Guest guest Posted October 26, 2006 Report Share Posted October 26, 2006 I've tried starting LDN twice now. The first time it was 4.5 mg capsules. I had to stop after two nights because of severe insomnia (something I already struggle with, so I wasn't surprised that LDN affected me this way based upon what I had read). It also seemed to make me constipated, which also posed a problem since constipation is also a symptom I deal with regularly (I have Crohn's Disease, but it is a very atypical case). Then I found out here that it might be better to start at 1.5 mg and slowly build up. However, after just two night of 1.5 mg from Skip's, I again had to stop for the same reasons. I'm wondering if anyone else out there has had a similar reaction, and if there's any way to overcome it. I am intrigued by the theory behind LDN and was very impressed by Dr. 's study results. I do not wish to take steroids, and Pentasa hasn't worked for me at all. LDN is my best hope at this point. Any help you could offer would be greatly appreciated. Best, Chris Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 26, 2006 Report Share Posted October 26, 2006 What about changing the filler to hopefully eliminate the constipation issue? chriskjezp wrote: >I've tried starting LDN twice now. The first time it was 4.5 mg capsules. I had to stop after >two nights because of severe insomnia (something I already struggle with, so I wasn't >surprised that LDN affected me this way based upon what I had read). It also seemed to >make me constipated, which also posed a problem since constipation is also a symptom I >deal with regularly (I have Crohn's Disease, but it is a very atypical case). > >Then I found out here that it might be better to start at 1.5 mg and slowly build up. >However, after just two night of 1.5 mg from Skip's, I again had to stop for the same reasons. > >I'm wondering if anyone else out there has had a similar reaction, and if there's any way to >overcome it. I am intrigued by the theory behind LDN and was very impressed by Dr. 's >study results. I do not wish to take steroids, and Pentasa hasn't worked for me at all. LDN is >my best hope at this point. > >Any help you could offer would be greatly appreciated. > >Best, >Chris > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 27, 2006 Report Share Posted October 27, 2006 it was a shitty situation here before the ldn got in his system fully.now its the same here every other day or 3rd day for a movement.still yrying to solve it.i go to bed at 2-3 am after marks ldn and hes still awake it does not seen to bother him but them all he has to do daily is sleep if need be. he does get long cat naps throughout the day.wwe are using a light laxative on 3rd day. sorry no help here;( >From: " chriskjezp " <chriskresser@...> >Reply-low dose naltrexone >low dose naltrexone >Subject: [low dose naltrexone] Constipation & insomnia >Date: Thu, 26 Oct 2006 22:31:02 -0000 > >I've tried starting LDN twice now. The first time it was 4.5 mg capsules. >I had to stop after >two nights because of severe insomnia (something I already struggle with, >so I wasn't >surprised that LDN affected me this way based upon what I had read). It >also seemed to >make me constipated, which also posed a problem since constipation is also >a symptom I >deal with regularly (I have Crohn's Disease, but it is a very atypical >case). > >Then I found out here that it might be better to start at 1.5 mg and slowly >build up. >However, after just two night of 1.5 mg from Skip's, I again had to stop >for the same reasons. > >I'm wondering if anyone else out there has had a similar reaction, and if >there's any way to >overcome it. I am intrigued by the theory behind LDN and was very >impressed by Dr. 's >study results. I do not wish to take steroids, and Pentasa hasn't worked >for me at all. LDN is >my best hope at this point. > >Any help you could offer would be greatly appreciated. > >Best, >Chris > > _________________________________________________________________ Get FREE company branded e-mail accounts and business Web site from Microsoft Office Live http://clk.atdmt.com/MRT/go/mcrssaub0050001411mrt/direct/01/ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 27, 2006 Report Share Posted October 27, 2006 > > Chris > > Dr McCandless developed a transdermal LDN cream for autistic kids.... this > bypasses the gut and maybe a solution for you. > > I forget offhand the pharmacy that compounds it. > > mjh ========== Here's that info If you're interested in transdermal LDN, your pharmacist can contact Coastal Compounding in Savannah, GA, phone 866- 354-5188, only a licensed pharmacist may call to get the recipe for making the TD LDN. Or if you want to order directly from Coastal Compounding in Savannah, GA, phone 866-354-5188 that's fine also. The TD LDN is applied anywhere on the body like stomach, legs, arms. And it's applied between the hours of 9pm and 3am. This TD LDN will bypass the gut and liver. