Guest guest Posted July 4, 1999 Report Share Posted July 4, 1999 Hi Cheryl, I tried to do a search for new drugs starting with Li, and nothing came up that looked like what you were looking for, sorry. Hugs, Marta. NJ >From: cheryl@... > ><<<I was hoping maybe you could help me. I heard on the news today that there is an experimental testing going on for a new drug that is supposed to help diminish lyme symptoms. I didn't catch the whole name of the new drug, but I believe the first two letters were " Li. " Anyway, the drug is supposedly just about to be released to the public, but it must be tested on humans. They need volunteers for this, and a close friend of mine is more than willing. I was wondering if you had any information about this new drug, or any kinda of experiment that is trying to end lyme disease AFTER it's been diagnosed. I have been searching for hours, and all I can find is vaccine information.>>> > >Got this email from someone looking for help. Does anyone know what this may be referring to? >thanks, >Cheryl Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 4, 1999 Report Share Posted July 4, 1999 hi cheryl, sorry i missed what you were looking for, ie: drug starting with LI. this link may help you find it. http://mentalhelp.net/guide/pro22.htm peace, kay p.s. send me a note what you are looking for. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 4, 1999 Report Share Posted July 4, 1999 duh...sorry cheryl, your post was attached to marta's response! try the fda homepage: http://www.fda.gov/default.htm kay Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 5, 1999 Report Share Posted July 5, 1999 Marta and Kay, Hi! Thanks for the tips. I was unable to find whatever it is this person is looking for (that was an email I received from a stranger). If I find out I will let yas know! But thanks so much for the sites....they are good to have handy for other things and I wasn't familiar with them! ) Cheryl (LI, NY) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 13, 2002 Report Share Posted December 13, 2002 I am a non-responder,WE ALL NEED TO PREASURE THE FDA TO FAST TRACK SOMETHING LIKE THIS, GET THIS INFO INTO THE NEWS AND TALK SHOWES.That's what I think. Country TV Ron 484 FM444 S. Inez,TX 77968-5002 V.(361)782-6419. F.(361)782-9149 e-mail: rlmbkm@... New Drug > HI.When I had my third PCR,after two positive results,I was kind of pessimistic but my Doc. told me that if I was positive again he would give me a new drug which works miracles in HCV 1 types and non-responders.It was still in the trial face but he would give it to me anyway.I was lucky the third time,negative but I got curious and recently askes my Doc. about this medicine.These are the facts:.It.s called BILN2061 protease-blocker,.It.s taken orally which no side-effects.Within 24hrs of taking the drug the viral load could only be detected with a very sensitive test.He told me and he.s is one of the leading specialist of HCV in Holland,Dr.Reesink,that this drug attacks part of the virus which is needed for reproducten,a protein,is very promising.So all you non-responders don.t give up hope and don.t believe the stories that there are no new medicines forthcoming in the nxt couple of years.A new European-wide trial is starting soon.If you can.t get it in the US come over here... > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 13, 2002 Report Share Posted December 13, 2002 I am a non-responder,WE ALL NEED TO PREASURE THE FDA TO FAST TRACK SOMETHING LIKE THIS, GET THIS INFO INTO THE NEWS AND TALK SHOWES.That's what I think. Country TV Ron 484 FM444 S. Inez,TX 77968-5002 V.(361)782-6419. F.(361)782-9149 e-mail: rlmbkm@... New Drug > HI.When I had my third PCR,after two positive results,I was kind of pessimistic but my Doc. told me that if I was positive again he would give me a new drug which works miracles in HCV 1 types and non-responders.It was still in the trial face but he would give it to me anyway.I was lucky the third time,negative but I got curious and recently askes my Doc. about this medicine.These are the facts:.It.s called BILN2061 protease-blocker,.It.s taken orally which no side-effects.Within 24hrs of taking the drug the viral load could only be detected with a very sensitive test.He told me and he.s is one of the leading specialist of HCV in Holland,Dr.Reesink,that this drug attacks part of the virus which is needed for reproducten,a protein,is very promising.So all you non-responders don.t give up hope and don.t believe the stories that there are no new medicines forthcoming in the nxt couple of years.A new European-wide trial is starting soon.If you can.t get it in the US come over here... > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 13, 2002 Report Share Posted December 13, 2002 I am a non-responder,WE ALL NEED TO PREASURE THE FDA TO FAST TRACK SOMETHING LIKE THIS, GET THIS INFO INTO THE NEWS AND TALK SHOWES.That's what I think. Country TV Ron 484 FM444 S. Inez,TX 77968-5002 V.(361)782-6419. F.