Re: Ernestnolan - Response from Dr. Gambrell

[Guest guest]

There must be some mechanism that causes an increase in E2 as I have seen

this in nearly every case of side effects with finasteride. E2 then serves

to suppress the HPTA and thus lower T production. For some reason the body

stays stuck in this inbalanced state of elevated E2 and lowered T reducing

the T to E2 ratio and hence the problems that go with that.

Comments?

snowking

_____

From: swrtw2001 [mailto:no_reply ]

Sent: 22 July 2004 17:01

Subject: Ernestnolan - Response from Dr. Gambrell

HI Ernestnolan,

I wrote to Dr. Don Gambrell yesterday and here's his response,

unfortunately he doesn't have experience with young men suffering

from the side effects of propecia, but atleast he does acknowledge my

T levels are low, unlike many of the doctor's I've seen.

----------------------------------------------------------------

Dear Steve

I have not had occasion to prescribe Propecia but am familiar with

its mechanism of action and have prescribed other testosterone enzyme

inhibitors. According to the product information, side effects such

as you mention, decreased libido, erectile dysfunction, and less

sustainable erections. Since the drug works by blocking the

conversion of testosterone to dihydrotestosterone, you would expect

the testosterone levels to be normal even while taking the drug. Your

levels are normal now and probably

always have been normal. Since you have not taken Propecia in 5 years

I do not see how it could be affecting your sexuality now. Although

your total testosterone is normal, it is slightly below the mid-

normal range. I suggest that you ask your doctor to prescribe one of

the testosterone patches or the new gel. It will not hurt you and

just might help.

R.

Don Gambrell. Jr., MD

At 08:40 PM 7/21/2004, you wrote:

>Dear Dr. Gambrell,

>

>I was referred to your website by one of your

>patients.

>

>Im writing to you because, 5 years ago I took the hair

>loss drug propecia for 6 months and am still

>experiencing the side effects today. I've been to many

>doctors but all they would do is refer me to

>psychologist, but I know the symptoms are not in my

>head cause I still have watery ejaculate. I also have

>problems ejaculating and orgasming, no libido, and my

>errections don't seem to be as strong as they use to.

>Non sexual dysfunctions include fatique, depression,

>lack of emotions, foggy thoughts.

>

>If you don't mind can you also look at my hormone

>profile and let me know what you think and if you've

>treated any patients with finasteride side effects. Is

>there anything you could recommend for me, and do you

>do remote consultations.

>

>My profile, Im 27 years old and had no problems prior

>to taking propecia.

>

>Free T 120.8 Range 50 -- 210 pg/mL

>Total T 462 Range 260 -- 1000 ng/dL

>DHT 37 Range 25 -- 75 ng/dL

>LH 3.9 Range 1.5 -- 9.3 miu/ML

>FSH 2.3 Range 1.4 -- 18.1 miu/ML

>Estradiol 59 Range 10 -- 51 pg/ML ***

>

>Thanks!!!

[Guest guest]

Hi,

I'm glad you shared his reply. I hoped he would respond.

My technical understanding is very limited and these alternative

products are something I've not studied at all.

ernestnolan

> >Dear Dr. Gambrell,

> >

> >I was referred to your website by one of your

> >patients.

> >

> >Im writing to you because, 5 years ago I took the hair

> >loss drug propecia for 6 months and am still

> >experiencing the side effects today. I've been to many

> >doctors but all they would do is refer me to

> >psychologist, but I know the symptoms are not in my

> >head cause I still have watery ejaculate. I also have

> >problems ejaculating and orgasming, no libido, and my

> >errections don't seem to be as strong as they use to.

> >Non sexual dysfunctions include fatique, depression,

> >lack of emotions, foggy thoughts.

> >

> >If you don't mind can you also look at my hormone

> >profile and let me know what you think and if you've

> >treated any patients with finasteride side effects. Is

> >there anything you could recommend for me, and do you

> >do remote consultations.

