Guest guest Posted January 20, 2000 Report Share Posted January 20, 2000 Seligiline (deprenyl) is a routine part of any comprehensive anti-aging program. I usually start it a 5mg/week at age 30, 5mg 2X/week at age 40, 5mg 3X/week at age 50, every other day at 60. Live and learn, long and well! R , MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 20, 2000 Report Share Posted January 20, 2000 Dr. , Are there any drug or herbal interactions to be aware with while on deprenyl? What way do you think it has helped you? What side effects have you seen? Thank you >Seligiline (deprenyl) is a routine part of any comprehensive anti-aging >program. I usually start it a 5mg/week at age 30, 5mg 2X/week at age 40, 5mg >3X/week at age 50, every other day at 60. > >Live and learn, long and well! > > R , MD > >------------------------------------------------------------------------ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 20, 2000 Report Share Posted January 20, 2000 I've read that Prozac is contraindicated while on deprenyl. Supposedly there are a few cases in the literature of serotonin syndrome occuring when people took both. However I cannot find any theoretical basis for it. As far as I know deprenyl does not increase secretion or block uptake of serotonin, so I don't understand how it could increase the risk of serotonin syndrome. -gts Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2000 Report Share Posted January 21, 2000 What is seretonin syndrome?? Re: deprenyl >I've read that Prozac is contraindicated while on deprenyl. Supposedly there >are a few cases in the literature of serotonin syndrome occuring when people >took both. However I cannot find any theoretical basis for it. As far as I >know deprenyl does not increase secretion or block uptake of serotonin, so I >don't understand how it could increase the risk of serotonin syndrome. > >-gts > > > >------------------------------------------------------------------------ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2000 Report Share Posted January 21, 2000 What about taking St. 's wart while on deprenyl? I understand a similar mode of action as Prozac. >I've read that Prozac is contraindicated while on deprenyl. Supposedly there >are a few cases in the literature of serotonin syndrome occuring when people >took both. However I cannot find any theoretical basis for it. As far as I >know deprenyl does not increase secretion or block uptake of serotonin, so I >don't understand how it could increase the risk of serotonin syndrome. > >-gts > > > >------------------------------------------------------------------------ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2000 Report Share Posted January 21, 2000 Serotonin syndrome is an unpleasant and sometimes dangerous condition that arises from having too much serotonin in the brain. It can cause dizziness, panic, and hyperthermia. Serotonin is a neurotransmitter and a hormone. Drugs like fluoxetine (Prozac) are SSRI's (Selective Serotonin Reuptake Inhibitors). SSRI's fight depression by preventing the brain cells from reuptaking serotonin. St 's Wort seems to work by increasing serotonin and/or inhibiting MAO, though not much is known yet about St 's Wort. I don't understand the mechanism by which selegiline (Deprenyl) might also increase serotonin, but in theory the combination of any serotonin-increasing drug or herb with deprenyl could result in serotonin syndrome. There could be some risk to taking 5-HTP with deprenyl as well, I think, because 5-HTP is the direct precursor to serotonin. I've also seen that one researcher has proposed that deprenyl should be okay to use with citalopram (Celexa), which is another SSRI. I have no idea why one SSRI might be okay but another not okay. Here is a page of links to research abstracts at my website: http://www.optexinc.com/deprenyl.htm -gts Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 22, 2000 Report Share Posted January 22, 2000 Here is an excellent article explaining the benefits of selegiline (Deprenyl). It is taken from http://www.smartbasics.com/glossary/deprenyl_glos.htm === Deprenyl Scientific evidence from laboratories around the world suggests that deprenyl, also known as selegiline, may have broad anti-aging benefits, both mental and physical. Among other things, this compound inhibits monoamine oxidase-B, a natural substance which at increased levels has been associated with brain aging, senescence and Alzheimer's disease. Long known as an antidepressant (although its role in