Re: Re: Porphyrins results, below range?

[Guest guest]

Regarding your original email:

Porphyrins testing produces invalid results very frequently. Here is an email

I wrote a few months ago regarding Porphyrins testing:

One way to determine mercury toxicity is to take a " Porphyrins,

Quantitative, Random Urine " test. In fact, this may be the most

accurate way to measure mercury burden in our bodies.

The problem is GETTING INVALID TEST RESULTS due to poor preperation

and/or handling. GETTING INVALID TEST RESULTS SEEMS TO BE A

CONSTANT PROBLEM!

Here is what I learned from a chemist:

SPECIFICALLY, the problems of GETTING INVALID TEST RESULTS are from:

1. NOT using a preservative (sodium carbonate and sometimes EDTA)

2. shaking it (to mix the sample)

3. exposing it to light

4. letting it warm to room temperature.

So how do you get a VALID test result?

1. Use a preservative! Educate your local Labcorp about their own

collection policies. Give your local labcorp a copy of this page

from Labcorp's own website:

http://www.labcorp.com/datasets/labcorp/html/chapter/mono/nf10003070.htm

Specifically, the page states, to use " 5 g/L sodium carbonate " as a

preservative. The preservative has to be in the container prior to

putting the urine in it! Highlight this and keep reminding the

local lab on how to handle the specimen.

If the lab is too lazy to learn anything new (very likely) just buy some

sodium carbonate (pretty cheap) and add it to the container before putting

sample in it. That is what I am doing ans so far, so good. Here is a place you

can buy it:

http://www.sciencestuff.com/prod/Chem-Rgnts/C2550

2. After collecting, try to minimize specimen shaking. However,

the preservative should minimize effects of shaking.

3. Don't expose specimen to light! According to labcorp's webpage:

" Use amber plastic urine cup and amber-top; order (LabCorp ID

20656). (If amber cups are unavailable, cover plastic container

completely, top and bottom, with aluminum foil. Identify specimen

with patient name directly on the container and on the outside of

the aluminum foil. Secure with tape.) " Again, educate your local

Labcorp about their own collection policies. Give your local

labcorp a copy Labcorp's collection policy from its own website.

Note that the preservative should minimize effects of light.

4. If not delivering specimen immediatley, put in refrigerator. Do

not let specimen warm to room temperature. Keep specimen cool

before delivering -- use ice packs, children's thermal carrying case

or some way to keep cool. Note that the preservative should

minimize effects of letting specimen warm to room temperature.

**********************************************

I hope this helps. Good luck.

arosenbl0 <arosenbl0@...> wrote:

Yeah I read that. I followed their directions. They give you a

" vaccutube " which is wrapped in foil and I filled it from a plastic

cup in a dark room, then wrapped it and fedexed it overnight to them.

They said once its in the tube with the preservative it should be OK.

However, they didn't get back to me about the results for like 1.5

months, and are offering to do a retest for free so maybe the sample

got lost or something. I guess I'll see what the second one says...

thanks

A

> > >

> > > Hey all,

> > >

> > > I got my porphyrins test back from the lab in france.

> Interestingly

> > > enough, my porphyrins values are below the ref range. They

> > > interpreted the test as " negative " for toxicity. I am wondering

> if

> > > there is something wrong since they all seem too low. Is that

> > > possible? Is this suspect for a false negative? Since metametrix

> > > doesn't do this anymore, is there another reputable lab that I

> can

> > use

> > > to confirm this? Is the quest one OK? thanks

> > >

> > > A

> > >

> > >

> > > Uroporphyrins I & III (UP) 5 ref. range: 7 - 14

> > > Heptacarboxy porphyrins (7cxP) 1,4 ref. range: 1,5 - 3,5

> > > Hexacarboxy porphyrins (6cxP) 0,1 ref. range: 0,4 - 0,8

> > > Pentacarboxy porphyrins (5cxP) 0,3 ref. range: 1,0 - 2,9

> > > Precoproporphyrin (prCP) 0,6 ref. range: 2 - 5

> > > Coproporphyrins I & III (cP) 17 ref. range: 50 - 90

> > >

> > > urinary creatinine 2021 mg/l

> > >

> > > PrCP/UP ratio : 0,12 range 0,2-0,5

> > > PrCP/CP ratio 4% range 4-8

> > > UP/CP ratio 0,29 range 0,14-0,1

> > >

> >

>

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