Re: Re LDN and flare ups

[Guest guest]

I think 1.5 just Teases the body, it starts things up but doesn't know how to Work on them.

I'd go to 3.0 ASAP and let the fun begin.

[low dose naltrexone] Re LDN and flare ups

Hi group,Not sure what to think at this point, I have now beenon LDN 10 days, the first 3 days didn't feel anydifferent for me. After that it has been sleepnessnights, and mpst recently a new flare. I have heard

[Guest guest]

One of the meds I was on was amitriptyline when I started on LDN 3

months ago. Its taken at night because it can cause drowsiness in a big

way and the theory is you sleep it off thru the night. I must say

that I stopped taking it about a month into LDN and it was amazing not

having that fog in my brian it left, it made me very drowsy all day!

And didn't really do much for the leg pain to be honest. But as far as

I know it is OK to take alongside LDN.

Helen UK

Diabetes type 1

Ankylosisng spondylitis

SPMS

Suzzie B wrote:

Hi group,

Not sure what to think at this point, I have now been

on LDN 10 days, the first 3 days didn't feel any

different for me. After that it has been sleepness

nights, and mpst recently a new flare. I have heard

from others that it is my body adjusting to the LDN

and over time will hopefully diminish. This new flare

is scary as the tightness in my limbs is worse and the

numbness in my torso has increased. I know I have to

stick with the meds until my system is regulated, only

I worry because I am only on 1.5kmg right now, and if

this is how I am responding on 1.5 how will I feel

when I increase to 3.0 and eventually 4.5. I have also

heard from the MS doctor that saw me recently in his

clinic to schedule a lower MRI from my torso down,

anybody ever had this test done? I have a hard time

with MRI's because I am so claustraphobic. He also

gave me a new drug to try for pain and some of my

symptoms called AMITRIPTYLINE also to be taken at

bedtime. Not sure if I will take this drug because of

potential interactions with LDN. I would appreciate

hearing from anyone who has some insight into all of

this.

Thanks,

__________________________________________________

[Guest guest]

>

> Hi group,

>

> Not sure what to think at this point, I have now been

> on LDN 10 days, the first 3 days didn't feel any

> different for me. After that it has been sleepness

> nights, and mpst recently a new flare. I have heard

> from others that it is my body adjusting to the LDN

> and over time will hopefully diminish. This new flare

> is scary as the tightness in my limbs is worse and the

> numbness in my torso has increased. I know I have to

> stick with the meds until my system is regulated, only

> I worry because I am only on 1.5kmg right now, and if

> this is how I am responding on 1.5 how will I feel

> when I increase to 3.0 and eventually 4.5.

Thanks,

>

>

>=============

When starting this LDN(Low Dose Naltrexone) therapy in the treatment

of MS, there may also be some initial transient, though temporary,

increase in MS symptoms.

Experience in using this method has demonstrated most commonly, such

as disturbed sleep, occasionally with vivid, bizarre and disturbing

dreams, tiredness, fatigue, spasm and pain. These increased symptoms

would not normally be expected to last more than seven to ten days.

Rarely, other transient symptoms have included more severe pain and

spasm, headache, diarrhea or vomiting. These additional symptoms would

appear to be associated with the previous frequent use of strong

analgesics, which effectively create an addiction and dependency, thus

increasing the body's sensitivity to pain. This temporary increase in

symptoms may also perhaps be explained when we consider the manner in

which this drug is expected to work.

Initially, MS occurs due to a reduction in the activity of the

controlling influence of the suppressor T-cells within the immune

system. During an acute relapse, the overall number of T-cells is

reduced, the normal balance of helper T-cells and suppressor T-cells

is disrupted and the damaging helper (CD-4) T-cells tend to

predominate. This is the situation most pronounced during an acute

relapse but occurs similarly, but to a lesser extent, in chronic

progressive MS. Under the influence of LDN there will be an expected

increase in the overall numbers of T-cells but, because the CD-4,

helper T-cells tend to predominate at this time, an increase in their

numbers will expectedly tend to increase MS symptoms. It is only when

the numbers of suppressor T-cells effectively " catch up " that the

normal balance is restored and symptoms once again diminish and

improve.

In addition, because LDN stimulates the immune system and many of the

drugs routinely used by the NHS in the treatment of MS further

suppress the immune system, LDN cannot be used in company with

steroids, beta interferon, methotrexate, azathioprine or mitozantrone

or any other immune suppressant drug. If there is any doubt, please

submit a full list of the drugs you are presently taking so that their

compatibility may be assessed. In addition, because LDN will also

block the analgesic effects of any opiate drugs (includes codeine,

dihydrocodeine, morphine, pethidine or diamorphine) presently being

taken, the use of LDN will initially greatly increase the level of

pain experienced. It is therefore advisable that any opiate-like drugs

be discontinued at least two weeks before this treatment is initiated.

