Re: mitoldies: pancreas and hearing

[Guest guest]

Barbara,

thanks for the info...I do know she has a fatty acid disorder just dont know

which one exactly..whatever it is it is secondary so who knows if we will

know.

I suppose this is reflected also in the malabsorption.

On the umdf website it states that there is an inability to make pancreatic

enzymes.

she had a incredibly high fat content in stool samples.

she has taken pancreatic enzymes since she was 3 she is 13 now...guess they

arent working anymore.

thanks again

[Guest guest]

Alice, thanks for the reply..

I will have to ask her about the ringing in the ears...Ill let you know

[Guest guest]

In a message dated 10/21/2004 1:22:04 PM Eastern Standard Time,

wheatchild@... writes:

Dr. Ingrid Tein has suggested that episodes of metabolic

decompensation may put patients at risk for developing pancretitis.

I believe pancretitis has also been reported in OXPHOS disorders,

but I cannot recall a particular case right now.

Hi Barbara,

Has Dr Tein published anything on this? This is the first time I have heard

this.

Thanks.

Malisa

[Guest guest]

,

I can't reply to the pancreas question. I'm sorry about that.

About hearing loss - I can definitely try to answer. It's really hard to say

whether her hearing issues are related to Mito but we all know that hearing loss

and mito go together. Sometimes this can be due to pressure in the ear and/or

wax. Sometimes it can even be due to constricting blood vessels. It's

something that a good otolaryngologist or otologist should look into.

Fluctuating hearing loss is one of the hardest things to trace and also hard to

deal with. Mine fuctuated before I lost it. My oldest daughter is dealing with

the same thing only her's goes in both ears and she has the constant worry that

it won't return. She's an adult. Does your daughter say she has any ringing or

noise in the ear as the hearing is going?

Alice

[Guest guest]

,

I can't reply to the pancreas question. I'm sorry about that.

About hearing loss - I can definitely try to answer. It's really hard to say

whether her hearing issues are related to Mito but we all know that hearing loss

and mito go together. Sometimes this can be due to pressure in the ear and/or

wax. Sometimes it can even be due to constricting blood vessels. It's

something that a good otolaryngologist or otologist should look into.

Fluctuating hearing loss is one of the hardest things to trace and also hard to

deal with. Mine fuctuated before I lost it. My oldest daughter is dealing with

the same thing only her's goes in both ears and she has the constant worry that

it won't return. She's an adult. Does your daughter say she has any ringing or

noise in the ear as the hearing is going?

Alice

[Guest guest]

In a message dated 10/21/2004 11:03:07 AM Eastern Standard Time,

MitomomX3@... writes:

My daughters doc called yesterday and said her pancreas is inflamed..is

this

a mito thing..she also has malabsorption and I know that is the

pancreas...

Hi ,

I have had chronic pancreatitis for the past 7 yrs. It is thought to be

secondary to the motility issues that I have in my gut, but I often wonder if

it's just part of the mito itself. Does she have gastroparesis? I have heard

that giving selenium can help patients in patients with acute pancreatitis,

especially if selenium levels are low to begin with.

Some articles below might help your doctor.....

Malisa

Trop Gastroenterol. 2004 Apr-Jun;25(2):69-72. _Related Articles,_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Display&dopt=pubmed\

_pubme

d&from_uid=15471319) _Links_ (javascript:PopUpMenu2_Set(Menu15471319)

Micronutrient antioxidant intake in patients with chronic pancreatitis.

Bhardwaj P, Thareja S, Prakash S, Saraya A.

Department of Gastroenterology and Human Nutrition Unit, All India Institute

of Medical Sciences, New Delhi, India.

Increased oxidative stress has been postulated to be an important mechanism

in the pathophysiology of chronic pancreatitis (CP). Micronutrient deficiency

may increase the oxidative stress as they assist in free radical clearance.

The present study was undertaken to assess the intake of micronutrients, i.e.

vitamins E and C, carotene, selenium, copper, zinc, manganese, magnesium,

sulphur, riboflavin, methionine and choline in patients with CP. All

consecutive patients with CP attending the Pancreas Clinic at the All India

Institute

of Medical Sciences were enrolled in the study. The usual dietary intake was

estimated by the 24-hour dietary recall method and food frequency

questionnaire. Dietary restrictions, if any, were also noted. The micronutrient

intake of

patients not on any nutritional supplements (n=75, 65 males and 10 females,

mean age 31.06 +/- 10.64 years) was compared with age- and sex- matched

healthy controls (n=75). The micronutrients were calculated as per the

Nutritive

value of Indian Foods given by the National Institute of Nutrition, Indian

Council of Medical Research, India and the US dietary intake guidelines as

applicable. It was found that the Body Mass Index (BMI) of patients was

significantly lower than that of healthy controls. The total intake in terms of

calorie

was lower in patients when compared to controls. The dietary intake of

vitamin E, riboflavin, choline, magnesium, copper manganese and sulfur was

significantly lower than that of controls as well as the Recommended Dietary

Allowance (RDA). Dietary intake of selenium and vitamin C was within the limits

of

the RDA but was lower than that of controls, while the intake of carotene was

similar in both the groups and met the RDA. We conclude that patients with CP

had significantly decreased micronutrient intake owing to diet modification

due to pain. Micronutrient deficiency might contribute to increased oxidative

stress in these patients.

