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epilepsy - TOPAMAX provides broad coverage of seizure types in both initial

monotherapy and adjunctive therapy. Learn more. Important Safety

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Top Stories

New Findings in Epilepsy From the 60th Annual Meeting of the American

Epilepsy Society: An Expert Interview With Gross, MD, PhD

Highlights of the 131st Annual Meeting of the American Neurological

Association

Managing Self-Injection Difficulties in Patients With Relapsing-Remitting

Multiple Sclerosis

Higher Vitamin D Levels Associated With Lower MS Risk

Biomarker for Sleepiness Identified

Browse Neurology and Neurosurgery Content by Topic

Feature Articles

Dementia

A " Reversible Dementia " : Diagnosis and Management of Normal Pressure

Hydrocephalus (Archived Web Conference)

In the archived version of this CME-accredited Webcast, learn the diagnosis

and treatment of normal pressure hydrocephalus, a syndrome with symptoms

similar to other common neurologic conditions, such as Parkinson's and

Alzheimer's diseases.

Conference Coverage

First North American Regional Epilepsy Congress: 60th Annual Meeting of the

American Epilepsy Society

Read clinically focused news coverage of key developments from the meeting.

New Findings in Epilepsy From the 60th Annual Meeting of the American

Epilepsy Society: An Expert Interview With Gross, MD, PhD

Learn about new data on generic substitution of AEDs and other key findings

from the 60th Annual Meeting of the American Epilepsy Society in this

interview with Dr. Gross.

Medscape Neurology & Neurosurgery 8(2) 2006

Update on Neuro-ophthalmology

In this report from AAO 2006, Dr. Newman reviews the latest findings

in neuro-ophthalmology, particularly how signs and symptoms relate to

systemic disease.

Medscape Ophthalmology 2006

Highlights of the 131st Annual Meeting of the American Neurological

Association

Learn about key studies presented at the 131st Annual Meeting of the

American Neurological Association.

Medscape Neurology & Neurosurgery 8(2) 2006

Sleep Disorders

Obstructive Sleep Apnea Syndrome in Children

Learn how to enhance sleep and improve outcomes in kids with OSAS.

Pediatr Nurs 32(5) 2006

Multiple Sclerosis

Managing Self-Injection Difficulties in Patients With Relapsing-Remitting

Multiple Sclerosis

Self-injection anxiety can usually be reduced with brief treatment.

Treatment manuals are available.

J Neurosci Nurs 38(3) 2006

Neurosurgery

Intraoperative Rupture of Brainstem Cavernous Malformation. Case Report

Learn about the risks encountered during the surgical approach to brainstem

cavernous malformation and insights into the pathophysiological mechanisms

underlying rupture of these lesions.

Neurosurg Focus 21(1) 2006

Molecular Genetics of Familial Cerebral Cavernous Malformations

The authors summarize the current understanding of the molecular events

underlying familial cerebral cavernous malformations.

Neurosurg Focus 21(1) 2006

Clinical Presentation and Optimal Management for Intramedullary Cavernous

Malformations

Intramedullary cavernous malformations account for 5% of intraspinal

lesions. Read about the spectrum of presentation and microsurgery results

for these benign, but clinically progressive, lesions.

Neurosurg Focus 21(1) 2006

Supratentorial Cerebral Cavernous Malformations: Clinical, Surgical, and

Genetic Involvement.

Read about efforts to develop, based on the authors' experience and a

literature review, a management algorithm to deal with supratentorial

cerebral cavernous malformations.

Neurosurg Focus 21(1) 2006

Review of the Literature on De Novo Formation of Cavernous Malformations of

the Central Nervous System After Radiation Therapy

De novo formation of cavernomas after radiation treatment is a relatively

rare phenomenon. The authors review the literature concerning de novo

cavernoma formation after radiation treatment.

Neurosurg Focus 21(1) 2006

Clinical Progression and Familial Occurrence of Cerebral Cavernous Angiomas:

The Role of Angiogenic and Growth Factors

Does the often progressive clinical course of sporadic and familial forms of

cavernous angiomas correlate with differential expression of angiogenic and

growth factors and proliferative indices?

Neurosurg Focus 21(1) 2006

Drug-Resistant Temporal Lobe Epilepsy Due to Cavernous Malformations

The authors discuss the preoperative workup and the surgical management of

eight consecutive patients undergoing surgery for drug-resistant temporal

lobe epilepsy due to cavernous malformations.