alleviating depression is controversial), deprenyl has recently come into its own as an adjunct to L-dopa treatment for Parkinson's disease. There are even impressive hints from animal studies that deprenyl lengthens life. In 1988 ph Knoll, M.D., of Semmelweis University of Medicine in Budapest found that the average life span of rats treated with deprenyl was 34 percent longer than that of untreated rats. He also noted that while untreated rats lost their sexual vitality with age, 64 of 66 of the deprenyl-treated animals retained sexual vigor. More recently, in 1991, a team from the Israeli Institute for Biological Research in Ness-Ziona, reported that deprenyl significantly improved learning and memory in elderly rats. Although deprenyl's effectiveness as an antidepressant remains controversial, a 1988 study by J. Mann, M.D., of the University of Pittsburgh Medical School, reported in our earlier article, concluded that deprenyl was three times better than placebo in alleviating depression. In a number of preliminary tests of deprenyl as a treatment for Alzheimer's disease, patients showed some improvement in mental functioning, especially memory, verbal communication and daily-living skills. The consensus among experts is that deprenyl is relatively free of adverse side effects. However, it can induce mild overstimulation similar to that from caffeine. Because deprenyl is approved by the FDA for treatment of Parkinson's disease (it is widely used for that purpose in both Europe and the US), it can be obtained with a doctor's prescription and is thus among the more readily available of the anti-aging drugs. It may be well worth discussing with your doctor as a potential sexual invigorator or even as a general antiaging therapy. Deprenyl Protects Against Death of Neurons Researchers have written a great about the benefits of deprenyl over the past few years, presenting evidence that deprenyl, in doses ranging from .5 mg every other day to 1.O mg per day, reverses the age-related increase in the enzyme monoamine oxidase B (MAO-, which degrades the neurotransmitter dopamine, the loss of which dampens our mood, throttles our sex drive, and unhinges our coordination. It's also been reported evidence that deprenyl combats the free radical mediated damage to neurons that plays an important role in pathologies associated with brain aging. But, perhaps, the most impressive evidence of deprenyl's ability to fight brain aging is its ability to rescue dying neurons in tissue culture. This finding suggests that deprenyl can prevent the most critical event in brain aging-the death of irreplaceable neurons. Effects of Deprenyl on Brain Microanatomy A variety of degenerative changes occur in the brain's microanatomy both in normal aging and senile dementia. A recent study at the University of La Sapienza in Rome, Italy (Mech. Of Aging & Devel., 73:113126:1994) was designed to determine the effects of long-term administration of deprenyl on microanatomical changes in the aging rat brain, especially in areas of the brain involved in cognition, such and the frontal cortex and hippocampus, as well as the cerebella cortex. The Italian scientists used male Sprague-Dawley rats of 11 and 19 months of age. Twenty 1 9-month-old rats were randomly allotted to two groups of 10 animals each, which were injected with either 0.25 mg/kg of deprenyl or saline every other day. Another group of 11-month-old untreated rats was used to compare the effects of deprenyl in aging animals to healthy normal adult animals. Both the experimental and control groups were sacrificed at 24 months of age and their brains examined for age dependent changes. Deprenyl Slows Microanatomical Brain Changes The scientists found that deprenyl was able to counteract, to some degree, all four of the age-dependent microanatomical changes in the rat brain examined in the study. The first is density of nerve cell profiles-a measure of the ability of the nervous system to receive, analyze, and store information-which is reduced progressively with advancing age in the rat brain. Less of a reduction in the density of nerve cell profiles was found in the rats given deprenyl, but this change was not statistically significant, except for the Purkinje neurons in the cerebellum. The second parameter studied was the density of Nissl's staining in the cytoplasm of pyramidal and Purkinje neurons, which is believed to be a measure of the ribonucleic acid content of nerve cells. Treatment with deprenyl restored the intensity of Nissl's