(361)782-9149 e-mail: rlmbkm@... New Drug > HI.When I had my third PCR,after two positive results,I was kind of pessimistic but my Doc. told me that if I was positive again he would give me a new drug which works miracles in HCV 1 types and non-responders.It was still in the trial face but he would give it to me anyway.I was lucky the third time,negative but I got curious and recently askes my Doc. about this medicine.These are the facts:.It.s called BILN2061 protease-blocker,.It.s taken orally which no side-effects.Within 24hrs of taking the drug the viral load could only be detected with a very sensitive test.He told me and he.s is one of the leading specialist of HCV in Holland,Dr.Reesink,that this drug attacks part of the virus which is needed for reproducten,a protein,is very promising.So all you non-responders don.t give up hope and don.t believe the stories that there are no new medicines forthcoming in the nxt couple of years.A new European-wide trial is starting soon.If you can.t get it in the US come over here... > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 13, 2002 Report Share Posted December 13, 2002 I am a non-responder,WE ALL NEED TO PREASURE THE FDA TO FAST TRACK SOMETHING LIKE THIS, GET THIS INFO INTO THE NEWS AND TALK SHOWES.That's what I think. Country TV Ron 484 FM444 S. Inez,TX 77968-5002 V.(361)782-6419. F.(361)782-9149 e-mail: rlmbkm@... New Drug > HI.When I had my third PCR,after two positive results,I was kind of pessimistic but my Doc. told me that if I was positive again he would give me a new drug which works miracles in HCV 1 types and non-responders.It was still in the trial face but he would give it to me anyway.I was lucky the third time,negative but I got curious and recently askes my Doc. about this medicine.These are the facts:.It.s called BILN2061 protease-blocker,.It.s taken orally which no side-effects.Within 24hrs of taking the drug the viral load could only be detected with a very sensitive test.He told me and he.s is one of the leading specialist of HCV in Holland,Dr.Reesink,that this drug attacks part of the virus which is needed for reproducten,a protein,is very promising.So all you non-responders don.t give up hope and don.t believe the stories that there are no new medicines forthcoming in the nxt couple of years.A new European-wide trial is starting soon.If you can.t get it in the US come over here... > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 13, 2002 Report Share Posted December 13, 2002 Hi.Some two years before Peg-interferon was avaible in the US it was avaiable in Holland,not in trials but over the counter so to speak.I know sometimes I get a bit over-excited but this drug is really very promising,it.s a new approach of attacking the virus itself and not boosting the immune-system.If my Doc. would give it to me I know it is good.I believe it was also mangened in a congress about liver disease in Boston,1 Nov.2002,recently.Claudine would know more about that.. New Drug > HI.When I had my third PCR,after two positive results,I was kind of pessimistic but my Doc. told me that if I was positive again he would give me a new drug which works miracles in HCV 1 types and non-responders.It was still in the trial face but he would give it to me anyway.I was lucky the third time,negative but I got curious and recently askes my Doc. about this medicine.These are the facts:.It.s called BILN2061 protease-blocker,.It.s taken orally which no side-effects.Within 24hrs of taking the drug the viral load could only be detected with a very sensitive test.He told me and he.s is one of the leading specialist of HCV in Holland,Dr.Reesink,that this drug attacks part of the virus which is needed for reproducten,a protein,is very promising.So all you non-responders don.t give up hope and don.t believe the stories that there are no new medicines forthcoming in the nxt couple of years.A new European-wide trial is starting soon.If you can.t get it in the US come over here... > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 13, 2002 Report Share Posted December 13, 2002 Hi.Some two years before Peg-interferon was avaible in the US it was avaiable in Holland,not in trials but over the counter so to speak.I know sometimes I get a bit over-excited but this drug is really very promising,it.s a new approach of attacking the virus itself and not boosting the immune-system.If my Doc. would give it to me I know it is good.I believe it was also mangened in a congress about liver disease in Boston,1 Nov.2002,recently.Claudine would know more about that.. New Drug > HI.When I had my third PCR,after two positive results,I was kind of pessimistic but my Doc. told me that if I was positive again he would give me a new drug which works miracles in HCV 1 types and non-responders.It was still in the trial face but he would give it to me anyway.I was lucky the third time,negative but I got curious and recently askes my Doc. about this medicine.These are the facts:.It.s called BILN2061 protease-blocker,.It.s taken orally which no side-effects.Within 24hrs of taking the drug the viral load could only be detected with a very sensitive test.He told me and he.s is one of the leading specialist of HCV in Holland,Dr.Reesink,that this drug attacks part of the virus which is needed for reproducten,a protein,is very promising.So all you non-responders don.t give up hope and don.t believe the stories that there are no new medicines