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Article :Granulomatous diseases in a Pt. w/ CF

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Journal of Cystic Fibrosis

Article in Press, Corrected Proof - Note to users

Copyright © 2003 European Cystic Fibrosis Society. Published by Elsevier

Science B. V. Case report

Granulomatous diseases in a patient with cystic fibrosis

J. Dobbin, Carmel Moriarty and T. P. Bye,

Department of Respiratory Medicine, E 11 South, Royal Prince Alfred

Hospital, Missenden Road, Camperdown NSW 2050, Australia

Available online 11 February 2003.

Abstract

We report the case of an adult with Crohn's disease and pulmonary

sarcoidosis on the background of cystic fibrosis (CF). There is a

recognized association between Crohn's colitis and CF, but cases of

pulmonary sarcoidosis in CF are rare. There may be a pathogenic link

between the two granulomatous disorders and CF with chronic immune

stimulation leading to hyperimmunoglobulinemia, circulating immune

complexes and subsequent granuloma formation. Author Keywords: Cystic

fibrosis; Crohn's disease; Sarcoidosis

  Corresponding author. Tel.: +61-2-9515-7427; fax: +61-2-9515-8196

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