staining in nerve cell populations of the hippocampus and the cerebella cortex in aged rats. " Third was age-dependent lipofuscin accumulation, which is believed to be a by-product of the peroxidative action of free radicals on membrane lipids. It was found that deprenyl decreased lipofuscin (aging pigment) accumulation in neurons, suggesting that it may have reduced oxidative stress on these cells. Last was sulphide-silver staining within the hippocampus, which is related to the density of zinc-containing synaptic junctions, which are critical in learning, memory, and information processing within the brain. The administration of deprenyl countered, in part, the reduction of sulphide silver staining, which the scientists believe may be related to the improvement of cognitive function produced by deprenyl treatment in aged rats. (Pharmacol Biochem Behav., 39:297304:1 991 ). These findings showing that deprenyl can slow important microanatomical changes in the aging rat brain provide further evidence to explain the ability of the drug to improve cognitive and behavioral function in both normally aging and demented humans by preventing the premature death of brain cells. New Studies on Deprenyl Every month, we see new studies on deprenyl showing it to be even more effective for aging than previously thought. Some of these new studies have duplicated the successful research conducted in Japan showing that one mechanism by which deprenyl extends lifespan is by boosting antioxidant enzyme levels of superoxide dismutase (SOD) and catalase. A new study has shown that oral doses of deprenyl given to dogs for only three weeks produced a dose-dependent increase of both SOD and catalase in the striatum, but not the hippocampus region of the brain (Life Sciences 54:201994). These results are in accordance with previously published results in rats. Endogenous antioxidant enzymes are more effective in preventing free radical damage than supplemental antioxidants. Deprenyl is well known to boost brain levels of dopamine by inhibiting monoamine oxidase-B (MAO-. Dopamine elevation conferred life extension benefits in an early study and is known to boost cognitive function and improve sexual performance. Raising base levels of SOD and catalase helps explain further the underlying mechanisms of deprenyl's antiaging effects. In a study in the Feb. 1994 issue of Mechanisms of Aging and Development, long term treatment with deprenyl was investigated on age dependent changes in the rat brain. Deprenyl treated rats (they were given the drug in their drinking water) were shown to have decreased levels of lipofuscin (aging pigment) in certain brain regions. Increased brain levels of lipofuscin have been linked to senile dementia in humans. The loss of density of certain neuronal fibers (especially in the hippocampus region of the brain) was reduced in animals receiving deprenyl (compared to the placebo group), which helps to explain deprenyl's ability to improve memory in Alzheimer's patients. Loss of neuronal fibers also occurs in " normal " aging. Based upon recent studies suggesting the benefits of higher oral doses of deprenyl, the following are commonly used doses for deprenyl: Age 40-50: 5 mg of Deprenyl three to four times a week Age 50-60: 5 mg of Deprenyl four to six times a week Age 60-70: 5 mg of Deprenyl daily Over 70: 5 to 10 mg of Deprenyl daily Every decade over age 40-45 results in the death of 13% of the dopamine producing neurons in humans. If you suffer from an accelerated decline in your dopamine producing neurons, you are said to have Parkinson's disease. Deprenyl protects against the death of dopamine producing neurons and for this reason alone, should be part of your life extension program if you are over 40 years of age. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2000 Report Share Posted February 2, 2000 I found the deprenyl on the web @ http://www.cytopharma.com/ They asked me where I heard about them as if they were a little leary of the call however, they said I'd be the proud owner of a bottle of certified deluxe grade deprenyl by Friday. Just 1 drop/mg in a glass of juice or my favorite fluid, thus 5 mg= 5 drops. There based in California. The web site looked legit as any of the rest as if that means anything. So far, I have never been burned by the web. But the body shop that fixed (didn't) my car; now that's a different story. How does one check to see if it is real deprenyl or something else? >From: " gts " <gts@...