LDN--totally weird side effect?

[Guest guest]

This is just so strange. I don't know if LDN is the cause or it's

unrelated but it's happened now twice.

First night, no problems. Second morning work up in state of extreme

anxiety which lasted all day. Took one, then another .5mg ativan,

which had no effect, also extremely unusual. So I took a break of a

couple of days and started LDN again.

First and second night, ok. Third morning woke up again in a panicked

state, couldn't breathe, and was extremely nauseus. This lasted all

day long, in addition to the unabating panic and really crazy head

feelings I just can't describe.

What makes it so confusing is that I do sometimes have anxiety attacks

(nothing like these last two) and I do have gastritis and acid reflux

problems, but never ever with nauseau and vomiting.

It's almost as if the LDN was mixing with a narcotic, except it wasn't.

Didn't take the LDN last night--too freaked. Today, I'm better but my

stomach has definitely taken a hit.

[Guest guest]

: Celiac disease (allergy to gluten protein) which most people

do not know does not come in an all or none fashion; there are many

degrees of celiac intolerance. Untold numbers of people eat wheat

since it is a staple food in our society and never feel good - they

have indigestion, stool irregularities, weight issues, and never know

that if they would eliminate wheat and casein they would feel like new

people. Many people who eat wheat and milk do not even know what

feeling good is like untill they remove these foods from their diet.

As I have said many times before on this board, anytime someone has a

negative reaction to LDN the first question I would ask is, What is

the diet like? If I had a disease such as ALS or MS, I would be more

than willing to see if my dietary exogenous opioids could be causing

the negative reaction to a drug that is helping most of these people

get off all their other drugs without progression of their disease.

The reason this is a worthwhile trial is that this intolerance is

affecting their general health and immunity in a negative way.

Unfortunately, sometimes it takes up to 6 months to get gluten out of

the system, so it is not so easy to test - I will try to find out if

there is a test for milder ranges of celiac if I can. Of course,

before bothering with diagnostic tests to see if there is an

intolerance, the person has to be willing to give up these foods if

the tests show reactions, or else there is no need wasting blood and

money. Food is so emotionally entrenched in most people's notions of

love and inner security, you would be amazed at what people will

endure to eat the foods to which they are addicted! I have a huge

respect for the power of addiction to foods and the difficulty in

making radical changes from the diet we are accustomed to. Usually it

takes an evaluation in the context of a serious illness for people to

even consider changing, and even then many will not.

Dr. JM

[Guest guest]

--

Thanks for the reply. If I understand correctly, you( quoting Dr.

McClandless)are saying that people can have undiagnosed food

intolerances and if so, they might have a reaction to LDN such as I

described, along with any number of other strange symptoms.

I know casein isn't an issue for me. I gave up all dairy more than 10

years ago (extreme lactose intolerance). In fact, except for the

occasional fish, my diet is vegan. As for gluten, that's a tough call

because I eat much less wheat than the average person and don't have

any of the other symptoms you've mentioned--weight or bowel issues.

The gastritis is the result of chemo drugs I've taken and possibly

even damage from radiation treatment I had 20 years ago. Also, hiatal

hernia doesn't help, and none of that is made any better than the

constant stress and anxiety of living on borrowed time with cancer,

which I have been for a very long time now.

As this point, I think I have to get a handle on the gastritis before

I try again with the LDN, or at least let enough time pass so that if

I try it again and the same thing happens, I'll know for sure there's

a connection. Also, I may have to start on a lower dose, because I've

noticed with other drugs that a little goes a long way. I once had an

extreme terrible reaction from just increasing zoloft from 50 to 100mg.

[Guest guest]

>

> --

>

> Thanks for the reply. If I understand correctly, you( quoting Dr.

> McClandless)are saying that people can have undiagnosed food

> intolerances and if so, they might have a reaction to LDN such as I

> described, along with any number of other strange symptoms.

>

> I know casein isn't an issue for me. I gave up all dairy more than

10

> years ago (extreme lactose intolerance). In fact, except for the

> occasional fish, my diet is vegan. As for gluten, that's a tough

call

> because I eat much less wheat than the average person and don't have

> any of the other symptoms you've mentioned--weight or bowel issues.

> The gastritis is the result of chemo drugs I've taken and possibly

> even damage from radiation treatment I had 20 years ago. Also,

hiatal

> hernia doesn't help, and none of that is made any better than the

> constant stress and anxiety of living on borrowed time with cancer,

> which I have been for a very long time now.

>

> As this point, I think I have to get a handle on the gastritis before

> I try again with the LDN, or at least let enough time pass so that

if

> I try it again and the same thing happens, I'll know for sure there's

> a connection. Also, I may have to start on a lower dose, because

I've

> noticed with other drugs that a little goes a long way. I once had an

> extreme terrible reaction from just increasing zoloft from 50 to

100mg.

>

>

>

============

You might want to converse with Dr. McCandless on your issues, she can

explain all this better than I. Since you are lactose intolerant you

may be gluten intolerant. If you are possibly gluten intolerant it

may be causing you to have exogenous opioids and that would cause

adverse side effects with LDN.

[Guest guest]

In a message dated 4/16/07 10:03:25 AM Eastern Daylight Time, patriciahelsing@... writes:

Third morning woke up again in a panicked

state, couldn't breathe, and was extremely nauseus. This lasted all

day long, in addition to the unabating panic and really crazy head

feelings I just can't describe.

It could be a reaction to the filler.************************************** See what's free at http://www.aol.com.

[Guest guest]

I was also allergic to Avicel, the filler they were using in my LDN. Once I changed to lactose all the side effects, including extreme nasea, cleared up in a few days. Check to see which filler the pharmacy used for your capsules, and change if it is avicel and see if it helps.

Good luck, LDN 3.0 is helping me with MS.

JoyceSee what's free at AOL.com.

[Guest guest]

How many mgs are you taking?

Re: [low dose naltrexone] LDN--totally weird side effect?

In a message dated 4/16/07 10:03:25 AM Eastern Daylight Time, patriciahelsing writes:

Third morning woke up again in a panickedstate, couldn't breathe, and was extremely nauseus. This lasted allday long, in addition to the unabating panic and really crazy headfeelings I just can't describe. It could be a reaction to the filler.**************************************See what's free at http://www.aol.com.

[Guest guest]

could be triggering instant withdrawals from old drugs in your system? or maybe revisiting your biggest old problems first.

Read post #45484

May not be able to get 'there' from 'here' without going through the full sequence of events.

[low dose naltrexone] LDN--totally weird side effect?

What makes it so confusing is that I do sometimes have anxiety attacks(nothing like these last two) and I do have gastritis and acid refluxproblems, but never ever with nauseau and vomiting.It's almost as if the LDN was

[Guest guest]

Dr. McCandless - i've suspected for quite some time now, that i may have celiac disease. when i asked my PCP to test me for it, he said all i had to do was stop eating wheat!! maybe, now that i have a new PCP, she will have me tested for it!! thanx for all the information you gave about celiac & gluten!!

marshirisSee what's free at AOL.com.

[Guest guest]

-

I am on prednisone (now down to 10 mg a day) Dr. Ayre knew this when he prescribed the LDN.

MeghannSee what's free at AOL.com.

[Guest guest]

meghann - are you an MS or a CROHN'S patient - taking LDN with prednisone?

marshirisSee what's free at AOL.com.

[Guest guest]

RRMS and I had Bells PalsySee what's free at AOL.com.

[Guest guest]

should you be taking an oral dose of prednisone for an

exacerbation, if you are taking LDN? ? Should you stop

the LDN while you are on the prednisone? Let me know.

Thanks