Side effects of LDN?

[Guest guest]

where is the excerpt from luigi? i'd like to read it!!

marshiris

[Guest guest]

I was on 3 mg for about a week with no problems accept some insomnia.

Three days ago I moved up to 4,5. Today, I have a headache and a

little nausia. Have I come up too fast?

Dave D

[Guest guest]

>

> Hello Dave D;

>

> I have attached an excerpt from a patent submitted by Dr Bihari. It

is long but does explain how naltrexone works and recommends

> a dosage of 1.5ml to 3 ml. per day. More is not necessarily better.

>

> Luigi

Dr. Bihari recommends 1.5ml to 3 ml per day?!! I thought he recommends

3.0mg to 4.5mg. at night.

[Guest guest]

The useful dosage range, at which Mu receptor sites are substantially blocked while the Delta sites are substantially unblocked, for naltrexone is about 1-10 mg/day daily. The limits of this range are not critical but below about 1 mg the therapeutic effect is quite small, while at levels several times above 10 mg at which these drugs have been generally administered in the past for other purposes, especially narcotic addiction, the effects of the preferential blocking action against Mu over Delta receptor sites disappears, since the amount of the drug is large enough to cause at least substantial blocking of Delta sites while the Mu sites remain fully blocked. A preferred range for naltrexone is about 1.5-3.0 mg/day daily.

[low dose naltrexone] Re: Side effects of LDN?

>> Hello Dave D;> > I have attached an excerpt from a patent submitted by Dr Bihari. It is long but does explain how naltrexone works and recommends > a dosage of 1.5ml to 3 ml. per day. More is not necessarily better. > > LuigiDr. Bihari recommends 1.5ml to 3 ml per day?!! I thought he recommends 3.0mg to 4.5mg. at night.

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[Guest guest]

>

> The useful dosage range, at which Mu receptor sites are

substantially blocked while the Delta sites are substantially

unblocked, for naltrexone is about 1-10 mg/day daily. The limits of

this range are not critical but below about 1 mg the therapeutic

effect is quite small, while at levels several times above 10 mg at

which these drugs have been generally administered in the past for

other purposes, especially narcotic addiction, the effects of the

preferential blocking action against Mu over Delta receptor sites

disappears, since the amount of the drug is large enough to cause at

least substantial blocking of Delta sites while the Mu sites remain

fully blocked. A preferred range for naltrexone is about 1.5-3.0

mg/day daily.

>

What dosage and frequency should my physician prescribe?

The usual adult dosage is 4.5mg taken once daily at night. Because of

the rhythms of the body's production of master hormones, LDN is best

taken between 9pm and 3am. Most patients take it at bedtime.

People who have multiple sclerosis that has led to muscle spasms are

advised to use only 3mg daily and to maintain that dosage.

Rarely, the naltrexone may need to be purchased as a solution — in

distilled water — with 1mg per ml dispensed with a 5ml medicine

dropper. If LDN is used in a liquid form, it is important to keep it

refrigerated.

The therapeutic dosage range for LDN is from 1.75mg to 4.5mg every

night. Dosages below this range are likely to have no effect at all,

and dosages above this range are likely to block endorphins for too

long a period of time and interfere with its effectiveness.

http://www.low dose naltrexone.org/index.htm#What_is_low_dose_naltrexone

[Guest guest]

That's what I thought as well. In fact, I had a phone consultation with him just yesterday (my first, to get a prescription) and he said that 4.5 was the appropriate adult dosage.

[low dose naltrexone] Re: Side effects of LDN?

>

> Hello Dave D;

>

> I have attached an excerpt from a patent submitted by Dr Bihari. It

is long but does explain how naltrexone works and recommends

> a dosage of 1.5ml to 3 ml. per day. More is not necessarily better.

>

> Luigi

Dr. Bihari recommends 1.5ml to 3 ml per day?!! I thought he recommends

3.0mg to 4.5mg. at night.

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[Guest guest]

Thanks everybody, I really appreciate it.

Dave D.

[Guest guest]

Oh, and what's the appropriate non-adult dosage?

Re: [low dose naltrexone] Re: Side effects of LDN?

That's what I thought as well. In fact, I had a phone consultation with him just yesterday (my first, to get a prescription) and he said that 4.5 was the appropriate adult dosage.

[Guest guest]

Dave, it sounds like you did increase the dosage too fast. Are you

taking LDN for MS?

Not everyone can tolerate 4.5, even if they move up slowly. Dr. Bihari

recommends 3 mg for people who have spasticity.