Here is a very interesting abstract

[Guest guest]

Just browsing medline today....

This would be very very convenient (injects every 6 weeks)...

Clin Endocrinol (Oxf). 1999 Dec;51(6):757-63. Related Articles, Links

Repeated intramuscular injections of testosterone undecanoate for

substitution therapy in hypogonadal men.

Nieschlag E, Buchter D, Von Eckardstein S, Abshagen K, Simoni M,

Behre HM.

Institute of Reproductive Medicine of the University, Munster,

Germany. nieschl@...

OBJECTIVE: To investigate the suitability of intramuscular

testosterone undecanoate (TU) injections for substitution therapy in

hypogonadal men. STUDY DESIGN: Clinical, open-label, non-randomized

trial of 13 hypogonadal men receiving 4 intramuscular injections of

1000 mg TU in 4-ml castor oil at 6-week intervals. General wellbeing,

sexual parameters, clinical chemistry, hormone levels, prostate size

and prostate-specific antigen (PSA) were evaluated over 24 weeks and

compared with baseline values. RESULTS: Testosterone serum levels

were never found below the lower limit of normal and only briefly

after the 3rd and 4th injection above the upper limit of normal,

while peak and trough values increased over the 24-week observation

period. Oestradiol and dihydrotestosterone followed this pattern, not

exceeding the normal limits. No serious side-effects were noted.

Slight increases in body weight, haemoglobin, haematocrit, prostate

volume and PSA, suppression of gonadotrophins as well as increased

ejaculation frequency occurred as signs of adequate testosterone

substitution. CONCLUSION: Testosterone undecanoate is well tolerated

by the patients. The injection intervals can be extended even beyond

the 6-week periods chosen in the present study. Altogether,

intramuscular testosterone undecanoate appears to be well suited for

long-term substitution therapy in hypogonadism and hormonal male

contraception.

[Guest guest]

Yikes! Am I readijng this correct? 4000 mg of T every 6 weeks! That

can't be what it says here... 4 injections of 1000 mg, every 6

weeks. Wow, and they claim nobody went too much over the limit? I

wonder if this was 1000 mg in 4 injections spread over 6 weeks.

Still sounds like a ton.

> Just browsing medline today....

>

> This would be very very convenient (injects every 6 weeks)...

>

> Clin Endocrinol (Oxf). 1999 Dec;51(6):757-63. Related Articles,

Links

>

>

> Repeated intramuscular injections of testosterone undecanoate for

> substitution therapy in hypogonadal men.

>

> Nieschlag E, Buchter D, Von Eckardstein S, Abshagen K, Simoni M,

> Behre HM.

>

> Institute of Reproductive Medicine of the University, Munster,

> Germany. nieschl@u...

>

> OBJECTIVE: To investigate the suitability of intramuscular

> testosterone undecanoate (TU) injections for substitution therapy

in

> hypogonadal men. STUDY DESIGN: Clinical, open-label, non-randomized

> trial of 13 hypogonadal men receiving 4 intramuscular injections of

> 1000 mg TU in 4-ml castor oil at 6-week intervals. General

wellbeing,

> sexual parameters, clinical chemistry, hormone levels, prostate

size

> and prostate-specific antigen (PSA) were evaluated over 24 weeks

and

> compared with baseline values. RESULTS: Testosterone serum levels

> were never found below the lower limit of normal and only briefly

> after the 3rd and 4th injection above the upper limit of normal,

> while peak and trough values increased over the 24-week observation

> period. Oestradiol and dihydrotestosterone followed this pattern,

not

> exceeding the normal limits. No serious side-effects were noted.

> Slight increases in body weight, haemoglobin, haematocrit, prostate

> volume and PSA, suppression of gonadotrophins as well as increased

> ejaculation frequency occurred as signs of adequate testosterone

> substitution. CONCLUSION: Testosterone undecanoate is well

tolerated

> by the patients. The injection intervals can be extended even

beyond

> the 6-week periods chosen in the present study. Altogether,

> intramuscular testosterone undecanoate appears to be well suited

for

> long-term substitution therapy in hypogonadism and hormonal male

> contraception.

[Guest guest]

From what I understand, I don't have the full abstract, but TU

(Testosterone undecanoate) has a very long half life so, it will last

in the body for a long time. So, from my read of the abstract, each

of the patients received one 1000mg shots every 6 weeks (not 4000mg

every six weeks). So, it was a 24 week study (6 weeks x 4 shots/6

weeks). From what the article said, no one went under normal and one

once did they go over normal. So, this would have a huge advantage

of only one shot every 6 weeks....without the swings (because of the

long half life).