> >

> >My profile, Im 27 years old and had no problems prior

> >to taking propecia.

> >

> >Free T 120.8 Range 50 -- 210 pg/mL

> >Total T 462 Range 260 -- 1000 ng/dL

> >DHT 37 Range 25 -- 75 ng/dL

> >LH 3.9 Range 1.5 -- 9.3 miu/ML

> >FSH 2.3 Range 1.4 -- 18.1 miu/ML

> >Estradiol 59 Range 10 -- 51 pg/ML ***

> >

> >Thanks!!!

>

>

>

>

>

>

>

>

[Guest guest]

Why does your doctor not comment on the high E2 level in your

test?.. this is the reason that your LH and particlarly your FSH is

low... hence the watery ejaculate, and average test levels. Propecia

must cause an imbalance which seems to hang around for some time

after treatment!

> >Dear Dr. Gambrell,

> >

> >I was referred to your website by one of your

> >patients.

> >

> >Im writing to you because, 5 years ago I took the hair

> >loss drug propecia for 6 months and am still

> >experiencing the side effects today. I've been to many

> >doctors but all they would do is refer me to

> >psychologist, but I know the symptoms are not in my

> >head cause I still have watery ejaculate. I also have

> >problems ejaculating and orgasming, no libido, and my

> >errections don't seem to be as strong as they use to.

> >Non sexual dysfunctions include fatique, depression,

> >lack of emotions, foggy thoughts.

> >

> >If you don't mind can you also look at my hormone

> >profile and let me know what you think and if you've

> >treated any patients with finasteride side effects. Is

> >there anything you could recommend for me, and do you

> >do remote consultations.

> >

> >My profile, Im 27 years old and had no problems prior

> >to taking propecia.

> >

> >Free T 120.8 Range 50 -- 210 pg/mL

> >Total T 462 Range 260 -- 1000 ng/dL

> >DHT 37 Range 25 -- 75 ng/dL

> >LH 3.9 Range 1.5 -- 9.3 miu/ML

> >FSH 2.3 Range 1.4 -- 18.1 miu/ML

> >Estradiol 59 Range 10 -- 51 pg/ML ***

> >

> >Thanks!!!

[Guest guest]

Dr Gambrell's response doesn't seem to well thought out to me.

Although T replacement is an option for you steve, it is a life long

commitment, so it shouldn't be taken lightly.

Armyguy

> >Dear Dr. Gambrell,

> >

> >I was referred to your website by one of your

> >patients.

> >

> >Im writing to you because, 5 years ago I took the hair

> >loss drug propecia for 6 months and am still

> >experiencing the side effects today. I've been to many

> >doctors but all they would do is refer me to

> >psychologist, but I know the symptoms are not in my

> >head cause I still have watery ejaculate. I also have

> >problems ejaculating and orgasming, no libido, and my

> >errections don't seem to be as strong as they use to.

> >Non sexual dysfunctions include fatique, depression,

> >lack of emotions, foggy thoughts.

> >

> >If you don't mind can you also look at my hormone

> >profile and let me know what you think and if you've

> >treated any patients with finasteride side effects. Is

> >there anything you could recommend for me, and do you

> >do remote consultations.

> >

> >My profile, Im 27 years old and had no problems prior

> >to taking propecia.

> >

> >Free T 120.8 Range 50 -- 210 pg/mL

> >Total T 462 Range 260 -- 1000 ng/dL

> >DHT 37 Range 25 -- 75 ng/dL

> >LH 3.9 Range 1.5 -- 9.3 miu/ML

> >FSH 2.3 Range 1.4 -- 18.1 miu/ML

> >Estradiol 59 Range 10 -- 51 pg/ML ***

> >

> >Thanks!!!

[Guest guest]

I guess I'm not positive its a life-long commitment if it is used

short term. Generally I agree, but I had a friend who had low T due

to high body fat. He got shots for a few months and lost weight, then

went off the shots. His levels are now normal.

