Re: can someone forward please

[Guest guest]

Hi j.g.

There are free downloads of Microsoft Word Reader and Adobe

Acrobat Reader. Try

http://www.doh.wa.gov/viewer.htm

I can't open some files. maybe theyre in WordPerfect or other text

format.

Text of the " Optimal T E2 Ratio.doc is:

-----

wolverfan Put the link below in our links section and it worked

well for sometime but you are now carried to search page of the

journal

T to E2 Ratio and T Gel Effects Study

Good study and info about hormone ratios and benefits of T gel

http://www.familypractice.com/journal/abfpjournal_frame.htm?m

ain=/journal/2001/v14.n01/1401.04/art-1401.04.htm

This is copy of my post from 9-13-03 RE:

" Found it "

Sat 9/13/2003 8:55 AM which quotes last paragraph of relevant

section of the journal article i.e. optimal T/E2 ratio

I had included T/E2 ratio material in a post to

Alt-Support-Impotence-ASI/

I haven't responded to Phil's post yet on how to calculate T/E2

ratio..he converts.I do not convert..more about that later.

T to E2 Ratio and T Gel Effects Study [NL]Good study and info

about hormone ratios and benefits of T gel

[NL]http://www.familypractice.com/journal/abfpjournal_frame.htm

?main=/jo

urna

l/2001/v14.n01/1401.04/art-1401.04.htm wolverfan

If you can open that link...scroll down until you see Table 3..

" Table 3 displays the results for changes in total androgen

levels, the total androgen-estradiol ratio, and luteinizing

hormone levels. All patients reached therapeutic levels of total

androgens (defined as testosterone plus dihydrotestosterone >

330 ng/dL). The pretreatment average was 149.3 ng/dL and

increased more than fourfold to 642.10 ng/dL (P = .001). A

striking change in the total androgen-estradiol ratio was

observed in all men; the average ratio of 5.10 ([ng/dL]/[pg/mL])

increased by a factor of greater than 3 to 17.08 (P < .002).

Normal ratios of total androgen-estradiol are defined as being

between 10 to 22.[27] In this analysis the ratios are slightly

higher because of the inclusion of the dihydrotestosterone

levels, which comprise a considerable portion of the androgen

pool in these men. "

OR eon

------------------

Bruce

>

> im having problems opening some files on the hypo

site. my comp

> has microsoft works and i think the files are word documents.

ive

> saved them and tried to re-open in wordpad but no luck. can

someone

> forward them so i can open or explain how to re-open them?

> im looking for " normal ranges for hormone tests in men.doc "

> and " optimal t e2 ratio.doc " help would be greatly appreciated

>

> thanks

> j.g.

[Guest guest]

Text of " Normal Ranges For Hormone Tests In Men " follows.

Note: When reading test results, ranges provided by the lab are

best for the specific test method.

Normal Ranges

For Hormone Tests In Men

<sum> Introduction

<sum> Standard test ranges for sex hormones in men

<sum> An explanation of test results for sex hormones in men

<sum> Normal ranges for hormone tests in men references

Introduction

Sex hormones, or steroidal hormones, are important for hair

growth. A lack of one or more of these hormones could lead to a

absence of body hair in adults, but more significantly an over

expression of steroidal hormones and/or a lack of antagonists to

steroidal hormones can result in the development of pattern

baldness. For women with a diagnosis of androgenetic

alopecia, a blood test to examine hormone levels might be

desirable to see if there is a systemic cause of the excessive

androgen activity. But for men with an androgenetic alopecia

diagnosis, a blood test is very rarely done.

Although hyperandrogenicity in men is possible with some

prostate and adrenal gland disorders, these conditions are rare.

Unless there are multiple symptoms pointing towards a prostate

or adrenal gland problem, hormone testing is not generally

conducted for men. Male pattern baldness has a distinctive

presentation that makes it easy to identify and little additional

information is gained from a blood analysis. Almost all men with

pattern baldness have normal steroid hormone ranges.

