Guest guest Posted December 30, 2007 Report Share Posted December 30, 2007 Has anyone on this list actually used this test? How much did it cost? Do they send you a test kit and then you pay when you send it in? Just curious how it works. Chris It is important to accurately diagnose vitamin B12 deficiency since treatment may be extensive. For example, individuals with neurologic manifestations, the recommendation is for a B12 injection intramuscular (IM) of 1,000 micrograms daily for 2 weeks, then every two weeks for 6 months, and then monthly for life.3 Some physicians may treat using high amounts of oral B124, intranasal B12 4A, or sublingual B12.5 However, adequate response to serious neurologic symptoms to oral therapy has not been conclusively proven.6 Follow up uMMA levels on individuals receiving oral, intranasal B12, or sublingual B12 will assess compliance as well as B12 absorption and assimilation for correction of B12 deficiency at the tissue level.5 For test kit requests or more information E-Mail NCL or Call toll free at 1-800-397-7408 Menu Home The Principle The Accuracy The Prevention The 1st Choice The Epidemic The History Who to Test? Cases Importance The Experts About NCL References Testimonials FAQ Page --------------------------------- B12.COM Brochure (Adobe Reader required) --------------------------------- " If you're interested in personal health, public health, or you just want to read an amazing story, I highly recommend this book. " Dr. Norman --------------------------------- Support a child from Uganda, East Africa. Click above for more information. Welcome to Norman Clinical Laboratory, Inc. Norman Clinical Laboratory, Inc. (NCL) provides a means to test individuals through the mail for cobalamin (vitamin B12 ) deficiency. The test measures methylmalonic acid (MMA) by selected ion monitoring isotope dilution gas chromatography mass spectrometry (GC/MS) in a random spot urine specimen. The MMA value is normalized to urine creatinine to correct for urine dilution. The urinary MMA/creatinine ratio (uMMA) test is more accurate than the blood test as it indicates tissue/cellular B12 deficiency. This test is often used by physicians wishing to make a conclusive diagnosis of vitamin B12 deficiency with a single test, individuals desiring to be tested by mail from the privacy of their home, and investigators seeking to conduct the most valid research study. Vitamin B12 deficiency can cause dementia identical to early stage Alzheimer's disease (AD). In addition, vitamin B12 deficiency has been implicated as a risk factor for developing AD. Vitamin B12 deficiency can also cause a wide range of neurologic and/or psychological symptoms, anemia, and is a risk factor for cardiovascular disease. Early detection and treatment usually with vitamin B12 injections can reverse disability. Strict vegetarians and breast fed infants of vegans are at risk of having B12 deficiency. Vitamin B12 is found only in animal sources such as meat, fish, eggs and milk. Unless a person is a vegetarian, vitamin B12 deficiency is usually caused from malabsorption due to lack of the stomach protein, intrinsic factor, resulting in pernicious anemia. A mild type B12 deficiency is found in some elderly individuals affected with atrophic gastritis. Eating fortified cereals and/or taking multivitamin supplements may eliminate some B12 deficiency in this population 1,2 but yearly uMMA screening is still warranted. It is important to accurately diagnose vitamin B12 deficiency since treatment may be extensive. For example, individuals with neurologic manifestations, the recommendation is for a B12 injection intramuscular (IM) of 1,000 micrograms daily for 2 weeks, then every two weeks for 6 months, and then monthly for life.3 Some physicians may treat using high amounts of oral B124, intranasal B12 4A, or sublingual B12.5 However, adequate response to serious neurologic symptoms to oral therapy has not been conclusively proven.6 Follow up uMMA levels on individuals receiving oral, intranasal B12, or sublingual B12 will assess compliance as well as B12 absorption and assimilation for correction of B12 deficiency at the tissue level.5 Vitamin B12 deficiency can also cause elevated levels of serum homocysteine (Hcys) which have been shown to be a risk factor for strokes, heart attacks and /or blood clots.7 The uMMA test was developed by J. Norman, Ph.D. in collaboration with the late M. Drue Denton, M.D. and co-workers at the Hematology Division of the University of Cincinnati College of Medicine, USA.8,9 This pioneering research continued to: Identify high prevalence of neurologic disease in vitamin B12 deficient patients without anemia. 