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This strikes me as a reasonable way of looking at the issues involved. I will add, however, that there is an issue of excess 'toxins' (or potentially toxic levels of vitamins) stored in fat. Walford has written about this among the biosphere participants during their weightloss, followed by an increase in pesticides & various toxins in the bloodstream.

Even if weightloss is targetted at a very large amount, over 3 years this could be less than a pound week, especially after the initial 'rush' of weightloss. 900 calories a day seems like very little & I'd be surprised if you didn't experience substantial loss at a higher level or even double that amount, especially for the first year.

Good luck & let us know how you do! Aside from the weighloss, longevity, etc..., many of the listmember from the mainlist have described it as a substantial 'control issue' as well, with the well-being and sense of accomplishment/control through CR feeling like control in other parts of one's life as well. Unfortunately, this is the same mechanism with eating disorders, but at least here it's been used constructively.

Best regards,

jamie

-----Original Message-----From: jessls2@... [mailto:jessls2@...]Sent: Monday, August 06, 2001 1:28 PM Subject: [ ] HowdyHello folks! Like Lee, I've been just reading for a while ("lurking"), and I have come out of my shell to introduce myself and to comment on a few posts I've seen recently. I have not yet started CR, because I feel as if I need to do a little more "thinking through"- the caloric restriction part is simple enough, however, it's the balancing (vitamins, amino acids, etc.) act that is a tad more difficult. :) I've been watching more closely what I've been putting in my mouth, and making more sensible decisions- which is a key first step, I assume. To comment on the posts about CR as a weight loss program: For those of us out there who are obese, any participation in a caloric restrictive program will ultimately make us lose weight- no matter what our intentions are (i.e., longevity). In my case, losing the excess weight will take care of a majority of my problems. Decreased risk of type II diabetes, decreased risk of breast cancer, heart disease, joint problems, back problems, ad infinitum. And losing weight and longevity DO go hand in hand! To be perfectly honest, as a 24 year old who has been struggling with my weight for a long time, I have participated in many "diets" the last of which was the Washington Obesity Clinic- which was a caloric restrictive program- 900 calories/day (all liquids), checked on every 2 weeks (EKG, blood tests, blood pressure, etc.). This brings me to addressing another topic I noticed on the posts: Losing weight "too fast." Those people out there who have to lose A LOT of weight, that is the single largest health problem they have. It will make their lives shorter, as it is scientifically proven. It's the root cause of so many evils. The symptom might be diabetes or a heart attack, but the cause is the large amount of weight they are lugging around with them. They also tend to lose weight a lot faster than "normal sized" people do. The fact remains- the fatter you are, the faster it comes off. (Granted, to a point. As you get closer to your goal weight, you of course "plateau.") When you lose such a large amount of weight, many problems simply stop occurring- I know many people who were once diabetic, who lost a significant amount of weight, and are no longer diabetic. Joints stop hurting, breathing is easier, and in general, as you start to lose, it becomes easier to do so, because the energy is there and exercise (while it may not be fun) is a hell of a lot easier! As a reminder for those of us who do have more weight to lose and have subscribed to the list, it's important to be smart, talk to your doctor, and keep in mind that 2-3 lbs/week is certainly not abnormal for the first few months- whether you are working with a commercially known weight loss group or your ultimate goal is longevity. For those of you who are lucky enough to not have experienced obesity, think of it as this: 2-3 lbs a week on an average framed woman who weighs 150 lbs is a lot of weight to lose in one week. 2-3lbs a week on an average framed woman who weighs 300 lbs, is not a lot of weight to lose in one week. As long as you are reaching your goals nutritionally, taking it step by step, and talking to your doctor, you will most likely be safe. The key is to be aware of what you are doing!

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Hi Jess,

Welcome to the group! Many of us, including myself, went a little too fast at first. Not that going too fast (i.e. 2-3 pounds a week) is a bad thing from a health perspective (i.e. all the things you mentioned)...but from a CR perspective (i.e. longevity...that is living longer than 110 years) losing weight that fast is counter productive according to the rat experiments.

All of us must find a balance between avoiding health risks (i.e. dieing before our time) and CR longevitiy (increasing our time).

Another potential problem with going to fast is bouncing back...but if you are committed to CR...that's not a real issue. We all know that yo-yo dieting is a bad thing.

So, be sensible, go faster at the start if you like...but as you suggest keep under the care of a good doc. and watch your nutrition...don't starve yourself into malnutrition. and WELCOME to the group....keep learning via the group and readings/study and you'll develop the approach that's best for you.

Thanks,

Todd R. BarberChairman, Reef Ball FoundationCEO, Reef Ball Development Group, Ltd.6916 22nd Street WestBradenton, FL 34207941-752-0169 (Office)941-752-0338 (Direct Line)941-752-1033 Fax941-720-7549 Cellreefball@...http://www.artificialreefs.orghttp://www.reefball.comhttp://www.reefball.org

----- Original Message -----

From: jessls2@...