You can of course insist on a blood test if the medical insurance

system in your country allows. The most basic hormone testing

in males often only includes FSH and testosterone and doctors

may be reluctant to do more, but a more comprehensive test

would provide more information. A comprehensive blood test for

men might include:

<sum> Sex hormone binding globulin (SHBG)

<sum> Estrogens (usually only the estradiol (E2) form is tested)

<sum> Dehydroepiandrosterone sulfate (DHEAS) and/or

Dehydroepiandrosterone (DHEA)

<sum> Total testosterone (T)

<sum> Free testosterone (that testosterone which is not bound to

other molecules like SHBG)

<sum> Androstenedione (possibly androstenediol too)

<sum> Follicular stimulating hormone (FSH)

Although dihydrotestosterone (DHT) is the primary promoter of

androgenetic alopecia it is not generally tested because DHT is

a relatively unstable molecule and levels can vary significantly

over a short space of time. In addition, the DHT in the blood

stream is not a particularly good reflection of the DHT in hair

follicles. Steroid hormone responsive hair follicles produce their

own DHT through enzyme conversion of DHEAS and T that they

receive through the blood stream. To define excessive systemic

androgen activity doctors look at the DHEAS, testosterone, and

androstenedione results.

Note that in terms of understanding androgenetic alopecia,

blood test results only present part of the story. The blood test

results indicate what is going on systemically in terms of

hormone production. A blood test does not provide an insight

into hormonal activity in the skin and hair follicles. Skin and hair

follicles produce their own enzymes that can convert mild

androgens like DHEA into potent androgens like DHT. So it is

possible to have normal blood test results but have significant

androgenic activity in the hair follicles. A normal blood test result

does not rule out a diagnosis of androgenetic alopecia.

Standard test ranges of hormones in men

Note; only the basic ranges are listed here. The values for

children can be significantly different. Normal ranges will be

slightly different in different laboratories as there is no calibration

of the tests between different labs.

Hormone / antagonist Life stage Value

Progesterone (nanograms per milliliter or nano-moles per liter)

Adult < 1.0 ng/ml

(< 3.18 nmol/L)

17-Hydroxyprogesterone (nanograms per deciliter or

nano-moles per liter) Prepubertal < 1.1 ng/dl

(< 3.3 nmol/L)

Adult 5 – 250 ng/dl

( 0.15 – 7.5 nmol/L)

Estradiol (picograms per milliliter or pico-moles per liter)

Prepubertal < 10 pg/ml

(< 37 pmol/L)

Pubertal < 23 pg/ml

(< 84 pmol/L)

Adult < 60 pg/ml

(< 185 pmol/L)

Estrone (picograms per milliliter or pico-moles per liter) Adult 10

– 50 pg/ml

(37 – 185 pmol/L)

Estriol (nanograms per milliliter or nano-moles per liter) Adult <

2 ng/ml

(< 7 nmol/L)

FSH (units per liter) Adult 1.0 – 12.0 U/L

LH (units per liter) Adult 2.0 – 14.0 U/L

SHBG (nano-moles per liter) Adult 6 – 50 nmol/L

Dehydroepiandrosterone (DHEA) (nanograms per deciliter or

nano-moles per liter) < 6 years 20 – 130 ng/dl

(0.7 – 4.5 nmol/L)

6-8 years 20 – 275 ng/dl

(0.7 – 9.5 nmol/L)

8-10 years 31 – 345 ng/dl

(1.1 – 12 nmol/L)

10-20 years 110 – 900 ng/dl

(3.8 – 31.2 nmol/L)

> 20 years 160 – 800 ng/dl

(5.6 – 27.8 nmol/L)

Dehydroepiandrosterone sulfate (DHEAS) (micrograms per

deciliter or micro-moles per liter) 1-8 years 10 – 20 µg/dl

(0.3 – 0.5 µmol/L)

