Re: he Anti-Ulcer Drug Cimetidine (Tagamet) is a Powerful Anti-Cancer Drug

[Guest guest]

any dosage you can advise ?

--- " susanmchallen "

wrote:

Cimetidine, the generic version of the popular anti-ulcer drug

Tagamet, is a potentially powerful anti-cancer drug, especially if

combined with other compounds.

This study shows that common, inexpensive, non-toxic cimetidine

blocks the activation of EGFR. When EGF, epidermal growth factor,

binds EGFR it initiates an autophosphorylation reaction which

activates the receptor and its tyrosine kinase activity.

Cimetidine

blocks this response, thereby blocking EGFRs ability to promote

cancer cell growth and the inhibition of apoptosis.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?

The authors found that cimetidine decreased the level of cyclic

AMP

in the cancer cells. The lack of cyclic AMP impaired the

autophosphorylation of the EGFR and inhibited its activity. This

is

an observation of monumental significance. Other histamine H2

receptor inhibitors, such as ranitidine and famotidine, do not

decrease the level of cyclic AMP in cells.

I have written extensively about the prostaglandin PGE2 and its

ability to suppress the immune response in general and its ability

to promote angiogenesis and the growth of cancer cells. PGE2

promotes the synthesis of cyclic AMP. I have also written about

the

role stress hormones, such as norepinephrine and epinephrine, play

in inhibiting the immune response and promoting cancer cell growth

and development. These hormones also activate cyclic AMP

synthesis.

Cimetidine could decrease cyclic AMP levels in cells by blocking

membrane adenylate cyclase, the enzyme that actually makes cyclic

AMP, or by increasing the activity of cyclic AMP

phosphodiesterase,

the enzyme that degrades cyclic AMP. To date, no one knows how

cimetidine influences cyclic AMP levels in cells.

Cimetidine, probably via decreased cyclic AMP levels, decreases

the

development of regulatory T cells. These cells, referred to as

TREG,

suppress immune functioning. These cells are activated by the

immune

hormones IL-10 and TGF-beta, hormones that cimetidine

downregulates.

In addition, cimetidine activates the synthesis of IL-12, the

major

enhancer of cell mediated immunity.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?

db=pubmed & cmd=Retrieve & dopt=Abstract & list_uids=18502198 & itool=pubmed_

docsum

>

> There are two major forms of TREG immune inhibitor cells. These

> cells inhibit a vigorous immune response against cancer, leukemia,

> bacterial and viral infections, such as HIV.

>

> http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?

>

db=pubmed & cmd=Retrieve & dopt=Abstract & list_uids=18613849 & itool=pubmed_

> docsum

>

> The IL-10/TGFbeta hormones responsible for the activation of this

> subset of TREG cells is inhibited by cimetidine due to its ability

> to reduce cyclic AMP levels in cells.

>

> The second subset, FOXP3 TREG cells, is also activated by cyclic

> AMP. This implies that cimetidine can inhibit this population of

> TREG cells as well.

>

> http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?

>

db=pubmed & cmd=Retrieve & dopt=Abstract & list_uids=16785520 & itool=pubmed_

> docsum

>

> The implications of this line of research are enormous.

Cimetidine,

> by lowering cyclic AMP levels in cells, can reactivate the immune

> response against cancer, HIV and other diseases while inhibiting

> angiogenesis and the growth of cancer cells.

>

> The daily dose is 800 mgs a day, 200 mgs four times a day. And you

> don't need a prescription.

>

> Stay tuned...

>

> Grouppe Kurosawa, Medicine in the Public Interest

> This essay is republished from our subscription blog in the public

> interest.

>