========================

Re: pancreatic disease (endocrine and exocrine dysfunction in

> mitochondrial

> disease) -

> 1. Leshinsky-Silver E. Levine A. Nissenkorn A. Barash V. Perach M.

> Buzhaker

> E. Shahmurov M. Polak-Charcon S. Lev D.

> Lerman-Sagie T. Neonatal liver failure and Leigh syndrome possibly due to

> CoQ-responsive OXPHOS deficiency. Molecular Genetics & Metabolism.

> 79(4):288-93, 2003;

> 2. Liou CW. Huang CC. Lin TK. Tsai JL. Wei YH. Correction of pancreatic

> beta-cell dysfunction with coenzyme Q(10) in a patient with mitochondrial

> encephalomyopathy, lactic acidosis and stroke-like episodes syndrome and

> diabetes mellitus. European Neurology. 43(1):54-5, 2000;

> 3. Odawara M. Yamashita K. Mitochondrial gene abnormalities and alpha- and

> beta-cell dysfunction. Diabetes Care. 19(10):1166-7, 1996;

> 4. Oexle K. Oberle J. Finckh B. Kohlschutter A. Nagy M. Seibel P. Seissler

> J. Hubner C. Islet cell antibodies in diabetes mellitus associated with a

> mitochondrial tRNA(Leu(UUR)) gene mutation. Experimental & Clinical

> Endocrinology & Diabetes. 104(3):212-7, 1996.

> 5. Onishi H. Hanihara T. Sugiyama N. Kawanishi C. Iseki E. Maruyama Y.

> Yamada Y. Kosaka K. Yagishita S. Sekihara H. Satoh S. Pancreatic exocrine

> dysfunction associated with mitochondrial tRNA(Leu)(UUR) mutation. Journal

> of Medical Genetics. 35(3):255-7, 1998;

> 6. Otabe S. Yasuda K. Mori Y. Shimokawa K. Kadowaki H. Jimi A. Nonaka K.

> Akanuma Y. Yazaki Y. Kadowaki T. Molecular and histological evaluation of

> pancreata from patients with a mitochondrial gene mutation associated with

> impaired insulin secretion. Biochemical & Biophysical Research

> Communications. 259(1):149-56, 1999;

> 7. Toyono M. Nakano K. Kiuchi M. Imai K. Suzuki H. Shishikura K. Osawa M.

> Shiratori K. Goto Y. Nonaka I. Sugie H. A case of MERRF associated with

> chronic pancreatitis. Neuromuscular Disorders. 11(3):300-4, 2001;

[Guest guest]

Malisa,

she has no gut dysmotility.

[Guest guest]

, I'm not sure on the pancreatic thing but I know Malisa has

problems with this so maybe she will reply. I'm thinking it relates

to the whole slow gastric motil,ity thing, as there can be trouble

with the pancreatic and gall bladder ducts as well as the alimentary

tube intself with these problems.Malabsorbtion problems can relate to

bacterial overgrowth problems which commonly come with slow moility

of the gut. Is your daughtrer treated with antibiotics to treat

bacterial overgrowth.This helps slow the development of malabsorption

problems. Celia

-- In , MitomomX3@a... wrote:

> Hello everyone,

> I have a question..o.k. maybe three..

> My daughters doc called yesterday and said her pancreas is

inflamed..is this

> a mito thing..she also has malabsorption and I know that is the

> pancreas...wonder if that is realted..the UMDF site says that there

can be a problem with

> pancreatic enzymes..but it doesnt say much more than that..

> also my oldest girl tells me she intermittently losses hearing in

one ear.

> Have any of you experience with this...she said her hearing will be

fine than

> it just goes out and returns later.

> no pain involved and no infection. There is no ear wax to blame so

I wonder

> if this may progress.

> thanks for any input..

>

>

>

>

>

[Guest guest]

Hi, Celia

I didn't know bacterial overgrowth was treated with an antibiotic.

Interesting. The antibiotic only kills the bad bacteria, and not the

good ones? I don't quite understand it. I thought taking antibiotics

could lead to a yeast overgrowth, because the antibiotic killed off too

many digestive bacteria, so I am surprised that antibiotics are good

for returning bacteria back to good balance. Has anyone had good luck

with this treatment?

