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ALA pipeline

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My husband had the following questions:

I preface this inquiry by saying that I am not challenging the efficacy

of chelation, I am sinmply interested in educating myself in more detail

about the mechanism.

From what I have been reading, it appears that chelation doses taken

less frequently than once per 3-4 hours are ineffective and

destructive. I find it very interesting that if you do not chelate for

at least a few half-lives, that nothing significant occurs. This

implies to me that some sort of pharmacokinetic pipeline is started,

which, if aborted, results in a significant amount of freed, unchelated

Hg left in the blood, whch then settles elsewhere.

If this is close to the case, can you tell me how the ALA frees Hg, but

does not grab and hold on to it?

Is it also the case then that tapering the dose at the end of the

recommended session would be warranted to reduce this effect?

What problem occurs in the case of, say, a one-a-day dose of ALA?

Is it true that if there is no recent poisoning, that the DMSA is

completely redundant, or, is the combination still useful 9 months after

amalgam removal?

Thanks,

(and Jim) in MD

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