8-10 years 30 – 50 µg/dl

(0.8 – 1.4 µmol/L)

10-12 years 30 – 40 µg/dl

(0.8-1.1 µmol/L)

12-14 years 80 – 140 µg/dl

(2.2 – 3.8 µmol/L)

14-50 years 110 – 690 µg/dl

(3.0 – 18.7 µmol/L)

Androstenedione (nanograms per milliliter or nano-moles per

liter) < 6 years 0.1 – 0.2

(0.3 – 0.7 nmol/L)

6-8 years 0.1 – 0.3

(0.3 – 1.0 nmol/L)

8-10 years 0.1 – 0.3

(0.3 – 1.0 nmol/L)

10-12 years 0.3 – 0.7

(1.0 – 2.4 nmol/L)

12-14 years 0.5 – 1.0

(1.7 – 3.5 nmol/L)

> 14 years 0.8 – 2.3

(2.8 – 8.0 nmol/L)

Androstenediol (nanograms per milliliter) 0.2 – 2 ng/ml

Total testosterone - morning sample (nanograms per deciliter or

nano-moles per liter) Prepubertal 8 – 14 ng/dl

(0.28 – 0.49 nmol/L)

Pubertal 84 – 480 ng/dl

(2.91 – 6.24 nmol/L)

Adult 300 – 1000 ng/dl

(10.4 – 34.7 nmol/L)

Free testosterone - morning sample (picrograms per milliliter or

pico-moles per liter) 20 –40 years 15.0 – 40.0 pg/ml

(520 – 1387 pmol/L)

41 –60 years 13.0 – 35.0 pg/ml

(451 – 1213 pmol/L)

61 –80 years 12.0 – 28.0 pg/ml

(416 – 971 pmol/L)

Dihydrotestosterone (nanograms per milliliter or nano-moles

per liter) Prepubertal < 3 – 13 ng/ml

(< 0.1 – 0.4 nmol/L)

Adult 30 – 100 ng/ml

(1.0 – 3.4 nmol/L)

Deoxycorticosterone (nanograms per milliliter or pico-moles per

liter) Prepubertal 2 – 34 ng/ml

(61 – 1030 pmol/L)

Adult 2 – 19 ng/ml

(61 – 576 pmol/L)

Cortisol (micrograms per milliliter or nano-moles per liter) Adult

morning 5 – 20 µg/ml

(140 – 552 nmol/L)

Adult afternoon 2.5 – 10 µg/ml

(69 – 276 nmol/L)

Prolactin (nanograms per milliliter) 0 – 15 ng/ml

An explanation of test results for sex hormones in men

Testosterone - Understanding the hormone test results from

men is much simpler than analyzing test results from women.

The average adult male, not surprisingly, produces significantly

more testosterone than women do. A high level of total

testosterone is not necessarily a problem in terms of

androgenetic alopecia susceptibility. If the testosterone is mostly

bound testosterone then the hormone is unable to activate

testosterone receptors. What is more important for

understanding androgenetic alopecia is the level of free

testosterone - those hormone molecules capable of interacting

with androgen receptors on cells. The percentage of

testosterone in the male body that is free is typically 0.3% - 5%.

An optimal level is about 2% free, unbound testosterone.

Excessively high levels of free testosterone may suggest a

hyperandrogenic problem. Free testosterone levels are highest

in the morning and gradually drop throughout the day so normal

values for a blood sample taken in the afternoon will be slightly

lower than those shown above. Testosterone production is

stimulated by Leydig cells in the testicles. Low levels of

testosterone combined with low FSH and LH are diagnostic of

hypogonadotropic hypogonadism.