> >Reply-longevityegroups ><longevityegroups> >Subject: Re: Deprenyl >Date: Wed, 2 Feb 2000 15:55:05 -0500 >MIME-Version: 1.0 >Received: from [207.138.41.146] by hotmail.com (3.2) with ESMTP id >MHotMailBA61E98200C7D820F3E0CF8A299215F353; Wed Feb 02 13:17:13 2000 >Received: from [10.1.2.41] by ml. with NNFMP; 02 Feb 2000 >21:02:32 -0000 >Received: (listserv $); by a1; 02 Feb 2000 21:02:32 -0000 >Received: (qmail 9904 invoked from network); 2 Feb 2000 20:54:37 -0000 >Received: from harrier.prod.itd.earthlink.net (207.217.121.12) by >qg. with SMTP; 2 Feb 2000 20:54:37 -0000 >Received: from mypc (1Cust170.tnt2.elizabethtown.ky.da.uu.net >[63.21.41.170]) by harrier.prod.itd.earthlink.net (8.9.3/8.9.3) with SMTP >id MAA00221 for <longevityegroups>; Wed, 2 Feb 2000 12:54:30 -0800 >(PST) >From longevity-return-461-jdbullis Wed Feb 02 13:18:10 2000 >X-eGroups-Return: >longevity-return-461-jdbullis=hotmail.comreturns (DOT) >Delivered-listsaver-egroups-longevityegroups >Message-ID: <054d01bf6dbf$cfcc0a20$b08a1b3f@mypc> >References: <20000202202935.17829.qmail@...> >Organization: Optexinc >X-Priority: 3 >X-MSMail-Priority: Normal >X-Mailer: Microsoft Outlook Express 5.00.2919.6600 >X-MimeOLE: Produced By Microsoft MimeOLE V5.00.2919.6600 >Mailing-List: contact longevity-owneregroups >X-Mailing-List: longevityegroups >Precedence: bulk >List-Help: <longevity/info.html>, ><mailto:longevity-helpegroups> >List-Unsubscribe: <mailto:longevity-unsubscribeegroups> >List-Archive: <longevity/> > > >If it is the liquid citrate from a company named Discovery in Florida then >the docs over at http://www.ceri.com like it. Where did you find it? I >thought the FDA had forced the company to stop selling it. > >-gts > > > > Deprenyl > > > > I asked my conventional physician for a script for Deprenyl. > > Guess what he said? No way! So, I hopped on the web and typed > > www.deprenyl.com and what came up....Pfizer's canine cognitive care >site. > > Yes, we'll give it to dogs, but not to . I finally found some >citrate > > for sixty bucks on the web. Think it's any good? JB > > ______________________________________________________ > > > > ------------------------------------------------------------------------ > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2000 Report Share Posted February 2, 2000 If it is the liquid citrate from a company named Discovery in Florida then the docs over at http://www.ceri.com like it. Where did you find it? I thought the FDA had forced the company to stop selling it. -gts Deprenyl > I asked my conventional physician for a script for Deprenyl. > Guess what he said? No way! So, I hopped on the web and typed > www.deprenyl.com and what came up....Pfizer's canine cognitive care site. > Yes, we'll give it to dogs, but not to . I finally found some citrate > for sixty bucks on the web. Think it's any good? JB > ______________________________________________________ > > ------------------------------------------------------------------------ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2000 Report Share Posted February 2, 2000 , > How does one check to see if it is real deprenyl or something else? I think you'll be able to feel it starting to have an effect. I can feel the 1 mg/day that I just started taking (actually it's 1.25 mg). I've also been taking piracetam for quite a while but its effects are very subtle. I sometimes wonder if I'm wasting my money with piracetam but I keep taking it because there is quite a lot of evidence for its intelligence enhancing effects. I ain't sure if them there smart drugs got me smarter but I sure do reckon they done got me broker. -gts Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 13, 2003 Report Share Posted May 13, 2003 IAS carries liquid Deprenyl (Seperyl) quite inexpensive. R. Gow, CPS The S2A Group, Michigan Div. (810) 599-9625 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 13, 2003 Report Share Posted May 13, 2003 GTS, I had not been aware of this product until now, either. I agree that the liquid deprenyl citrate (LDC) may be preferred, based on numerous anecdotal reports. On the other hand, because of the difficulty to obtain LDC, this new low-dose sublingual form of deprenyl looks like the best option for most people, in terms of sublingual delivery and ability to titrate the dose. Any idea of the cost? Ward [Thanks for commenting. I looked for Zelapar at www.drugstore.com but apparently they don't carry it. Perhaps will tell us the price he paid. Mike points out that liquid deprenyl is available at IAS, for people who