> > Just browsing medline today....

> >

> > This would be very very convenient (injects every 6 weeks)...

> >

> > Clin Endocrinol (Oxf). 1999 Dec;51(6):757-63. Related Articles,

> Links

> >

> >

> > Repeated intramuscular injections of testosterone undecanoate for

> > substitution therapy in hypogonadal men.

> >

> > Nieschlag E, Buchter D, Von Eckardstein S, Abshagen K, Simoni M,

> > Behre HM.

> >

> > Institute of Reproductive Medicine of the University, Munster,

> > Germany. nieschl@u...

> >

> > OBJECTIVE: To investigate the suitability of intramuscular

> > testosterone undecanoate (TU) injections for substitution therapy

> in

> > hypogonadal men. STUDY DESIGN: Clinical, open-label, non-

randomized

> > trial of 13 hypogonadal men receiving 4 intramuscular injections

of

> > 1000 mg TU in 4-ml castor oil at 6-week intervals. General

> wellbeing,

> > sexual parameters, clinical chemistry, hormone levels, prostate

> size

> > and prostate-specific antigen (PSA) were evaluated over 24 weeks

> and

> > compared with baseline values. RESULTS: Testosterone serum levels

> > were never found below the lower limit of normal and only briefly

> > after the 3rd and 4th injection above the upper limit of normal,

> > while peak and trough values increased over the 24-week

observation

> > period. Oestradiol and dihydrotestosterone followed this pattern,

> not

> > exceeding the normal limits. No serious side-effects were noted.

> > Slight increases in body weight, haemoglobin, haematocrit,

prostate

> > volume and PSA, suppression of gonadotrophins as well as

increased

> > ejaculation frequency occurred as signs of adequate testosterone

> > substitution. CONCLUSION: Testosterone undecanoate is well

> tolerated

> > by the patients. The injection intervals can be extended even

> beyond

> > the 6-week periods chosen in the present study. Altogether,

> > intramuscular testosterone undecanoate appears to be well suited

> for

> > long-term substitution therapy in hypogonadism and hormonal male

> > contraception.

[Guest guest]

Yes. That makes sense. And for sure that would be nice.

> > > Just browsing medline today....

> > >

> > > This would be very very convenient (injects every 6 weeks)...

> > >

> > > Clin Endocrinol (Oxf). 1999 Dec;51(6):757-63. Related

Articles,

> > Links

> > >

> > >

> > > Repeated intramuscular injections of testosterone undecanoate

for

> > > substitution therapy in hypogonadal men.

> > >

> > > Nieschlag E, Buchter D, Von Eckardstein S, Abshagen K, Simoni

M,

> > > Behre HM.

> > >

> > > Institute of Reproductive Medicine of the University, Munster,

> > > Germany. nieschl@u...

> > >

> > > OBJECTIVE: To investigate the suitability of intramuscular

> > > testosterone undecanoate (TU) injections for substitution

therapy

> > in

> > > hypogonadal men. STUDY DESIGN: Clinical, open-label, non-

> randomized

> > > trial of 13 hypogonadal men receiving 4 intramuscular

injections

> of

> > > 1000 mg TU in 4-ml castor oil at 6-week intervals. General

> > wellbeing,

> > > sexual parameters, clinical chemistry, hormone levels,

prostate

> > size

> > > and prostate-specific antigen (PSA) were evaluated over 24

weeks

> > and

> > > compared with baseline values. RESULTS: Testosterone serum

levels

> > > were never found below the lower limit of normal and only

briefly

> > > after the 3rd and 4th injection above the upper limit of

normal,

> > > while peak and trough values increased over the 24-week

> observation

> > > period. Oestradiol and dihydrotestosterone followed this

pattern,

> > not

> > > exceeding the normal limits. No serious side-effects were

noted.

> > > Slight increases in body weight, haemoglobin, haematocrit,

> prostate

> > > volume and PSA, suppression of gonadotrophins as well as

> increased

> > > ejaculation frequency occurred as signs of adequate

testosterone

> > > substitution. CONCLUSION: Testosterone undecanoate is well

> > tolerated

> > > by the patients. The injection intervals can be extended even

> > beyond

> > > the 6-week periods chosen in the present study. Altogether,

> > > intramuscular testosterone undecanoate appears to be well

suited

> > for

> > > long-term substitution therapy in hypogonadism and hormonal

male

> > > contraception.