This is a home test for A Vitmain B12 Deficiency; the website is: www.B12.com;

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It is important to accurately diagnose vitamin B12 deficiency since treatment

may be extensive. For example, individuals with neurologic manifestations, the

recommendation is for a B12 injection intramuscular (IM) of 1,000 micrograms

daily for 2 weeks, then every two weeks for 6 months, and then monthly for

life.3 Some physicians may treat using high amounts of oral B124, intranasal B12

4A, or sublingual B12.5 However, adequate response to serious neurologic

symptoms to oral therapy has not been conclusively proven.6 Follow up uMMA

levels on individuals receiving oral, intranasal B12, or sublingual B12 will

assess compliance as well as B12 absorption and assimilation for correction of

B12 deficiency at the tissue level.5

For test kit requests or more information

E-Mail NCL

or

Call toll free at 1-800-397-7408

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" If you're interested in personal health, public health, or you just want to

read an amazing story, I highly recommend this book. "

Dr. Norman

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Support a child from Uganda, East Africa. Click above for more information.

Welcome to Norman Clinical Laboratory, Inc. Norman Clinical

Laboratory, Inc. (NCL) provides a means to test individuals through the mail for

cobalamin (vitamin B12 ) deficiency. The test measures methylmalonic acid (MMA)

by selected ion monitoring isotope dilution gas chromatography mass spectrometry

(GC/MS) in a random spot urine specimen. The MMA value is normalized to urine

creatinine to correct for urine dilution. The urinary MMA/creatinine ratio

(uMMA) test is more accurate than the blood test as it indicates tissue/cellular

B12 deficiency.

This test is often used by physicians wishing to make a conclusive

diagnosis of vitamin B12 deficiency with a single test, individuals desiring to

be tested by mail from the privacy of their home, and investigators seeking to

conduct the most valid research study.

Vitamin B12 deficiency can cause dementia identical to early stage

Alzheimer's disease (AD). In addition, vitamin B12 deficiency has been

implicated as a risk factor for developing AD. Vitamin B12 deficiency can also

cause a wide range of neurologic and/or psychological symptoms, anemia, and is a

risk factor for cardiovascular disease. Early detection and treatment usually

with vitamin B12 injections can reverse disability.

Strict vegetarians and breast fed infants of vegans are at risk of having

B12 deficiency. Vitamin B12 is found only in animal sources such as meat, fish,

eggs and milk. Unless a person is a vegetarian, vitamin B12 deficiency is

usually caused from malabsorption due to lack of the stomach protein, intrinsic

factor, resulting in pernicious anemia. A mild type B12 deficiency is found in

some elderly individuals affected with atrophic gastritis. Eating fortified

cereals and/or taking multivitamin supplements may eliminate some B12 deficiency

in this population 1,2 but yearly uMMA screening is still warranted.

It is important to accurately diagnose vitamin B12 deficiency since

treatment may be extensive. For example, individuals with neurologic

manifestations, the recommendation is for a B12 injection intramuscular (IM) of

1,000 micrograms daily for 2 weeks, then every two weeks for 6 months, and then

monthly for life.3 Some physicians may treat using high amounts of oral B124,

intranasal B12 4A, or sublingual B12.5 However, adequate response to serious

neurologic symptoms to oral therapy has not been conclusively proven.6 Follow up

uMMA levels on individuals receiving oral, intranasal B12, or sublingual B12

will assess compliance as well as B12 absorption and assimilation for correction

of B12 deficiency at the tissue level.5

Vitamin B12 deficiency can also cause elevated levels of serum

homocysteine (Hcys) which have been shown to be a risk factor for strokes, heart

attacks and /or blood clots.7

The uMMA test was developed by J. Norman, Ph.D. in collaboration

with the late M. Drue Denton, M.D. and co-workers at the Hematology Division of

the University of Cincinnati College of Medicine, USA.8,9 This pioneering

research continued to:

Identify high prevalence of neurologic disease in vitamin B12 deficient

patients without anemia. 9-13

Identify high prevalence of metabolic B12 deficiency in older

populations.9,12-14

Identify high prevalence of metabolic B12 deficiency in individuals with a

normal serum vitamin B12.14-16

Validate the urinary MMA test as a screening tool for identifying tissue B12

deficiency in older populations.14

Establish the first commercial laboratory (1985) for measuring normal levels

of MMA using gas chromatography mass spectrometry making the assay an available

clinical test.

Establish the first Internet web site (1996) specifically for providing

mailing kits and information for the early, non-invasive detection of metabolic

vitamin B12 deficiency.

For test kit requests or more information

E-Mail NCL

or

Call toll free at 1-800-397-7408

" Not by might, nor by power, but by my Spirit, says the Lord of hosts "