Sent: Monday, August 06, 2001 3:28 PM

Subject: [ ] Howdy

Hello folks! Like Lee, I've been just reading for a while ("lurking"), and I have come out of my shell to introduce myself and to comment on a few posts I've seen recently. I have not yet started CR, because I feel as if I need to do a little more "thinking through"- the caloric restriction part is simple enough, however, it's the balancing (vitamins, amino acids, etc.) act that is a tad more difficult. :) I've been watching more closely what I've been putting in my mouth, and making more sensible decisions- which is a key first step, I assume. To comment on the posts about CR as a weight loss program: For those of us out there who are obese, any participation in a caloric restrictive program will ultimately make us lose weight- no matter what our intentions are (i.e., longevity). In my case, losing the excess weight will take care of a majority of my problems. Decreased risk of type II diabetes, decreased risk of breast cancer, heart disease, joint problems, back problems, ad infinitum. And losing weight and longevity DO go hand in hand! To be perfectly honest, as a 24 year old who has been struggling with my weight for a long time, I have participated in many "diets" the last of which was the Washington Obesity Clinic- which was a caloric restrictive program- 900 calories/day (all liquids), checked on every 2 weeks (EKG, blood tests, blood pressure, etc.). This brings me to addressing another topic I noticed on the posts: Losing weight "too fast." Those people out there who have to lose A LOT of weight, that is the single largest health problem they have. It will make their lives shorter, as it is scientifically proven. It's the root cause of so many evils. The symptom might be diabetes or a heart attack, but the cause is the large amount of weight they are lugging around with them. They also tend to lose weight a lot faster than "normal sized" people do. The fact remains- the fatter you are, the faster it comes off. (Granted, to a point. As you get closer to your goal weight, you of course "plateau.") When you lose such a large amount of weight, many problems simply stop occurring- I know many people who were once diabetic, who lost a significant amount of weight, and are no longer diabetic. Joints stop hurting, breathing is easier, and in general, as you start to lose, it becomes easier to do so, because the energy is there and exercise (while it may not be fun) is a hell of a lot easier! As a reminder for those of us who do have more weight to lose and have subscribed to the list, it's important to be smart, talk to your doctor, and keep in mind that 2-3 lbs/week is certainly not abnormal for the first few months- whether you are working with a commercially known weight loss group or your ultimate goal is longevity. For those of you who are lucky enough to not have experienced obesity, think of it as this: 2-3 lbs a week on an average framed woman who weighs 150 lbs is a lot of weight to lose in one week. 2-3lbs a week on an average framed woman who weighs 300 lbs, is not a lot of weight to lose in one week. As long as you are reaching your goals nutritionally, taking it step by step, and talking to your doctor, you will most likely be safe. The key is to be aware of what you are doing!

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  • 8 years later...
Guest guest

Hi Marcos,

So glad to hear that you continue to do well on Gleevec.

I just don't understand his attitude. He is the doctor and should be making

the medical decisions. If he thinks that you should go to another medication

then he should make the suggestion and explain why the switch is necessary.

I don't know of any CML specialist that will suggest switching medication

when the current medication is doing so well. Changing medication can result

in side effects that could change your QOL.

Zavie

Zavie (age 72)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.6 log reduction Apr/08

3.6 log reduction Sep/08

3.7 log reduction Jan/09

3.8 log reduction May/09

3.8 log reduction Aug/09

4.0 log reduction Dec/09

4.4 log reduction Apr/10

e-mail: <mailto:zmiller@...> zmiller@...

Tel: 613-726-1117

Fax: 613-482-4801

Cell: 613-282-0204

ID: zaviem

From: [mailto: ] On Behalf Of Marcos

Perreau Guimaraes

Sent: August-05-10 1:37 PM

Subject: [ ] howdy

I hope everybody on the list is doing well. Just a quick hello from

San , CA. I haven t posted for a while as life is pretty busy

right now with my girlfriend going to UCLA in the fall. I got another

negative PCR yesterday so everything is as good as possible on that

front. My dr mentioned a few months ago the possibility (if and when I

want) to switch to one of the 2nd generation drugs but I declined, I

don t see why to fix something that s working so well (I am on 400mg

of gleevec since March 2005). I wish everybody a good upcoming

week-end,

Cheers,

Marcos

--

Marcos Perreau Guimaraes

Suppes Brain Lab

Ventura Hall - CSLI

Stanford University

220 Panama street

Stanford CA 94305-4101

650 721 9305

408 219 9622 (cell)

marcospg@... <mailto:marcospg%40stanford.edu>

montereyunderwater@... <mailto:montereyunderwater%40gmail.com>

www.stanford.edu/~marcospg/

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