Re: Porphyrins Urine Test for detection of toxic metals Poisoning

[Guest guest]

,

My son has had the porphyrins run thru Lab Corp

3 times. First time, all levels were low and the coproporphyrin was actually

below the reference range.

Once we started chelation, the hepta and hexacarboxylporphyrins shot up to 2x

the reference range, but the rest stayed well below normal. What would you make

of that? I have yet to find anyone who can tell me what the hepta and hexa

elevation means. Is it a reaction to the chelation?

BTW, my son does display most of the other lab markers you listed as

signs of toxicity. (high IgE, low CD8, very low NKs, high 3-methylhistidine).

We have done only 4 rounds of chelation, no sign of mercury, not even a trace-

just nickel and a bit of lead. Low mercury on hair, urine , and blood. I'm

getting ready to send in one of his baby teeth to be analyzed. All the clinical

signs of toxicity, but no mercury in sight. (we've done 24 hr urines with each

round.)

Becky

[Guest guest]

NOTE: The following opinion is not intended to substitute for

medical advice. Therefore, all parties reading this opinion are

advised to seek advice from a qualified, licensed, health

practitioner.

While a properly performed Porphyrin urin test may not be the

perfect aurgument supporting metals poisoning if levels are high, it

may possibly be the best, scientific, supporting aurgument against

metals poisoning if your levels are normal, and/or below normal,

especially, when combined with hair analysis as a supporting factor.

Therefore, had I been you, and my son's Porphyrin tests came back

negative and hair analysis supported that finding, then I would not

have proceeded with chelation therapy until further evaluation took

place as there is no justification in proceeding in opposition to

preliminary findings.

Many forget that all metals are present in the earth and enter our

bodies naturally at low levels therefore, it is only normal for all

of us to have a presence of metals within. It is the accumulation of

metals at higher than normal levels in our bodies, due to the

ignorance of mankind, which many believe results in disease/illness.

Therefore, regarding your son's chelation therapy, I believe that it

is entirely possible that chelation could effect the Porphyrin test

results even if he has normal levels of metals. Furthermore, it is

not advisable to proceed with chelation therapy, unless diagnoses

warrants such therapy, as chelation can deplete the body of much

needed minerals upsetting natual body chemistry thereby, encouraging

onset of illness of which, potential for problems is magnified with

younger patients.

While I believe that toxic levels of metals play a role in the

increase in illness/disease in our society, let us not forget there

are many other culprets that play a more significant role in

illness/disease such as sugar, salt, caffine, cows milk, city water,

flouride, the numerous preservatives and chemicals in our everday

lives, etc., etc., etc.

Furtheremore, let us not forget that symptoms of various different

illness can, and often do, overlap. Thus, what one initially

believes to be the problem may very well turn out to be something

entirely different which is why comprehensive evaluation and

resulting diagnosis is advised before beginning treatment as one can

do more harm than good by proceeding down the wrong path.

In conclusion, if your son's Porphyrin and hair tests were negative

then, I would be more apt to believe that the other markers that are

out of balance may be a result of another problem and not metals

poisoning. I would step back, take a deap breath, and not get in a

hurry. Then, I would disconnect the microwave and put him on a whole

foods diet with many fresh juices cutting out all sweets, caffine,

salt, cows milk, city water, etc., etc. Also, be sure to not buy any

products in plastic containers or let him eat or drink from any

plastic ware. Also, buy him an all-natural mattress/pillow and

replace your carpet with hard flooring as the poison fumes we inhale

from the synthetic material in our own homes is off the chart. Also,

if he has the proper diet, he does not need supplementation as he

will be getting his vitamins and minerals from the natural whole

foods source which is always better than supplements. Then after you

have done everything in your power to ensure an all-natural

environment and an all-natural diet, after 90-days, I would order

comprehensive blood work to establish a baseline and begin

evaluation once again. Once an all-natural baseline, without

influence, has been established it is much easier to make a proper

diagnoses and recommend appropriate treatment.

Once one has done everything in their power to live a whole foods,

environmental friendly life and problems still persist in lieu of

normal test results, then one must also consider genetics may play a

role while not giving up hope in finding an answer.

I wish you the best in your search for answers. If I can be of

further help do not hesistate to ask.

>

> ,

>

> My son has had the porphyrins run thru Lab Corp

> 3 times. First time, all levels were low and the coproporphyrin

was actually below the reference range.

> Once we started chelation, the hepta and hexacarboxylporphyrins

shot up to 2x the reference range, but the rest stayed well below

normal. What would you make of that? I have yet to find anyone who

can tell me what the hepta and hexa elevation means. Is it a

reaction to the chelation?

>

> BTW, my son does display most of the other lab markers

you listed as signs of toxicity. (high IgE, low CD8, very low NKs,

high 3-methylhistidine). We have done only 4 rounds of chelation,

no sign of mercury, not even a trace- just nickel and a bit of

lead. Low mercury on hair, urine , and blood. I'm getting ready to

send in one of his baby teeth to be analyzed. All the clinical

signs of toxicity, but no mercury in sight. (we've done 24 hr urines

with each round.)

>

> Becky

>

>

>

>

[Guest guest]

I think I can add two things to this, first, mercury on hair tests are lower

with kids on the spectrum. And, it is not uncommon NOT to get mercury pulls

early on in chelation.

The only way the hair test could support that mercury was not in the body would

be lots of it showing up in the hair, not an absence.

[ ] Re: Porphyrins Urine Test for detection of toxic

metals Poisoning

NOTE: The following opinion is not intended to substitute for

medical advice. Therefore, all parties reading this opinion are

advised to seek advice from a qualified, licensed, health

practitioner.

While a properly performed Porphyrin urin test may not be the

perfect aurgument supporting metals poisoning if levels are high, it

may possibly be the best, scientific, supporting aurgument against

metals poisoning if your levels are normal, and/or below normal,

especially, when combined with hair analysis as a supporting factor.

Therefore, had I been you, and my son's Porphyrin tests came back

negative and hair analysis supported that finding, then I would not

have proceeded with chelation therapy until further evaluation took

place as there is no justification in proceeding in opposition to

preliminary findings.

Many forget that all metals are present in the earth and enter our

bodies naturally at low levels therefore, it is only normal for all

of us to have a presence of metals within. It is the accumulation of

metals at higher than normal levels in our bodies, due to the

ignorance of mankind, which many believe results in disease/illness.

Therefore, regarding your son's chelation therapy, I believe that it

is entirely possible that chelation could effect the Porphyrin test

results even if he has normal levels of metals. Furthermore, it is

not advisable to proceed with chelation therapy, unless diagnoses

warrants such therapy, as chelation can deplete the body of much

needed minerals upsetting natual body chemistry thereby, encouraging

onset of illness of which, potential for problems is magnified with

younger patients.

