More info on Morphine and SOD

[Guest guest]

I was reading our on-line pharmacy information about morphine

and ran into this caution. It made me think of a question that

was posted recently about using morphine when having SOD

spasm, etc. I thought it may interest some of you:

(it came from DrugDX I think)

B. BILIARY PAIN

* 1. Of five studies investigating the effects of morphine on the

SPHINCTER OF ODDI, four reported an increase in basal

pressure following morphine administration, with one study

indicated a possibly dose relationship. However, the one study

that did not report an increase in pressure did report an increase

in contraction frequency(Isenhower & Mueller, 1998).

* 2. Within minutes of intravenous MORPHINE administration,

the sphincter of Oddi and the lower common bile duct contract

with a resultant increase in intraluminal ductal pressure that may

last from 4 to 6 hours. The spasmogenic effect of MORPHINE is

readily reversed by NALOXONE (Worobetz et al, 1982).

* 3. MEPERIDINE and KETOROLAC do not contract the sphincter

of Oddi and would be preferred over MORPHINE for analgesia in

patients with biliary pain, or in situations where biliary tract

spasm is undesirable (Thune et al, 1990; Krimmer et al, 1992).