Re: Crosspost: - PEGysomal DMSA- anyone heard of it or tried it?/

[Guest guest]

HI Andy,

Thanks for your response.

" DMSA is not stable in solution unless it is strongly acidified,

sealed under nitrogen, etc. "

****

I found this study done on mice which states that the liposomal form

is more effective. However they compared it to DMSA being injected

and do not know if that is the difference as it would obviously be a

liquid as well. It says that the liposomal form decreased side

effects of the DMSA chelating the minerals. I thought that was

interesting. IT shows the zinc levels increasing with this form of

chelation instead of decreasing or remaining the same.

http://www.journalarchive.jst.go.jp/jnlpdf.php?

cdjournal=indhealth1963 & cdvol=38 & noissue=4 & startpage=408 & lang=en & from=

jnlabstract

Here's the abstract.

Galactosylated Liposomes as rs for Targeting Meso-2, 3-

dimercaptosuccinic Acid to Cadmium Storage Sites in Cadmium Exposed

Mice

Jai Raj BEHARI1) and Minakshi NIHAL (nee Misra)1)

1) Industrial Toxicology Research Centre

[Received: 1999/09/30]

[Released: 2007/03/29]

Abstract:

In this study an attempt has been made to examine the efficacy of

meso-2, 3-dimercaptosuccinic acid (DMSA) using galactosylated

liposomes as carriers for mobilization of cadmium from the body of

mice preexposed to cadmium chloride (0.005 mmoles/kg

intraperitoneally daily for 4 days). Cadmium-exposed mice after a

rest period of 8 weeks were administered DMSA intravenously, two

injections 15 ìmoles/kg with an interval of 48 h, as free form of

DMSA, or DMSA encapsulated in liposomes composed of phosphatidyl

choline, cholesterol and phosphatidyl ethanolamine (7:2:1; PC-lip-

DMSA) or in liopsomes to which p-aminophenyl galactoside had been

anchored (Gal-lip-DMSA). Excretion of cadmium through urine and feces

was monitored for 5 days. Thereafter animals were sacrified, liver,

kidneys, spleen and isolated hepatocytes were analysed for cadmium,

copper and zinc concentration. Efficacy for cadmium mobilization from

the body was found to be in the order Gal-lip-DMSA>PC-lip-DMSA>DMSA.

These results show that liposomes can be used as targeted carrier

system for chelating agents safely and efficiently as compared to

administration of free chelating agent.

Thanks for any further insight.

TamiW

Gavin's mom

>

> > >

> > > I came across this website with lyposomal DMSA. Has anyone

ever heard

> > > of or tried this product? I would imagine (if it is a good

product)

> > > that dosing would be very easy with a liquid form of DMSA. I

just

> > > called the company and they said that they have had the product

for

> > > years but because of lack of interest, they are discontinuing.

(Only

> > > the DMSA, the EDTA and other lyposomal detox products they are

not

> > > discontinuing) So that made me even more curious if any

parents have

> > > tried it. Thanks for any feedback!

> > > http://www.life-enhancement.com/product.asp?SID=1 & id=571#desc

> > >

> > > TamiW

> > > Gavin's mom

> > >

> >

>

[Guest guest]

----- Original Message -----

From: Tami Wilken

It says that the liposomal form decreased side

effects of the DMSA chelating the minerals. I thought that was

interesting.

====>In the chelation study Jim just completed he reported he found NO

chelation of any minerals with Dmsa, just as Andy has said.