don't mind doing business my mail order with overseas companies. My own experience with IAS has always been good. -gts] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 13, 2003 Report Share Posted May 13, 2003 I see that the sublingual deprenyl is also available at IAS in addition to the citrate liquid. ---- Deprenyl Sublingual (ZelaparR) 30 x 1.25mg tablets Price: (3 or fewer items) $169.95 Price: (4 or more items) $160.00 Unique new sublingual form of selegiline. Technically, one tablet equal to at least 5mg of oral tablet. could be useful for those persons who have to take high dosages and want to avoid potential side effects. ---- It's expensive. A 300 mg bottle of liquid deprenyl citrate is only $70. -gts Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 13, 2003 Report Share Posted May 13, 2003 Because Deprenyl is an MAO-B inhibiter, and helps increase dopamine levels in the brain, it should help ease depression and, if you are like me and eat out of boredom/depression, it might help ease the hunger cravings in the head. mikeg R. Gow, CPS The S2A Group, Michigan Div. (810) 599-9625 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 2, 2003 Report Share Posted June 2, 2003 I just bought the citrate liquid which goes under the name of Selepryl. 1 drop equals 1 mg. My only problem is there are no instructions as to how to take it. Should I put the drops under my tongue (as with Zelapar) or mix them in water? Anyway, there is no doubt that it is a lot less expensive. Can anyone give me some advice? [Coincidently, I just today also received a shipment of deprenyl (Selepryl) from IAS. I don't think it matters whether you mix it in liquid or drop it under the tongue -- either method should work -- but placing drops under the tongue might give better absorption. -gts] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 2, 2003 Report Share Posted June 2, 2003 I take mine under the tongue - some find this distasteful and take it in water . I don't believe it matters - I knew of one fellow who took his in coffee, not knowing the heat tolerance of Dep I suggested against this. Under the tongue as gts says should be more effective but I don't think the difference will matter greatly. I would go for the sublingual unless I found the taste intolerable. Let us know how you like the effects of Dep - I've used it for years and would not be without. [The citrate base gives it a tangy citrus flavor. Very pleasant, at least to me. Looks like I'll be letting my supply of 5 mg tabs rot on the shelf. -gts] Pellegrini wrote: > I just bought the citrate liquid which goes under the name of > Selepryl. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 2, 2003 Report Share Posted June 2, 2003 Thank you very much. I have been doing both and find that drops followed by water are fine. I was a little concerned because the directions for Zelapar mention not drinking anything for five minutes after placing it on your tongue. Having tried Selepryl however, I don't see any reason for buying Zelapar. The effect of the drops is pronounced and quite relaxing. [You're welcome. Taking the Zelapar brand with water would defeat the purpose of its sublingual method of absorption. Assuming the liquid citrate form can be absorbed sublingually (and I think that's a safe assumption) then this would also be true of the drops. It's probably best to let the liquid sit in the mouth for a few minutes without swallowing, as you're doing. -gts] RE: deprenyl I just bought the citrate liquid which goes under the name of Selepryl. 1 drop equals 1 mg. My only problem is there are no instructions as to how to take it. Should I put the drops under my tongue (as with Zelapar) or mix them in water? Anyway, there is no doubt that it is a lot less expensive. Can anyone give me some advice? [Coincidently, I just today also received a shipment of deprenyl (Selepryl) from IAS. I don't think it matters whether you mix it in liquid or drop it under the tongue -- either method should work -- but placing drops under the tongue might give better absorption. -gts] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 3, 2003 Report Share Posted June 3, 2003 have been using Sepryl for approx. month, mixing five drops with water, washing down vitamins. just did five? drops under tongue, what is the effect I am, specifically, looking for? thanks mikeg R. Gow, CPS The S2A Group, Michigan Div. (810) 599-9625 [some good articles about the potential benefits of selegiline (aka deprenyl) can be found here: