Yeast used to open nasal cells

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http://news.bbc.co.uk/1/hi/health/4674386.stm

Yeast used to open cells of nose to allow in insulin.

Yeast 'could allow insulin spray'

More than 1.7m people in England have diabetes

Diabetes patients could be able to receive insulin via a nasal spray using

yeast, scientists believe.

Leeds University researchers found the fungus, traditionally used to make

beer and bread, opened nasal cells to allow insulin to pass through nose tissue.

They hope it will allow a spray to be developed to replace injections.

A Diabetes UK spokeswoman said it would welcome " any safe, effective

advances which make the treatment of diabetes easier and more comfortable " .

Getting insulin into the bloodstream through the nose is tricky because

the layers of tissue lining the nose, known as the nasal mucosa, can block the

molecule.

Laboratory results show that yeast cells successfully enhanced the

penetration of insulin

Lead researcher Fuller

But in preliminary research, the scientists found that yeast, which is

non-toxic, opened up the tight junctions between nasal cells.

Lead researcher Fuller said: " Transport of large molecules, such as

insulin, through the nasal mucosa is limited because of the tight structure of

the cell layer which forms an impenetrable barrier.

" Our laboratory results show that yeast cells successfully enhanced the

penetration of insulin. "

The team, which presented its findings at the British Pharmaceutical

Conference in Manchester, said more research was needed.

Drug protection

Researchers also said they were looking at yeast's properties as a drug

delivery system.

They said it might be possible to encapsulate active drugs inside yeast

cells to protect them until they get to the site of action.

Zoe on, care advisor at Diabetes UK, said: " In the UK, there are

around 700,000 people with diabetes whose only treatment option is daily insulin

injections.

" Although this nasal therapy is in its very early stages, Diabetes UK

welcomes any safe, effective advances which make the treatment of diabetes

easier and more comfortable.

" We will await the results of the first clinical trials with interest. "