Guest guest Posted May 23, 2003 Report Share Posted May 23, 2003 Does anyone know if there are any studies out there regarding resistance to Tobi? We are treating our 9 mo.-old Abby with Tobi for non-mucoid PA (her 2nd pos. culture) This is her 3rd round of Tobi and I'm getting concerned about resistance. Does Tobi encourage the formation of mucoid PA? I wonder if the PA " runs " from the Tobi and what doesn't get killed speeds up the formation of the defense mechanism of the biofilm shield. She doesn't, since she's a baby, do a thorough job of inhaling the drug deeply although we make sure to seal it well around her face and get as much as possible in her. I feel like we should either pound it thoroughly with antibiotics or either leave it alone. To make an example, if you sting something a few times with a BB gun it's going to be harder to get a kill shot with a rifle later. In the hospital they did a rotten job with the Tobi - I just didn't know better at the time. Even with her IV tobra and timentin - it was a week into her treatment before they got the drug levels where they should be. And that was because I figured out what they were doing and made them pull the sample at the correct time. If anyone has info on this I'd appreciate it. Joe (Dad of Kelsi, 6; Chloe, 2 and Abby 9mos.w/cf) Quote Link to comment Share on other sites More sharing options...
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