While I believe that toxic levels of metals play a role in the

increase in illness/disease in our society, let us not forget there

are many other culprets that play a more significant role in

illness/disease such as sugar, salt, caffine, cows milk, city water,

flouride, the numerous preservatives and chemicals in our everday

lives, etc., etc., etc.

Furtheremore, let us not forget that symptoms of various different

illness can, and often do, overlap. Thus, what one initially

believes to be the problem may very well turn out to be something

entirely different which is why comprehensive evaluation and

resulting diagnosis is advised before beginning treatment as one can

do more harm than good by proceeding down the wrong path.

In conclusion, if your son's Porphyrin and hair tests were negative

then, I would be more apt to believe that the other markers that are

out of balance may be a result of another problem and not metals

poisoning. I would step back, take a deap breath, and not get in a

hurry. Then, I would disconnect the microwave and put him on a whole

foods diet with many fresh juices cutting out all sweets, caffine,

salt, cows milk, city water, etc., etc. Also, be sure to not buy any

products in plastic containers or let him eat or drink from any

plastic ware. Also, buy him an all-natural mattress/pillow and

replace your carpet with hard flooring as the poison fumes we inhale

from the synthetic material in our own homes is off the chart. Also,

if he has the proper diet, he does not need supplementation as he

will be getting his vitamins and minerals from the natural whole

foods source which is always better than supplements. Then after you

have done everything in your power to ensure an all-natural

environment and an all-natural diet, after 90-days, I would order

comprehensive blood work to establish a baseline and begin

evaluation once again. Once an all-natural baseline, without

influence, has been established it is much easier to make a proper

diagnoses and recommend appropriate treatment.

Once one has done everything in their power to live a whole foods,

environmental friendly life and problems still persist in lieu of

normal test results, then one must also consider genetics may play a

role while not giving up hope in finding an answer.

I wish you the best in your search for answers. If I can be of

further help do not hesistate to ask.

>

> ,

>

> My son has had the porphyrins run thru Lab Corp

> 3 times. First time, all levels were low and the coproporphyrin

was actually below the reference range.

> Once we started chelation, the hepta and hexacarboxylporphyrins

shot up to 2x the reference range, but the rest stayed well below

normal. What would you make of that? I have yet to find anyone who

can tell me what the hepta and hexa elevation means. Is it a

reaction to the chelation?

>

> BTW, my son does display most of the other lab markers

you listed as signs of toxicity. (high IgE, low CD8, very low NKs,

high 3-methylhistidine). We have done only 4 rounds of chelation,

no sign of mercury, not even a trace- just nickel and a bit of

lead. Low mercury on hair, urine , and blood. I'm getting ready to

send in one of his baby teeth to be analyzed. All the clinical

signs of toxicity, but no mercury in sight. (we've done 24 hr urines

with each round.)

>

> Becky

>

>

>

>

[Guest guest]

> The only way the hair test could support that mercury was not in the

body would be lots of it showing up in the hair, not an absence.

Well, lots of it in the hair would mean lots of it in the body, but at

least being excreted. I think there's a subgroup of ASD kids who do

have high hair Hg -- maybe Lyn Redwood's son? -- so even though they

could excrete it, the exposure was high enough to cause problems anyway.

Nell

[Guest guest]

The chelating agent actually encircles a mineral or metal ion and

carries it from the body via the urine and feces thus, elevations in

urine and feces results post chelation are expected with an

elevation in hair less likely to occur.

Also, I believe that the poster was referring to hair analysis

results pre-chelation however, I could be wrong. Either way, I'm not

a believer in hair analysis as a stand alone test due to

inconsistancies (mainly due to inadequate labs and not the science)

and only use such to support findings of other more reliable tests

such as the Porphyrin urine test which is why I referenced hair

analysis.

Although I'm a believer in chelation therapy after a proper toxic

metals diganoses has been made, I'm not sold on challeged

urine/stool tests using chelators such as EDTA, DMSA, DMPS to

determine metals poisoning as, IMHO, there is just no credible,

acceptable, baseline from which to judge such tests. In fact, I will

go out on a limb here and say that I believe the main purpose of

these challenged tests using chelators are to scare those who don't

know into therapy they don't need.

" Reference ranges for upper safe limits for metals, including

mercury in urine, are often printed on laboratory report forms with

ranges that apply only to urine collected without first giving a

chelator. Reference ranges printed on such report forms will be much

lower than even the lowest level commonly excreted after a provoked

chelation. The safe upper limit on the report form will thus be

much higher after a chelator. If proper procedures are followed, a

large majority of people tested will be in the nontoxic range. As

heavy metal testing is now reported by laboratories that cater to

chelationists, a deceptively high percentage of patients will appear

to be in the toxic range for some metal or other. "

Sincerely,

References: HEAVY METAL TOXICITY

Aaseth, J., sen, D., Andersen, O., Wickstron, E. Treatment of

mercury and lead poisonings with dimercaptosuccinic acid (DMSA) and

sodium dimmercapto-propanesulfonate (DMPS). Analyst 1995 Mar; 120:

853ff.

AHA. Chelation Therapy. AHA Recommendation 2001 Dec 3. Dallas, TX:

American Heart Association.

Anderton, R.M. ADA Statement on Dental Amalgam 2001 May. Chicago,

IL: American Dental Association.

Anon. Alzheimer's and aluminum: canning the myth. Food Insight Sep-

Oct 1993. Washington, D.C.: International Food Information Council

Foundation.

Anon. Management of the Poisoned/Overdosed Patient. Continuing

Education (No. 430-000-99-026-H01). U.S. Pharmacist 2001. New York:

Jobson.

Anuradha, B., Varalakshmi, P. Protective role of DL-alpha-lipoic

acid against mercury-induced neural lipid peroxidation. Pharmacol.

Res. 1999 Jan; 39(1): 67-80.

Bardin, J.A., Eisen, E.E., Wegman, D.H., Kriebel, D. Woskie, S.R.,

Gore, R.J. Case-Control Studies of Liver, Gallbladder and Pancreatic

Cancer and Metalworking Fluid Exposure in the Automobile Industry.

Paper presented to the 128th Annual Meeting of the American Public

Health Association, November 14, 2000. Washington, D.C.: American

Public Health Association.

Beers, M.H., Berkow, M.D. The Merck Manual of Diagnosis and Therapy.

Section 23. Chapter 307. Poisoning 1999. Whitehouse Station, NJ:

Merck & Co.

Brink, W. Lactoferrin: the bioactive peptide that fights disease.

Life Extension Magazine 2000 Oct; 6(10): 20-6. Ft. Lauderdale, FL:

Life Extension Foundation.