forthcoming in the nxt couple of years.A new European-wide trial is starting soon.If you can.t get it in the US come over here... > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 13, 2002 Report Share Posted December 13, 2002 Hi.Some two years before Peg-interferon was avaible in the US it was avaiable in Holland,not in trials but over the counter so to speak.I know sometimes I get a bit over-excited but this drug is really very promising,it.s a new approach of attacking the virus itself and not boosting the immune-system.If my Doc. would give it to me I know it is good.I believe it was also mangened in a congress about liver disease in Boston,1 Nov.2002,recently.Claudine would know more about that.. New Drug > HI.When I had my third PCR,after two positive results,I was kind of pessimistic but my Doc. told me that if I was positive again he would give me a new drug which works miracles in HCV 1 types and non-responders.It was still in the trial face but he would give it to me anyway.I was lucky the third time,negative but I got curious and recently askes my Doc. about this medicine.These are the facts:.It.s called BILN2061 protease-blocker,.It.s taken orally which no side-effects.Within 24hrs of taking the drug the viral load could only be detected with a very sensitive test.He told me and he.s is one of the leading specialist of HCV in Holland,Dr.Reesink,that this drug attacks part of the virus which is needed for reproducten,a protein,is very promising.So all you non-responders don.t give up hope and don.t believe the stories that there are no new medicines forthcoming in the nxt couple of years.A new European-wide trial is starting soon.If you can.t get it in the US come over here... > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 13, 2002 Report Share Posted December 13, 2002 Hi.Some two years before Peg-interferon was avaible in the US it was avaiable in Holland,not in trials but over the counter so to speak.I know sometimes I get a bit over-excited but this drug is really very promising,it.s a new approach of attacking the virus itself and not boosting the immune-system.If my Doc. would give it to me I know it is good.I believe it was also mangened in a congress about liver disease in Boston,1 Nov.2002,recently.Claudine would know more about that.. New Drug > HI.When I had my third PCR,after two positive results,I was kind of pessimistic but my Doc. told me that if I was positive again he would give me a new drug which works miracles in HCV 1 types and non-responders.It was still in the trial face but he would give it to me anyway.I was lucky the third time,negative but I got curious and recently askes my Doc. about this medicine.These are the facts:.It.s called BILN2061 protease-blocker,.It.s taken orally which no side-effects.Within 24hrs of taking the drug the viral load could only be detected with a very sensitive test.He told me and he.s is one of the leading specialist of HCV in Holland,Dr.Reesink,that this drug attacks part of the virus which is needed for reproducten,a protein,is very promising.So all you non-responders don.t give up hope and don.t believe the stories that there are no new medicines forthcoming in the nxt couple of years.A new European-wide trial is starting soon.If you can.t get it in the US come over here... > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2003 Report Share Posted January 7, 2003 has anyone heard of a new tnf drug - I beleive this is the way it's spelled. " Humira " I saw some advertising on this last week. Thanks, Jan [see: /message/23905 ] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2003 Report Share Posted January 7, 2003 Hi Jan - I posted last week that Humira had just been approved by the feds for use in treating rheumatoid arthritis. It is taken once every two weeks and is inline with Enbrel and Remicade but I don't think it is so difficult to engineer as Enbrel so shouldn't be as hard to get. It has not been approved for PA though. J [ ] Re: new drug has anyone heard of a new tnf drug - I beleive this is the way it's spelled. " Humira " I saw some advertising on this last week. Thanks, Jan [see: /message/23905 ] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 7, 2003 Report Share Posted June 7, 2003 > Just this month my > Rhuematologist said that I had " broken thru " the Enbrel and > started me on Humira, which was just approved in January by the > FDA. I have to tell you that it is a " Godawful " shot, painful > as hell. I must say your message floored me, Dolores. I've been on Humira for about four months so far and have never experienced any significant pain at all when giving myself Humira injections. I suggest you have your rheumy or a nurse supervise your next injection to make sure you are doing it correctly. Humira injections are given with a tiny 27 gauge needle, which is close to the smallest diameter needle available. The injections are supposed to be given " subcutaneously " into flab... er, I mean into the fat ;-) underneath the skin of either the stomach or thigh area. I also suggest you review the instructions that come with the syringes. Basically, you're supposed to: 1. Swab the area with an alcohol swab 2. Holding the needle so that it points upwards, depress the plunger on the syringe to expel all of the air from it. 3. Gather up a handful of flab... er, skin, with your free hand, and then holding the syringe like a pencil, insert the half-inch needle at a 45 degree angle into the bunched-up fat. 4. Let go of the bunched up skin you were holding with your free hand. 5. Pull back slightly on the plunger of the syringe to make sure you haven't hit a vein (you shouldn't draw up any blood when you pull back on the syringe - if so, try a different spot). 