Walsh/ methylation/christine

[Guest guest]

> --- In , " jornmatt " <kjorn@t...> .

> Dr. Walsh from

> > Pfieffer had some great updates and graciously answered my

List 'O

> > Questions.

> > > - explained the glitch with folic acid/B12 and undermethylation

>

> Hi :

>

> Can you please explain the glitch with folic acid/b12 (especially

if

> he refers to methyl b-12 shots and undermethylation that Dr. Walsh

> mentioned.

>

> FYI, my son is finally tolerating 1 capsule of ZP and AFP

> peptizyde. I'm sooooo excited! I'm already seeing positive

results after 2 days of this dosage.

So totally awesome!!! Congratualtions to your family. I would give

the enzymes another week before challenging GFCF. I might be fine,

but this will allow him to get throughly used to the enzymes and

better digestion first. If the challenge doesn't go well at first,

wait another 3 weeks to a month for more gut healing to happen and

try again.

Do you have a specific question on the B-12 and methylation? I have a

mathylation article in the Files section and also at the link below:

I couldn't figure out why there was an inconsistency and it is

written into the article (that there is an inconsistency in one

place). If someone isn't familiar with the methylation pathway, this

article explains it and one link andrew provided has a very nice

illustration of it.

http://www.enzymestuff.com/methylation.htm

Basically the glitch is that most people look at the methylation

pathway in autism assuming that it works in isolation and everything

else is functioning well. However, at one point, there is a side-

reaction which also utilizes folic acid thus draining it off or

converting it. All the folic acid put in is not necessarily 100$

devoted only to the methylation cycle. People forget it is there and

then wonder why 100% of the folic acid put in isn't working right.

Walsh said he has explained this over and over to dan doctors but

they just keep 'forgetting' or just blank out on it.

Another glitch is that the homocysteine created can back up...in a

healthy cycle it goes forward to pick up more B-12 proceed around

again. But in broken pathways, some co-factors for this conversion

aren't there working right and the homocysteine does not go forward

to pick up the b-12 and folic acid (and proceed forward). The

homocysteine backs up and starts pushing the cycle in reverse. Thus

adding more B-12/folic acid at the wrong times can worsen the

condition (because of the backup) instead of improve it.

This is a little hard to follow if you aren't looking at the picture.

You might want to print this out and look at the diagram as you read

through it.

I am been wondering about this for 2 years. Now I have a direct line

to a head techy person at Pfeiffer and can pursue these questions

quicker.

Oh, another complication or advantage is that TMG can creat a short-

cut through the pathway completely skipping over the B-12/folic acid

part of the cycle. If you are planning on this happening and you are

the right type of methylator, you can either take advantage of this

short-cut or be unpleasantly surprised and get very worse reactions.

I have read so many parents saying they added TMG or DMG and got

horrible reactions (my son was one of them). But other people get

great improvements with DMG (TMG might too). This may be a reason why.

Another reason is that people were not respecting doses of folic

acid. They might be a little under the level of folic acid they

needed and dose higher than necessary. So they overshoot the mark and

then the cycle is out of balance and doesn't proceed as needed. Even

though the person might benefit from a little folic acid and do well,

the doctors would get heavy handed on the mega-dosing, give too much

and get negative reactions (the old erroneous thinking that if a

little is helpful, a lot more would be much more helpful).

Walsh said he thinks now that the B-12 is more important than the

folic acid.

From an enzyme point of view (this is my thoughts, Walsh didn't say

this), B-12 is taken up in the ileum in the small intestine (located

at the end of the small intestine and right at the beginning of the

large. With many colon problems and intestine gut injury the ileum is

not functioning well, so B-12 is not being absorbed. Taking enzymes

to pro-actively heal the gut, you are helping to restore this natural

function rather than live with food eliminations and lots of B-12

shots for ever. At least with enzymes you could use a few shots as

backups with nutrition. I believe b-12 is made in the colon by good

bacteria too and colon problems seriously mess this up. I need to

double check that.

Getting back to methylation, if you look at the diagram, you notice

magnesium is a key co-factor needed to faciliate the reaction. With a

lot of people being magnesium deficient, adding more magnesium can

help this cycle too.

.