New LDN article, New LDN book!

[Guest guest]

Hello everyone,

You will want to read this new article on LDN. It includes exciting

information recently gathered from some of the leading LDN

researchers, including Dr. Ian Zagon at Penn State, Dr. Jarred

Younger at Stanford, Dr. Yash Agrawal at Cornell, and many more.

Benefits of Low Dose Naltrexone - Immunomodulatory and Biochemical

Effects of LDN

http://autoimmunedisease.suite101.com/article.cfm/benefits_of_low_dose

_naltrexone

All of what we learned will be in the upcoming LDN book Elaine

invited me to co-author with her, to be published by McFarland in

September 2008. I am honored to be involved in this project. It took

an expert like Elaine with a broad breadth of medical knowledge to do

justice to this humble little pill, which holds solid promise of

relief from so many serious diseases.

Elaine's established reputation as a medical author on autoimmunity

guarantees this book will be on the shelf of every medical reference

library. Now you can present your doctor with a reference from a

respected author and publisher, a handy reference covering every

paper written, every clinical trial, on LDN and Opioid Growth Factor.

The book has chapters on all conditions being researched: Autism,

Cancer, Autoimmune Diseases, Multiple Sclerosis, Neurodegeneration,

HIV/AIDS, Wound Healing, and Infections.

For anyone with an autoimmune disease, you should check out her

medical reference books that span several different conditions, from

autoimmune diseases to Alzheimer's. These references can help you to

become a patient-expert on your illness. See

http://www.elainemoore.net/

SammyJo

http://LDNers.org

[Guest guest]

Hi SammyJo,Congratulations your upcoming LDN book!The article is very interesting. However, I would take exception to the following statement:"Low Dose Naltrexone (LDN) refer to doses of Naltrexone ranging from 1 to 10 mg daily."It is my understanding that the optimal dose of LDN is 4.5 mg. Doses lower than 4.5 mg are sometimes used for children, underweight adults, and to minimize side effects. Unless a person is grossly overweight, doses higher that 4.5 mg are considered counterproductive (unless given for very short periods to help counteract MS exacerbations, and that practice is currently controversial).I hope your and Elaine's book will be a more accurate reflection of LDN's dosing recommendations than her article.Sincerely,Dudley Delany

dudley_delanyFrom: redtruck99

Sent: Tuesday, March 4, 2008 1:12 AM

low dose naltrexone

Subject: [low dose naltrexone] New LDN article, New LDN book!

Hello everyone,

You will want to read this new article on LDN. It includes exciting

information recently gathered from some of the leading LDN

researchers, including Dr. Ian Zagon at Penn State, Dr. Jarred

Younger at Stanford, Dr. Yash Agrawal at Cornell, and many more.

Benefits of Low Dose Naltrexone - Immunomodulatory and Biochemical

Effects of LDN

http://autoimmunedisease.suite101.com/article.cfm/benefits_of_low_dose

_naltrexone

All of what we learned will be in the upcoming LDN book Elaine

invited me to co-author with her, to be published by McFarland in

September 2008. I am honored to be involved in this project. It took

an expert like Elaine with a broad breadth of medical knowledge to do

justice to this humble little pill, which holds solid promise of

relief from so many serious diseases.

Elaine's established reputation as a medical author on autoimmunity

guarantees this book will be on the shelf of every medical reference

library. Now you can present your doctor with a reference from a

respected author and publisher, a handy reference covering every

paper written, every clinical trial, on LDN and Opioid Growth Factor.

The book has chapters on all conditions being researched: Autism,

Cancer, Autoimmune Diseases, Multiple Sclerosis, Neurodegeneration,

HIV/AIDS, Wound Healing, and Infections.

For anyone with an autoimmune disease, you should check out her

medical reference books that span several different conditions, from

autoimmune diseases to Alzheimer's. These references can help you to

become a patient-expert on your illness. See

http://www.elainemoore.net/

SammyJo

http://LDNers.org

[Guest guest]

Thanks Dudley!

What we did in the book is just report the facts, from the

scientists, and from patient self-experience. I've been following

this board and many others since 2003, so I think I covered the

patient part pretty well.

The article was a short synopsis of some of the info in the book. In

the book we cover all the protocols. The dose range 0f 1-10mg is

based on the formula of 4.5 mg per 60 kg that Dr. Zagon came up with

during his first mouse studies back in the 80's. Dr. Bihari spoke

with him and then tried this dose himself and for patients, but he

didn't find a need to vary it by weight. In the book we state that at

this point, until trials are done specifically on dosage, go with the

vast patient experience that says 4.5 at bed time is best, and don't

vary dose or time unless the sleep disturbance and stiffness is too

great.

