High-fat diet-induced hyperglycemia and obesity in mice: differential effects of dietary oils.

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Hi All,

In The Omega Diet, on page 80 is an interesting diagram showing how different

diets, with identical cals and % of fat,

had dramatic effects on body weight of test mice.

1) Soybean oil diet - 45 g

2) Lard diet - 40 g

3) Safflower oil diet - 34 g

4) Fish oil diet - 26 g

Here is the referenced research paper for more details:

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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=8\

969289 & dopt=Abstract

Metabolism 1996 Dec;45(12):1539-46 Related Articles, Books, LinkOut

High-fat diet-induced hyperglycemia and obesity in mice: differential effects of

dietary oils.

Ikemoto S, Takahashi M, Tsunoda N, Maruyama K, Itakura H, Ezaki O.

Division of Clinical Nutrition, National Institute of Health and Nutrition,

Tokyo, Japan.

Mice fed a high-fat diet develop hyperglycemia and obesity.

Using non-insulin-dependent diabetes mellitus (NIDDM) model mice, we

investigated the effects of seven different dietary

oils on glucose metabolism:

1) Palm oil, which contains mainly 45% palmitic acid (16:0) and 40% oleic acid

(18:1);

2) Lard oil, 24% palmitic and 44% oleic acid;

3) Rapeseed oil, 59% oleic and 20% linoleic acid (18:2);

4) Soybean oil, 24% oleic and 54% linoleic acid;

5) Safflower oil, 76% linoleic acid;

6) Perilla oil, 58% alpha-linolenic acid;

7) Tuna fish oil, 7% eicosapentaenoic acid and 23% docosahexaenoic acid.

C57BL/6J mice received each as a high-fat diet (60% of total calories) for 19

weeks (n = 6 to 11 per group).

After 19 weeks of feeding, body weight induced by the diets was in the following

order (heaviest first):

1) Soybean [ 45 g..gw]

2) Palm

3) Lard [40 g..gw]

4) Rapeseed

5) Safflower [34 g..gw]

6) Perilla

7) Fish oil [26 g..gw]

Glucose levels 30 minutes after a glucose load were:

1) Highest for safflower oil (approximately 21.5 mmol/L),

2) Modest for rapeseed oil, soybean oil, and lard (approximately 17.6 mmol/L),

3) Mild for perilla, fish, and palm oil (approximately 13.8 mmol/L),

4) Minimal for high-carbohydrate meals (approximately 10.4 mmol/L).

Only palm oil-fed mice showed fasting hyperinsulinemia (P < .001). By stepwise

multiple regression analysis, body weight

(or white adipose tissue [WAT] weight) and intake of linoleic acid (or n-3/n-6

ratio) were chosen as independent

variables to affect glucose tolerance. By univariate analysis, the linoleic acid

intake had a positive correlation with

blood glucose level (r = .83, P = .02) but not with obesity (r = .46, P = .30).

These data indicate that (1) fasting blood insulin levels vary among fat

subtypes, and a higher fasting blood insulin

level in palm oil-fed mice may explain their better glycemic control

irrespective of their marked obesity; (2) a

favorable glucose response induced by fish oil feeding may be mediated by a

decrease of body weight; and (3) obesity and

a higher intake of linoleic acid are independent risk factors for dysregulation

of glucose tolerance.

PMID: 8969289 [PubMed - indexed for MEDLINE]

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The weight differences were like that for a 225 lb person verus a 150 lb person,

even though the diets contained the

same amount of calories and the same % of fat. While I'm not suggesting a diet

of 60 % fat is something we would want

to adopt, the results are still very intriguing.

Amazing stuff EPA as it alters gene expression, shunting fat away from storage

and into being burnt for fuel and lowers

insulin resistance / improves glucose disposal.

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Good Health & Long Life,

Greg ,

http://www.ozemail.com.au/~gowatson

gowatson@...