Brown, D.J. Characterizing Risk at Metal Finishing Facilities.

Report EPA/600/R-97/111 May 1998. Washington, D.C.: U.S.

Environmental Protection Agency.

Cai, L., Koropatnick, J., Cherian, M.G. Roles of vitamin C in

radiation-induced DNA damage in presence and absence of copper.

Chem. Biol. Interact. 2001 Jul 31; 137(1): 75-88.

Cha, C.W. A study on the effect of garlic to the heavy metal

poisoning of rat. J. Korean Med. Sci. 1987 Dec; 2(4): 213-24.

Chouchane, S., Snow, E.T. In vitro effect of arsenical compounds on

glutathione-related enzymes. Chem. Res. Toxicol. 2001 May; 14(5):

517-22.

son, T.W. Mercury: an element of mystery. N. Engl. J. Med.

1990; 323: 1137-9.

Clayman, C.B. Ed. The American Medical Association Encyclopedia of

Medicine 1989. New York: Random House.

Cruz, T., Galvez, J. Ocete, M.A., Crespo, M.E., de Medina,

L.-H.F., Zarzuelo, A. Oral administration of rutoside can ameliorate

inflammatory bowel disease in rats. Life Sci. 1998; 62(7): 687-95.

Daggett, E.A., Oberley, T.D., , S.A., , L.S., Kornguth,

S.E., Siegel, F.L. Effects of lead on rat kidney and liver: GST

expression and oxidative stress. Toxicology 1998 Jul 17; 128(3): 191-

206.

De Flora, S., Izzotti, A., D'Agostini, F., Balansky, R.M. Mechanisms

of N-acetylcysteine in the prevention of DNA damage and cancer, with

special reference to smoking-related end-points. Carcinogenesis 2001

Jul; 22(7): 999-1013.

Deschner, E.E., Ruperto, J.F., Wong, G.Y., Newmark, H.L. The effect

of dietary quercetin and rutin on AOM-induced acute colonic

epithelial abnormalities in mice fed a high-fat diet. Nutr. Cancer

1993; 20(3): 199-204.

Dhir, H., Roy, A.K., Sharma, A. Relative efficiency of Phyllanthus

emblica fruit extract and ascorbic acid in modifying lead and

aluminium-induced sister-chromatid exchanges in mouse bone marrow.

Environ. Mol. Mutagen 1993; 21(3): 229-36.

Dhir, H., Roy, A.K., Sharma, A., Talukder, G. Modification of

clastogenicity of lead and aluminium in mouse bone marrow cells by

dietary ingestion of Phyllanthus emblica fruit extract. Mutat. Res.

1990 Jul; 241(3): 305-12.

Dr. ph F. Medical Library. Heavy Metal Poisoning 2001 Nov.

Wassau, WI: Medical Library/Thomson.

Dupler, D. Heavy metal poisoning. Gale Encyclopedia of Alternative

Medicine 2001. Farmington Hills, MI: Gale Group.

Esteves, A.C., Felcman, J. Study of the effect of the administration

of Cd(II), cysteine, methionine, and Cd(II) together with cysteine

or methionine on the conversion of xanthine dehydrogenase into

xanthine oxidase. Biol. Trace Elem. Res. 2000 Jul; 76(1): 19-30.

Ewan, K., Pamphlett, R. Increased inorganic mercury in spinal motor

neurons following chelating agents. Neurotoxicology 1996; 17(2): 343-

9.

FDA. DMPS 1999. Washington, D.C.: Food and Drug Administration

(http://www.fda.gov/cder/fdama/pclist.txt).

Ferner, D.J. Toxicity, heavy metals. eMed. J. 2001 May 25; 2(5): 1.

Fournier, L. , G., Garnier, R. et al. 2,3-Dimercaptosuccinic

acid treatment of heavy metal poisoning in humans. Med. Toxicol.

Adverse Drug Exp. 1988; 3: 499-504.

Galvez, J., Cruz, T., Crespo, E., Ocete, M.A., Lorente, M.D.,

de Medina, F., Zarzuelo, A. Rutoside as mucosal protective

in acetic acid-induced rat colitis. Planta Med. 1997; 63(5): 409-14.

Gebel, T., Dunkelberg, H. Influence of chewing gum consumption and

dental contact of amalgam fillings to different metal restorations

on urine mercury content. Zentralbl. Hyg. Umweltmed. 1996 Nov; 199

(1): 69-75 (in German).

Ghio, A.J., Kennedy, T.P., Crissman, K.M., s, J.H., Hatch,

G.E. Depletion of iron and ascorbate in rodents diminishes lung

injury after silica. Exp. Lung Res. 1998 Mar-Apr; 24(2): 219-32.

Girodon, F. Galan, P. Monget, A.L., Boutron-Ruault, M.C., Brunet-

Lecomte, P., Preziosi, P., Arnaud, J., Manuguerra, J.C., Herchberg,

S. Impact of trace elements and vitamin supplementation on immunity

and infections in institutionalized elderly patients: a randomized

controlled trial. MIN.VIT.AOX. geriatric network. Arch. Intern. Med.

1999 Apr 12; 159(7): 748-54.

Glanze, W.D. Mosby Medical Encyclopedia, Revised Edition 1996. St.

Louis MO: C.V. Mosby.

Goering, P.L., Aposhian, H.V., Mass, M.J., Cebrian, M., Beck, B.D,

Waalkes, M.P. The enigma of arsenic carcinogenesis: role of

metabolism. Toxicol. Sci. 1999 May; 49(1): 5-14.

-Correa, J.A., de la Cruz, J.P., Gordillo, J., Urena, I.,

Redondo, L., de la Cuesta, F. Effects of silymarin MZ-80 on

hepatic oxidative stress in rats with biliary obstruction.

Pharmacology 2002 Jan; 64(1): 18-27.

Goyer, R.A. Toxic effects of metals: mercury. Casarett and Doull's

Toxicology: The Basic Science of Poisons, Fifth Edition 1996. New

York: McGraw-Hill.

Gubrelay, U., Mathur, R., Kannan, G.M., Flora, S.J. Role of S-

adenosyl-L-methionine in potentiating cadmium mobilization by

diethylenetriamine penta acetic acid in mice. Cytobios 2001; 104

(406): 99-105.

Gurer, H., Ozgunes, H., Oztezcan, S., Ercal, N. Antioxidant role of

alpha-lipoic acid in lead toxicity. Free Radic. Biol. Med. 1999 Jul;

27(1-2): 75-81.

Horikoshi, T., Nakajima, A., and Sakaguchi, T. Uptake of uranium by

various cell fractions of Chlorella regularis. Radioisotopes 1979

Aug; 28(8): 485-8.