6. Slowly press in the plunger to inject the Humira. When I first did this under the supervision of my rheumy's nurse, I started to just push in the plunger all the way in one fell swoop but the nurse chastised me saying that I should do it slowly, though I must confess I don't know why(?) The Humira burns slightly going in, but it's trivial compared to the aches and pains that we experience on a daily basis as the result of PA. I've been stuck with so many needles over the years (as I'm sure we all have) that I sometimes feel like a pincushion. For me, the Humira injection isn't any worse than any other needle prick. One tip I have for you is to let the Humira sit outside of the refrigerator for a half-hour or so to come to room temperature before injecting it. Doing so seems to reduce the slight burning sensation that occurs when it's injected cold straight from the refrigerator. I'm not disputing that the Humira injection is painful for you Delores, I guess this is just another example of how we all react differently to things, but I wouldn't want people in general to shy away from Humira out of fear of injecting it because for some (me for example), it isn't painful at all. > He said that I probably wont experience any favorable > results(?) until I have taken it for 3 months. I am now into > my second month and he is telling the truth. I feel worse than > when I was on Enbrel. I am physically exhausted all the time, I > must nap all during the day and especially after meals, and > have had to up my dose of Percoset daily in order to stand the > pain. Has anybody out there had any experiences with Humira > yet or is still too new? When I switched from Remicade to Humira, my improvement continued just as it had with Remicade. Since starting on Remicade, and then switching to Humira about four months ago I haven't had a flare-up or experienced any pain at all, except for pain in my hands when I grip things - but I think that's a result of permanent damage to the joints of my hands rather than to any ongoing inflammation. My SED rate was 20 the last time my doctor checked it. I tend to sleep quite a bit for the first couple of days after my Humira injection, but it's a relaxed sort of feeling (almost as though I'd taken a low dose of Valium or something) instead of the sense of weary exhaustion that I used to experience all the time because of PA. I would have started Enbrel if it had been available when I needed it, but when I decided to switch to a self-injectable biological drug for financial reasons (ie; due to the terms of my health insurance plan, Remicade is significantly more expensive than self-injectable drugs), Humira was available so I selected it because of it's ease of use (smaller needle than Enbrel, pre-filled syringes so there's no mixing, etc). I would recommend Humira to others unequivocally. -- Ron Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 8, 2003 Report Share Posted June 8, 2003 In a message dated 6/7/2003 5:25:01 PM Eastern Daylight Time, aobee2@... writes: > Just this month my Rhuematologist said that I had " broken > thru " the Enbrel and started me on Humira, which was just approved in > January by the FDA. How long were you on the Enbrel before this happened. It seems it worked for me for a few weeks and that was it. Janet Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 8, 2003 Report Share Posted June 8, 2003 I second that!!!! --- doloresstatman <aobee2@...> wrote: started me on Humira, which was > just approved in > January by the FDA. I have to tell you that it is a > " Godawful " shot, > painful as hell. He said that I probably wont > experience any > favorable results(?) until I have taken it for 3 > months. I am now > into my second month and he is telling the truth. I > feel worse than > when I was on Enbrel. I am physically exhausted all > the time, I must > nap all during the day and especially after meals, > and have had to > up my dose of Percoset daily in order to stand the > pain. Has anybody > out there had any experiences with Humira yet or is > still too new? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 5, 2005 Report Share Posted October 5, 2005 Has anyone heard about a new TNF drug being released in about 6 months, I just came off Humira. Jan from Alabama Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 9, 2005 Report Share Posted October 9, 2005 Have you read this report? http://www.hopkins-arthritis.som.jhmi.edu/rheumatoid/tnf.html Although it was last updated within the last month, it doesn't appear to be cutting-edge new to me, but it may have info you haven't seen. