MAO-B type enzyme. This allows it to avoid blocking MAO-A in the intestines which cause problems of excessive hypertension (and stroke, etc.) in interactions with certain foods and medications (e.g. stimulants, decongestants, etc.). MAO inhibitors are great antidepressants. Low blood pressure is one of the most common side effects, not high blood pressure. I think they tend to be more effective than the other antidepressants. The problem is that they have so many interactions with other medications and have so many limits in what foods a person can eat (e.g. no pizza), that many people do not want the lifestyle changes and many doctors are afraid of it and of others using it. Hopefully, the MAO patch will at least reduce the intestinal food/medication interaction risks and improve safety. Deprenyl/selegiline is relatively safe at low doses. I say " relatively " because it depends on an individual's susceptibility to side effects. Many people still have significant MAO-A inhibition no matter how small a dose of Deprenyl is used - thus running the risk of death, etc. Even at low doses, Deprenyl/selegiline, in general, cannot be used with another serotonergic medication because of the risk of death from serotonin syndrome (excessive serotonin activity). Unfortunately, since Deprenyl/selegiline is classified as a Antiparkinson medication, many clinicians do not realize this and may inadvertently add a serotonergic medication thinking it is safe - though it is not. I've seen this mistake happen and it was not pretty. If it was classified as an MAO inhibitor, automatically this would be known. Adding Deprenyl/selegiline even at 10 mg or less a day to Prozac or other serotonin reuptake inhibitor is very risky. It can be done but one must be careful. Many medications increase serotonin and this has to be taken into account. For example, the pain medication Tramadol/Ultram works as a serotonin reuptake inhibitor, as one of its mechanisms. The primary problem of oral Deprenyl/selegiline is that the doses needed to keep specificity for MAO-B is too low for it to be effective in most cases as an antidepressant. At higher doses, a person is just as well off using other MAOs with lower cost, such as Nardil. It is still worthwhile considering as an alternative in treatment resistant cases. MAO Inhibitors primarily increase serotonin levels as their main effect, though they also significantly increase dopamine and norepinephrine. Given the risks of the use of MAO inhibitors, and the primary mechanism of increasing serotonin levels, the serotonin reuptake inhibitors largely replaced them in general use. Deprenyl/Selegiline can be looked at as a " smart drug " or " nootropic " - and is used by some practitioners as such. By its stimulant properties and antioxidant properties, it may improve one's thinking capacity. Perhaps. I think your mileage may vary as with anything else. One still has to be very careful about the potential for significant interactions and risks. One using any MAO Inhibitor should carry a medical tag informing others of this so that in emergencies, the paramedic, ER doctor, etc. does not accidentlly harm the patient by giving the wrong medication. Simple things such as the over-the-counter decongestant, pseudoephedrine are off-limits. __________________ Any statement I make on this site is for educational purposes only and is subject to change. It does not constitute medical advice, does not substitute for proper medical evaluation from physician, does not create a doctor/patient relationship or liability. If you want medical advice, you will have to pay for it. Thank you. --------------------------------- theta_2k <pohare@...> wrote: Phil, At 10mg or less a day there is no problem with foods, but some caution with some meds. At the start 1-2mg was like lightning hit me it was so amazing, after a month or so even 10mg did nothing i could tell. Here is a good read here and lots of fun links. http://www.selegiline.com/ > > > > What can anyone tell me about how it helps with Low T and libido in > > low doses. > > Phil > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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