Huang, K.-C. The Pharmacology of Chinese Herbs 1993. Boca Raton, FL:

CRC Press.

Ichimura, S. Report. General meeting of the Pharmaceutical Society

of Japan, Hokuriku Branch, Toyoma City, Japan, October 27, 1973.

International Occupational Safety and Health Information Centre.

Metals 1999 Sep. Geneva: International Labour Organization.

Isacsson, G., Barregard, L., Selden, A., Bodin, L. Impact of

nocturnal bruxism on mercury uptake from dental amalgams. Eur. J.

Oral Sci. 1997 Jun; 105(3): 251-7.

, D. General Methods for Treating Poisoning 2001. Alberta,

Canada: University of Alberta.

Klein-Schwartz, W., Oderda, G.M. Clinical toxicology. Textbook of

Therapeutics: Drug and Disease Management, 7th Edition 2000, p. 51.

Baltimore, MD: & Wilkins.

Kostyuk, V.A., Potapovich, A.I. Antiradical and chelating effects in

flavoinoid protection against silica-induced cell injury. Arch.

Biochem. Biophys. 1998 Jul 1; 355(1): 43-8.

Kostyuk, V.A., Potapovich, A.I., Speransky, S.D., Maslova, G.T.

Protective effect of nautral flavonoids on rat peritoneal

macrophages injury caused by asbestos fibers. Free Radic. Biol. Med.

1996; 21(4): 487-93.

Leung, F.Y. Trace elements that act as antioxidants in parenteral

micronutrition. Can. J. Nutr. Biochem. 1998; 9(6): 304-7.

Lide, D. CRC Handbook of Chemistry and Physics, 73rd Edition 1992.

Boca Raton, FL: CRC Press.

Lorico, A., Bertola, A., Baum, C., Fodstad, O., Rappa, G. Role of

the Multidrug Resistance Protein 1 in protection from heavy metal

oxyanions: investigations in vitro and in MRP1-deficient mice.

Biochem. Biophys. Res. Commun. 2002 Mar 1; 291(3): 617-22.

Lupton, G., Kao, G., , F. et al. Cutaneous mercury granuloma:

a clinicopathologic study and review of the literature. J. Am. Acad.

Dermatol. 1985; 12: 296-303.

Maiti, S., Chatterjee, A.K. Effects on levels of glutathione and

some related enzymes in tissues after an acute arsenic exposure in

rats and their relationship to dietary protein deficiency. Arch.

Toxicol. 2001 Nov; 75(9): 531-7.

Marcus, S. Toxicity, lead. eMed. J. 2001 Jun 4; 2(6): 7.

Medical Management Guidelines (MMGs). Managing Hazardous Material

Incidents, Volume III 2001. Atlanta, GA: Agency for Toxic Substances

and Disease Registry (http://www.atsdr.cdc.gov).

Micromedex. B.A.L.™ 1999. Greenwood Village, CO: Thomson.

Milchak, L.M., Bricker, J. The effects of glutathione and

vitamin E on iron toxicity in isolated rat hepatocytes. Toxicol.

Lett. 2002 Feb 7; 126(3): 169-77.

Muller, L. Protective effects of DL-alpha-lipoic acid on cadmium-

induced deterioration of rat hepatocytes. Toxicology 1989 Oct 2; 58

(2): 175-85.

Muller, L., Menzel, H. Studies on the efficacy of lipoate and

dihydrolipoate in the alteration of cadmium 2+ toxicity in isolated

hepatocytes. Biochim. Biophys. Acta 1990 May 22; 1052(3): 386-91.

Muller, U., Krieglstein, J. Prolonged pretreatment with alpha-lipoic

acid protects cultured neurons against hypoxic, glutamate-, or iron-

induced injury. J. Cereb. Blood Flow Metab. 1995 Jul; 15(4): 624-30.

National Medical Library. Poisoning first aid. Medical Encyclopedia

2001. Bethesda, MD: National Institutes of Health.

O'Brien, J. Mercury amalgam toxicity. Life Extension Magazine 2001

May. 7(5): 43-51. Ft. Lauderdale, FL: Life Extension Foundation.

Omura, Y., Beckman, S.L. Role of mercury (Hg) in resistant

infections and effective treatment of Chlamydia trachomatis and

Herpes family viral infections (and potential treatment for cancer)

by removing localized Hg deposits with Chinese parsley and

delivering effective antibiotics using various drug uptake

enhancement methods. Acupunct. Electrother. Res. 1995; 20(3-4): 195-

229.

Omura, Y., Shimotsuura, Y., Fukuoka, A., Fukuoka, H., Nomoto, T.

Significant mercury deposits in internal organs following the

removal of dental amalgam, and development of pre-cancer on the

gingiva and the sides of the tongue and their represented organs as

a result of inadvertent exposure to strong curing light (used to

solidify synthetic dental filling material) and effective treatment:

a clinical case report, along with organ representation areas for

each tooth. Acupunct. Electrother. Res. 1996; 1(2): 133-60.

Pakdaman, A. Symptomatic treatment of brain tumor patients with

sodium selenite, oxygen, and other supportive measures. Biol. Trace

Elem. Res. 1998 Apr-May; 62(1-2): 1-6.

Paredes, S.R., Kozicki, P.A., Batlle, A.M. S-adenosyl-L-methionine a

counter to lead intoxication? Comp. Biochem. Physiol. B 1985; 82(4):

751-7.

Guerrero, C., , J.J., Marhuenda, E. Prevention by rutin

of gastric lesions induced by ethanol in rats: role of endogenous

prostaglandins. Gen. Pharmacol. 1994 May; 25(3): 575-80.

Pietrangelo, A., Borella, F., Casalgrandi, G., Montosi, G.,

Ceccarelli, D., Gallesi, D., Giovannini, F., Gasparetto, A., Masini,

A. Antioxidant activity of silybin in vivo during long-term iron

overload in rats. Gastroenterology 1995 Dec; 109(6): 1941-9.

Porter, J.M., Ivatury, R.R., Azimuddin, K., Swami, R. Antioxidant

therapy in the prevention of organ dysfunction syndrome and

infectious complications after trauma: early results of a

prospective randomized study. Am. Surg. 1999 Sep; 65(9): 902.

Prater, G. MSM: the multi-purpose compound. Life Extension Magazine

1999 Sep; 5(9): 71-2. Ft. Lauderdale, FL: Life Extension Foundation.

Pryor, W.A. Vitamin E and heart disease: basic science to clinical

intervention trials. Free Radic. Biol. Med. 2000 Jan 1; 28(1): 141-

64.

Quig, D. Cysteine metabolism and metal toxicity. Altern. Med. Rev.

1998 Aug; 3(4): 262-70.

Ringwood, A.H., Conners, D.E. The effects of glutathione depletion

on reproductive success in oysters, Crassostrea virginica. Mar.