9-13 Identify high prevalence of metabolic B12 deficiency in older populations.9,12-14 Identify high prevalence of metabolic B12 deficiency in individuals with a normal serum vitamin B12.14-16 Validate the urinary MMA test as a screening tool for identifying tissue B12 deficiency in older populations.14 Establish the first commercial laboratory (1985) for measuring normal levels of MMA using gas chromatography mass spectrometry making the assay an available clinical test. Establish the first Internet web site (1996) specifically for providing mailing kits and information for the early, non-invasive detection of metabolic vitamin B12 deficiency. For test kit requests or more information E-Mail NCL or Call toll free at 1-800-397-7408 " Not by might, nor by power, but by my Spirit, says the Lord of hosts " Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 31, 2007 Report Share Posted December 31, 2007 Hi Chris: Why not just go to the webiste; www.B12.com and read the info for yourself; that is how i got the information; by reading the info. The test costs $150 and is supposed to be a very accurate B12 test. If you know of another test that is better or less expensive; I pray you; please enlighten us; for we are all in this boat together. > > Has anyone on this list actually used this test? How much did it cost? Do > they send you a test kit and then you pay when you send it in? Just > curious how it works. > > Chris > > It is important to accurately diagnose vitamin B12 deficiency since > treatment may be extensive. For example, individuals with neurologic > manifestations, the recommendation is for a B12 injection intramuscular (IM) > of 1,000 micrograms daily for 2 weeks, then every two weeks for 6 months, > and then monthly for life.3 Some physicians may treat using high amounts of > oral B124, intranasal B12 4A, or sublingual B12.5 However, adequate response > to serious neurologic symptoms to oral therapy has not been conclusively > proven.6 Follow up uMMA levels on individuals receiving oral, intranasal > B12, or sublingual B12 will assess compliance as well as B12 absorption and > assimilation for correction of B12 deficiency at the tissue level.5 > > For test kit requests or more information > E-Mail NCL > or > Call toll free at 1-800-397-7408 > Menu > Home The Principle The Accuracy The Prevention The 1st Choice The Epidemic > The History Who to Test? Cases Importance The Experts About NCL References > Testimonials FAQ Page > --------------------------------- > > B12.COM Brochure > (Adobe Reader required) > --------------------------------- > > " If you're interested in personal health, public health, or you just want to > read an amazing story, I highly recommend this book. " > > Dr. Norman > --------------------------------- > > Support a child from Uganda, East Africa. Click above for more information. > > Welcome to Norman Clinical Laboratory, Inc. Norman Clinical Laboratory, Inc. > (NCL) provides a means to test individuals through the mail for cobalamin > (vitamin B12 ) deficiency. The test measures methylmalonic acid (MMA) by > selected ion monitoring isotope dilution gas chromatography mass > spectrometry (GC/MS) in a random spot urine specimen. The MMA value is > normalized to urine creatinine to correct for urine dilution. The urinary > MMA/creatinine ratio (uMMA) test is more accurate than the blood test as it > indicates tissue/cellular B12 deficiency. > This test is often used by physicians wishing to make a conclusive diagnosis > of vitamin B12 deficiency with a single test, individuals desiring to be > tested by mail from the privacy of their home, and investigators seeking to > conduct the most valid research study. > Vitamin B12 deficiency can cause dementia identical to early stage > Alzheimer's disease (AD). In addition, vitamin B12 deficiency has been > implicated as a risk factor for developing AD. Vitamin B12 deficiency can > also cause a wide range of neurologic and/or psychological symptoms, anemia, > and is a risk factor for cardiovascular