Guest guest Posted May 1, 2004 Report Share Posted May 1, 2004 http://www.who.int/mediacentre/notes/np8/en/ the disease kills more than one million people every year, mostly children under the age of five in Africa http://www.who.int/tdr/publications/tdrnews/news63/artemotil.htm Clinical studies in patients with severe malaria were carried out first in adults and later in children who could not be treated with oral medication, or who had critical cerebral malaria, in Africa and Thailand. No serious or inconvenient side effects were reported. Although, with artemisinin compounds in general, degenerative neurotoxic effects have been reported during pre-clinical safety studies in animals, these have occured at cumulative doses above 100 mg per kg body weight, whereas, in clinical treatment with artemotil, the cumulative dose reached is 11.2 mg per kg. Also, throughout the world, during treatment of millions of patients with various artemisinin derivatives, no neurotoxic effects have been reported. Nor has neurotoxicity been observed during controlled studies in volunteers and patients. Thus there is no reason for restriction of clinical use of artemotil. Quote Link to comment Share on other sites More sharing options...
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