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 27, 2006 Report Share Posted October 27, 2006 > > Here's that info > > If you're interested in > transdermal LDN, your > pharmacist can contact > Coastal Compounding in > Savannah, GA, phone 866- > 354-5188, only a licensed > pharmacist may call to > get the recipe for making > the TD LDN. Or if you > want to order directly > from Coastal Compounding > in Savannah, GA, phone > 866-354-5188 that's fine > also. > > The TD LDN is applied > anywhere on the body like > stomach, legs, arms. And > it's applied between the > hours of 9pm and 3am. > > This TD LDN will bypass > the gut and liver. > > ========= Cyndi and or Skip, Would this TD LDN be an option at your pharmacy for those with gut issues? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 27, 2006 Report Share Posted October 27, 2006 , I think what is getting at is that he feels it is the endorphin process that's what is causing the problem, and no matter how he gets the naltrexone into his system, it's six of one, half a dozen of the other. Do you have any knowledge of naltrexone/endorphins causing an issue like this, like those other drugs he had mentioned? [low dose naltrexone] Re: Constipation & insomnia > > Here's that info> > If you're interested in > transdermal LDN, your > pharmacist can contact > Coastal Compounding in > Savannah, GA, phone 866-> 354-5188, only a licensed > pharmacist may call to > get the recipe for making > the TD LDN. Or if you > want to order directly > from Coastal Compounding > in Savannah, GA, phone > 866-354-5188 that's fine > also. > > The TD LDN is applied > anywhere on the body like > stomach, legs, arms. And > it's applied between the > hours of 9pm and 3am.> > This TD LDN will bypass > the gut and liver.> > =========Cyndi and or Skip,Would this TD LDN be an option at your pharmacy for those with gut issues? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 > The TD LDN is applied > anywhere on the body like > stomach, legs, arms. And > it's applied between the > hours of 9pm and 3am. > > This TD LDN will bypass > the gut and liver. > Wow, this is great! I had no idea such an option existed. It will at least deal with one of my side effects (the constipation), and it seems that it would be healthier for the body since it doesn't have to be processed by the liver. Can it be made up in the same doses, i.e. 1.5 mg, 3 mg, 4.5 mg? How does one know how much cream to apply? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 any pharmacy can compound it but they need to use EMU oil -if they call this pharmacy in Georgia (?) the pharmacist there will forward the formula.cyndiOn Oct 27, 2006, at 7:36 AM, foxhillers@... wrote:  Dr McCandless developed a transdermal LDN cream for autistic kids.... this bypasses the gut and maybe a solution for you.  I forget offhand the pharmacy that compounds it.  mjh"The Basil Book"http://foxhillfarm.us/FireBasil/  I'm wondering if anyone else out there has had a similar reaction, and if there's any way to overcome it. I am intrigued by the theory behind LDN and was very impressed by Dr. 's study results. I do not wish to take steroids, and Pentasa hasn't worked for me at all. LDN is my best hope at this point.Any help you could offer would be greatly appreciated.Best,Chris Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 yes it would. and they are formulas not recipes (lol) i think most of the ldn pharmacists have the recipes from coastal cyndi On Oct 27, 2006, at 1:45 PM, Bren wrote: > >> >> Here's that info >> >> If you're interested in >> transdermal LDN, your >> pharmacist can contact >> Coastal Compounding in >> Savannah, GA, phone 866- >> 354-5188, only a > licensed >> pharmacist may call to >> get the recipe for > making >> the TD LDN. Or if you >> want to order directly >> from Coastal > Compounding >> in Savannah, GA, phone >> 866-354-5188 that's > fine >> also. >> >> The TD LDN is applied >> anywhere on the body > like >> stomach, legs, arms. > And >> it's applied between > the >> hours of 9pm and 