defensins, innate immune system peptides

[Guest guest]

i guess that means they are enzymes. but i am really feeling that the

jump to understanding bolstering the innate immune system is needed

on this board otherwise you just get caught in a revolving door of

improvement and regression.

i hope my advice on the right sun is not wasted like last year

iodine etc continues to be wasted though i see dan are moving in a

bit and no doubt it will suddenly become acceptable since is paid for

and free advice is worthless i notice or even to be discouraged as

per pecan bread moderation

i am learning that the childrens interests are usually last\

anyway

" The role of defensins in the pathogenesis of inflammatory bowel

disease]

[Article in German]

Schmid M, Fellermann K, Wehkamp J, Herrlinger K, Stange EF.

Abteilung Innere Medizin I, -Bosch-Krankenhaus, Stuttgart.

Defensins are endogenous antimicrobial peptides with a broad activity

spectrum. Even at micromolar concentrations gramnegative and

grampositive bacteria, but also mycobacteria, as well as fungi

(candida), viruses (herpes) and protozoa (giardia lamblia) are

destroyed. As part of the innate immune system defensins are

expressed by the intestinal epithelium and contribute to the

maintenance of the mucosal barrier. This barrier appears to be

defective in inflammatory bowel diseases since on one hand, the

immune response is directed against the " normal " luminal bacterial

flora and on the other hand, mucosal adherent and invasive bacteria

have been observed in these diseases. A defective defensin expression

may well explain these phenomena. Indeed, Crohn's disease of the

terminal ileum, especially if associated with a NOD2 mutation, is

characterised by a diminished alpha-defensin (human defensin 5 and 6)

expression, and in inflamed Crohn's colitis, in contrast to

ulcerative colitis, the beta-defensin (human beta-defensins 2 and 3)

response is reduced. Through a deficient chemical mucosal barrier

this defect could lead to increased bacterial invasion into the

intestinal mucosa and might well explain an adequate inflammatory

response. Although the final proof that this deficient defensin

response leads to a reduced antibacterial activity of the intestinal

mucosa is still lacking, the most plausible concept of pathogenesis

of Crohn's disease is a defensin deficiency syndrome.

from healing crow where pecan bread are trying to shuffle me to.

how can i tell them i don't have colitis because of the way i eat and

supplement and probably enough of the right sun in childhood and

teenage years? lol

the effect of probiotics may not be enhancement of bacterial

populations but a temporary redirection of the innate immune system

[Guest guest]

Hi ,

I remember you posting about the sun last year.

I thought I read somewhere that for the Chicago area, the best time

to be outside to get the benefits of the sun is between 12:00 and

12:30pm.

But I just want to verify this. Do you know of a link that may be

helpful?

P.S. I'm with you on the sunscreen issue. I don't use it either.

Thanks,

i hope my advice on the right sun is not wasted like last year

>

[Guest guest]

What do you mean by " redirecting the innate immune system " ? Do you mean an

autoimmune disorder? Am I giving the immune system a different target by

piling in all the probiotics so it doesn't have a chance to target his gut?

If that's the case, I don't want to buy time forever supplying the

probiotics. Are there any studies or theories on how to redirect the immune

system to attack only the bad foreign bacteria? My son is completely IgA

deficient, he does not produce any, which makes him a bit of a rarity. I am

thoroughly convinced I won't heal his gut or completely catch up his

neurological development until I straighten out his immune system, although,

to the degree the central nervous system and various other parts of the

brain " work " the immune system and the fact that so much of the immune

system is located in the gut, I'm in a bit of a chicken and egg quandary.

What will be the magic strategy? Supplements, enzymes, cleaning up his

environment, better nutrition, rewiring things a bit upstairs, minimizing

sensory issues, they all have their place, but is there a way to reverse

switch all these problems that were " flipped on " by my poor excuse for a

host environment womb, crappy genes and vaccine stressors?

defensins, innate immune system peptides

> i guess that means they are enzymes. but i am really feeling that the

> jump to understanding bolstering the innate immune system is needed

> on this board otherwise you just get caught in a revolving door of

> improvement and regression.

>

> i hope my advice on the right sun is not wasted like last year

>

> iodine etc continues to be wasted though i see dan are moving in a

> bit and no doubt it will suddenly become acceptable since is paid for

> and free advice is worthless i notice or even to be discouraged as

> per pecan bread moderation

>

> i am learning that the childrens interests are usually last\

>

> anyway

>

> " The role of defensins in the pathogenesis of inflammatory bowel

> disease]

>

> [Article in German]

>

> Schmid M, Fellermann K, Wehkamp J, Herrlinger K, Stange EF.

>

> Abteilung Innere Medizin I, -Bosch-Krankenhaus, Stuttgart.

>

> Defensins are endogenous antimicrobial peptides with a broad activity

> spectrum. Even at micromolar concentrations gramnegative and

> grampositive bacteria, but also mycobacteria, as well as fungi

> (candida), viruses (herpes) and protozoa (giardia lamblia) are

> destroyed. As part of the innate immune system defensins are

> expressed by the intestinal epithelium and contribute to the

> maintenance of the mucosal barrier. This barrier appears to be

> defective in inflammatory bowel diseases since on one hand, the

> immune response is directed against the " normal " luminal bacterial

> flora and on the other hand, mucosal adherent and invasive bacteria

> have been observed in these diseases. A defective defensin expression

> may well explain these phenomena. Indeed, Crohn's disease of the

> terminal ileum, especially if associated with a NOD2 mutation, is

> characterised by a diminished alpha-defensin (human defensin 5 and 6)

> expression, and in inflamed Crohn's colitis, in contrast to

> ulcerative colitis, the beta-defensin (human beta-defensins 2 and 3)

> response is reduced. Through a deficient chemical mucosal barrier

> this defect could lead to increased bacterial invasion into the

> intestinal mucosa and might well explain an adequate inflammatory

> response. Although the final proof that this deficient defensin

> response leads to a reduced antibacterial activity of the intestinal

> mucosa is still lacking, the most plausible concept of pathogenesis

> of Crohn's disease is a defensin deficiency syndrome.

>

> from healing crow where pecan bread are trying to shuffle me to.

>

> how can i tell them i don't have colitis because of the way i eat and

> supplement and probably enough of the right sun in childhood and

> teenage years? lol

>

> the effect of probiotics may not be enhancement of bacterial

> populations but a temporary redirection of the innate immune system

>

>

>

>

>

>

>

>

>

>

>

>

[Guest guest]

i'm not up with ig's i presume there is an enzyme somewhere involved

and if its missing then there msut be a heavy metals and mineral

transport issue and gene expression that has been drastically

affected.

bascially my synergistic approach as per my web page seem to slowly

improve gene expression...........

on the other hand the only people doing this are me and another

family who i help with supplements so it may simply be too diffcult

for people to do. if nothing else a tolerance for whey needs to be

worked towards and vitmain d and skin vitamin are essential for re-

expression of gene immune function.