Regards, all

Sunny

>

> , I'm not sure on the pancreatic thing but I know Malisa has

> problems with this so maybe she will reply. I'm thinking it relates

> to the whole slow gastric motil,ity thing, as there can be trouble

> with the pancreatic and gall bladder ducts as well as the alimentary

> tube intself with these problems.Malabsorbtion problems can relate to

> bacterial overgrowth problems which commonly come with  slow moility

> of the gut. Is your daughtrer treated with antibiotics to treat 

> bacterial overgrowth.This helps slow the development of malabsorption

> problems. Celia

>

> -- In , MitomomX3@a... wrote:

> > Hello everyone,

> > I have a question..o.k. maybe three..

> > My daughters doc called yesterday and said her pancreas is

> inflamed..is  this

> > a mito thing..she also has malabsorption and I know that is the 

> > pancreas...wonder if that is realted..the UMDF site says that there

> can be a  problem with

> > pancreatic enzymes..but it doesnt say much more than that..

> > also my oldest girl tells me she intermittently losses hearing in

> one ear. 

> > Have any of you experience with this...she said her hearing will be

> fine than

> > it  just goes out and returns later.

> > no pain involved and no infection.  There is no ear wax to blame so

> I  wonder

> > if this may progress.

> > thanks for any input..

> >

> > 

> >

> >

> >

[Guest guest]

Pancretitis has been associated with some disorders of fat

metabolism. Dr. Ingrid Tein has suggested that episodes of metabolic

decompensation may put patients at risk for developing pancretitis.

I believe pancretitis has also been reported in OXPHOS disorders,

but I cannot recall a particular case right now.

Barbara

> Hello everyone,

> I have a question..o.k. maybe three..

> My daughters doc called yesterday and said her pancreas is

inflamed..is this

> a mito thing..she also has malabsorption and I know that is the

> pancreas...wonder if that is realted..the UMDF site says that

there can be a problem with

> pancreatic enzymes..but it doesnt say much more than that..

> also my oldest girl tells me she intermittently losses hearing in

one ear.

> Have any of you experience with this...she said her hearing will

be fine than

> it just goes out and returns later.

> no pain involved and no infection. There is no ear wax to blame

so I wonder

> if this may progress.

> thanks for any input..

>

>

>

>

>

[Guest guest]

I thought this was probably the daughter with the secondary fatty

acid disorder. I sure hope she gets better soon. Bless your heart,

you've had more than your share of problems recently.

Take care,

Barbara

> Barbara,

> thanks for the info...I do know she has a fatty acid disorder just

dont know

> which one exactly..whatever it is it is secondary so who knows if

we will

> know.

> I suppose this is reflected also in the malabsorption.

> On the umdf website it states that there is an inability to make

pancreatic

> enzymes.

> she had a incredibly high fat content in stool samples.

> she has taken pancreatic enzymes since she was 3 she is 13

now...guess they

> arent working anymore.

> thanks again

>

>

>

>

[Guest guest]

Yes. Here is one case pasted below.

Barbara

J Pediatr. 1994 Jun;124(6):938-40.

Carnitine palmitoyltransferase II deficiency: a new cause of

recurrent pancreatitis.

Tein I, Christodoulou J, Donner E, McInnes RR.

Division of Neurology, Hospital for Sick Children, Toronto, Ontario,

Canada.

An 18-year-old female patient had a history of recurrent

pancreatitis after prolonged periods of exercise coupled with a high-

fat diet at the ages of 12 and 15 years. After the onset of

recurrent myoglobinuria when she was 16 years old, deficiency of

carnitine palmitoyltransferase type II (32% residual activity) was

diagnosed on the basis of cultured skin fibroblasts. We conclude

that deficiency of carnitine palmitoyltransferase type II may be a

cause of pancreatitis and should be considered in the differential

diagnosis, even in the absence of overt myoglobinuria.

For more details on the case not included in the abstract, visit

http://www.spiralnotebook.org/samedifference/index.html

>

> In a message dated 10/21/2004 1:22:04 PM Eastern Standard Time,

> wheatchild@n... writes:

>

> Dr. Ingrid Tein has suggested that episodes of metabolic

> decompensation may put patients at risk for developing

pancretitis.

> I believe pancretitis has also been reported in OXPHOS disorders,

> but I cannot recall a particular case right now.

>

>

>

>

> Hi Barbara,

> Has Dr Tein published anything on this? This is the first time I

have heard

> this.

> Thanks.

> Malisa

>

>

>

[Guest guest]

In a message dated 10/21/2004 4:36:38 PM Eastern Standard Time,

wheatchild@... writes:

Yes. Here is one case pasted below.

Thank you, Barbara!

Malisa