Re: things to avoid-long

[Guest guest]

Thank you, Laurie!

I have seen some of this information, but not all. It has already been

printed up to digest and keep for my records.

I would love to have the attachments, if it is not too much trouble -

whenever you are able to send them.

Regards

Sunny

> Hi Sunny

>

> Here is a summary of things to avoid, put together by one of our

> members from information gathered at one of the mito conferences. I

> have some of the original articles that I can send as an attachment

> privately.

>

> laurie

>

> MEDICATIONS CONTRAINDICATED IN MITOCHONDRIAL DIESASE

>

> On page 269 of the Syllabus for the International Conference on Mito

> Disease, 1997 you will find the following recommendations:

> " Treatment remains largely symptomatic and does not significantly

> alter the course of the disease. It includes avoidance of drugs and

> procedures known to have a detrimental effect, symptomatic treatments,

> supplementation with co-factors, prevention of oxygen radical damage

> to mitochondrial membranes and dietary recommendations. "

> " It is advisable to avoid Sodium Valproate and barbiturates which

> inhibit the respiratory chain and have occasionally been shown to

> precipitate hepatic failure in respiratory enzyme deficient children.

> Tetracyclines and chloramphenical should be avoided as well, as they

> inhibit protein synthesis. "

> As well certain types of anaesthesia are also contraindicated. There

> is a wonderful and comprehensive article dealing with the safety of

> anaesthesia in mitochondrial cytopathy patients in the October 98

> issue

> of the United Mitochondrial Disease Federation newsletter, as well as

> at the UMDF site.

> It is not always possible to avoid these drugs but at least if you are

> informed ahead of time and the possibility of an alternative exists,

> you can make an informed decision. There is no doubt that some folks

> with

> mitochondrial cytopathy have used these drugs uneventfully, although

> the potential is still there. Be an informed consumer!

>

> Cohen and Shoffner lists about anaesthetic agents.

> Barbiturates - Inhibits complex I activity at high levels

> Benzodiazepines - Inhibits adenosine nucleotide translocase

> Propofol and/or lipid carrier - Inhibits mitochondrial function

> Halothane - Increased risk for heart rhythm disturbance

> Nitrous Oxide - Neurotoxic, possibly by increasing nitric oxide

> production, which inhibits cisacotinase and iron-containing electron

> transport enzymes: affecting energy production

> Non-depolarizing Agents - Increased sensitivity to the paralytic

> effects and prolonged responses reported

> Local Anaesthetics - Bupivacaine uncouples oxidation and

> phosphorylation

> Should never use Lactated Ringer's solution (Ringer's Lactate) because

> it contains lactic acid.

> Depolarizing agents (Succinylcholine) bothers some people.

> ****************************

> Valproate or Depakote (Valproic Acid) is an anti-convulsant. It is

> known to be a potential toxin to those with either mitochondrial

> disorders or metabolic disease. It can cause severe hepatoxicity or

> liver failure in susceptible persons.

> Phenobarbital is another potential mitochondrial toxin that can also

> be dangerous to those with mitochondrial cytopathy. It is wise to

> always ask your pharmacist for the generic name of any drug being

> prescribed for someone with mitochondrial cytopathy.

> Hormonal Birth Control

> Aminoglycosides are ototoxic for *some forms of Mitochondrial

> Cytopathies - a specific genetic variation ( Mitochondrial 12S and 16S

> ribosomal RNA - mutation of A to G in the 12S rRNA at position 1555)*

> {Hutchins, Cortopassi 1994}. Aminoglycosides are *some* of the

> antibiotics which end in " _______mycin " . Ototoxic means that these

> drugs can cause hearing loss or deafness. ASK YOUR PHARMACIST AND

> PRESCRIBING DOCTOR.

>

> Ergotamines due to the impact on hepatic function.

> Neuroleptic drugs such as Haloperidol, Chlorpromazine, and

> Thiothixene.

>

> Lipitor should not be used by someone with Mitochondrial disease as it

> depletes CoQ10 from the cells.

> Steroids can be used but should be used only when absolutely necessary

> and this should be a very low dosage and not for an extended period of

> time.

>

> Friendly alternatives (?)

> Lamictal seems to be being used successfully. Topomax also appears to

> be mitochondrial-friendly for intractable seizures.

>

>

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