Environ. Res. 2000 Jul-Dec; 50(1-5): 207-11.

, J.R. Metal Toxicity in Children. Training Manual on

Pediatric Environmental Health: Putting It Into Practice 1999 Dec

10. Emeryville, CA: Children's Environmental Health Network.

Sallsten, G., Thoren, J., Barregard, L., Schutz, A., Skarping, G.

Long-term use of nicotine chewing gum and mercury exposure from

dental amalgam fillings. J. Dent. Res. 1996 Jan; 75(1): 594-8.

Saxe, S.R., Wekstein, M.W., Kryscio, R.J., Henry, R.G., Cornett,

C.R., Snowdon, D.A., Grant, F.T., Schmitt, F.A., Donegan, S.J.,

Wekstein, D.R., Ehmann, W.D., Markesbery, W.R. Alzheimer's disease,

dental amalgam and mercury. J. Am. Dent. Assoc. 1999 Feb; 130(2):

191-9.

Schumacher, K. Effect of selenium on the side effect profile of

adjuvant chemotherapy-radiotherapy in patients with breast

carcinoma. Design for a clinical study. Med. Klin. 1999 Oct 15; 94

(Suppl. 3): 45-8 (in German).

Shaikh, Z.A., Northup, J.B., Vestergaard, P. Dependence of cadmium-

metallothionein nephrotoxicity on glutathione. J. Toxicol. Environ.

Health A 1999a Jun 11; 57(3): 211-22.

Shaikh, Z.A., Tang, W. Protection against chronic cadmium toxicity

by glycine. Toxicology 1999b Feb 15; 132(2-3): 139-46.

Shukla, G.S., Srivastava, R.S., Chandra, S.V. Glutathione status and

cadmium neurotoxicity: studies in discrete brain regions of growing

rats. Fundam. Appl. Toxicol. 1988 Aug; 11(2): 229-35.

Sidhu, M., Sharma, M., Bhatia, M., Awasthi, Y.C., Nath, R. Effect of

chronic cadmium exposure on glutathione S-transferase and

glutathione peroxidase activities in rhesus monkey: the role of

selenium. Toxicology 1993 Oct 25; 83(1-3): 203-13.

Skottova, N., Krecman, V., Simanek, V. Activities of silymarin and

its flavonolignans upon low density lipoprotein oxidizability in

vitro. Phytother. Res. 1999 Sep; 13(6): 535-7.

, S.R., Jaffe, D.M., Skinner, M.A. Case report of metallic

mercury injury. Pediatr. Emer. Care 1997; 13: 114-6.

-Barbaro, P., Hanson, D., Reddy, B.S. Carcinogen binding to

various types of dietary fiber. J. Natl. Cancer Inst. 1981 Aug; 67

(2): 495-7.

Sonnebichler, J., Goldberg, M., Hane, L., Madubunyi, I., Vogl, S.,

Zetl, I. Stimulatory effect of silibinin on the DNA synthesis in

partially hepatectomized rat livers: non-response in hepatoma and

other malign cell lines. Biochem. Pharmacol. 1986 Feb 1; 35(3): 538-

41.

Sonnebichler, J., Scalera, F., Sonnenbichler, I., Weyhenmeyer, R.

Stimulatory effects of silibinin and silicristin from the milk

thistle Silybum marianum on kidney cells. J. Pharmacol. Exp. Ther.

1999 Sep; 290(3): 1375-83.

Stella, V., Postaire, E. Evaluation of the antiradical protector

effect of multifermented milk serum with reiterated dosage in rats.

C. R. ces Soc. Biol. Fil. 1995; 189(6): 1191-7 (in French).

Tager, M., Dietzmann, J., Thiel, U., Hinrich Neumann, K., Ansorge,

S. Restoration of the cellular thiol status of peritoneal

macrophages from CAPD patients by the flavonoids silibinin and

silymarin. Free Radic. Res. 2001 Feb; 34(2): 137-51.

Tandon, S.K., Singh, S., Dhawan, M. Preventive effect of vitamin E

in cadmium intoxication. Biomed. Environ. Sci. 1992 Mar; 5(1): 39-

45.

Tang, W., Sadovic, S., Shaikh, Z.A. Nephrotoxicity of cadmium-

metallothionein: protection by zinc and role of glutathione.

Toxicol. Appl. Pharmacol. 1998 Aug; 151(2): 276-82.

Tjalkens, R.B., Valerio, L.G., Jr., Awasthi, Y.C., sen, D.R.

Association of glutathione S-transferase isozyme-specific induction

and lipid peroxidation in two inbred strains of mice subjected to

chronic dietary iron overload. Toxicol. Appl. Pharmacol. 1998 Jul;

151(1): 174-81.

ToxFAQs™ for Aluminum. CAS 7429-90-5. 1999 Jun. Atlanta, GA: Agency

for Toxic Substances and Disease Registry.

ToxFAQs™ for Arsenic. CAS 7440-38-2. 2001 Jul. Atlanta, GA: Agency

for Toxic Substances and Disease Registry.

ToxFAQs™ for Cadmium. CAS 7440-43-9. 1999 Jun. Atlanta, GA: Agency

for Toxic Substances and Disease Registry.

ToxFAQs™ for Lead. CAS 7439-92-1. 1999 Jun. Atlanta, GA: Agency for

Toxic Substances and Disease Registry.

ToxFAQs™ for Mercury. CAS 7439-97-6. 1999 Apr. Atlanta, GA: Agency

for Toxic Substances and Disease Registry.

Tripathi, N., Flora, S.J. Effects of some thiol chelators on

enzymatic activities in blood, liver and kidneys of acute arsenic

(III) exposed mice. Biomed. Environ. Sci. 1998 Mar; 11(1): 38-45.

Turan, B., Delilbasi, E., Dalay, N., Sert, S., Afrasyap, L., Sayal,

A. Serum selenium and glutathione-peroxidase activities and their

interaction with toxic metals in dialysis and renal transplantation

patients. Biol. Trace Elem. Res. 1992 Apr-Jun; 33: 95-102.

USNLM/NIH. Deferoxamine (Systemic) 2001a. Bethesda, MD: U.S.

National Laboratory of Medicine

(http://www.nlm.nih.gov/medlineplus/druginfo).

USNLM/NIH. DMSA (Succimer Systemic) 2001b. Bethesda, MD: U.S.

National Laboratory of Medicine

(http://www.nlm.nih.gov/medlineplus/druginfo).

USNLM/NIH. EDTA (Edetate Disodium Systemic) 2001c. Bethesda, MD:

U.S. National Laboratory of Medicine

(http://www.nlm.nih.gov/medlineplus/druginfo).