When starting the treatment it is essential that any untoward or

adverse side-effects are reported immediately so that the treatment

process can be further assessed and, if necessary, modified.

Dr. M R Lawrence

Posted by

[Guest guest]

>

> Hi group,

>

> Not sure what to think at this point, I have now been

> on LDN 10 days, the first 3 days didn't feel any

> different for me. After that it has been sleepness

> nights, and mpst recently a new flare. I have heard

> from others that it is my body adjusting to the LDN

> and over time will hopefully diminish. This new flare

> is scary as the tightness in my limbs is worse and the

> numbness in my torso has increased. I know I have to

> stick with the meds until my system is regulated, only

> I worry because I am only on 1.5kmg right now, and if

> this is how I am responding on 1.5 how will I feel

> when I increase to 3.0 and eventually 4.5. I have also

> heard from the MS doctor that saw me recently in his

> clinic to schedule a lower MRI from my torso down,

> anybody ever had this test done? I have a hard time

> with MRI's because I am so claustraphobic. He also

> gave me a new drug to try for pain and some of my

> symptoms called AMITRIPTYLINE also to be taken at

> bedtime. Not sure if I will take this drug because of

> potential interactions with LDN. I would appreciate

> hearing from anyone who has some insight into all of

> this.

>

> Thanks,

>

>

>

> __________________________________________________

>

[Guest guest]

I started 3.0mgs LDN March 2005. One month later went up to 4.5mgs

without serious problems. If I were you I'd try to get to the optimal

adult dosage as soon as possible then deal with side-effects as they

come. Lack of sleep = Melatonin, Valerian, 5-HTP. Stiffness =

Magnesium. Exacerbation = Dr. Lawernce's protocol.

First time I had an MRI I panicked a bit but since then I close my

eyes and take a nap. Actually look forward to getting one now.

Amitriptyline is okay to use with LDN although it could cause some

problems on it's own:

Common side effects of using amitriptyline are extreme weight gain,

drowsiness, nervousness, dizziness, and insomnia. Some rare side

effects include tinnitus, hypotension, mania, psychosis,

anticholinergic effects, heart block, arrhythmias, extrapyramidal

symptoms, depression, and hepatic toxicity.

http://en.wikipedia.org/wiki/Amitriptyline

Art

--

>

> Hi group,

>

> Not sure what to think at this point, I have now been

> on LDN 10 days, the first 3 days didn't feel any

> different for me. After that it has been sleepness

> nights, and mpst recently a new flare. I have heard

> from others that it is my body adjusting to the LDN

> and over time will hopefully diminish. This new flare

> is scary as the tightness in my limbs is worse and the

> numbness in my torso has increased. I know I have to

> stick with the meds until my system is regulated, only

> I worry because I am only on 1.5kmg right now, and if

> this is how I am responding on 1.5 how will I feel

> when I increase to 3.0 and eventually 4.5. I have also

> heard from the MS doctor that saw me recently in his

> clinic to schedule a lower MRI from my torso down,

> anybody ever had this test done? I have a hard time

> with MRI's because I am so claustraphobic. He also

> gave me a new drug to try for pain and some of my

> symptoms called AMITRIPTYLINE also to be taken at

> bedtime. Not sure if I will take this drug because of

> potential interactions with LDN. I would appreciate

> hearing from anyone who has some insight into all of

> this.

>

> Thanks,

>

>

[Guest guest]

Hi ,

A transient increase in MS symptoms is fairly normal when first starting LDN but

should lessen and hopefully disappear in time.

In addition to LDN, you would be well advised to consider other treatment

options, including a low-fat diet, food supplements, a low-stress lifestyle,

etc. For more information, visit

http://tinyurl.com/grpm9

With best wishes,

Dudley Delany

dudley_delany

[low dose naltrexone] Re LDN and flare ups

Hi group,

Not sure what to think at this point, I have now been

on LDN 10 days, the first 3 days didn't feel any

different for me. After that it has been sleepness

nights, and mpst recently a new flare. I have heard

from others that it is my body adjusting to the LDN

and over time will hopefully diminish. This new flare

is scary as the tightness in my limbs is worse and the

numbness in my torso has increased. I know I have to

stick with the meds until my system is regulated, only

I worry because I am only on 1.5kmg right now, and if

this is how I am responding on 1.5 how will I feel

when I increase to 3.0 and eventually 4.5. I have also

heard from the MS doctor that saw me recently in his

clinic to schedule a lower MRI from my torso down,

anybody ever had this test done? I have a hard time

with MRI's because I am so claustraphobic. He also

gave me a new drug to try for pain and some of my

symptoms called AMITRIPTYLINE also to be taken at

bedtime. Not sure if I will take this drug because of

potential interactions with LDN. I would appreciate

hearing from anyone who has some insight into all of

this.

