: What tumor tests to get-Another Question

[Guest guest]

I've heard of the following tests: Nuclear Grade, DNA ploidy,

diploid/aneuploid, S phase, HER2/neu, Nottingham grade. You didn't mention

those tests below, just curious why? Do they not apply to a mucinous tumor?

Or are these tests outdated?

Also, what is different with invasive ductal carcinoma which is Mucinous

that gives it a better prognosis than other invasive ductal carcinomas?

Her tumor is very close to the chest wall (they were worried about

puncturing the lung on biopsy). Wouldn't it be helpful to shrink the tumor

before having further surgery so they can get clear margins without going

into the chest muscle? The diagnosis is very new so she hasn't even heard

what her doctor recommends for treatment choices. She is also considering

consulting with a couple of Mexican clinics and Nick in New York

before making any decisions.

Thanks,

Renate

From: VGammill

As the specimen has been sent out there is little chance that you can

have more tests added, and so often the physicians resent being told

what to do. They will probably do the usual receptor studies and

maybe get another opinion to as to diagnosis as it might be a

mucocelelike tumor. The prognosis is generally good and I wouldn't

worry too much about her. If she has surgery she might consider

following it up with any of a number of mucin-type vaccines as an

immunotherapy. I am usually not impressed with autologous vaccines

but this might be an excellent case for one. If she has surgery have

the pathologist freeze the tumor in PBS. Meanwhile she can look

around for a vaccine chemist. Tell him/her that you want the mucin

conjugated to KLH or BSA. There are many good adjuvants to kick it

up. If she does talk to her physician about receptor studies tell

her to ask for a Ki-67. I would also be curious about sialic acid.

[Guest guest]

Renate,

Mucinous tumors tend to be less metastatic. They are generally

ER and PR positive, very little aneuploidy, and c-erbB-2 and EGFR

negative. Patients tend to be older with a very high survival

rate. This is not a cancer that should keep her up at night worrying.

05:52 PM 2/22/2006, you wrote:

>I've heard of the following tests: Nuclear Grade, DNA ploidy,

>diploid/aneuploid, S phase, HER2/neu, Nottingham grade. You didn't mention

>those tests below, just curious why? Do they not apply to a mucinous tumor?

>Or are these tests outdated?

>

>Also, what is different with invasive ductal carcinoma which is Mucinous

>that gives it a better prognosis than other invasive ductal carcinomas?

>

>Her tumor is very close to the chest wall (they were worried about

>puncturing the lung on biopsy). Wouldn't it be helpful to shrink the tumor

>before having further surgery so they can get clear margins without going

>into the chest muscle? The diagnosis is very new so she hasn't even heard

>what her doctor recommends for treatment choices. She is also considering

>consulting with a couple of Mexican clinics and Nick in New York

>before making any decisions.

>

>Thanks,

>

>Renate

>

>From: VGammill

>As the specimen has been sent out there is little chance that you can

>have more tests added, and so often the physicians resent being told

>what to do. They will probably do the usual receptor studies and

>maybe get another opinion to as to diagnosis as it might be a

>mucocelelike tumor. The prognosis is generally good and I wouldn't

>worry too much about her. If she has surgery she might consider

>following it up with any of a number of mucin-type vaccines as an

>immunotherapy. I am usually not impressed with autologous vaccines

>but this might be an excellent case for one. If she has surgery have

>the pathologist freeze the tumor in PBS. Meanwhile she can look

>around for a vaccine chemist. Tell him/her that you want the mucin

>conjugated to KLH or BSA. There are many good adjuvants to kick it

>up. If she does talk to her physician about receptor studies tell

>her to ask for a Ki-67. I would also be curious about sialic acid.

>

>

>

>

>

>

>

>

>

>

[Guest guest]

She will be happy to hear that! And yes she is older so she falls into the

pattern.

Renate

From: VGammill

Renate,

Mucinous tumors tend to be less metastatic. They are generally

ER and PR positive, very little aneuploidy, and c-erbB-2 and EGFR

negative. Patients tend to be older with a very high survival

rate. This is not a cancer that should keep her up at night worrying.