USNLM/NIH. Penicillamine (Systemic) 2001d. Bethesda, MD: U.S.

National Laboratory of Medicine

(http://www.nlm.nih.gov/medlineplus/druginfo).

Valenzuela, A., Garrido, A. Biochemical bases of the pharmacological

action of the flavonoid silymarin and of its structural isomer

silibinin. Biol Res. 1994; 27(2): 105-12.

Van Vleet, J.F., Boon, G.D., Ferrans, V.J. Induction of lesions of

selenium-vitamin E deficiency in ducklings fed silver, copper,

cobalt, tellurium, cadmium, or zinc: protection by selenium or

vitamin E supplements. Am. J. Vet. Res. 1981 Jul; 42(7): 1206-17.

Vij, A.G., Satija, N.K., Flora, S.J. Lead induced disorders in

hematopoietic and drug metabolizing enzyme system and their

protection by ascorbic acid supplementation. Biomed. Environ. Sci.

1998 Mar; 11(1): 7-14.

Villamor, E., Fawzi, W.W. Vitamin A supplementation: implications

for morbidity and mortality in children. J. Infect. Dis. 2000 Sep;

182(Suppl.1): S122-S133.

Vimy, M.J., Takahashi, Y., Lorscheider, F.L. Maternal-fetal

distribution of mercury (203Hg) released from dental amalgam

fillings. Am. J. Physiol. 1990 Apr; 258(4, Pt. 2): R939-45.

Wellington, K., Jarvis, B. Silymarin: a review of its clinical

properties in the management of hepatic disorders. BioDrugs 2001; 15

(7): 465-89.

Wentz, P.W. Chelation Therapy: Conventional Treatments 2000 May.

Burlington, NC: Advance for Administrators of the Laboratory/LabCorp.

West, W.L., Knight, E.M., , C.H., Manning, M., Spurlock, B.,

, H., , A.A., Oyemade, U.J., Cole, O.J., Westney, O.E.

et al. Maternal low level lead and pregnancy outcomes. J. Nutr. 1994

Jun; 124(6 Suppl.): 981S-986S.

WHO. Aluminum. Guidelines for Drinking-Water Quality, Second

Edition, Health Criteria and Other Supporting Information 1998, pp.

3-13. Geneva: World Health Organization.

Willershausen-Zonnchen, B., Zimmermann, M., Defregger, A., Schramel,

P., Hamm, G. Mercury concentration in the mouth mucosa of patients

with amalgam fillings. Dtsch. Med Wochenschr. 1992 Nov 13; 117(46):

1743-7 (in German).

, L.S., Kornguth, S.E., Oberley, T.D., Siegel, F.L. Effects of

lead on glutathione S-transferase expression in rat kidney: a dose-

response study. Toxicol. Sci. 1998 Dec; 46(2): 254-9.

Yamanaka, K., Hayashi, H., Tachikawa, M., Kato, K., Hasegawa, A.,

Oku, N., Okada, S. Metabolic methylation is a possible genotoxicity-

enhancing process of inorganic arsenics. Mutat. Res. 1997 Nov 27; 394

(1-3): 95-101.

Zayas, L. Ozuah, P. Mercury use in espiritismo: a survey of

botanicas. Am. J. Public Health 1996; 86: 111-2.

> >

> > ,

> >

> > My son has had the porphyrins run thru Lab Corp

> > 3 times. First time, all levels were low and the

coproporphyrin

> was actually below the reference range.

> > Once we started chelation, the hepta and

hexacarboxylporphyrins

> shot up to 2x the reference range, but the rest stayed well

below

> normal. What would you make of that? I have yet to find anyone

who

> can tell me what the hepta and hexa elevation means. Is it a

> reaction to the chelation?

> >

> > BTW, my son does display most of the other lab markers

> you listed as signs of toxicity. (high IgE, low CD8, very low

NKs,

> high 3-methylhistidine). We have done only 4 rounds of

chelation,

> no sign of mercury, not even a trace- just nickel and a bit of

> lead. Low mercury on hair, urine , and blood. I'm getting ready

to

> send in one of his baby teeth to be analyzed. All the clinical

> signs of toxicity, but no mercury in sight. (we've done 24 hr

urines

> with each round.)

> >

> > Becky

> >

> >

> >

> >

[Guest guest]

To my knowledge there has not been a clear explanation of the

different names associated with the Porphyrins Urine Test leading to

much confusion about the appropriate test offered by various labs.

Therefore, after much research, I am starting this subject in hopes

of making life easier for those who do not understand the different

medical terminology associated with the aforementioned test.

First, I direct you to the heart of why this test is important:

http://www.beatcfsandfms.org/references/refs1x.html#ref5

After reading reference #5 in the link above, you will note... " In

rats, exposure for a prolonged period to mercury as methyl mercury

hydroxide was associated with urinary porphyrin changes, which were

uniquely characterized by highly elevated levels of 4- and 5-

carboxyl porphyrins and by the expression of an atypical porphyrin

( " precoproporphyrin " ) not found in urine of unexposed animals. "

Thus, one needs to determine if 4 and 5 carboxyl porphyrins are

elevated and the existance of precoproporphyrin. Not as easy as it

sounds for the layman as there are some different names associated

with these two.

I will therefore give a brief education on what I know to date:

7-carboxyl porphyrins = Heptacarboxl porphyrins

6-carboxyl porphyrins = Hexacarboxyl porphyrins

5-carboxyl porphyrins = Pentacarboxyl porphyrins (look for elevation)

4-carboxyl porphyrins = Tetracarboxyl porphyrins = III

Coproporphyrins (look for elevation)

A-typical porphyrin = pre-coproporphyrin (look for existance)

Here is the link for above: http://72.14.203.104/search?

q=cache:BZstzblGpTwJ:www.mayoclinicproceedings.com/inside.asp%3FAID%

3D169%26UID%3D+5-carboxyl+porphyrin+6-carboxyl+porphyrin+7-

carboxyl+porphyrin & hl=en & gl=us & ct=clnk & cd=2

Now to clear up some more confusion. Since many refer to the test as

a " fractionated " test you might get confused as some of the biggest

labs don't use the word " fractionated " in the name of their test.

Fractionated simply means to sperate results which means the

majority of labs offer the fractionated test even though they don't

have the word " fractionated " in the name of their test.

Also, 24-hr urine vs random urine? In all my research the majority

say that 24-hr is the best.

Also, preservative or no preservative. Both are acceptable. If you

desire a preservative method, the preferred preservative is sodium

carbonate. However, if you choose the test with preservative then

you cannot get the creatinine which some feel is important as a more

accurate gauge however, I'm not sure I agree, as the scientific

studies to my knowledge did not gauge with creatinine as the results

of Porphyrins are rather consistant eliminating the need for such a

comparison.