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 9, 2005 Report Share Posted October 9, 2005 haven't heard anything, but if i may ask... why did you come off humira? was it not working for you? did it work and then stop working? i just started it and would love to hear your experiences with it... take care, zac > > Has anyone heard about a new TNF drug being released in about 6 months, I just came off Humira. > Jan from Alabama > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 10, 2005 Report Share Posted October 10, 2005 The name of the new TNF factor is Orencia by Merck. I believe it should be released in about 6 months. Jan [Editor's Note: When you reply to a message received via the digest, please delete all of the messages in the digest in your reply. If they aren't deleted, all of the digest messages will be repeated in your reply. It can be really hard for the moderators who are also suffering from PA to have to delete numerous messages a day. Thanks. Kathy F.] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 15, 2006 Report Share Posted March 15, 2006 Public release date: 13-Mar-2006[ Print Article | E-mail Article | Close Window ]Contact: A. Pennejpenne@...713-792-0662University of Texas M. D. Cancer Center Drug that switches on genes improves myelodysplastic syndrome treatment A potent member of a new class of drugs increases survival in some patients with myelodysplastic syndrome (MDS), and may become the new standard of therapy for this group of pre-cancer disorders, say researchers at The University of Texas M. D. Cancer Center who led a national study of the agent. The drug, decitabine, is designed to turn on genes that cancer had switched off, and in this study, patients who were treated with it achieved a significantly higher overall response rate, compared to patients receiving supportive care, which includes transfusions of red blood cells and platelets. Results of the randomized Phase III clinical trial, published March 13, 2006 in the online version of the journal Cancer, also concluded that in treated patients who responded to the drug, the median time to progression of the disease, or death, was 17.5 months, compared to 9.8 months in patients who did not. "This is a very promising drug that we believe works even better when patients use it for a period that is longer than that tested in this trial," says lead author, Hagop Kantarjian, M.D., chair of the Department of Leukemia at M. D. . For example, interim analysis of an ongoing study demonstrated a 40 percent complete response rate when the drug was given in lower doses over a longer period of time, said Kantarjian, who presented these results in December 2005, at the annual meeting of the American Society of Hematology. In contrast, the 83 patients treated with decitabine in this study received comparatively fewer rounds of therapy, and the response rate was 17 percent, he said. "The data suggest to us that prolonged treatment is important for response but the optimal schedule for using decitabine is being studied," said Kantarjian. Still, he says a significant response rate represents "a vast improvement" in the care of these pre-cancers, which are a group of diseases in which the bone marrow progenitor cells that normally morph into red and white blood cells and platelets, fail to respond to normal growth controls. That results in too many progenitor cells (also known as blasts) and too few mature blood cells, and in about 30 percent of patients, the disease progresses to acute myeloid leukemia (AML). About three-fourths of MDS patients succumb to either MDS or to AML within about 2-3 years from diagnosis. MDS is difficult to treat, especially since it usually strikes the elderly. Ten years ago, there was little to offer patients other than blood transfusions and supportive care, Kantarjian says, and newer treatments, which include the use of stem cell transplants, are not for every patient. Decitabine is a "biological disease modifier" that was given fast-track approval by the Food and Drug Administration in April 2003. It is a DNA hypomethylating agent that fights cancer by reversing a chemical process (methylation) that turns off tumor-suppressor genes that protect cells from becoming cancerous. Methylation is the gradual addition of chemical units known as methyl groups to genes, and as these groups accumulate, the gene gradually shuts down. Decitabine prevents the methylation process, enabling the gene to become active again. In addition to increased survival and time-to-progression in some patients, decitabine improved quality of life in patients who responded and eliminated the need for frequent transfusions, Kantarjian said. ### Other institutions that participated in the study were The University of Rochester Medical Center, Washington University School of Medicine, Memorial Sloan-Kettering Cancer Center, Roswell Park Cancer Institute, Duke University Medical Center, University of Illinois, Southwest Regional Cancer Center, Rush Medical Center, and H. Lee Moffitt Cancer Center. The study was funded by Supergen Inc., which developed decitabine. [ Print Article | E-mail Article | Close Window ] Quote Link to comment Share on other sites More sharing options...
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