disease. Early detection and > treatment usually with vitamin B12 injections can reverse disability. > Strict vegetarians and breast fed infants of vegans are at risk of having > B12 deficiency. Vitamin B12 is found only in animal sources such as meat, > fish, eggs and milk. Unless a person is a vegetarian, vitamin B12 deficiency > is usually caused from malabsorption due to lack of the stomach protein, > intrinsic factor, resulting in pernicious anemia. A mild type B12 deficiency > is found in some elderly individuals affected with atrophic gastritis. > Eating fortified cereals and/or taking multivitamin supplements may > eliminate some B12 deficiency in this population 1,2 but yearly uMMA > screening is still warranted. > > It is important to accurately diagnose vitamin B12 deficiency since > treatment may be extensive. For example, individuals with neurologic > manifestations, the recommendation is for a B12 injection intramuscular (IM) > of 1,000 micrograms daily for 2 weeks, then every two weeks for 6 months, > and then monthly for life.3 Some physicians may treat using high amounts of > oral B124, intranasal B12 4A, or sublingual B12.5 However, adequate response > to serious neurologic symptoms to oral therapy has not been conclusively > proven.6 Follow up uMMA levels on individuals receiving oral, intranasal > B12, or sublingual B12 will assess compliance as well as B12 absorption and > assimilation for correction of B12 deficiency at the tissue level.5 > > Vitamin B12 deficiency can also cause elevated levels of serum homocysteine > (Hcys) which have been shown to be a risk factor for strokes, heart attacks > and /or blood clots.7 > > The uMMA test was developed by J. Norman, Ph.D. in collaboration with > the late M. Drue Denton, M.D. and co-workers at the Hematology Division of > the University of Cincinnati College of Medicine, USA.8,9 This pioneering > research continued to: > > Identify high prevalence of neurologic disease in vitamin B12 deficient > patients without anemia. 9-13 > Identify high prevalence of metabolic B12 deficiency in older > populations.9,12-14 > Identify high prevalence of metabolic B12 deficiency in individuals with a > normal serum vitamin B12.14-16 > Validate the urinary MMA test as a screening tool for identifying tissue B12 > deficiency in older populations.14 > Establish the first commercial laboratory (1985) for measuring normal levels > of MMA using gas chromatography mass spectrometry making the assay an > available clinical test. > Establish the first Internet web site (1996) specifically for providing > mailing kits and information for the early, non-invasive detection of > metabolic vitamin B12 deficiency. > > For test kit requests or more information > E-Mail NCL > or > Call toll free at 1-800-397-7408 > " Not by might, nor by power, but by my Spirit, says the Lord of hosts " > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 31, 2007 Report Share Posted December 31, 2007 This is mostly nonsense wrapped around a bit of sense to sell an expensive and unnecessary test. Lab tests are not magical. The real test is response to B-12, and a bottle of B-12 sublingual tablets costs a lot less than $150 and doesn't require sticking needles in your kid. If they need B12 there will be some response to this, and you can decide if they need more. Cheap tests that catch it with reasonable frequency include elevation of MCV or MCH on a blood count, and elevation of methylmalonic acid on an organic acid test. Andy Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2008 Report Share Posted January 7, 2008 Yeah chris; the beauty of this Vitamin B12 test @ www.b12.com is: This home B12 Test is a home Urine test; which you mail to the lab. they can check the Urine for Vitamin B12 defieincies. the test is $150 and you just seal the kid's urine in a little tube and mail back to the company; I think this is a real deal myslef. Because a Vitamin B12 Deficiney left untreated can result in the disease of Pernicous Anemai; which can exaserbate to a bad disease; if the Vitamin B12 is not given as a supplemnents; a shot; or IV; CHRIS; I HAVE NOT LOCATED THE THIAMIEN VIT. B1 co. I was mentioning. When I do find the best THIAMINE B1 and or Vitamin B-Complex I will notify you through this forum. THIAMINE is oh soooo important; . > > > > Has anyone on this list actually used this