You may also be interested in knowing that you do not need a doctor

to get this test run. There is a company called www.directlabs.com

who will issue a test requisition to Lab Corp, one of the largest

most reputable labs in the USA. I recommend you contact Leigh

Wilkerson at direct labs 1-800-908-0000 extension #206 or

Leigh@...

Lab Corps tests can be found at the following link:

http://www.labcorp.com/datasets/labcorp/html/chapter/chap1.htm

LabCorp's test is " Porphyrins, Qauntitative, 24-hr Urine " test

#003194. Thier test comes with preservative and therefore, not with

creatinine. If you desire creatinine, you will have to also order

LabCorp's test " Creatinine 24-hr, Urine " test #003012. If you

ordered the Porphyrins and Creatinine, notify directlabs to make

a " special instructions " notation on the requisition form that

states... " No preservative, include Creatinine results, same

specimen " .

Also, many of the labs do not list the Coproporphyrins seperately

and do not list the precoproporphyrin. Remember, Coproporphyrin III

is also the same as 4-carboxylporphyrin and tetracarboxylporphyrin.

You need to know Coproporphyrin III and Precoproporphyrin.

Therefore, ask directlabs to make a " special instructions " notation

on the requisition form that states... " Please list Coprophyrins I

and III and their respective reference intervals seperately and list

Pre-coprophyrins. "

I elected to go with the Porphyrins, Qauntitative, 24-hr Urine test

with preservative, not including the Creatinine and also a hair

toxic metals analysis which I also ordered through directlabs.com.

Again, I recommend you contact Leigh Wilkerson at direct labs 1-800-

908-0000 extension #206 or Leigh@... if you would like to

have this test performed at a very reasonable cost without the need

of your doctor's prescription. LabCorp has more than 1,100 patient

service centers around the nation thus, they are sure to have a

location near you.

Sincerely,

> >

> > ,

> >

> > My son has had the porphyrins run thru Lab Corp

> > 3 times. First time, all levels were low and the

coproporphyrin

> was actually below the reference range.

> > Once we started chelation, the hepta and

hexacarboxylporphyrins

> shot up to 2x the reference range, but the rest stayed well

below

> normal. What would you make of that? I have yet to find anyone

who

> can tell me what the hepta and hexa elevation means. Is it a

> reaction to the chelation?

> >

> > BTW, my son does display most of the other lab markers

> you listed as signs of toxicity. (high IgE, low CD8, very low

NKs,

> high 3-methylhistidine). We have done only 4 rounds of

chelation,

> no sign of mercury, not even a trace- just nickel and a bit of

> lead. Low mercury on hair, urine , and blood. I'm getting ready

to

> send in one of his baby teeth to be analyzed. All the clinical

> signs of toxicity, but no mercury in sight. (we've done 24 hr

urines

> with each round.)

> >

> > Becky

> >

> >

> >

> >

[Guest guest]

Has anyone ordered this test through directlabs lately? I just spoke with them

and they

didn't seem to know what to make of the " special instructions " to " Please list

Coprophyrins

I and III and their respective reference intervals seperately and list

Pre-coprophyrins. " I

asked them to check with Labcorp and they claimed they didn't know what a Pre-

copproporphyrin was. Is there some special way I need to do this? I'd like to

get it done

through Labcorp if possible since our insurance will pay for it.

thanks

> You may also be interested in knowing that you do not need a doctor

> to get this test run. There is a company called www.directlabs.com

> who will issue a test requisition to Lab Corp, one of the largest

> most reputable labs in the USA. I recommend you contact Leigh

> Wilkerson at direct labs 1-800-908-0000 extension #206 or

> Leigh@

>

> Lab Corps tests can be found at the following link:

> http://www.labcorp.com/datasets/labcorp/html/chapter/chap1.htm

>

> LabCorp's test is " Porphyrins, Qauntitative, 24-hr Urine " test

> #003194. Thier test comes with preservative and therefore, not with

> creatinine. If you desire creatinine, you will have to also order

> LabCorp's test " Creatinine 24-hr, Urine " test #003012. If you

> ordered the Porphyrins and Creatinine, notify directlabs to make

> a " special instructions " notation on the requisition form that

> states... " No preservative, include Creatinine results, same

> specimen " .

>

> Also, many of the labs do not list the Coproporphyrins seperately

> and do not list the precoproporphyrin. Remember, Coproporphyrin III

> is also the same as 4-carboxylporphyrin and tetracarboxylporphyrin.

> You need to know Coproporphyrin III and Precoproporphyrin.

> Therefore, ask directlabs to make a " special instructions " notation

> on the requisition form that states... " Please list Coprophyrins I

> and III and their respective reference intervals seperately and list

> Pre-coprophyrins. "

>

> I elected to go with the Porphyrins, Qauntitative, 24-hr Urine test

> with preservative, not including the Creatinine and also a hair

> toxic metals analysis which I also ordered through directlabs.com.

> Again, I recommend you contact Leigh Wilkerson at direct labs 1-800-

> 908-0000 extension #206 or Leigh@ if you would like to

> have this test performed at a very reasonable cost without the need

> of your doctor's prescription. LabCorp has more than 1,100 patient

> service centers around the nation thus, they are sure to have a

> location near you.

>

> Sincerely,

>

>

>

>

>

>

>

>

> > >

> > > ,

> > >

> > > My son has had the porphyrins run thru Lab Corp

> > > 3 times. First time, all levels were low and the

> coproporphyrin

> > was actually below the reference range.

> > > Once we started chelation, the hepta and

> hexacarboxylporphyrins

> > shot up to 2x the reference range, but the rest stayed well

> below

> > normal. What would you make of that? I have yet to find anyone

> who

> > can tell me what the hepta and hexa elevation means. Is it a

> > reaction to the chelation?

> > >

> > > BTW, my son does display most of the other lab markers

> > you listed as signs of toxicity. (high IgE, low CD8, very low

> NKs,

> > high 3-methylhistidine). We have done only 4 rounds of

> chelation,

> > no sign of mercury, not even a trace- just nickel and a bit of

> > lead. Low mercury on hair, urine , and blood. I'm getting ready

> to

> > send in one of his baby teeth to be analyzed. All the clinical

> > signs of toxicity, but no mercury in sight. (we've done 24 hr

> urines

> > with each round.)

> > >

> > > Becky

> > >

> > >

> > >

> > >

[Guest guest]

I have been doing LabCorp's " Porphyrins, Quantitative, 24-hr Urine " test for a

few years now.  Note that here in land, Labcorp has never given a

preservative.  Also note that Labcorp staff is VERY INCOMPETENT in handling a

urine sample.