And we can't ignore Penn State's research, they have had very

successful human trials for major stuff like pancreatic cancer and

Crohn's with daytime dosing.

The German MS study was only 10 days long, on inpatient progressive

MS, so there are other factors to consider in the low response rate

in addition to time of day. Dr. Mir is looking forward to the

upcoming MS trial results, because he knows it has good effects, and

in fact is still prescribing it to his patients.

For a good peak at how many days to response, see slide 11 in Dr.

Skip's excellent study (207 MS randomized from 7800 LDN

prescriptions) http://ldninfo.org/_conf2005/S_Lenz.pdf

We felt it important to cover all the research, all the protocols,

because this book is going to be read by researchers considering new

trials, and they need to weed through what has been done already.

But here's a proposal for you and everyone on the board. How about we

design our own " ideal " LDN trial? We could publish it on our sites,

and it would provide some valuable input for researchers. I'll send

more on this after I locate a few example protocols.

SammyJo

LDNers.org

>

> Hi SammyJo,

>

> Congratulations your upcoming LDN book!

>

> The article is very interesting. However, I would take exception to

the following statement:

>

> " Low Dose Naltrexone (LDN) refer to doses of Naltrexone ranging

from 1 to 10 mg daily. "

>

> It is my understanding that the optimal dose of LDN is 4.5 mg.

Doses lower than 4.5 mg are sometimes used for children, underweight

adults, and to minimize side effects. Unless a person is grossly

overweight, doses higher that 4.5 mg are considered counterproductive

(unless given for very short periods to help counteract MS

exacerbations, and that practice is currently controversial).

>

> I hope your and Elaine's book will be a more accurate reflection of

LDN's dosing recommendations than her article.

>

> Sincerely,

>

> Dudley Delany

>

> dudley_delany

>

>

> [low dose naltrexone] New LDN article, New LDN book!

>

> Hello everyone,

> You will want to read this new article on LDN. It includes exciting

> information recently gathered from some of the leading LDN

> researchers, including Dr. Ian Zagon at Penn State, Dr. Jarred

> Younger at Stanford, Dr. Yash Agrawal at Cornell, and many more.

>

> Benefits of Low Dose Naltrexone - Immunomodulatory and Biochemical

> Effects of LDN

>

http://autoimmunedisease.suite101.com/article.cfm/benefits_of_low_dose

> _naltrexone

>

> All of what we learned will be in the upcoming LDN book Elaine

> invited me to co-author with her, to be published by McFarland in

> September 2008. I am honored to be involved in this project. It

took

> an expert like Elaine with a broad breadth of medical knowledge to

do

> justice to this humble little pill, which holds solid promise of

> relief from so many serious diseases.

>

> Elaine's established reputation as a medical author on autoimmunity

> guarantees this book will be on the shelf of every medical

reference

> library. Now you can present your doctor with a reference from a

> respected author and publisher, a handy reference covering every

> paper written, every clinical trial, on LDN and Opioid Growth

Factor.

> The book has chapters on all conditions being researched: Autism,

> Cancer, Autoimmune Diseases, Multiple Sclerosis, Neurodegeneration,

> HIV/AIDS, Wound Healing, and Infections.

>

> For anyone with an autoimmune disease, you should check out her

> medical reference books that span several different conditions,

from

> autoimmune diseases to Alzheimer's. These references can help you

to

> become a patient-expert on your illness. See

> http://www.elainemoore.net/

>

> SammyJo

> http://LDNers.org

>

[Guest guest]

Hi SammyJo

Your trial suggestion is intriguing -- I've kinda' constructed on my

own trial approach to my LDN adventure, however I think having a

documented / structured approach available to LDN folks at-large will

provide a lot more constructive information --- especially for the new

folk.

I'll look forward to any more information you think of...or if I can

help please let me know.

Best wishes...

Jann

[Guest guest]

SammyJo,

For designing your study, on the MS part, can you include a segment for those that have followed their MRI's.?