http://qualitycounts.com/fpdeprenyl.html -gts] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 3, 2003 Report Share Posted June 3, 2003 have been using Sepryl for approx. month, mixing five drops with water, washing down vitamins. just did five? drops under tongue, what is the effect I am, specifically, looking for? thanks mikeg R. Gow, CPS The S2A Group, Michigan Div. (810) 599-9625 [some good articles about the potential benefits of selegiline (aka deprenyl) can be found here: http://qualitycounts.com/fpdeprenyl.html -gts] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 3, 2003 Report Share Posted June 3, 2003 I have just received a bottle of liquid Selepryl from IAS as I just ran out of Cyprenil. I find the two identical and the bottle label appears to list the same ingredients as well. Is Sepryl another brand of a citrate of selegiline? Is selegiline a delicate molecule? I have simply put the drops on my tongue and swallowed it down. What benefit would I get from taking this sublingually? Thanks for your reply. >have been using Sepryl for approx. month, mixing five drops with water, >washing down vitamins. just did five? drops under tongue, what is the >effect I am, specifically, looking for? >thanks >mikeg > R. Gow, CPS >The S2A Group, Michigan Div. >(810) 599-9625 > >[some good articles about the potential benefits of selegiline (aka deprenyl) >can be found here: http://qualitycounts.com/fpdeprenyl.html -gts] > MSN 8 helps ELIMINATE E-MAIL VIRUSES. Get 2 months FREE*. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 3, 2003 Report Share Posted June 3, 2003 Bullis wrote: > I have just received a bottle of liquid Selepryl from IAS as I just > ran out of Cyprenil. I find the two identical and the bottle label > appears to list the same ingredients as well. Is Sepryl another brand > of a citrate of selegiline? Is selegiline a delicate molecule? I have > simply put the drops on my tongue and swallowed it down. What benefit > would I get from taking this sublingually? Thanks for your reply. > Yes, Selepryl is another brand of liquid deprenyl (selegiline) citrate. I don't know for certain however if they are from the same manufacturer. Dr. Dean might know. I don't believe it is an especially delicate molecule. The benefit of taking it sublingually is that more of it should reach the bloodstream intact. -gts Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 3, 2003 Report Share Posted June 3, 2003 Bullis wrote: > I have just received a bottle of liquid Selepryl from IAS as I just > ran out of Cyprenil. I find the two identical and the bottle label > appears to list the same ingredients as well. Is Sepryl another brand > of a citrate of selegiline? Is selegiline a delicate molecule? I have > simply put the drops on my tongue and swallowed it down. What benefit > would I get from taking this sublingually? Thanks for your reply. > Yes, Selepryl is another brand of liquid deprenyl (selegiline) citrate. I don't know for certain however if they are from the same manufacturer. Dr. Dean might know. I don't believe it is an especially delicate molecule. The benefit of taking it sublingually is that more of it should reach the bloodstream intact. -gts Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 31, 2004 Report Share Posted March 31, 2004 Not sure about the on-line thing and getting in trouble. I ordered some online but had a script. If you are after the libido thing, then take this approach... Ask your doctor about Uprima. This is a new ED drug that is a dopamine agonist like deprenyl. Once he makes that leap, mention deprenyl for the same thing. You heard about it here, that it works better, and is more reasonibly proced (which it is). Just my 2 cents. y > hello- > i am very interested in trying deprenyl > > as a young male (25) w/ secondary hypogonadism currently on hrt, do > i have a legit case that most doctors would be willing to give > deprenyl or would this be seen as bizarre > if so, how would you recommend i approach a doctor about this > i am primarily just interested in it to see if it helps with libido > (havent noticed that much since starting trt in that department) and > mental focus > > also, is this illegal to order online sans prescription > i realize that it is, but i guess i am asking if you could actually > get in trouble for this or, worst case scenario, it would just be > confiscated by customs > > thanks for any input! Quote Link to comment Share on other sites More sharing options...
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