test? How much did it > cost? Do > > they send you a test kit and then you pay when you send it in? > Just > > curious how it works. > > > > Chris > > > > It is important to accurately diagnose vitamin B12 deficiency since > > treatment may be extensive. For example, individuals with neurologic > > manifestations, the recommendation is for a B12 injection > intramuscular (IM) > > of 1,000 micrograms daily for 2 weeks, then every two weeks for 6 > months, > > and then monthly for life.3 Some physicians may treat using high > amounts of > > oral B124, intranasal B12 4A, or sublingual B12.5 However, adequate > response > > to serious neurologic symptoms to oral therapy has not been > conclusively > > proven.6 Follow up uMMA levels on individuals receiving oral, > intranasal > > B12, or sublingual B12 will assess compliance as well as B12 > absorption and > > assimilation for correction of B12 deficiency at the tissue level.5 > > > > For test kit requests or more information > > E-Mail NCL > > or > > Call toll free at 1-800-397-7408 > > Menu > > Home The Principle The Accuracy The Prevention The 1st Choice The > Epidemic > > The History Who to Test? Cases Importance The Experts About NCL > References > > Testimonials FAQ Page > > --------------------------------- > > > > B12.COM Brochure > > (Adobe Reader required) > > --------------------------------- > > > > " If you're interested in personal health, public health, or you > just want to > > read an amazing story, I highly recommend this book. " > > > > Dr. Norman > > --------------------------------- > > > > Support a child from Uganda, East Africa. Click above for more > information. > > > > Welcome to Norman Clinical Laboratory, Inc. Norman Clinical > Laboratory, Inc. > > (NCL) provides a means to test individuals through the mail for > cobalamin > > (vitamin B12 ) deficiency. The test measures methylmalonic acid > (MMA) by > > selected ion monitoring isotope dilution gas chromatography mass > > spectrometry (GC/MS) in a random spot urine specimen. The MMA value > is > > normalized to urine creatinine to correct for urine dilution. The > urinary > > MMA/creatinine ratio (uMMA) test is more accurate than the blood > test as it > > indicates tissue/cellular B12 deficiency. > > This test is often used by physicians wishing to make a conclusive > diagnosis > > of vitamin B12 deficiency with a single test, individuals desiring > to be > > tested by mail from the privacy of their home, and investigators > seeking to > > conduct the most valid research study. > > Vitamin B12 deficiency can cause dementia identical to early stage > > Alzheimer's disease (AD). In addition, vitamin B12 deficiency has > been > > implicated as a risk factor for developing AD. Vitamin B12 > deficiency can > > also cause a wide range of neurologic and/or psychological > symptoms, anemia, > > and is a risk factor for cardiovascular disease. Early detection and > > treatment usually with vitamin B12 injections can reverse > disability. > > Strict vegetarians and breast fed infants of vegans are at risk of > having > > B12 deficiency. Vitamin B12 is found only in animal sources such as > meat, > > fish, eggs and milk. Unless a person is a vegetarian, vitamin B12 > deficiency > > is usually caused from malabsorption due to lack of the stomach > protein, > > intrinsic factor, resulting in pernicious anemia. A mild type B12 > deficiency > > is found in some elderly individuals affected with atrophic > gastritis. > > Eating fortified cereals and/or taking multivitamin supplements may > > eliminate some B12 deficiency in this population 1,2 but yearly uMMA > > screening is still warranted. > > > > It is important to accurately diagnose vitamin B12 deficiency since > > treatment may be extensive. For example, individuals with neurologic > > manifestations, the recommendation is for a B12 injection > intramuscular (IM) > > of 1,000 micrograms daily for 2 weeks, then every two weeks for 6 > months, > > and then monthly for life.3 Some physicians may treat using high > amounts of > > oral B124, intranasal B12 4A, or sublingual B12.5 However, adequate > response > > to serious neurologic symptoms to oral therapy has not been > conclusively > > proven.6 Follow up uMMA levels on individuals receiving oral, > intranasal > > B12, or sublingual B12 will assess compliance as well as B12 > absorption and > > assimilation for correction of B12 deficiency at the tissue level.5 > > > > Vitamin B12 deficiency can also cause elevated levels of serum > homocysteine > > (Hcys) which have been shown to be a risk factor for strokes, heart > attacks > > and /or blood clots.7 > > > > The uMMA test was developed by J. Norman, Ph.D. in > collaboration with > > the late M. Drue Denton, M.D. and co-workers at the Hematology > Division of > > the University of Cincinnati College of Medicine, USA.8,9 This > pioneering > > research continued to: > > > > Identify high prevalence of neurologic disease in vitamin B12 > deficient > > patients without anemia. 