3am. >> >> This TD LDN will bypass >> the gut and liver. >> >> > ========= > > Cyndi and or Skip, > > Would this TD LDN be an > option at your pharmacy > for those with gut issues? > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 > > yes it would. > and they are formulas not recipes > (lol) > i think most of the ldn pharmacists have the recipes from coastal > cyndi Cyndi, Do you know why the TD cream was developed in the first place? What was the advantage of it over the capsules? I understand that it bypasses the gut and liver that way, but wouldn't the mechanism of action (i.e. upregulating endorphin production) be the same as with the capsules? Thanks, Chris Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 > > > > yes it would. > > and they are formulas not recipes > > (lol) > > i think most of the ldn pharmacists have the recipes from coastal > > cyndi > > Cyndi, > > Do you know why the TD cream was developed in the first place? What was the advantage of > it over the capsules? I understand that it bypasses the gut and liver that way, but wouldn't > the mechanism of action (i.e. upregulating endorphin production) be the same as with the > capsules? > > Thanks, > Chris > ========= The TD LDN was developed by Dr. Jaquelyn McCandless because Autistic children have such severe gut issues and the TD LDN does not travel through the gut. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 Yes, the outcome is the same. As far as Dr Mccandless is concerned, most of her patients are kids, the cream is a heck of a lot easier to apply than getting a kid to swallow a pill.> >> > yes it would.> > and they are formulas not recipes> > (lol)> > i think most of the ldn pharmacists have the recipes from coastal> > cyndi> > Cyndi,> > Do you know why the TD cream was developed in the first place? What was the advantage of > it over the capsules? I understand that it bypasses the gut and liver that way, but wouldn't > the mechanism of action (i.e. upregulating endorphin production) be the same as with the > capsules?> > Thanks,> Chris> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 > > yes it would. > and they are formulas not recipes > (lol) > i think most of the ldn pharmacists have the recipes from coastal > cyndi ======== Cyndi I never noticed the word recipe in there until now. I copied that from someone else's post a good while back and just pasted that info onto my website. Oh well, recipe and formula have the same meanings in the dictionary in that they can both mean medicinal preparations so I think when the original writer of that info wrote that, it's probably what they were thinking. In Skip's profession it'd be more professional sounding to call it formula's. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 it was developed because dr mccandles felt that it difficult to give the autistic kids ldn in capsule-but it also had to do with the fact that the parents could rub it in even if the kids were sleeping cyndi On Oct 27, 2006, at 9:33 PM, chriskjezp wrote: > >> >> yes it would. >> and they are formulas not recipes >> (lol) >> i think most of the ldn pharmacists have the recipes from coastal >> cyndi > > Cyndi, > > Do you know why the TD cream was developed in the first place? > What was the advantage of > it over the capsules? I understand that it bypasses the gut and > liver that way, but wouldn't > the mechanism of action (i.e. upregulating endorphin production) be > the same as with the > capsules? > > Thanks, > Chris > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 Hi Cyndi, I think a 3rd reason was that Autistic children tend to have problems with their gut or liver (can't remember which), and by using the cream it by-passes the problem. I am so very impressed that our bodies can actually take in meds thru our skin. How amazing. It makes me wonder much more about things we put on our skin, and pollutants in the air. I guess we should be much more careful and selective. My very best to you (cuz you are soooo cool), Aletha Re: [low dose naltrexone] Re: Constipation & insomnia > it was developed because dr mccandles felt that it difficult to give > the autistic kids ldn in capsule-but it also had to do with the fact > that the parents could rub it in even if the kids were sleeping > cyndi > On Oct 27, 2006, at 9:33 PM, chriskjezp wrote: > >> >>> >>> yes it would. >>> and they are formulas not recipes >>> (lol) >>> i think most of the ldn pharmacists have the recipes from coastal >>> cyndi >> >> Cyndi, >> >> Do you know why