 

Sample needs to be places in a light-proof container and should not be shaken

too much.  Use aluminum foil in-case Labcorp gives you the wrong type of

container.

From: arosenbl0 <arosenbl0@...>

Subject: [ ] Re: Porphyrins Urine Test  for detection of toxic

metals Poisoning

Date: Tuesday, October 7, 2008, 12:15 PM

Has anyone ordered this test through directlabs lately? I just spoke with them

and they

didn't seem to know what to make of the " special instructions " to " Please list

Coprophyrins

I and III and their respective reference intervals seperately and list

Pre-coprophyrins. " I

asked them to check with Labcorp and they claimed they didn't know what a Pre-

copproporphyrin was. Is there some special way I need to do this? I'd like to

get it done

through Labcorp if possible since our insurance will pay for it.

thanks

> You may also be interested in knowing that you do not need a doctor

> to get this test run. There is a company called www.directlabs. com

> who will issue a test requisition to Lab Corp, one of the largest

> most reputable labs in the USA. I recommend you contact Leigh

> Wilkerson at direct labs 1-800-908-0000 extension #206 or

> Leigh@

>

> Lab Corps tests can be found at the following link:

> http://www.labcorp. com/datasets/ labcorp/html/ chapter/chap1. htm

>

> LabCorp's test is " Porphyrins, Qauntitative, 24-hr Urine " test

> #003194. Thier test comes with preservative and therefore, not with

> creatinine. If you desire creatinine, you will have to also order

> LabCorp's test " Creatinine 24-hr, Urine " test #003012. If you

> ordered the Porphyrins and Creatinine, notify directlabs to make

> a " special instructions " notation on the requisition form that

> states... " No preservative, include Creatinine results, same

> specimen " .

>

> Also, many of the labs do not list the Coproporphyrins seperately

> and do not list the precoproporphyrin. Remember, Coproporphyrin III

> is also the same as 4-carboxylporphyrin and tetracarboxylporphy rin.

> You need to know Coproporphyrin III and Precoproporphyrin.

> Therefore, ask directlabs to make a " special instructions " notation

> on the requisition form that states... " Please list Coprophyrins I

> and III and their respective reference intervals seperately and list

> Pre-coprophyrins. "

>

> I elected to go with the Porphyrins, Qauntitative, 24-hr Urine test

> with preservative, not including the Creatinine and also a hair

> toxic metals analysis which I also ordered through directlabs.com.

> Again, I recommend you contact Leigh Wilkerson at direct labs 1-800-

> 908-0000 extension #206 or Leigh@ if you would like to

> have this test performed at a very reasonable cost without the need

> of your doctor's prescription. LabCorp has more than 1,100 patient

> service centers around the nation thus, they are sure to have a

> location near you.

>

> Sincerely,

>

>

>

>

>

>

>

>

> > >

> > > ,

> > >

> > > My son has had the porphyrins run thru Lab Corp

> > > 3 times. First time, all levels were low and the

> coproporphyrin

> > was actually below the reference range.

> > > Once we started chelation, the hepta and

> hexacarboxylporphyr ins

> > shot up to 2x the reference range, but the rest stayed well

> below

> > normal. What would you make of that? I have yet to find anyone

> who

> > can tell me what the hepta and hexa elevation means. Is it a

> > reaction to the chelation?

> > >

> > > BTW, my son does display most of the other lab markers

> > you listed as signs of toxicity. (high IgE, low CD8, very low

> NKs,

> > high 3-methylhistidine) . We have done only 4 rounds of

> chelation,

> > no sign of mercury, not even a trace- just nickel and a bit of

> > lead. Low mercury on hair, urine , and blood. I'm getting ready

> to

> > send in one of his baby teeth to be analyzed. All the clinical

> > signs of toxicity, but no mercury in sight. (we've done 24 hr

> urines

> > with each round.)

> > >

> > > Becky

> > >

> > >

> > >

> > >

[Guest guest]

Did you get them to report the pre-coproporphryin value as well?

> > > >

> > > > ,

> > > >

> > > > My son has had the porphyrins run thru Lab Corp

> > > > 3 times. First time, all levels were low and the

> > coproporphyrin

> > > was actually below the reference range.

> > > > Once we started chelation, the hepta and

> > hexacarboxylporphyr ins

> > > shot up to 2x the reference range, but the rest stayed well

> > below

> > > normal. What would you make of that? I have yet to find anyone

> > who

> > > can tell me what the hepta and hexa elevation means. Is it a

> > > reaction to the chelation?

> > > >

> > > > BTW, my son does display most of the other lab markers

> > > you listed as signs of toxicity. (high IgE, low CD8, very low

> > NKs,

> > > high 3-methylhistidine) . We have done only 4 rounds of

> > chelation,

> > > no sign of mercury, not even a trace- just nickel and a bit of

> > > lead. Low mercury on hair, urine , and blood. I'm getting ready

> > to

> > > send in one of his baby teeth to be analyzed. All the clinical

> > > signs of toxicity, but no mercury in sight. (we've done 24 hr

> > urines

> > > with each round.)

> > > >

> > > > Becky

> > > >

> > > >

> > > >

> > > >

[Guest guest]

,

 

No, I just reviewed lab results.  Labs do not show " pre-coproporphryin " .  Isn't

coproporphryin I and III enough to show mercury toxicity?

 

Thanks.

 

Abid

From: arosenbl0 <arosenbl0@...>

Subject: [ ] Re: Porphyrins Urine Test  for detection of toxic

metals Poisoning

Date: Tuesday, October 7, 2008, 5:58 PM

Did you get them to report the pre-coproporphryin value as well?

> > > >

> > > > ,

> > > >

> > > > My son has had the porphyrins run thru Lab Corp

> > > > 3 times. First time, all levels were low and the

> > coproporphyrin

> > > was actually below the reference range.

> > > > Once we started chelation, the hepta and

> > hexacarboxylporphyr ins

> > > shot up to 2x the reference range, but the rest stayed well

> > below

> > > normal. What would you make of that? I have yet to find anyone

> > who

> > > can tell me what the hepta and hexa elevation means. Is it a

> > > reaction to the chelation?

> > > >

> > > > BTW, my son does display most of the other lab markers

> > > you listed as signs of toxicity. (high IgE, low CD8, very low

> > NKs,

> > > high 3-methylhistidine) . We have done only 4 rounds of

> > chelation,

> > > no sign of mercury, not even a trace- just nickel and a bit of

> > > lead. Low mercury on hair, urine , and blood. I'm getting ready

> > to

> > > send in one of his baby teeth to be analyzed. All the clinical

> > > signs of toxicity, but no mercury in sight. (we've done 24 hr

> > urines

> > > with each round.)

> > > >

> > > > Becky

> > > >

> > > >

> > > >

> > > >