9-13 > > Identify high prevalence of metabolic B12 deficiency in older > > populations.9,12-14 > > Identify high prevalence of metabolic B12 deficiency in individuals > with a > > normal serum vitamin B12.14-16 > > Validate the urinary MMA test as a screening tool for identifying > tissue B12 > > deficiency in older populations.14 > > Establish the first commercial laboratory (1985) for measuring > normal levels > > of MMA using gas chromatography mass spectrometry making the assay > an > > available clinical test. > > Establish the first Internet web site (1996) specifically for > providing > > mailing kits and information for the early, non-invasive detection > of > > metabolic vitamin B12 deficiency. > > > > For test kit requests or more information > > E-Mail NCL > > or > > Call toll free at 1-800-397-7408 > > " Not by might, nor by power, but by my Spirit, says the Lord of > hosts " > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 13, 2008 Report Share Posted January 13, 2008 I am not familar with the term you use EE panel; I just thought for some Mothers's who couln't get to Doc. this www.b12.com test might be conveninet. I am still searching for a particualar Vitamin B; when i find this I will post the info on the groupl but just to say again the only message I have is this: CERTAIN NUTRITIONAL DEFICIENES LIKE A DEFICIENY OF VITMAIN B1 AND VITMAIN B12 (just ot mention a few); LOOK JUST LIKE AUTISM (oh and the good news is: Vitamins reverse these symptons); and this is my message; thankss chris; I hope to help a lot of kids; (to avoid being misdiaagnoses and prescribed drugs inappropraitely. A. )pps how is the vitamin B12 regieme going;WHAT BEST TYPE OF VIT. B12? > > > > > > Has anyone on this list actually used this test? How much did it > > cost? Do > > > they send you a test kit and then you pay when you send it in? > > Just > > > curious how it works. > > > > > > Chris > > > > > > It is important to accurately diagnose vitamin B12 deficiency > since > > > treatment may be extensive. For example, individuals with > neurologic > > > manifestations, the recommendation is for a B12 injection > > intramuscular (IM) > > > of 1,000 micrograms daily for 2 weeks, then every two weeks for 6 > > months, > > > and then monthly for life.3 Some physicians may treat using high > > amounts of > > > oral B124, intranasal B12 4A, or sublingual B12.5 However, > adequate > > response > > > to serious neurologic symptoms to oral therapy has not been > > conclusively > > > proven.6 Follow up uMMA levels on individuals receiving oral, > > intranasal > > > B12, or sublingual B12 will assess compliance as well as B12 > > absorption and > > > assimilation for correction of B12 deficiency at the tissue > level.5 > > > > > > For test kit requests or more information > > > E-Mail NCL > > > or > > > Call toll free at 1-800-397-7408 > > > Menu > > > Home The Principle The Accuracy The Prevention The 1st Choice The > > Epidemic > > > The History Who to Test? Cases Importance The Experts About NCL > > References > > > Testimonials FAQ Page > > > --------------------------------- > > > > > > B12.COM Brochure > > > (Adobe Reader required) > > > --------------------------------- > > > > > > " If you're interested in personal health, public health, or you > > just want to > > > read an amazing story, I highly recommend this book. " > > > > > > Dr. Norman > > > --------------------------------- > > > > > > Support a child from Uganda, East Africa. Click above for more > > information. > > > > > > Welcome to Norman Clinical Laboratory, Inc. Norman Clinical > > Laboratory, Inc. > > > (NCL) provides a means to test individuals through the mail for > > cobalamin > > > (vitamin B12 ) deficiency. The test measures methylmalonic acid > > (MMA) by > > > selected ion monitoring isotope dilution gas chromatography mass > > > spectrometry (GC/MS) in a random spot urine specimen. The MMA > value > > is > > > normalized to urine creatinine to correct for urine dilution. The > > urinary > > > MMA/creatinine ratio (uMMA) test is more accurate than the blood > > test as it > > > indicates tissue/cellular B12 deficiency. > > > This test is often used by physicians wishing to make a > conclusive > > diagnosis > > > of vitamin B12 deficiency with a single test, individuals > desiring > > to be > > > tested by mail from the privacy of their home, and investigators > > seeking to > > > conduct the most valid research study. > > > Vitamin B12 deficiency can cause dementia identical to early stage > > > Alzheimer's disease (AD). In addition, vitamin B12 deficiency has > > been > > > implicated as a risk factor for developing AD. Vitamin B12 > > deficiency can > > > also cause a wide range of neurologic and/or psychological > > symptoms, anemia, > > > and is a risk factor for cardiovascular disease. Early detection > and > > > treatment usually with vitamin B12 injections can reverse > > disability. > > > Strict vegetarians and breast fed infants of vegans are at risk > of > > having > > > B12 deficiency. Vitamin B12 is found only in animal sources such > as > > meat, > > > fish, eggs and milk. Unless a person is a vegetarian, vitamin B12 > > deficiency > > > is usually caused from malabsorption due to lack of the stomach > > protein, > > > intrinsic factor, resulting in pernicious anemia. A mild type B12 > > deficiency > > > is found in some elderly individuals affected with atrophic > > gastritis. > > > Eating fortified cereals and/or taking multivitamin supplements > may > > > eliminate some B12 deficiency in this population 1,2 but yearly > uMMA > > > screening is still warranted. > > > > > > It is important to accurately diagnose vitamin B12 deficiency > since > > > treatment may be extensive. For example, individuals with > neurologic > > > manifestations, the recommendation is for a B12 injection > > intramuscular (IM) > > > of 1,000 micrograms daily for 2 weeks, then every two weeks for 6 > > months, > > > and then monthly for life.3 Some physicians may treat using high > > amounts of > > > oral B124, intranasal B12 4A, or sublingual B12.5 However, > adequate > > response > > > to serious neurologic symptoms to oral therapy has not been > > conclusively > > > proven.6 Follow up uMMA levels on individuals receiving oral, > > intranasal > > > B12, or sublingual B12 will assess compliance as well as B12 > > absorption and > > > assimilation for correction of B12 deficiency at the tissue > level.5 > > > > > > Vitamin B12 deficiency can also cause elevated levels of serum > > homocysteine > > > (Hcys) which have been shown to be a risk factor for strokes, > heart > > attacks > > > and /or blood clots.7 > > > > > > The uMMA test was developed by J. Norman, Ph.D. in > > collaboration with > > > the late M. Drue Denton, M.D. and co-workers at the Hematology > > Division of > > > the University of Cincinnati College of Medicine, USA.8,9 This > > pioneering > > > research continued to: > > > > > > Identify high prevalence of neurologic disease in vitamin B12 > > deficient > > > patients without anemia. 9-13 > > > Identify high prevalence of metabolic B12 deficiency in older > > > populations.9,12-14 > > > Identify high prevalence of metabolic B12 deficiency in > individuals > > with a > > > normal serum vitamin B12.14-16 > > > Validate the urinary MMA test as a screening tool for identifying > > tissue B12 > > > deficiency in older populations.14 > > > Establish the first commercial laboratory (1985) for measuring > > normal levels > > > of MMA using gas chromatography mass spectrometry making the > assay > > an > > > available clinical test. > > > Establish the first Internet web site (1996) specifically for > > providing > > > mailing kits and information for the early, non-invasive > detection > > of > > > metabolic vitamin B12 deficiency. > > > > > > For test kit requests or more information > > > E-Mail NCL > > > or > > > Call toll free at 1-800-397-7408 > > > " Not by might, nor by power, but by my Spirit, says the Lord of > > hosts " > > > > > > Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.