[enzymes]/was: Re: Methyl B-12 chewables?

[Guest guest]

Hi :

Thanks for the article. May I have permission to forward this article?

Re: Methyl B-12 chewables?

> Here is the article I saw (I read it in print, but it is at this

> link). Then I pull up the actual abstract which follows. .

>

> http://www.foodconsumer.org/777/8/High-

> dose_oral_vitamin_B12_as_effective_as_shots_and_cheaper_study_finds.sh

> tml

>

>

> ===== The actual abstract

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> 1: Cochrane Database Syst Rev. 2005 Jul 20;(3):CD004655. Related

> Articles, Links

>

>

> Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12

> deficiency.

>

> Vidal-Alaball J, CC, Cannings- R, Goringe A, Hood K,

> McCaddon A, McDowell I, Papaioannou A.

>

> National Public Health Service for Wales, 36 Orchard Street, Swansea,

> Wales, UK, SA1 5AQ. p.Vidal-Alaball@...

>

> BACKGROUND: Vitamin B12 deficiency is common and rises with age. Most

> people with vitamin B12 deficiency are treated in primary care with

> intramuscular vitamin B12 which is a considerable source of work for

> health care professionals. Several case control and case series

> studies have reported equal efficacy of oral administration of

> vitamin B12 but it is rarely prescribed in this form, other than in

> Sweden and Canada. Doctors may not be prescribing oral formulations

> because they are unaware of this option or have concerns regarding

> effectiveness. OBJECTIVES: To assess the effectiveness of oral

> vitamin B12 versus intramuscular vitamin B12 for vitamin B12

> deficiency. SEARCH STRATEGY: Searches were undertaken of The Cochrane

> Library, MEDLINE, EMBASE and Lilacs in early 2005. The bibliographies

> of all relevant papers identified using this strategy were searched.

> In addition we contacted authors of relevant identified studies and

> Vitamin B12 research and pharmaceutical companies to enquire about

> other published or unpublished studies and ongoing trials. SELECTION

> CRITERIA: Randomised controlled trials (RCTs) examining the use of

> oral or intramuscular vitamin B12 to treat vitamin B12 deficiency.

> DATA COLLECTION AND ANALYSIS: All abstracts or titles identified by

> the electronic searches were independently scrutinised by two

> reviewers. When a difference between reviewers arose, we obtained and

> reviewed a hard copy of the papers and made decisions by consensus.

> We obtained a copy of all pre-selected papers and two researchers

> independently extracted the data from these studies using piloted

> data extraction forms. The whole group checked whether inclusion and

> exclusion criteria were met, and disagreement was decided by

> consensus. The methodological quality of the included studies was

> independently assessed by two researchers and disagreements were

> brought back to the whole group and resolved by consensus. MAIN

> RESULTS: Two RCT's comparing oral with intramuscular administration

> of vitamin B12 met our inclusion criteria. The trials recruited a

> total of 108 participants and followed up 93 of these from 90 days to

> four months. High oral doses of B12 (1000 mcg and 2000 mcg) were as

> effective as intramuscular administration in achieving haematological

> and neurological responses. AUTHORS' CONCLUSIONS: The evidence

> derived from these limited studies suggests that 2000 mcg doses of

> oral vitamin B12 daily and 1000 mcg doses initially daily and

> thereafter weekly and then monthly may be as effective as

> intramuscular administration in obtaining short term haematological

> and neurological responses in vitamin B12 deficient patients.

>

> Publication Types:

> Review

>

> PMID: 16034940 [PubMed - in process]

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[Guest guest]

Okay with me. It's located on several sites on the internet, in case

you need it again. The abstract is from Pubmed. .

>>> Thanks for the article. May I have permission to forward this

article?