But you are right, in most cases it probably is. At least until if or

when they come up with a way to fix the underlying problems. Who

knows what they'll find with the latest research into genetics, stem

cells, etc.

Mark

> Dr Gambrell's response doesn't seem to well thought out to me.

> Although T replacement is an option for you steve, it is a life long

> commitment, so it shouldn't be taken lightly.

>

> Armyguy

[Guest guest]

Interesting.

> > Dr Gambrell's response doesn't seem to well thought out to me.

> > Although T replacement is an option for you steve, it is a life

long

> > commitment, so it shouldn't be taken lightly.

> >

> > Armyguy

[Guest guest]

Hi,

No idea why.

Best to send a note asking specifically what you want answers for.

He's a pretty easy going guy and will probably give you the best

answer available.

ernestnolan

> > >Dear Dr. Gambrell,

> > >

> > >I was referred to your website by one of your

> > >patients.

> > >

> > >Im writing to you because, 5 years ago I took the hair

> > >loss drug propecia for 6 months and am still

> > >experiencing the side effects today. I've been to many

> > >doctors but all they would do is refer me to

> > >psychologist, but I know the symptoms are not in my

> > >head cause I still have watery ejaculate. I also have

> > >problems ejaculating and orgasming, no libido, and my

> > >errections don't seem to be as strong as they use to.

> > >Non sexual dysfunctions include fatique, depression,

> > >lack of emotions, foggy thoughts.

> > >

> > >If you don't mind can you also look at my hormone

> > >profile and let me know what you think and if you've

> > >treated any patients with finasteride side effects. Is

> > >there anything you could recommend for me, and do you

> > >do remote consultations.

> > >

> > >My profile, Im 27 years old and had no problems prior

> > >to taking propecia.

> > >

> > >Free T 120.8 Range 50 -- 210 pg/mL

> > >Total T 462 Range 260 -- 1000 ng/dL

> > >DHT 37 Range 25 -- 75 ng/dL

> > >LH 3.9 Range 1.5 -- 9.3 miu/ML

> > >FSH 2.3 Range 1.4 -- 18.1 miu/ML

> > >Estradiol 59 Range 10 -- 51 pg/ML ***

> > >

> > >Thanks!!!

[Guest guest]

Hi,

Dr. Gambrell will probably answer your specific concerns is you send

him a note. No idea what his assumptions were in his reply.

A short specific note will probably get a reply.

ernestnolan

> > >Dear Dr. Gambrell,

> > >

> > >I was referred to your website by one of your

> > >patients.

> > >

> > >Im writing to you because, 5 years ago I took the hair

> > >loss drug propecia for 6 months and am still

> > >experiencing the side effects today. I've been to many

> > >doctors but all they would do is refer me to

> > >psychologist, but I know the symptoms are not in my

> > >head cause I still have watery ejaculate. I also have

> > >problems ejaculating and orgasming, no libido, and my

> > >errections don't seem to be as strong as they use to.

> > >Non sexual dysfunctions include fatique, depression,

> > >lack of emotions, foggy thoughts.

> > >

> > >If you don't mind can you also look at my hormone

> > >profile and let me know what you think and if you've

> > >treated any patients with finasteride side effects. Is

> > >there anything you could recommend for me, and do you

> > >do remote consultations.

> > >

> > >My profile, Im 27 years old and had no problems prior

> > >to taking propecia.

> > >

> > >Free T 120.8 Range 50 -- 210 pg/mL

> > >Total T 462 Range 260 -- 1000 ng/dL

> > >DHT 37 Range 25 -- 75 ng/dL

> > >LH 3.9 Range 1.5 -- 9.3 miu/ML

> > >FSH 2.3 Range 1.4 -- 18.1 miu/ML

> > >Estradiol 59 Range 10 -- 51 pg/ML ***

> > >

> > >Thanks!!!