Haldol

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From Nurse's Drug Guide 2004 pub by Prentice Hall

Tourette's Disorder

Child: PO (oral) 0.05-0.75 mg/kg/d in 2-3 divided doses

USES: Management of manifestation sof psychotic disorders and for control of

tics and vocal utterances of Gilles de la Tourette's dyndrome; for treatment of

agitated states in acute and chronic psychoses. Used for short-term treatment

of hyperactive children and for severe behaviorproblems in children of

combative, explosive hyperexcitability.

CONTRAINDICATIONS: Parkinson's disease, parkinsonism, seizure

disorders, coma; alcoholism; severe mental depression, CNS depression,

thyrotoxicosis. Safe for use during pregnancy (category C), lactation or in

children <3y is not established.

CAUTIOUS USE: Older adult or debilitated patients, urinary retention,

glaucoma, severe cardiovascular disorders; patients receiving

anticonvulsant, anticoagulant or lithium therapy.

ADVERSE EFFECTS (>1%) CNS Estrapyramidal reactions (common):

Parkinsonian symptoms, dystonia, akathisia, tardive dyskinesia (life

threatening) (after long term use); insomnia, restlessness, anxiety, euphoria,

agitation, drowsiness, mental depression, lethargy, anxiety, euphoria,

agitation, drowsiness, mental depression, lethargy, fatigue, weakness, tremor,

ataxia, headache, confusion, vertigo; neuroleptic malignant syndrome (life

threatening), hyperthermia, grand mal seizures, exacerbation of psychotic

symptoms. CV: Tachycardia, ECG changes, hypotension, hypertension (with

overodsage). ENDOCRINE: Menstrual irregularities, galactorrhea, lactation,

gynecomastica, impotence, increases libido, hyponatremia, hyperglycemia,

hypoglycemia. SPECIAL SENSES: Blurred vision HEMATOLOGIC: mild

transient leukopenia, agranulocytosis (life threatening, rare) GI: Dry mouth,

anorexia, nausea, vomiting, constipation, diarrhea, hypersalivation.

UROGENITAL: Urinary retention, priapism RESPIRATORY: Laryngospasm

(life threatening), bronchospasm, increased depth of respiration,

bronchopneumonai, respiratory depression (life threatening) SKIN:

Diaphoresis, maculopapular and acneiform rash, photosensitivity. OTHER:

Cholestatic jaundice, variations in liver function tests, decreased serum

cholesterol.

INTERACTIONS: Drug CNS depressants, opiates, alcohol increase CNS

depression; may antagonize activity of oral anticoagulants, anticholinergics

may increase intraocular pressure; methylodopa may precipitate dementia.