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Top Stories

Higher Serum Calcium Associated With Smaller Ischemic Stroke Volumes

CME Sleep Apnea Often Seen With Chronic Opioid Use

Delayed Natalizumab Allergy Seen in Patient With Multiple Sclerosis

CME/CE " Opt-out " HIV Testing and First-line Therapy

Accuracy of Pain Intensity Scale

Feature Articles

Stroke

Higher Serum Calcium Associated With Smaller Ischemic Stroke Volumes

Elevated serum calcium levels in patients with acute ischemic stroke are

associated with smaller infarct volumes, according to a new report.

Reuters Health Information 2007

Thyroxine Derivatives Protect Mice Against Stroke

The novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce

transient hypothermia and marked neuroprotection against stroke injury in a

murine model, researchers report in the September issue of Stroke.

Reuters Health Information 2007

Middle Cerebral Artery Flow Velocity Associated With Stroke Risk

Increased middle cerebral artery flow velocity as measured by transcranial

Doppler (TCD) is associated with an increased risk of stroke, according to a

report in the September issue of Stroke.

Reuters Health Information 2007

Headache

Lower Cervical Disc Prolapse May Cause Cervicogenic Headache

In rare cases, disc prolapse of the lower cervical spine will lead not only

to neck pain and pain radiating into the arms, but also headache, results of

a prospective controlled study indicate.

Reuters Health Information 2007

Multiple Sclerosis

Switching Therapy in Multiple Sclerosis: Challenge and Potential

When your patient continues to experience relapses and progressive

disability despite a proven beneficial MS treatment, how do you find the

best next step?

Medscape Neurology & Neurosurgery 2007

Delayed Natalizumab Allergy Seen in Patient With Multiple Sclerosis

Although most hypersensitive reactions to natalizumab occur within hours of

the first dose, such responses may be delayed, according to a case report by

German researchers.

Reuters Health Information 2007

Parkinson's Disease

A Case of Levodopa-Responsive Camptocormia Associated With Advanced

Parkinson's Disease

This case illustrates the challenge of optimizing dopaminergic therapy to

control symptoms of advanced Parkinson's disease, which in this patient

included the intriguing phenomenon of camptocormia.

Nat Clin Pract Neurol 3(9) 2007

Considerations in Neuroprotection in Parkinson's Disease

Learn about pharmacologic agents that may be neuroprotective in Parkinson's

disease patients and issues regarding clinical trial methodology evaluating

an agent's potential to provide neuroprotection.

Medscape Neurology & Neurosurgery 2007

Alzheimer's Disease

Functional MRI May Detect Early Alzheimer's Disease

On functional MRI, impaired deactivation in the posteromedial cortices of

the brain may help identify patients in the early stages of Alzheimer's

disease, according to a report in the October issue of Radiology.

Reuters Health Information 2007

No Association of CSF Biomarkers with APOE 4, Plaque and Tangle Burden in

Definite Alzheimer's Disease

In 50 autopsy-confirmed Alzheimer's disease patients, no association was

found between the levels of amyloid peptide, total tau protein, and tangle

and plaque burden in AD patients.

Brain 130(9) 2007

Sleep Medicine

Sleep Apnea Often Seen With Chronic Opioid Use

According to an observational study with the use of polysomnography,

sleep-disordered breathing was common in patients receiving opioids for

chronic pain.

Reuters Health Information 2007

Epilepsy

Male Offspring of Mothers With Epilepsy May Have Diminished Adult

Intelligence

Results of a study published in the September issue of Epilepsia suggest

that nearly 20 years after birth, maternal epilepsy is associated with

reduced adult intelligence in male offspring.

Reuters Health Information 2007

Diagnosis and Management of Nonconvulsive Status Epilepticus in Children

In children, nonconvulsive status epilepticus (NCSE) is associated with

various conditions, including acute neurological injuries and childhood

epilepsy syndromes. Prognosis, and treatment recommendations for NCSE are

discussed.

Nat Clin Pract Neurol 3(9) 2007

Other Neurology Topics

CME/CE " Opt-out " HIV Testing and First-line Therapy

Opt-out HIV testing in all healthcare settings may mean earlier treatment

for the individual patient and help to curtail the spread of HIV. Dr.

G. Bartlett reviews the latest on both issues.

CME Skin Biopsy as a Diagnostic Tool in Peripheral Neuropathy

Skin biopsy is a safe, minimally invasive, painless and cheap diagnostic

tool for use in small nerve fibers. Its advantages and how it compares with

other methods in diagnosing neuropathy are described.

CME/CE Medication Errors and Patient Safety in Mental Health

Programs to increase PCPs' recognition of disorders have not shown improved

treatment outcomes. What has? How can psychiatrists and others improve

patient safety in their practices and in society?

CME/CE Multidisciplinary Perspectives on Management of Glioblastoma

Multiforme

In this video CME activity, a multidisciplinary panel of experts discusses

local therapies for patients with glioblastoma, with particular focus on

intracavitary chemotherapy.

Temporal Trends in Eversion Carotid Endarterectomy for Carotid

Atherosclerosis: Single-Center Experience with 5,034 Patients

This large single-center series of ECEA reports a decline in perioperative

mortality and morbidity.

Vascular 15(4) 2007

Recognizing Involuntary Emotional Expression Disorder

Involuntary laughing or crying is common among patients with stroke and

other neurological disorders. How can we assist patients and families?

J Neurosci Nurs 39(4) 2007

FDA Issues Public Health Advisory for Fentora

The agency emphasizes that fentanyl buccal tablets should be used only for

approved indications, and physicians should ensure appropriate

dosing/titration to reduce the risk for respiratory depression.

Medscape Medical News 2007

Aprotinin in Cardiac Surgery: A Summary of the FDA Panel Hearing to Assess

Safety

The panel voted in favor of keeping aprotinin on the market for high-risk

patients undergoing on-pump CABG surgery, but emphasized the need for

additional randomized studies to assess safety.

Medscape Cardiology 2007

Mycotic Aneurysm of the Internal Carotid Artery Presenting with Multiple

Cerebral Septic Emboli

A case of a 79-year-old male with an extracranial internal carotid artery

mycotic aneurysm during Staphylococcus aureus bacteremia.

Vascular 15(4) 2007

Editorials

Please Help Us Provide Needed Mental Healthcare for Returning Vets

Barbara V. Romberg, PhD, Licensed Clinical Psychologist, Founder and

Executive Director, Give an Hour Nonprofit Organization, Washington, DC,

tells us how we can volunteer our needed services.

Medscape General Medicine 9(3) 2007

By Financial Disclosures, We're Fixing the Wrong Problem

Jerome P. Kassirer, MD, Distinguished Professor of Medicine at Tufts

University School of Medicine, NEJM's doctor, speaks about financial

conflicts of interest.

Medscape General Medicine 9(3) 2007

Opinion Poll

Accuracy of Pain Intensity Scale

A study in the October issue of the Journal of General Internal Medicine

discusses the accuracy of identifying pain intensity using a numeric 0-to-10

scale. How accurately do you think such a scale gauges your patients' pain

levels? To vote or view results of the poll, click on the title above.

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