Dehydroepiandrosterone (DHEA) - However, the total

testosterone and free testosterone levels only present part of the

androgen story. Androgen responsive hair follicles produce

enzymes capable of converting other, less potent androgen

hormones into, testosterone and dihydrotestosterone. The

primary source converted is DHEA or DHEAS. Potentially, the

more DHEA in the blood, the more that can be converted to more

potent androgens in the hair follicles. A high DHEA and/or

DHEAS level signals a potential increase in androgenetic

alopecia susceptibility. Dehydroepiandrosterone sulfate

(DHEAS) is the sulfated form of Dehydroepiandrosterone

(DHEA). DHEA is a relatively unstable molecule and it mostly

gets converted to DHEAS before circulating in the blood stream.

For the purpose of understanding androgenetic alopecia, DHEA

and DHEAS can be regarded as basically the same thing.

Luteinizing Hormone (LH) - In men, LH stimulates Leydig cells

and production of testosterone. A problem with LH levels alone

is very rarely seen, so testing is only needed if the testosterone

level is found to be abnormally low.

Prolactin - A level two or three times that of normal may indicate

a pituitary tumor, such as a prolactinoma, which may lead to

decreased sperm production. Elevated levels can be treated with

the drug bromocriptine.

Sex Hormone Binding Globulin (SHBG) - Increased androgen

production in general leads to lower SHBG. The normal range

for SHBG in men is lower than in women. SHBG is an antagonist

to testosterone. SHBG binds to testosterone and renders it

inactive. Bound testosterone cannot interact with androgen

receptors on cells so it has no impact on hair follicles. A reduced

SHBG level suggests a possible increase in susceptibility to

androgenetic alopecia. However, while a high SHBG level is

theoretically good in terms of avoiding androgenic hair loss, too

much SHBG can be a problem for men. Men require a certain

amount of free testosterone to maintain muscle mass, sex drive,

and possibly bone mass too. An excessively high SHBG level

can reduce the net action of androgens in maintenance of these

body systems. So an SHBG level at the upper end of the normal

range is the ideal situation limiting the risk of androgen action on

hair follicles while permitting an acceptable level of free

testosterone to maintain other body functions.

Normal ranges for hormone tests in men references

<sum> Fischbach FT. A manual of laboratory and diagnostic tests.

Lippincott, Philadelphia, ISBN: 039755186X. 1998

<sum> Kratz A, Lewandrowski KB. Case records of the

Massachusetts General Hospital. Weekly clinicopathological

exercises. Normal reference laboratory values. N Engl J Med.

1998 Oct 8;339(15):1063-72.

<sum> Greenspan FS, Gardner DG. Basic & Clinical Endocrinology.

7th edition. Norwalk: Appleton-Lange, ISBN: 0071402977, 2003

JE, JD. Disorders of the testes and the male

reproductive tract. In: JD, DW, editors. 's

Textbook of Endocrinology. 8th ed. Philadelphia: Saunders Co.,

1992

>

> im having problems opening some files on the hypo

site. my comp

> has microsoft works and i think the files are word documents.

ive

> saved them and tried to re-open in wordpad but no luck. can

someone

> forward them so i can open or explain how to re-open them?

> im looking for " normal ranges for hormone tests in men.doc "

> and " optimal t e2 ratio.doc " help would be greatly appreciated

>

> thanks

> j.g.

[Guest guest]

im having problems opening some files on the hypo site.

my comp has microsoft works and i think the files are word

documents. ive saved them and tried to re-open in wordpad but no

luck.----

Files with .doc suffix open in Microsoft Word.

(There is a file: Word Reader Download.doc that is described as:

a no cost download of Word Viewer for those of you that do not have

Word.

However since this file is itself an MS Word document, it would seem

the solution is as inaccesssable as the documents themselves!)

I reloaded the files you want

as " NormalRangesforHormoneTestsinMen.htm "

and " OptimalTtoE2Ratio.html "

They should open for you in Internet Explorer (or Microsoft Front

Page.)

Just clicking on either file in the files section at

/files/

should open it if you have Int. Explorer on your computer. Not

necessary to download them.