Abstract : CF and Home IV's

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Infection

ISSN: 0300-8126 (printed version)

ISSN: 1439-0973 (electronic version)Table of Contents Abstract Volume 30

Issue 6 (2002) pp 387-391

DOI 10.1007/s15-0

clinical and epidemiological study: Home and Hospital Antibiotic

Treatment Prove Similarly Effective in Cystic Fibrosis

J. Riethmueller, A. Busch, V. Damm, R. Ziebach, M. Stern

University Children's Hospital, Hoppe-Seyler-Str. 1, D-72076 Tuebingen,

Germany. joachim.riethmueller@...

Received: August 20, 2001 · Revision accepted: April 3, 2002Abstract.

Background: Home intravenous antibiotic treatment has added to

therapeutic options against Pseudomonas aeruginosa in cystic fibrosis

(CF) patients leading to increased flexibility. A prospective clinical

study was carried out to compare home and hospital iv antibiotic

treatment in CF patients with chronic P. aeruginosa infection. Patients

and Methods: Treatment courses were planned selectively, exacerbations

were excluded. 28 consecutive hospital courses (group 1) were compared

with 30 home care courses (group 2). Chest physiotherapy and nutrition

therapy were carried on in both groups. Antibiotic treatment in both

groups consisted of tobramycin and ceftazidime, with equal dosage and

application. Groups were compared using clinical, inflammatory and

microbiological parameters. Results: There was a significant difference

(p \leq 0.05) in peripheral leukocyte counts before and after therapy in

both groups. The same was true for forced expiratory volume in 1 sec

(FEV1; p \leq 0.05), weight for height (p \leq 0.005) and for Pseudomonas

counts (p \leq 0.005) in sputa. There was no statistical difference

between the two groups for any of the parameters tested. Conclusion: It

is concluded that, when exacerbations are excluded, home iv therapy is an

effective therapeutic option in CF. Long-term comparison is still needed

to effectively evaluate the pros and cons of home and hospital antibiotic

treatment in CF. Article in PDF format (114 KB)

Becki

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