Neurosurg Focus 21(1) 2006

Other Neurology Topics

Depression and ADHD: What You Need to Know

More than 30% of patients with depression have comorbid ADHD, and symptoms

of the 2 disorders can overlap. How can you distinguish one from the other

when they co-occur? What treatments work for both?

Medscape Psychiatry & Mental Health 11(2) 2006

Moral Priorities in a Teaching Hospital

Should patients be able to refuse to participate in training during their

stay at a teaching hospital? This article examines how to approach this

sensitive subject.

Hastings Cent Rep 36(6) 2006

Idiopathic Osteomyelitis at the Base of the Skull

A 58-year-old man presented with a 3-month history of headache, diplopia,

hoarseness, and impaired hearing, without evidence of infection.

South Med J 99(10) 2006

The Neuro-Ophthalmology of Pituitary Tumors

Pituitary tumors commonly manifest through the visual system. What are the

signs and symptoms of these tumors and how are they managed?

Comp Ophthalmol Update 7(5) 2006

Shades of Gray: New Insights into the Vegetative State

This article takes a closer look at new findings relative to our current

understanding of the vegetative state.

Hastings Cent Rep 36(6) 2006

Editorials

Reader's Response and Author's Reply to " Our Patients Are Sicker -- Posting

Grades on the Classroom, Office, or Hospital Door "

A reader responds to " Our Patients Are Sicker -- Posting Grades on the

Classroom, Office, or Hopital Door " and Dr. Leob's response.

Medscape General Medicine 8(4) 2006

Off-label Prescriptions: Do We Need More Restraint or More Evidence?

Carolyn Clancy, MD, Director of the US Agency for Healthcare Research and

Quality, tells us about concerns of off-label prescriptions.

Medscape General Medicine 8(4) 2006

Ban Trans Fats in 2007

Dansinger, MD, of the Division of Endocrinology, Diabetes, and

Metabolism at Tufts-New England Medical Center, tells us why demanding the

elimination of artificial fat should be immediate.

Medscape General Medicine 8(4) 2006

Reader's Response to " Endocannabinoids -- the Brain's Own Marijuana -- May

Be Linked to the Metabolic Syndrome "

A reader responds to Dr. g's WVE " Endocannabinoids -- the

Brain's Own Marijuana -- May Be Linked to the Metabolic Syndrome "

Medscape General Medicine 8(4) 2006

Industry Spotlight

Information from Industry

BETASERON® (Interferon beta-1b) for SC Injection (ramipril)- Review Full

Prescribing Information and Important Safety Information.

The Neuroscience Institute - provides cutting-edge neuroscience information,

including research reports, news, conference coverage and expert commentary

on areas of interest within the neurosciences.

News

Sleep Medicine

Biomarker for Sleepiness Identified

Salivary levels of amylase appear to provide a " simple and quantifiable

biomarker of sleepiness, " according to a report in the December 11th Early

Edition of the Proceedings of the National Academy of Sciences.

Reuters Health Information 2006

Daytime Sleepiness Caused by OSA Strongly Linked to Impaired Cardiac

Function

Daytime sleepiness caused by obstructive sleep apnea is independently

associated with impaired cardiac function, a new study suggests.

Medscape Medical News 2006

Stroke

Raloxifene May Increase Fatal Stroke Risk in Postmenopausal Women

Secondary analysis from the RUTH trial suggests a small potential increase

in the risk for fatal strokes, although not in the overall stroke risk, in

postmenopausal women at risk for coronary heart disease.

Medscape Medical News 2006

Intra-Arterial Thrombolysis Provides Long-Term Benefit After Stroke

The benefit of intra-arterial thrombolysis (IAT) after stroke is sustained

for at least 2 years, according to a report in the December issue of Stroke.

Reuters Health Information 2006

Impaired Awareness of Bladder Needs Predicts Worse Outcome After Acute

Stroke

Urinary incontinence associated with impaired awareness of bladder needs is

associated with poor outcome after acute stroke, according to a report in

the December Journal of the American Geriatrics Society.

Reuters Health Information 2006

Epilepsy

Implantable Device Shows Promise in Refractory Epilepsy

An implantable neurostimulator that detects the onset of seizures and

interrupts them by delivering a small electrical discharge is showing

promise in adults with medically refractory partial epilepsy.

Medscape Medical News 2006

High-Dose Vitamin D Improves Bone Density in Patients on Anticonvulsants

High-dose vitamin D therapy significantly improves bone mineral density

(BMD) in adults and children on long-term anticonvulsants, according to the

findings of two parallel randomized, controlled trials published in the

December issue of Neurology.

