beta-glucan

[Guest guest]

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beta-glucan

Could somebody give me a brandname & /or a website where I can purchase some

beta-glucan? I'm having a tough time finding it around here, and I really don't

want to just randomly pick someplace to get it off the net. Thanks again for

the help

Kim

[Guest guest]

Dear Kim maybe you could ask this hospital which did the research with

betaglucan or try the other references below, otherwise go to this adres in the

Netherlands they sell good betaglucan in the Netherlands and probably know

adresses abroad www.aov-vitamines.nl :

Mol Urol 2000;4(1):7-14

Induction of Apoptosis in Human Prostatic Cancer Cells with beta-Glucan (Maitake

Mushroom Polysaccharide).

Fullerton SA, Samadi AA, Tortorelis DG, Choudhury MS, Mallouh C,

Tazaki H, Konno S

Department of Urology, New York Medical College, Valhalla, New York.

[Record supplied by publisher]

Purpose: To explore more effective treatment for hormone-refractory prostate

cancer, we investigated the potential antitumor effect of beta-glucan, a

polysaccharide of the Maitake mushroom, on prostatic cancer cells in vitro.

Materials and Methods: Human prostate cancer PC-3 cells were treated with

various concentrations of the highly purified beta-glucan preparation

Grifron-D® (GD), and viability was determined at 24 h. Lipid peroxidation

(LPO) assay and in situ hybridization (ISH) were performed to unravel the

antitumor mechanism of GD.

Results: A dose-response study showed that almost complete (>95%) cell death was

attained in 24 h with GD >/= 480 mug/mL. Combinations of GD in a concentration

as low as 30 to 60

mug/mL with 200 muM vitamin C were as effective as GD alone at 480 mug/mL,

inducing >90% cytotoxic cell death. Simultaneous use with various anticancer

drugs showed little potentiation of their efficacy except for the carmustine/GD

combination ( approximately

90% reduction in cell viability). The significantly (twofold) elevated LPO level

and positive ISH staining of GD-treated cells indicated oxidative membrane

damage resulting in apoptotic cell death.

Conclusion: A bioactive beta-glucan from the Maitake mushroom has a cytotoxic

effect, presumably through oxidative stress, on prostatic cancer cells in

vitro, leading to apoptosis. Potentiation of GD action by vitamin C and the

chemosensitizing effect of GD on

carmustine may also have clinical implications. Therefore, this unique mushroom

polysaccharide may have great a potential as an alternative therapeutic

modality for prostate cancer.

Referenties

1. Ohno N et al: 'Effect of beta-glucans on the nitric oxide synthesis by

peritonial macrophage in mice'; Biol. & Pharmac. Bull. 19(4):608B612, april

1996.

2. Adachi et al: 'Activation of murine kupffer cells by administration with

gel-forming 1,3-beta-D-glucan from Grifola frondosa'; Biol. & Pharmac. Bull.

21(3):278B283, maart 1998.

3. Felippe, Silva, Maciel, Sores, Mendes: 'Infection Prevention In Trauma

Patients With Severe Multiple Trauma With The Immunomodulator Beta 1-3

Polyglucose (Glucan)'; Surgery, Gynecology & Obstetrics, oktober 1993.

4. Fitzpatrick FW, DiCarlo JF: 'Zymosan' in: ls of the New York Academy of

Sciences; V.118, 233B262, 1964.

5. Di Luzio NR: 'Immunopharmacology of glucan: a broad spectrum enhancer of host

defense mechanisms'; Trends in Pharmacol. Sc. 4:344B347, 1983.

6. Czop JK, Austen KF: 'A b-glucan inhibitable receptor on human monocytes: its

identity with the phagocytic receptor for particulate activators of the

alternative complement pathway'; J. Immunol. 134:2588B2593, 1985.

7. DiLuzio, : 'Protective Effect of Glucan Against Systemic

Stapyloccocus aureau Septicemia in Normal and Leukemic Mice'; Infection and

Immunity, juni 1978.

8. Mansell, DiLuzio, McNamee: 'Recognition Factors and Nonspecific Macrophage

Activation in the Treatment of Neoplastic Disease'; Rowden & Proctor, ls

New York Academy of Sciences.

9. DiLuzio, McNamee, , Kitahama: 'Comparative Tumor-Inhibitory and

Anti-Bacterial Activity of Soluble and Particulate Glucan'; Int. J. Cancer 24,

1979.

10. Patchen ML, McVittie TJ: 'Stimulated hemopoesis and enhanced survival

following glucan treatment in sublethally and lethally irradiated mice'; Int.

J. Immunopharmac. 7:923B932, 1985.

11. Patchen ML, McVittie TJ: 'Hemopoietic effects of intravenous soluble glucan

administration'; J. Immunopharmacol. 8(3):407B425, 1986.

12. Seljelid R: 'Tumor regression after treatment with aminated beta 1-3D

Polyglucose is initiated by circulatory failure'; Scand. J. Immunol.

29(2):181192, febr. 1989.

13. Browder W, D, Pretus H et al: 'Beneficial Effect of Enhanced

Macrophage Function in the Trauma Patients'; Ann. Surg. Vol. 211:605B613,

1990.

14. MEDLINE: http://medlineplus.gov

Gr. kees braam

Webmaster www.kanker-actueel.nl

Citeren k & Kim <exnyers@...>:

> Could somebody give me a brandname & /or a website where I can purchase some

> beta-glucan? I'm having a tough time finding it around here, and I really

> don't want to just randomly pick someplace to get it off the net. Thanks

> again for the help

>

> Kim

>

>

>

[Guest guest]

I've been reading about the positive/negative effects of beta-glucan. One thing

that concerns me are some pubmed abstracts that associates it with inflammatory

conditions, like RA. Anyone know anything about this?

TIA,

Debi

's Little Sister ISBN 1-4137-1724-1 www.debityree.com

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