Thanks

Aletha

[low dose naltrexone] New LDN article, New LDN book!> > Hello everyone,> You will want to read this new article on LDN. It includes exciting > information recently gathered from some of the leading LDN > researchers, including Dr. Ian Zagon at Penn State, Dr. Jarred > Younger at Stanford, Dr. Yash Agrawal at Cornell, and many more.> > Benefits of Low Dose Naltrexone - Immunomodulatory and Biochemical > Effects of LDN> http://autoimmunedisease.suite101.com/article.cfm/benefits_of_low_dose> _naltrexone> > All of what we learned will be in the upcoming LDN book Elaine > invited me to co-author with her, to be published by McFarland in > September 2008. I am honored to be involved in this project. It took > an expert like Elaine with a broad breadth of medical knowledge to do > justice to this humble little pill, which holds solid promise of > relief from so many serious diseases. > > Elaine's established reputation as a medical author on autoimmunity > guarantees this book will be on the shelf of every medical reference > library. Now you can present your doctor with a reference from a > respected author and publisher, a handy reference covering every > paper written, every clinical trial, on LDN and Opioid Growth Factor. > The book has chapters on all conditions being researched: Autism, > Cancer, Autoimmune Diseases, Multiple Sclerosis, Neurodegeneration, > HIV/AIDS, Wound Healing, and Infections. > > For anyone with an autoimmune disease, you should check out her > medical reference books that span several different conditions, from > autoimmune diseases to Alzheimer's. These references can help you to > become a patient-expert on your illness. See > http://www.elainemoore.net/> > SammyJo> http://LDNers.org>

[Guest guest]

Where could I get this book?

Thanks

Celia

What we did in the book is just report the facts, from the scientists, and from patient self-experience. I've been following this board and many others since 2003, so I think I covered the patient part pretty well.

[Guest guest]

I'm sorry, I should have repeated that the LDN book won't be in print

until Sept. 2008.

However, many of the research reports referenced in the book are at

http://ldners.org/research.htm

And here is the article under discussion, and several other's on LDN

by my co-author, Elaine :

Low Dose Naltrexone Update

http://autoimmunedisease.suite101.com/article.cfm/low_dose_naltrexone_

update

The Use of LDN for MS, Crohn's, and Other Autoimmune Diseases

http://autoimmunedisease.suite101.com/article.cfm/low_dose_naltrexone

SammyJo

>

> Where could I get this book?

> Thanks

> Celia

>

>

> What we did in the book is just report the facts, from the

> scientists, and from patient self-experience. I've been following

> this board and many others since 2003, so I think I covered the

> patient part pretty well.

>

[Guest guest]

Sammy Jo,

Thanks for the reply, are you going to discuss LDN for cancer in the book? Put me down for a couple of copies..... I bought my GP and onco a copy of Up The Creek with a Paddle....... have to keep them informed, they are watching me like a hawk!!:-)))

Thanks

Celia

[Guest guest]

> The book has chapters on all conditions being researched: Autism,

> Cancer, Autoimmune Diseases, Multiple Sclerosis, Neurodegeneration,

> HIV/AIDS, Wound Healing, and Infections.

Someone I know may have a diagnosis of adrenoleukodystrophy, a neurodegenerative

disorder. This person is a female who also may have M.S., but will not know

until a

neurologist in NYC evaluates her.

Question: IF this person does not have M.S., but DOES have ADL, would LDN be at

all

helpful since ADL is considered to be an X-linked inherited metabolic disorder,

not an

autoimmune disorder.

The movie, Lorenzo's Oil, is about a boy with ADL. It is more severe in males,

since it is

X-linked. And in females it is less severe since they have two X chromosomes.

Does anyone know of a female who has this rare genetic disorder who is taking

LDN and

has found it to be helpful?

Thanks.

Quick

>

> Hello everyone,

> You will want to read this new article on LDN. It includes exciting

> information recently gathered from some of the leading LDN

> researchers, including Dr. Ian Zagon at Penn State, Dr. Jarred

> Younger at Stanford, Dr. Yash Agrawal at Cornell, and many more.

>

> Benefits of Low Dose Naltrexone - Immunomodulatory and Biochemical

> Effects of LDN

> http://autoimmunedisease.suite101.com/article.cfm/benefits_of_low_dose

> _naltrexone

>

> All of what we learned will be in the upcoming LDN book Elaine

> invited me to co-author with her, to be published by McFarland in

> September 2008. I am honored to be involved in this project. It took

> an expert like Elaine with a broad breadth of medical knowledge to do

> justice to this humble little pill, which holds solid promise of

> relief from so many serious diseases.

>

> Elaine's established reputation as a medical author on autoimmunity

> guarantees this book will be on the shelf of every medical reference

> library. Now you can present your doctor with a reference from a

> respected author and publisher, a handy reference covering every

> paper written, every clinical trial, on LDN and Opioid Growth Factor.

> The book has chapters on all conditions being researched: Autism,

> Cancer, Autoimmune Diseases, Multiple Sclerosis, Neurodegeneration,

> HIV/AIDS, Wound Healing, and Infections.

>

> For anyone with an autoimmune disease, you should check out her

> medical reference books that span several different conditions, from

> autoimmune diseases to Alzheimer's. These references can help you to

> become a patient-expert on your illness. See

> http://www.elainemoore.net/

>

> SammyJo

> http://LDNers.org

>