Reuters Health Information 2006

Multiple Sclerosis

Higher Vitamin D Levels Associated With Lower MS Risk

High circulating serum levels of vitamin D are associated with a lower risk

of multiple sclerosis, according to a large, prospective study.

Medscape Medical News 2006

Pain

Spinal Cord Involved Early in Diabetic Peripheral Neuropathy

The size of the spinal cord is significantly diminished long before symptoms

of neuropathy appear in patients with type 1 diabetes, according to British

researchers reporting in the December issue of Diabetes Care.

Reuters Health Information 2006

Pain Management May Be Lacking for Patients With Dementia

Many older patients with dementia and pain who are seen as outpatients do

not appear to receive adequate pharmacological treatment for their pain,

according to researchers.

Reuters Health Information 2006

Labopharm Responds to FDA Over Tramadol

Labopharm Inc. said on Wednesday it has responded to concerns from U.S.

regulators about its once-daily formulation for its pain medication

tramadol.

Reuters Health Information 2006

Medical Marijuana Use Relieves Pain in Most Patients

The findings of a new study support the medical use of marijuana for the

management of chronic pain.

Reuters Health Information 2006

Parkinson's Disease

High BMI Increases Risk of Parkinson's Disease

The results of a study published in the December issue of Neurology suggest

an association between high body mass index (BMI) and an increased risk of

Parkinson's disease in middle-age women and men.

Reuters Health Information 2006

Other Neurology Topics

Animal Studies and Clinical Trial Findings Often at Odds

When a clinical trial investigates a particular drug, the conclusion is

often completely different from the findings first generated in animal

studies, according to a systematic review of data from both types of studies

published online by the British Medical Journal today.

Reuters Health Information 2006

Supine Sleep Position in Infants Linked to Early Lags in Motor Skills

The incidence of sudden infant death syndrome has dropped substantially

since the widely promoted recommendation that infants be placed on their

backs to sleep. It now appears that this position may result in slightly

slowed early motor development, investigators in Canada report in the

Journal of Pediatrics for November.

Reuters Health Information 2006

Cognitive Training May Have Long-Term Benefits on Activities of Daily Living

in the Elderly

In the Advanced Cognitive Training for Independent and Vital Elderly study,

cognitive training was linked with improved self-reported activities of

daily living 5 years after the training sessions.

Medscape Medical News 2006

Cerebral Palsy Linked With Preterm Birth, Maternal Age and Other Factors

Several perinatal factors, such as preterm birth, are associated with the

development of cerebral palsy (CP), according to the results of a study

conducted in Sweden and reported in the December issue of Obstetrics &

Gynecology.

Reuters Health Information 2006

Taste Perceptions Altered by Neurotransmitters

Sensitivity to taste is altered by changing levels of the neurotransmitters

serotonin and noradrenaline and possibly by mood states, British

investigators report.

Reuters Health Information 2006

Regulatory Rulings

FDA Strengthens Safety Warning on Aprotinin Label

The FDA has strengthened the label safety warning for the antifibrinolytic

drug aprotinin, emphasizing the importance of limiting use of the agent to

patients undergoing CABG.

US Approval of New Novartis Renin Blocker Delayed

The US FDA has extended its review of aliskiren, the first in a new class of

antihypertensives, by three months, following submission of new clinical

data by the developing company, Novartis. The firm is confident that

aliskiren, an oral renin inhibitor, will be approved in the new year.

Heartwire 2006

FDA Approves Filterwire EZ Embolic-Protection Device for Carotid Stenting

The FDA has granted marketing clearance for the FilterWire EZ

embolic-protection system for use in carotid stenting, Boston Scientific

announced.

Heartwire 2006

FDA Safety Changes: Cordarone, Prozac, Symbyax, Ethrane

The FDA has approved safety label revisions for amiodarone (Cordarone),

fluoxetine (Prozac), fluoxetine/olanzapine (Symbyax), and enflurane volatile

liquid for inhalation (Ethrane).

Medscape Medical News 2006

Cooling Cap to Cut Neonatal Brain Damage Wins U.S. Approval

Babies deprived of oxygen during birth may now be treated with a cap that

cools the head to prevent or reduce brain damage, U.S. health officials said

Wednesday.

Reuters Health Information 2006

Instant Poll

Weight Gain During the Holidays

Many Americans reportedly gain weight during the period from Thanksgiving to

New Year's Day, although the amount ranges from a pound or two to several

pounds. What do you think is the most significant cause of weight gain

during this time? To vote or view results of the poll, click on the title

above.

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