Thanks,

__________________________________________________

[Guest guest]

Hi all,

I started on LDN 10 days at 1.5 and 3 days ago I started taking 3.0. As I wrote before, I didn't have the prpoblems with sleep nor vivid dreams but I did have a headache/migrane everyday. After a week it got better. I realized this morning when I saw your email () that I had stopped taking amitripityline the same day I stopped Betaferon which was 3 days before I started LDN and I think this was why I got the headaches. My neurologist said I could keep taking the amitriptyline with LDN but I decided to quit. The only medication I stayed on is neurontin for pain and hope to get off slowly in a couple of months. I was on Betaferon for 9 years and amitriptyline for 3 yrs.. Last year there was a problem here with this medication and the pharmacies were completely out. That's when I found out it is also a pain killer. Patients were calling their doctors screaming bloody murder and I was one of them, everyone needed it for pain control and not for depression (MS patients). Finally another brand became available and it took 2 weeks to kick in. when I figured out that my headaches were due to stopping this medication, I realized that they were gone and that I actually didn't have much pain compared to my former experience - I think it's thanks to LDN. Next week I plan to go to 4.5. Hope that I feel even better!

Miki

[low dose naltrexone] Re LDN and flare ups

Hi group,Not sure what to think at this point, I have now beenon LDN 10 days, the first 3 days didn't feel anydifferent for me. After that it has been sleepnessnights, and mpst recently a new flare. I have heardfrom others that it is my body adjusting to the LDNand over time will hopefully diminish. This new flareis scary as the tightness in my limbs is worse and thenumbness in my torso has increased. I know I have tostick with the meds until my system is regulated, onlyI worry because I am only on 1.5kmg right now, and ifthis is how I am responding on 1.5 how will I feelwhen I increase to 3.0 and eventually 4.5. I have alsoheard from the MS doctor that saw me recently in hisclinic to schedule a lower MRI from my torso down,anybody ever had this test done? I have a hard timewith MRI's because I am so claustraphobic. He alsogave me a new drug to try for pain and some of mysymptoms called AMITRIPTYLINE also to be taken atbedtime. Not sure if I will take this drug because ofpotential interactions with LDN. I would appreciatehearing from anyone who has some insight into all ofthis.Thanks,__________________________________________________

[Guest guest]

Hello again:

Thank-you everyone who replied to my posting here. I

am so glad I found this forum. I am definitely

sticking to this drug and hoping that the side effects

subside over time.

Stay well.

--- Miki Kalkus <m.kalkus@...> wrote:

> Hi all,

> I started on LDN 10 days at 1.5 and 3 days ago I

> started taking 3.0. As I wrote before, I didn't have

> the prpoblems with sleep nor vivid dreams but I did

> have a headache/migrane everyday. After a week it

> got better. I realized this morning when I saw your

> email () that I had stopped taking

> amitripityline the same day I stopped Betaferon

> which was 3 days before I started LDN and I think

> this was why I got the headaches. My neurologist

> said I could keep taking the amitriptyline with LDN

> but I decided to quit. The only medication I stayed

> on is neurontin for pain and hope to get off slowly

> in a couple of months. I was on Betaferon for 9

> years and amitriptyline for 3 yrs.. Last year there

> was a problem here with this medication and the

> pharmacies were completely out. That's when I found

> out it is also a pain killer. Patients were calling

> their doctors screaming bloody murder and I was one

> of them, everyone needed it for pain control and not

> for depression (MS patients). Finally another brand

> became available and it took 2 weeks to kick in.

> when I figured out that my headaches were due to

> stopping this medication, I realized that they were

> gone and that I actually didn't have much pain

> compared to my former experience - I think it's

> thanks to LDN. Next week I plan to go to 4.5. Hope

> that I feel even better!

> Miki

> [low dose naltrexone] Re LDN and flare ups

>

>

> Hi group,

>

> Not sure what to think at this point, I have now

> been

> on LDN 10 days, the first 3 days didn't feel any

> different for me. After that it has been sleepness

> nights, and mpst recently a new flare. I have

> heard

> from others that it is my body adjusting to the

> LDN

> and over time will hopefully diminish. This new

> flare

> is scary as the tightness in my limbs is worse and

> the

> numbness in my torso has increased. I know I have

> to

> stick with the meds until my system is regulated,

> only

> I worry because I am only on 1.5kmg right now, and

> if

> this is how I am responding on 1.5 how will I feel

> when I increase to 3.0 and eventually 4.5. I have

> also

> heard from the MS doctor that saw me recently in

> his

> clinic to schedule a lower MRI from my torso down,

> anybody ever had this test done? I have a hard

> time

> with MRI's because I am so claustraphobic. He also

> gave me a new drug to try for pain and some of my

> symptoms called AMITRIPTYLINE also to be taken at

> bedtime. Not sure if I will take this drug because

> of

> potential interactions with LDN. I would

> appreciate

> hearing from anyone who has some insight into all

> of

> this.

>

> Thanks,

>

>

>

> __________________________________________________

>