Re: MTX - Oral vs. Injection

October 30, 1999

Thanks patty..

Im currently taking mtx. by mouth. I was curious about

the difference. I have an appt. at the beginning of

nov. and will discuss this with my rheumy.

Thanks

--- PHDRWD@... wrote:

> What is the difference between mtx. by mouth and

> injecting mtx.? I'm

> confused..

> >>

>

> Same medication, different route of entry to the

> body. In my very limited

> experience, the side effects that occur after

> injecting MTX are less than

> those experienced when taking the pills. Taking MTX

> by injection obviously

> allows you to bypass the stomach. etc. so

> theoretically and hopefully in

> practice the incidence of gastrointestinal side

> effects is reduced. In my

> experience, as my dosage went up, the side effects I

> experienced did too, so

> my doc suggested I change from oral MTX to

> injectable MTX.

>

> Also, I have read the medication is more effective

> in most patients as an

> injection, as the med is absorbed directly into the

> body, rather than having

> to pass through the digestive system. Again,

> theoretically, if a specific

> dose is more effective when injected than when

> orally ingested, the patient

> would need a smaller dosage via injection to get the

> same efficacy as through

> the oral meds.

>

> Hope this helps - Patty

>

------------------------------------------------------------------------

> Please visit our new web page at:

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>

<HR>

<html>

>

October 31, 1999

Hi all --

I have been on record about my experience w/ MTX

before but the recent threads have encouraged me to

reiterate:

1. I think MTX has done more for me that any other

single drug on the market, including Enbrel. My

sausage digits are gone and my overall pain is greatly

reduced.

2. I prefer the injected form to the oral. The oral

dosage gave me stomach upset, though that was reduced

after a short haitus from the medication. The stomach

trouble disappeared completly when I went to the

injectible form. I inject subcutaneously according to

my doctors explicit instructions and the injections

themselves have become routine and uneventful.

3. I experience no side effects from the injected

methotrexate -- I have no hair loss or thinning. I am

injecting the maximum dosage.

Of course this all is going to vary from person to

person, but these are my experiences with the drug.

=====

, NJ Highlands

raharris@...

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