Re: cause of PA Hope for us all

[Guest guest]

In a message dated 5/2/2003 3:42:15 AM Eastern Daylight Time,

mickyszcz@... writes:

> Has anyone else on here heard about Osteoclasts and osteoblasts ???

>

I know this has to do with your bone cells and the stage that they are in.

One is a newly formed cell and the other is when the cell is matue and about

to die.

Janet

[Guest guest]

In a message dated 5/2/2003 3:42:15 AM Eastern Daylight Time,

mickyszcz@... writes:

> From what I could make of it they have found the underlying cause of

> PA and it's to do with those cells above and something else called

> RankL which we all have alot of, Maybe too much

Can you tell me where I could read more about this?

Jant

[Guest guest]

Although I know nothing about osteoclasts and osteoblasts, my rhuematologist did

mention to me several times that although I'm not lucky to have PA, I am lucky I

have it in this day and age. He told me that new progress and discoveries are

being made on a weekly basis and a cure is foreseeable in the very near future.

Hearing that has kept my spirits up and optimism high. Micky

[Guest guest]

Micky,

Where did you read this article? Is it on the web? Can you send us or a link?

Or if it is out of a magazine, can you scan it or tell us where we can get a

copy? I would love to read it myself.

[ ] cause of PA Hope for us all

Hi Everybody

Has anyone else on here heard about Osteoclasts and osteoblasts ???

I was reading about these the other day and wondered if anyone else

had come across these Names.

The reason I ask, is that the Guy who discovered the process which

allows for all these new biological drugs (Namely Anti TNF) has just

made another breakthrough in the Disease process of PA. It's all got

something to do with the above cells and why they work in Normal ppl

and not in ppl suffering with PA. It sounded pretty Impressive and

although I would love to say I knew what he was on about I really

didn't have a clue! I knew I should have studied Biology at school!

LOL

From what I could make of it they have found the underlying cause of

PA and it's to do with those cells above and something else called

RankL which we all have alot of, Maybe too much !! Anyway anyone else

out there who has read about it ???I would like to hear what they

thought of it. It gave me alot more hope as he also mentioned that

they would have much better Drugs because of this discovery, even

better than the new ones that are on the market now.

[Guest guest]

Hi Janet

sorry for not replying earlier but have been a little busy with

moving house and My childs first Communion. but here are the details

you might find interesting.

You can read more about this at the following sites:-

http://www.jci.org/

http://www.arthritissupport.com/library/showarticle.cfm/id/678

I hope it's of interest not only to you, but everybody else on here.

Seems to me like the guy who discovered the involvement of TNF in PA

has now gone further and discovered that it is a probable genetic

fault we have, that causes our Osteoclasts ( cells that break down

bones) to multiply and instead of dissolving the top layer of bone

and then allowing our Osteoblasts to come in and lay down new bone

(which happens every day)the multiple numbers of these osteoclast

cells is causing an inbalance which is slowly dissolving our bones

ever so slowly hence the pain and joint destruction!!. read about it

at the journal of clinical investigation they have pictures and

diagrams that show what is happening with ppl with PA.

At least now they are taking this disease seriously, I'm just glad I

have got it in the 21st century and not in the previous one

I think everybody should have a little prayer for

Ritchlin MD because if anybody is going to get to the bottom of this

disease then he Might just be the man.

>

Micky

London

> Can you tell me where I could read more about this?

> Jant

[Guest guest]

> "

> I think everybody should have a little prayer for

> Ritchlin MD because if anybody is going to get to the bottom of

this

> disease then he Might just be the man. "

> >

Dr. Ritchlin is my rheumy and it is so exciting to read about his

work. He is currently working on 5 additional clinical trials for

other formulations of biologics as well as differnt therapies.

He says that the pharmaceutical companies are finally interested in

this disease, and while it is a lot of work for him - it's a great

development for hope of remission.

Carin in Rochester, NY

[Guest guest]

>

> > "

> > I think everybody should have a little prayer for

> > Ritchlin MD because if anybody is going to get to the bottom of

> this

> > disease then he Might just be the man. "

> > >

>

> Dr. Ritchlin is my rheumy and it is so exciting to read about his

> work. He is currently working on 5 additional clinical trials for

> other formulations of biologics as well as differnt therapies.

> He says that the pharmaceutical companies are finally interested in

> this disease, and while it is a lot of work for him - it's a great

> development for hope of remission.

>

>

Carin in Rochester, NY

These developments and work do indeed sound exciting. Please tell

Dr.Ritchlin as someone who has suffered from PA almost all of my life

and not been understood too often...Thankyou and my prayers are with

him. I imagine many members might feel as I do.

Marti

[Guest guest]

> > Dr. Ritchlin is my rheumy and it is so exciting to read about his

> > work. > >

> >

> Carin in Rochester, NY

Carin,

Tell Dr Ritchlin from me that he's fantastic man, It must be

brilliant having him as your Rheumy If anyone knows what we are going

through it's him.

What else does he say about PA does he give you any other info that

may be helpful to us ? would love to know your thoughts

Micky

London

>

[Guest guest]

In a message dated 5/6/2003 10:57:05 PM Eastern Daylight Time, mlw402@...

writes:

> These developments and work do indeed sound exciting. Please tell

> Dr.Ritchlin as someone who has suffered from PA almost all of my life

> and not been understood too often...Thankyou and my prayers are with

> him. I imagine many members might feel as I do.

> Marti

|

you said exactly the same thung that I was feeling. It's wonderful to hear

that someone really understands waht is going on with this disease.

Janet

[Guest guest]

In a message dated 5/6/2003 7:21:44 PM Eastern Daylight Time,

mickyszcz@... writes:

> Seems to me like the guy who discovered the involvement of TNF in PA

> has now gone further and discovered that it is a probable genetic

> fault we have, that causes our Osteoclasts ( cells that break down

> bones) to multiply

Micky,

Thanks for the great info you sent. I was driving in the car today and

listening to a health talk show and he was also talking about the osteoblasts

and clasts. It sounds like Dr. Ritchlin may be on to something. I know

Enbrel works on TNF. I just hope it starts working on mine soon!!!

Janet

[Guest guest]

--- Micky,

I've told Dr. Ritchlin about this group, but perhaps I can get him to

post a message about what he's working on (in general terms at least).

Actually, because the Enbrel is working so well, I just had a check

up and won't see him directly for another six months.

I will contact him via e-mail and see if he has any additional info.

Take care,

Carin