the TD cream was developed in the first place? >> What was the advantage of >> it over the capsules? I understand that it bypasses the gut and >> liver that way, but wouldn't >> the mechanism of action (i.e. upregulating endorphin production) be >> the same as with the >> capsules? >> >> Thanks, >> Chris >> >> >> >> >> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 you know what-its on the dvd -i'm too tired to watch it-anyone else? cyndi On Oct 27, 2006, at 11:14 PM, Aletha Wittmann wrote: > Hi Cyndi, > > I think a 3rd reason was that Autistic children tend to have > problems with > their gut or liver (can't remember which), and by using the cream it > by-passes the problem. I am so very impressed that our bodies can > actually > take in meds thru our skin. How amazing. It makes me wonder much > more > about things we put on our skin, and pollutants in the air. I > guess we > should be much more careful and selective. > > My very best to you (cuz you are soooo cool), > > Aletha > > Re: [low dose naltrexone] Re: Constipation & insomnia > > >> it was developed because dr mccandles felt that it difficult to give >> the autistic kids ldn in capsule-but it also had to do with the fact >> that the parents could rub it in even if the kids were sleeping >> cyndi >> On Oct 27, 2006, at 9:33 PM, chriskjezp wrote: >> >>> >>>> >>>> yes it would. >>>> and they are formulas not recipes >>>> (lol) >>>> i think most of the ldn pharmacists have the recipes from coastal >>>> cyndi >>> >>> Cyndi, >>> >>> Do you know why the TD cream was developed in the first place? >>> What was the advantage of >>> it over the capsules? I understand that it bypasses the gut and >>> liver that way, but wouldn't >>> the mechanism of action (i.e. upregulating endorphin production) be >>> the same as with the >>> capsules? >>> >>> Thanks, >>> Chris >>> >>> >>> >>> >>> >>> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 Actually, I think the third reason was that with the cream it was easy to adjust the dosage.> >>>> >>> yes it would.> >>> and they are formulas not recipes> >>> (lol)> >>> i think most of the ldn pharmacists have the recipes from coastal> >>> cyndi> >>> >> Cyndi,> >>> >> Do you know why the TD cream was developed in the first place?> >> What was the advantage of> >> it over the capsules? I understand that it bypasses the gut and> >> liver that way, but wouldn't> >> the mechanism of action (i.e. upregulating endorphin production) be> >> the same as with the> >> capsules?> >>> >> Thanks,> >> Chris> >>> >>> >>> >>> >>> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 Hmmmmmmm, now we're confused. You dont feel then that the naltrexone/endorphin connection is causing the constipation, you think it's the filler??? [low dose naltrexone] Re: Constipation & insomnia > The TD LDN is applied > anywhere on the body like > stomach, legs, arms. And > it's applied between the > hours of 9pm and 3am.> > This TD LDN will bypass > the gut and liver.> Wow, this is great! I had no idea such an option existed. It will at least deal with one of my side effects (the constipation), and it seems that it would be healthier for the body since it doesn't have to be processed by the liver. Can it be made up in the same doses, i.e. 1.5 mg, 3 mg, 4.5 mg? How does one know how much cream to apply? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 there you goso simple.cyndiOn Oct 27, 2006, at 11:41 PM, outtabodyexperience wrote: Actually, I think the third reason was that with the cream it was easy to adjust the dosage.>> Hi Cyndi,> > I think a 3rd reason was that Autistic children tend to have problems with > their gut or liver (can't remember which), and by using the cream it > by-passes the problem. I am so very impressed that our bodies can actually > take in meds thru our skin. How amazing. It makes me wonder much more > about things we put on our skin, and pollutants in the air. I guess we > should be much more careful and selective.> > My very best to you (cuz you are soooo cool),> > Aletha>Â Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 > > > The TD LDN is applied > > anywhere on the body like > > stomach, legs, arms. And > > it's applied between the > > hours of 9pm and 3am. > > > > This TD LDN will bypass > > the gut and liver. > > > > > Wow, this is great! I had no idea such an option existed. It will at least deal with one of my > side effects (the constipation), and it seems that it would be healthier for the body since it > doesn't have to be processed by the liver. > > Can it be made up in the same doses, i.e. 1.5 mg, 3 mg, 4.5 mg? How does one know how > much cream to apply? > =========== From what I understand Tyrus puts the cream in a syringe without the needle of course and you measure out the amount you want. Start with 1.5mg and build to 4.5mg. The measurement is done by lines on the syringe I believe so get all that info explained to you when you order. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 Applying a full dose at once can cause sleep disruption. We moved up line by line on the syringe to avoid this, increasing by one line over five days or so, until we reached the full dose. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 Dave, I really don't know what to think at this point. Personally, I can't see why the filler would be constipating. Yet clearly there was a reason why Dr. McCandles believed that the cream would be better tolerated by those with digestive/gut issues. Perhaps she wasn't specifically addressing constipation there, but I'm at least willing to give the cream a try in the hope that it affects my gut differently. I still have a question about how upregulating endorphin production affects gut motility, as I said in my last post. But the cream will at least settle the question of whether the filler is causing the constipation, or the LDN is. Maybe not the final answer for me, but a step forward... Chris Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 > > Applying a full dose at once can > cause sleep disruption. We moved > up line by line on the syringe to > avoid this, increasing by one line > over five days or so, until we > reached the full dose. > > By " full dose " , do you mean 4.5 mg? Chris Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 > > > > Applying a full dose at once can > > cause sleep disruption. We moved > > up line by line on the syringe to > > avoid this, increasing by one line > > over five days or so, until we > > reached the full dose. > > > > > > > By " full dose " , do you mean 4.5 mg? > > Chris > ====== For small children full dose is less than 4.5mg but for adults 100 pounds and over 4.5mg is full dose. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 29, 2006 Report Share Posted October 29, 2006 Hello and a big Thanks to Dave and all others who contributed to this post. I've been dealing with my own major gut issues for quite some time. A year ago was treated with heavy duty anti-biotics for an H.Pylori/ulcer problem which resolved but re-newed an old candida/dysbiosis problem. Just when I thought I was getting this new problem under control, I began LDN in Feb. of this year and noticed more difficulties with constipation/candida. It's been a long roller coaster ride trying so many different things - the candida diet, pro-biotics, grapefruit seed extract, colloidal silver, Threelac, the latest being oil of wild oregano and combinations of all the above. Have only had limited success after spending many $$. The candida was so bad + making me feel so aweful, that I almost gave up on LDN thinking it wasn't working for the MS and like my doctors, blaming my symptoms on MS rather than candida. Glad I didn't !! Have been seeing a GI doctor who has not been very helpful - they don't really have a clue when it comes to gut flora imbalance. She's done every test possible on me to diagnose my abdominal pain/constipation/weakness etc. and has come up with my gallbladder contracting less than normal and suggesting it being removed. I refused and am seeing a new GI doctor this coming Tuesday. Will be seriously checking into this transdermal option. Thanks again for connecting the dots. Andre > > Dave, > > I really don't know what to think at this point. Personally, I can't > see why the filler would be constipating. Yet clearly there was a > reason why Dr. McCandles believed that the cream would be better > tolerated by those with digestive/gut issues. Perhaps she wasn't > specifically addressing constipation there, but I'm at least willing > to give the cream a try in the hope that it affects my gut > differently. I still have a question about how upregulating > endorphin production affects gut motility, as I said in my last > post. But the cream will at least settle the question of whether the > filler is causing the constipation, or the LDN is. Maybe not the > final answer for me, but a step forward... > > Chris > Quote Link to comment Share on other sites More sharing options...
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