Methylglyoxyl

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Posted over at cures for cancer list. Worth seeing:

   From: " szukidavis@... " szukidavis@...

Subject: Mercola and Methylglyoxal

In a message dated 6/1/06 1:27:34 PM Eastern Daylight Time,

jennyhauf@... writes:

You should call the Center for the Study of Natural Oncology, they are

using Methylglyoxal, with promising results. You can reach them at:

858-523-9144 or give me a call at 269-876-8475. Methylglyoxal is in

liquid form.

[mercola.com]

Indian Cancer Solution " Methylglyoxal "

Indian cancer researchers have taken a giant step on the road to

discovering a solution for cancer by developing a drug that selectively

targets the cancer cells without harming the healthy ones.

Researchers in Kolkata claim that patients in " very advanced stages " of

cancer for whom all other treatments had failed have been brought back

to " excellent " health with the help of a drug formulation they have

developed after research spanning more than a decade.

" We have what we think magic bullet against cancer, " says Manju Ray, a

biochemist at the Indian Association of the Cultivation of Science

(IACS) where the drug was developed under a project funded by the

Department of Science and Technology and the Council of Scientific and

Industrial Research. Most currently available anti-cancer drugs are

toxic because they also damage the normal cells. Ray says the IACS

formulation, containing " Methylglyoxal " as the lead ingredient, combats

only the diseased cells, the cherished goal of cancer researchers

worldwide. Methylglyoxal is a metabolite in the human body produced

during glucose breakdown.

Others involved in the project are Swapna Ghosh of IACS, Manoj Kar and

Subhankar Ray of the University College of Science, and Santajit Datta,

a medical practitioner. Results of human trial conducted by them with

the new drug have recently appeared in the Indian Journal of Physics.

While Americans are going ga-ga with their new anticancer drug " Glivec "

- that was featured on the cover of May 28 issue of Time magazine - the

low-profile, cash-strapped Kolkata researchers have been working quietly

for over a decade shunning publicity until they obtained proof from

human trials nine weeks ago.

According to their published paper, the Methylglyoxal-based formulation

had " a dramatic positive effect on the patients " . For instance, the

condition of 11 out of the 19 patients treated - most of them in a very

advanced stage when the treatment began -- are now stated to be in

" excellent physical condition " . Five are in stable condition and only

three died during the course of the study.

Since the submission of the paper, the number of patients treated has

crossed 40 mark with more than 70 per cent success, according to Manju

Ray. Most remarkable fact, according to the scientists was that

Methylglyoxal was successful against different types of cancer unlike

" Glivec " which targets only the chronic myeloid leukemia.

Those whose health returned to " excellent " condition after treatment

with Methylglyoxal included patients in " a very advanced stages " of

colon cancer, acute myeloid leukemia, non-Hodgkin's lymphoma, and

cancers of ovary, breast, liver, lung, bone, gall bladder, pancreas and

oral cavity. The patients were inducted for the trial, from January to

June 2000, after obtaining permission from the Drug Controller General

of India, the scientists said. The drug was administered orally for

about six months with gradual reduction of daily dosage from the initial

25 milligrams per kilogram of body weight.

Researchers said development of the drug was preceded by years of basic

research involving human cancer cells in culture and animal experiments

that showed that Methylglyoxal selectively killed the cancer cells

without affecting normal cells by exploiting " a very significant "

biochemical difference between the two.

Explaining the mechanism of action, the scientists said cancer cells

required a large amount of energy providing substance called ATP

(Adenosine-5-Triphosphate) for survival.

" Methylglyoxal inactivates the enzyme (Glyceraldehyde-3- Phosphate

Dehydrogenase) needed for ATP production in cancer cells and thereby

starves them to death. Normal cells remain unaffected. "

Manju ray said that chemists knew Methylglyoxal molecule for about four

decades and its anticancer effects in animals had also been studied.

" But surprisingly, no one bothered to initiate further research leading

to human trials, " she said.

The researchers said concern in some quarters about safety of

Methylglyoxal were not borne out from the clinical trials, which showed

that in combination with protective agent like Ascorbic Acid and

vitamins, the drug Methylglyoxal had no major toxic effect. They said

there was scope for further enhancing the drug's efficacy.

Hindustan Times Hyderabaad May 28, 2001

Dr. Mercola's Comment:I normally do not focus on cancer as it is such a

controversial area and is not something I have carefully studied.

However, I am confident that the first step of cancer therapy is an

aggressive application of the food choice program that I have developed

with special attention to the vegetable juicing program and avoiding ALL

types of sugar, as sugar serves as a major fuel source for cancer cells

(see link below). Of course, the best approach is to start your

optimized food choices prior to cancer arriving, as you will most likely

prevent the cancer from ever having occurred in the first place.

However, methylglyoxal does appear to be a promising agent with much

potential.

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